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Q8NBZ7 (UXS1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UDP-glucuronic acid decarboxylase 1

EC=4.1.1.35
Alternative name(s):
UDP-glucuronate decarboxylase 1
Short name=UGD
Short name=UXS-1
Gene names
Name:UXS1
ORF Names:UNQ2538/PRO6079
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length420 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose. Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis.

Catalytic activity

UDP-D-glucuronate = UDP-D-xylose + CO2.

Cofactor

NAD.

Pathway

Nucleotide-sugar biosynthesis; UDP-alpha-D-xylose biosynthesis; UDP-alpha-D-xylose from UDP-alpha-D-glucuronate: step 1/1.

Subunit structure

Interacts with AKT1 By similarity.

Subcellular location

Golgi apparatusGolgi stack membrane; Single-pass type II membrane protein By similarity.

Sequence similarities

Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8NBZ7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8NBZ7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     40-40: M → MSFLLN
Isoform 3 (identifier: Q8NBZ7-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-168: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 420420UDP-glucuronic acid decarboxylase 1
PRO_0000183269

Regions

Topological domain1 – 1919Cytoplasmic Potential
Transmembrane20 – 4021Helical; Signal-anchor for type II membrane protein; Potential
Topological domain41 – 420380Lumenal Potential
Nucleotide binding119 – 14426NAD
Nucleotide binding231 – 2355NAD
Nucleotide binding273 – 2775Substrate
Nucleotide binding290 – 2978Substrate
Nucleotide binding357 – 3615Substrate

Sites

Active site2311Proton acceptor By similarity
Binding site2281Substrate
Binding site2601Substrate
Binding site2721NAD

Amino acid modifications

Modified residue941Phosphothreonine Ref.6
Modified residue1021Phosphoserine Ref.6
Modified residue1051Phosphothreonine Ref.6
Glycosylation3161N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence1 – 168168Missing in isoform 3.
VSP_016756
Alternative sequence401M → MSFLLN in isoform 2.
VSP_016757

Secondary structure

.................................................... 420
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: FD7DC0E1B1D02157

FASTA42047,577
        10         20         30         40         50         60 
MVSKALLRLV SAVNRRRMKL LLGIALLAYV ASVWGNFVNM RSIQENGELK IESKIEEMVE 

        70         80         90        100        110        120 
PLREKIRDLE KSFTQKYPPV KFLSEKDRKR ILITGGAGFV GSHLTDKLMM DGHEVTVVDN 

       130        140        150        160        170        180 
FFTGRKRNVE HWIGHENFEL INHDVVEPLY IEVDQIYHLA SPASPPNYMY NPIKTLKTNT 

       190        200        210        220        230        240 
IGTLNMLGLA KRVGARLLLA STSEVYGDPE VHPQSEDYWG HVNPIGPRAC YDEGKRVAET 

       250        260        270        280        290        300 
MCYAYMKQEG VEVRVARIFN TFGPRMHMND GRVVSNFILQ ALQGEPLTVY GSGSQTRAFQ 

       310        320        330        340        350        360 
YVSDLVNGLV ALMNSNVSSP VNLGNPEEHT ILEFAQLIKN LVGSGSEIQF LSEAQDDPQK 

       370        380        390        400        410        420 
RKPDIKKAKL MLGWEPVVPL EEGLNKAIHY FRKELEYQAN NQYIPKPKPA RIKKGRTRHS 

« Hide

Isoform 2 [UniParc].

Checksum: 155C013E0C58C159
Show »

FASTA42548,151
Isoform 3 [UniParc].

Checksum: A4A1687AED8AF62D
Show »

FASTA25228,275

References

« Hide 'large scale' references
[1]"The SQV-1 UDP-glucuronic acid decarboxylase and the SQV-7 nucleotide-sugar transporter may act in the Golgi apparatus to affect Caenorhabditis elegans vulval morphogenesis and embryonic development."
Hwang H.-Y., Horvitz H.R.
Proc. Natl. Acad. Sci. U.S.A. 99:14218-14223(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING.
[2]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
Tissue: Placenta.
[4]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Placenta.
[6]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-94; SER-102 AND THR-105, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[7]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[8]"Crystal structure of human UDP-glucoronic acid decarboxylase."
Structural genomics consortium (SGC)
Submitted (OCT-2005) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (1.21 ANGSTROMS) OF 85-402 IN COMPLEX WITH NAD AND UDP.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY147934 mRNA. Translation: AAN39844.1.
AY358541 mRNA. Translation: AAQ88905.1.
AK027244 mRNA. Translation: BAB15705.1.
AK075120 mRNA. Translation: BAC11415.1.
AK075170 mRNA. Translation: BAC11448.1.
AC018878 Genomic DNA. Translation: AAY15085.1.
BC009819 mRNA. Translation: AAH09819.2.
CCDSCCDS46378.1. [Q8NBZ7-1]
CCDS58720.1. [Q8NBZ7-3]
CCDS58721.1. [Q8NBZ7-2]
RefSeqNP_001240804.1. NM_001253875.1. [Q8NBZ7-2]
NP_001240805.1. NM_001253876.1. [Q8NBZ7-3]
NP_079352.2. NM_025076.4. [Q8NBZ7-1]
UniGeneHs.469561.
Hs.743389.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2B69X-ray1.21A85-402[»]
4GLLX-ray2.50A/B85-420[»]
4LK3X-ray2.64A/B/C/D/E/F85-420[»]
4M55X-ray2.86A/B/C/D/E/F85-420[»]
ProteinModelPortalQ8NBZ7.
SMRQ8NBZ7. Positions 88-399.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid123139. 1 interaction.
IntActQ8NBZ7. 1 interaction.
STRING9606.ENSP00000387019.

PTM databases

PhosphoSiteQ8NBZ7.

Polymorphism databases

DMDM74730150.

Proteomic databases

MaxQBQ8NBZ7.
PaxDbQ8NBZ7.
PRIDEQ8NBZ7.

Protocols and materials databases

DNASU80146.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000283148; ENSP00000283148; ENSG00000115652. [Q8NBZ7-2]
ENST00000409032; ENSP00000387096; ENSG00000115652. [Q8NBZ7-3]
ENST00000409501; ENSP00000387019; ENSG00000115652. [Q8NBZ7-1]
GeneID80146.
KEGGhsa:80146.
UCSCuc002tdl.3. human. [Q8NBZ7-1]
uc002tdn.3. human. [Q8NBZ7-2]

Organism-specific databases

CTD80146.
GeneCardsGC02M106709.
H-InvDBHIX0030285.
HGNCHGNC:17729. UXS1.
HPAHPA008825.
MIM609749. gene.
neXtProtNX_Q8NBZ7.
PharmGKBPA38465.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0451.
HOGENOMHOG000168004.
HOVERGENHBG094144.
KOK08678.
OMAEMVEPLR.
OrthoDBEOG73FQMK.
PhylomeDBQ8NBZ7.
TreeFamTF105736.

Enzyme and pathway databases

UniPathwayUPA00796; UER00771.

Gene expression databases

ArrayExpressQ8NBZ7.
BgeeQ8NBZ7.
CleanExHS_UXS1.
GenevestigatorQ8NBZ7.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR001509. Epimerase_deHydtase.
IPR016040. NAD(P)-bd_dom.
IPR021761. UXS1_N.
[Graphical view]
PfamPF01370. Epimerase. 1 hit.
PF11803. UXS1_N. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ8NBZ7.
GeneWikiUXS1.
GenomeRNAi80146.
NextBio70422.
PROQ8NBZ7.
SOURCESearch...

Entry information

Entry nameUXS1_HUMAN
AccessionPrimary (citable) accession number: Q8NBZ7
Secondary accession number(s): Q8NBX3, Q9H5C2
Entry history
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

PATHWAY comments

Index of metabolic and biosynthesis pathways

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM