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Protein

C-type lectin domain family 1 member A

Gene

CLEC1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • carbohydrate binding Source: UniProtKB-KW
  • transmembrane signaling receptor activity Source: ProtInc

GO - Biological processi

  • cell surface receptor signaling pathway Source: ProtInc
  • defense response Source: ProtInc
Complete GO annotation...

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
C-type lectin domain family 1 member A
Alternative name(s):
C-type lectin-like receptor 1
Short name:
CLEC-1
Gene namesi
Name:CLEC1A
Synonyms:CLEC1
ORF Names:UNQ569/PRO1131
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:24355. CLEC1A.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 52CytoplasmicSequence analysisAdd BLAST52
Transmembranei53 – 73Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini74 – 280ExtracellularSequence analysisAdd BLAST207

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • intracellular Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000150048.
PharmGKBiPA142672097.

Polymorphism and mutation databases

BioMutaiCLEC1A.
DMDMi116241301.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000466091 – 280C-type lectin domain family 1 member AAdd BLAST280

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi95N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi165 ↔ 257PROSITE-ProRule annotation
Glycosylationi169N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi236 ↔ 249PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NC01.
PeptideAtlasiQ8NC01.
PRIDEiQ8NC01.

PTM databases

PhosphoSitePlusiQ8NC01.

Expressioni

Tissue specificityi

Expressed preferentially in dendritic cells.1 Publication

Gene expression databases

BgeeiENSG00000150048.
CleanExiHS_CLEC1A.
ExpressionAtlasiQ8NC01. baseline and differential.
GenevisibleiQ8NC01. HS.

Organism-specific databases

HPAiHPA056307.
HPA061929.

Interactioni

Protein-protein interaction databases

BioGridi119421. 1 interactor.
IntActiQ8NC01. 2 interactors.
STRINGi9606.ENSP00000326407.

Structurei

3D structure databases

ProteinModelPortaliQ8NC01.
SMRiQ8NC01.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini144 – 258C-type lectinPROSITE-ProRule annotationAdd BLAST115

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00700000104266.
HOGENOMiHOG000111777.
HOVERGENiHBG103475.
InParanoidiQ8NC01.
KOiK10069.
OMAiFQFYQLS.
OrthoDBiEOG091G0K57.
PhylomeDBiQ8NC01.
TreeFamiTF336674.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR016187. CTDL_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NC01-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQAKYSSTRD MLDDDGDTTM SLHSQGSATT RHPEPRRTEH RAPSSTWRPV
60 70 80 90 100
ALTLLTLCLV LLIGLAALGL LFFQYYQLSN TGQDTISQME ERLGNTSQEL
110 120 130 140 150
QSLQVQNIKL AGSLQHVAEK LCRELYNKAG AHRCSPCTEQ WKWHGDNCYQ
160 170 180 190 200
FYKDSKSWED CKYFCLSENS TMLKINKQED LEFAASQSYS EFFYSYWTGL
210 220 230 240 250
LRPDSGKAWL WMDGTPFTSE LFHIIIDVTS PRSRDCVAIL NGMIFSKDCK
260 270 280
ELKRCVCERR AGMVKPESLH VPPETLGEGD
Length:280
Mass (Da):31,952
Last modified:October 17, 2006 - v2
Checksum:i138235ED47553F4B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti68L → W in AAF36830 (PubMed:10671229).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05010626G → A.4 PublicationsCorresponds to variant rs2306894dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF200949 mRNA. Translation: AAF36830.1.
AY358587 mRNA. Translation: AAQ88950.1.
AK075114 mRNA. Translation: BAC11410.1.
BC039072 mRNA. Translation: AAH39072.1.
BC067746 mRNA. Translation: AAH67746.1.
CCDSiCCDS8612.1.
RefSeqiNP_001284677.1. NM_001297748.1.
NP_001284678.1. NM_001297749.1.
NP_001284679.1. NM_001297750.1.
NP_001284680.1. NM_001297751.1.
NP_057595.2. NM_016511.3.
UniGeneiHs.29549.

Genome annotation databases

EnsembliENST00000315330; ENSP00000326407; ENSG00000150048.
GeneIDi51267.
KEGGihsa:51267.
UCSCiuc001qxb.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF200949 mRNA. Translation: AAF36830.1.
AY358587 mRNA. Translation: AAQ88950.1.
AK075114 mRNA. Translation: BAC11410.1.
BC039072 mRNA. Translation: AAH39072.1.
BC067746 mRNA. Translation: AAH67746.1.
CCDSiCCDS8612.1.
RefSeqiNP_001284677.1. NM_001297748.1.
NP_001284678.1. NM_001297749.1.
NP_001284679.1. NM_001297750.1.
NP_001284680.1. NM_001297751.1.
NP_057595.2. NM_016511.3.
UniGeneiHs.29549.

3D structure databases

ProteinModelPortaliQ8NC01.
SMRiQ8NC01.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119421. 1 interactor.
IntActiQ8NC01. 2 interactors.
STRINGi9606.ENSP00000326407.

PTM databases

PhosphoSitePlusiQ8NC01.

Polymorphism and mutation databases

BioMutaiCLEC1A.
DMDMi116241301.

Proteomic databases

PaxDbiQ8NC01.
PeptideAtlasiQ8NC01.
PRIDEiQ8NC01.

Protocols and materials databases

DNASUi51267.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000315330; ENSP00000326407; ENSG00000150048.
GeneIDi51267.
KEGGihsa:51267.
UCSCiuc001qxb.4. human.

Organism-specific databases

CTDi51267.
GeneCardsiCLEC1A.
HGNCiHGNC:24355. CLEC1A.
HPAiHPA056307.
HPA061929.
MIMi606782. gene.
neXtProtiNX_Q8NC01.
OpenTargetsiENSG00000150048.
PharmGKBiPA142672097.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00700000104266.
HOGENOMiHOG000111777.
HOVERGENiHBG103475.
InParanoidiQ8NC01.
KOiK10069.
OMAiFQFYQLS.
OrthoDBiEOG091G0K57.
PhylomeDBiQ8NC01.
TreeFamiTF336674.

Miscellaneous databases

ChiTaRSiCLEC1A. human.
GeneWikiiCLEC1A.
GenomeRNAii51267.
PROiQ8NC01.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000150048.
CleanExiHS_CLEC1A.
ExpressionAtlasiQ8NC01. baseline and differential.
GenevisibleiQ8NC01. HS.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR016187. CTDL_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCLC1A_HUMAN
AccessioniPrimary (citable) accession number: Q8NC01
Secondary accession number(s): Q8IUW7, Q9NZH3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: October 17, 2006
Last modified: November 30, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.