Q8NC06 (ACBD4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acyl-CoA-binding domain-containing protein 4

Gene names

Name:	ACBD4
ORF Names:	HMFT0700

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	268 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds medium- and long-chain acyl-CoA esters and may function as an intracellular carrier of acyl-CoA esters.
Sequence similarities	Contains 1 ACB (acyl-CoA-binding) domain.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	Lipid-binding
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	fatty-acyl-CoA binding Inferred from electronic annotation. Source: InterPro lipid binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8NC06-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8NC06-2)

The sequence of this isoform differs from the canonical sequence as follows:
     192-268: SSGQHLEESV...SSLTLSVRLE → VWTEQRAASG...LFRMFRTQKR

Isoform 3 (identifier: Q8NC06-3)

The sequence of this isoform differs from the canonical sequence as follows:
     168-191: ESHSPRDLDSEVFCDSLEQLEPEL → ASLWAVTLPTPPQSPIHPGTWTPRFSVIPWSSWSLSWFGQ
     260-268: SLTLSVRLE → RGRSPGPVLGHGPLGSRGPRCSSSSCGPSSSSGSSECFGPKRGDCQWRGLCSQLRLSCCALSLPRV

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 268

268

Acyl-CoA-binding domain-containing protein 4

PRO_0000214032

Regions

Domain

12 – 101

90

ACB

Region

23 – 32

10

Acyl-CoA binding

Region

43 – 47

5

Acyl-CoA binding

Sites

Binding site

69

1

Acyl-CoA

Binding site

88

1

Acyl-CoA

Natural variations

Alternative sequence

168 – 191

24

ESHSP…LEPEL → ASLWAVTLPTPPQSPIHPGT WTPRFSVIPWSSWSLSWFGQ in isoform 3.

VSP_014088

Alternative sequence

192 – 268

77

SSGQH…SVRLE → VWTEQRAASGGKRDPRNSPV PPTKKEGLRGSPPGPQELDV WLLGTVRALQESMQEVQARV QSLESMPRPPEQRPQPRPSA RPWPLGLPGPALLFFLLWPF VVQWLFRMFRTQKR in isoform 2.

VSP_014089

Alternative sequence

260 – 268

9

SLTLSVRLE → RGRSPGPVLGHGPLGSRGPR CSSSSCGPSSSSGSSECFGP KRGDCQWRGLCSQLRLSCCA LSLPRV in isoform 3.

VSP_014090

Natural variant

118

1

P → L.
Corresponds to variant rs901754 [ dbSNP | Ensembl ].

VAR_055478

Natural variant

242

1

R → G.
Corresponds to variant rs16939879 [ dbSNP | Ensembl ].

VAR_059109

Experimental info

Sequence conflict

166

1

S → G in BAC11403. Ref.2

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

268

Helix Strand Turn

Details...

Helix

14 – 25

12

Helix

36 – 51

16

Helix

64 – 74

11

Turn

75 – 78

4

Helix

81 – 100

20

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 7, 2005. Version 2. Checksum: 0F337D89924CDE2E	FASTA	268	30,308
	10 20 30 40 50 60 MGTEKESPEP DCQKQFQAAV SVIQNLPKNG SYRPSYEEML RFYSYYKQAT MGPCLVPRPG 70 80 90 100 110 120 FWDPIGRYKW DAWNSLGKMS REEAMSAYIT EMKLVAQKVI DTVPLGEVAE DMFGYFEPLY 130 140 150 160 170 180 QVIPDMPRPP ETFLRRVTGW KEQVVNGDVG AVSEPPCLPK EPAPPSPESH SPRDLDSEVF 190 200 210 220 230 240 CDSLEQLEPE LSSGQHLEES VIPGTAPCPP QRKRGCGAAR RGPRSWTCGC WGQFEHYRRA 250 260 CRRCRRGCRA WRACPGPLSS LTLSVRLE
	Isoform 2 [UniParc]. Checksum: 1EB97FF94E682547	FASTA	305	34,756
	10 20 30 40 50 60 MGTEKESPEP DCQKQFQAAV SVIQNLPKNG SYRPSYEEML RFYSYYKQAT MGPCLVPRPG 70 80 90 100 110 120 FWDPIGRYKW DAWNSLGKMS REEAMSAYIT EMKLVAQKVI DTVPLGEVAE DMFGYFEPLY 130 140 150 160 170 180 QVIPDMPRPP ETFLRRVTGW KEQVVNGDVG AVSEPPCLPK EPAPPSPESH SPRDLDSEVF 190 200 210 220 230 240 CDSLEQLEPE LVWTEQRAAS GGKRDPRNSP VPPTKKEGLR GSPPGPQELD VWLLGTVRAL 250 260 270 280 290 300 QESMQEVQAR VQSLESMPRP PEQRPQPRPS ARPWPLGLPG PALLFFLLWP FVVQWLFRMF RTQKR
	Isoform 3 [UniParc]. Checksum: EFF98088514D8F23	FASTA	341	37,786
	10 20 30 40 50 60 MGTEKESPEP DCQKQFQAAV SVIQNLPKNG SYRPSYEEML RFYSYYKQAT MGPCLVPRPG 70 80 90 100 110 120 FWDPIGRYKW DAWNSLGKMS REEAMSAYIT EMKLVAQKVI DTVPLGEVAE DMFGYFEPLY 130 140 150 160 170 180 QVIPDMPRPP ETFLRRVTGW KEQVVNGDVG AVSEPPCLPK EPAPPSPASL WAVTLPTPPQ 190 200 210 220 230 240 SPIHPGTWTP RFSVIPWSSW SLSWFGQSSG QHLEESVIPG TAPCPPQRKR GCGAARRGPR 250 260 270 280 290 300 SWTCGCWGQF EHYRRACRRC RRGCRAWRAC PGPLSRGRSP GPVLGHGPLG SRGPRCSSSS 310 320 330 340 CGPSSSSGSS ECFGPKRGDC QWRGLCSQLR LSCCALSLPR V

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas." Yamada S., Ohira M., Horie H., Ando K., Takayasu H., Suzuki Y., Sugano S., Hirata T., Goto T., Matsunaga T., Hiyama E., Hayashi Y., Ando H., Suita S., Kaneko M., Sasaki F., Hashizume K., Ohnuma N., Nakagawara A. Oncogene 23:5901-5911(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Hepatoblastoma.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Ovary and Placenta.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3). Tissue: Brain and Colon.
[5]	"Crystal structure of human acyl-CoA binding domain 4." Structural genomics consortium (SGC) Submitted (APR-2009) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) OF 7-110 IN COMPLEX WITH STEAROYL-COENZYME A.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AB073387 mRNA. Translation: BAD38638.1.
AK023384 mRNA. Translation: BAB14553.1.
AK075104 mRNA. Translation: BAC11403.1.
CH471178 Genomic DNA. Translation: EAW51550.1.
CH471178 Genomic DNA. Translation: EAW51551.1.
CH471178 Genomic DNA. Translation: EAW51552.1.
BC029164 mRNA. Translation: AAH29164.1.
BC041143 mRNA. Translation: AAH41143.1.

IPI

IPI00216847.
IPI00419689.
IPI00604619.

RefSeq

NP_001129176.1. NM_001135704.1.
NP_001129177.1. NM_001135705.1.
NP_001129178.1. NM_001135706.1.
NP_001129179.1. NM_001135707.1.
NP_078998.1. NM_024722.2.

UniGene

Hs.110298.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2WH5	X-ray	2.60	A/B/C/D/E/F	7-110	[»]

ProteinModelPortal

Q8NC06.

ModBase

Search...

Protein-protein interaction databases

STRING

9606.ENSP00000314440.

PTM databases

PhosphoSite

Q8NC06.

Polymorphism databases

DMDM

67460567.

Proteomic databases

PaxDb

Q8NC06.

PRIDE

Q8NC06.

Protocols and materials databases

DNASU

79777.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000321854; ENSP00000314440; ENSG00000181513.
ENST00000376955; ENSP00000366154; ENSG00000181513.
ENST00000398322; ENSP00000381367; ENSG00000181513.
ENST00000431281; ENSP00000405969; ENSG00000181513.
ENST00000586346; ENSP00000465484; ENSG00000181513.
ENST00000591859; ENSP00000465610; ENSG00000181513.

GeneID

79777.

KEGG

hsa:79777.

UCSC

uc002iic.3. human.
uc002iid.2. human.
uc002iie.3. human.

Organism-specific databases

CTD

79777.

GeneCards

GC17P043209.

HGNC

HGNC:23337. ACBD4.

HPA

HPA051772.

neXtProt

NX_Q8NC06.

PharmGKB

PA134897893.

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG4281.

HOGENOM

HOG000231479.

HOVERGEN

HBG028530.

OMA

IPWSSWS.

Gene expression databases

Bgee

Q8NC06.

CleanEx

HS_ACBD4.

Genevestigator

Q8NC06.

GermOnline

ENSG00000181513. Homo sapiens.

Family and domain databases

Gene3D

1.20.80.10. 1 hit.

InterPro

IPR022408. Acyl-CoA-binding_prot_CS.
IPR000582. Acyl-CoA-binding_protein.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
[Graphical view]

Pfam

PF00887. ACBP. 1 hit.
[Graphical view]

PRINTS

PR00689. ACOABINDINGP.

SUPFAM

SSF47027. ACBP. 1 hit.

PROSITE

PS00880. ACB_1. 1 hit.
PS51228. ACB_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q8NC06.

GenomeRNAi

79777.

NextBio

69267.

Entry information

Entry name

ACBD4_HUMAN

Accession

Primary (citable) accession number: Q8NC06
Secondary accession number(s): D3DX64, Q8IUT1, Q9H8Q4

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 7, 2005
Last sequence update:	June 7, 2005
Last modified:	May 1, 2013
This is version 84 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.