Reviewed, UniProtKB/Swiss-Prot Q8NC06 (ACBD4_HUMAN)

Names and origin

Protein names

Recommended name:
    Acyl-CoA-binding domain-containing protein 4

Gene names

Name:	ACBD4
ORF Names:	HMFT0700

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	268 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Sequence similarities

Contains 1 ACB (acyl-CoA-binding) domain.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Molecular function	acyl-CoA binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8NC06-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8NC06-2)

The sequence of this isoform differs from the canonical sequence as follows:
     192-268: SSGQHLEESV...SSLTLSVRLE → VWTEQRAASG...LFRMFRTQKR

Isoform 3 (identifier: Q8NC06-3)

The sequence of this isoform differs from the canonical sequence as follows:
     168-191: ESHSPRDLDSEVFCDSLEQLEPEL → ASLWAVTLPTPPQSPIHPGTWTPRFSVIPWSSWSLSWFGQ
     260-268: SLTLSVRLE → RGRSPGPVLGHGPLGSRGPRCSSSSCGPSSSSGSSECFGPKRGDCQWRGLCSQLRLSCCALSLPRV

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 268	268	Acyl-CoA-binding domain-containing protein 4		PRO_0000214032
Regions
	Domain	12 – 101	90	ACB
Natural variations
	Alternative sequence	168 – 191	24	ESHSP…LEPEL → ASLWAVTLPTPPQSPIHPGT WTPRFSVIPWSSWSLSWFGQ in isoform 3.		VSP_014088
	Alternative sequence	192 – 268	77	SSGQH…SVRLE → VWTEQRAASGGKRDPRNSPV PPTKKEGLRGSPPGPQELDV WLLGTVRALQESMQEVQARV QSLESMPRPPEQRPQPRPSA RPWPLGLPGPALLFFLLWPF VVQWLFRMFRTQKR in isoform 2.		VSP_014089
	Alternative sequence	260 – 268	9	SLTLSVRLE → RGRSPGPVLGHGPLGSRGPR CSSSSCGPSSSSGSSECFGP KRGDCQWRGLCSQLRLSCCA LSLPRV in isoform 3.		VSP_014090
	Natural variant	118	1	P → L: dbSNP rs901754.		VAR_055478
	Natural variant	242	1	R → G: dbSNP rs16939879.		VAR_059109
Experimental info
	Sequence conflict	166	1	S → G in BAC11403. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 7, 2005. Version 2. Checksum: 0F337D89924CDE2E	FASTA	268	30,308
	10 20 30 40 50 60 MGTEKESPEP DCQKQFQAAV SVIQNLPKNG SYRPSYEEML RFYSYYKQAT MGPCLVPRPG 70 80 90 100 110 120 FWDPIGRYKW DAWNSLGKMS REEAMSAYIT EMKLVAQKVI DTVPLGEVAE DMFGYFEPLY 130 140 150 160 170 180 QVIPDMPRPP ETFLRRVTGW KEQVVNGDVG AVSEPPCLPK EPAPPSPESH SPRDLDSEVF 190 200 210 220 230 240 CDSLEQLEPE LSSGQHLEES VIPGTAPCPP QRKRGCGAAR RGPRSWTCGC WGQFEHYRRA 250 260 CRRCRRGCRA WRACPGPLSS LTLSVRLE
	Isoform 2. Checksum: 1EB97FF94E682547	FASTA	305	34,756
	10 20 30 40 50 60 MGTEKESPEP DCQKQFQAAV SVIQNLPKNG SYRPSYEEML RFYSYYKQAT MGPCLVPRPG 70 80 90 100 110 120 FWDPIGRYKW DAWNSLGKMS REEAMSAYIT EMKLVAQKVI DTVPLGEVAE DMFGYFEPLY 130 140 150 160 170 180 QVIPDMPRPP ETFLRRVTGW KEQVVNGDVG AVSEPPCLPK EPAPPSPESH SPRDLDSEVF 190 200 210 220 230 240 CDSLEQLEPE LVWTEQRAAS GGKRDPRNSP VPPTKKEGLR GSPPGPQELD VWLLGTVRAL 250 260 270 280 290 300 QESMQEVQAR VQSLESMPRP PEQRPQPRPS ARPWPLGLPG PALLFFLLWP FVVQWLFRMF RTQKR
	Isoform 3. Checksum: EFF98088514D8F23	FASTA	341	37,786
	10 20 30 40 50 60 MGTEKESPEP DCQKQFQAAV SVIQNLPKNG SYRPSYEEML RFYSYYKQAT MGPCLVPRPG 70 80 90 100 110 120 FWDPIGRYKW DAWNSLGKMS REEAMSAYIT EMKLVAQKVI DTVPLGEVAE DMFGYFEPLY 130 140 150 160 170 180 QVIPDMPRPP ETFLRRVTGW KEQVVNGDVG AVSEPPCLPK EPAPPSPASL WAVTLPTPPQ 190 200 210 220 230 240 SPIHPGTWTP RFSVIPWSSW SLSWFGQSSG QHLEESVIPG TAPCPPQRKR GCGAARRGPR 250 260 270 280 290 300 SWTCGCWGQF EHYRRACRRC RRGCRAWRAC PGPLSRGRSP GPVLGHGPLG SRGPRCSSSS 310 320 330 340 CGPSSSSGSS ECFGPKRGDC QWRGLCSQLR LSCCALSLPR V

References

[1]	"Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas." Yamada S., Ohira M., Horie H., Ando K., Takayasu H., Suzuki Y., Sugano S., Hirata T., Goto T., Matsunaga T., Hiyama E., Hayashi Y., Ando H., Suita S., Kaneko M., Sasaki F., Hashizume K., Ohnuma N., Nakagawara A. Oncogene 23:5901-5911(2004) [PubMed: 15221005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Hepatoblastoma.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Ovary and Placenta.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3). Tissue: Brain and Colon.

Cross-references

Sequence databases

EMBLGenBankDDBJ

AB073387 mRNA. Translation: BAD38638.1.
AK023384 mRNA. Translation: BAB14553.1.
AK075104 mRNA. Translation: BAC11403.1.
BC029164 mRNA. Translation: AAH29164.1.
BC041143 mRNA. Translation: AAH41143.1.

IPI

IPI00216847.
IPI00419689.
IPI00604619.

RefSeq

NP_001129176.1.
NP_001129177.1.
NP_001129178.1.
NP_001129179.1.
NP_078998.1.

UniGene

Hs.110298

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2WH5	X-ray	2.60	A/B/C/D/E/F	7-110	[»]

ModBase

Search...

Proteomic databases

PRIDE

Q8NC06.

Genome annotation databases

Ensembl

ENST00000376955; ENSP00000366154; ENSG00000181513; Homo sapiens. [Genome view]

GeneID

79777.

KEGG

hsa:79777.

UCSC

uc002iic.1. human.
uc002iid.1. human.
uc002iie.1. human.

Organism-specific databases

CTD

79777.

GeneCards

GC17P040565.

HGNC

HGNC:23337. ACBD4.

PharmGKB

PA134897893.

GenAtlas

Search...

Phylogenomic databases

HOVERGEN

Q8NC06.

OMA

GSSDSFG

Gene expression databases

ArrayExpress

Q8NC06.

Bgee

Q8NC06.

CleanEx

HS_ACBD4.

Genevestigator

Q8NC06.

GermOnline

ENSG00000181513. Homo sapiens.

Family and domain databases

InterPro

IPR000582. Acyl-CoA-binding_protein.
IPR014352. FERM/acyl-CoA_bd_prot_3-hlx.
[Graphical view]

Gene3D

G3DSA:1.20.80.10. ACBP. 1 hit.

PANTHER

PTHR23310. ACBP. 1 hit.

Pfam

PF00887. ACBP. 1 hit.
[Graphical view]

PRINTS

PR00689. ACOABINDINGP.

PROSITE

PS00880. ACB_1. 1 hit.
PS51228. ACB_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

69267.

Entry information

Entry name

ACBD4_HUMAN

Accession

Primary (citable) accession number: Q8NC06
Secondary accession number(s): Q8IUT1, Q9H8Q4

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 7, 2005
Last sequence update:	June 7, 2005
Last modified:	November 24, 2009
This is version 57 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.