SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8NBZ7

- UXS1_HUMAN

UniProt

Q8NBZ7 - UXS1_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

UDP-glucuronic acid decarboxylase 1

Gene
UXS1, UNQ2538/PRO6079
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose. Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis.

Catalytic activityi

UDP-D-glucuronate = UDP-D-xylose + CO2.

Cofactori

NAD.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei228 – 2281Substrate
Active sitei231 – 2311Proton acceptor By similarity
Binding sitei260 – 2601Substrate
Binding sitei272 – 2721NAD

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi119 – 14426NADAdd
BLAST
Nucleotide bindingi231 – 2355NAD
Nucleotide bindingi273 – 2775Substrate
Nucleotide bindingi290 – 2978Substrate
Nucleotide bindingi357 – 3615Substrate

GO - Molecular functioni

  1. NAD+ binding Source: UniProt
  2. protein homodimerization activity Source: UniProt
  3. UDP-glucuronate decarboxylase activity Source: UniProt

GO - Biological processi

  1. protein tetramerization Source: UniProt
  2. UDP-D-xylose biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Ligandi

NAD

Enzyme and pathway databases

UniPathwayiUPA00796; UER00771.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronic acid decarboxylase 1 (EC:4.1.1.35)
Alternative name(s):
UDP-glucuronate decarboxylase 1
Short name:
UGD
Short name:
UXS-1
Gene namesi
Name:UXS1
ORF Names:UNQ2538/PRO6079
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:17729. UXS1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1919Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei20 – 4021Helical; Signal-anchor for type II membrane protein; Reviewed predictionAdd
BLAST
Topological domaini41 – 420380Lumenal Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. Golgi cisterna membrane Source: UniProtKB-SubCell
  3. integral component of membrane Source: UniProtKB-KW
  4. mitochondrion Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38465.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 420420UDP-glucuronic acid decarboxylase 1PRO_0000183269Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei94 – 941Phosphothreonine1 Publication
Modified residuei102 – 1021Phosphoserine1 Publication
Modified residuei105 – 1051Phosphothreonine1 Publication
Glycosylationi316 – 3161N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ8NBZ7.
PaxDbiQ8NBZ7.
PRIDEiQ8NBZ7.

PTM databases

PhosphoSiteiQ8NBZ7.

Expressioni

Gene expression databases

ArrayExpressiQ8NBZ7.
BgeeiQ8NBZ7.
CleanExiHS_UXS1.
GenevestigatoriQ8NBZ7.

Organism-specific databases

HPAiHPA008825.

Interactioni

Subunit structurei

Interacts with AKT1 By similarity.

Protein-protein interaction databases

BioGridi123139. 1 interaction.
IntActiQ8NBZ7. 1 interaction.
STRINGi9606.ENSP00000387019.

Structurei

Secondary structure

1
420
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi90 – 945
Turni95 – 973
Helixi99 – 11012
Beta strandi114 – 1196
Beta strandi122 – 1243
Helixi126 – 1283
Helixi130 – 1323
Beta strandi138 – 1425
Beta strandi154 – 1585
Helixi165 – 1684
Helixi172 – 19322
Beta strandi196 – 2027
Helixi203 – 2064
Beta strandi210 – 2145
Beta strandi224 – 2263
Helixi229 – 24921
Beta strandi253 – 2586
Helixi273 – 28311
Beta strandi287 – 2937
Beta strandi296 – 2983
Helixi302 – 31312
Beta strandi321 – 3244
Beta strandi328 – 3303
Helixi331 – 34212
Beta strandi348 – 3514
Helixi366 – 3727
Helixi380 – 39819

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2B69X-ray1.21A85-402[»]
4GLLX-ray2.50A/B85-420[»]
4LK3X-ray2.64A/B/C/D/E/F85-420[»]
4M55X-ray2.86A/B/C/D/E/F85-420[»]
ProteinModelPortaliQ8NBZ7.
SMRiQ8NBZ7. Positions 88-399.

Miscellaneous databases

EvolutionaryTraceiQ8NBZ7.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0451.
HOGENOMiHOG000168004.
HOVERGENiHBG094144.
KOiK08678.
OMAiEMVEPLR.
OrthoDBiEOG73FQMK.
PhylomeDBiQ8NBZ7.
TreeFamiTF105736.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR001509. Epimerase_deHydtase.
IPR016040. NAD(P)-bd_dom.
IPR021761. UXS1_N.
[Graphical view]
PfamiPF01370. Epimerase. 1 hit.
PF11803. UXS1_N. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8NBZ7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MVSKALLRLV SAVNRRRMKL LLGIALLAYV ASVWGNFVNM RSIQENGELK    50
IESKIEEMVE PLREKIRDLE KSFTQKYPPV KFLSEKDRKR ILITGGAGFV 100
GSHLTDKLMM DGHEVTVVDN FFTGRKRNVE HWIGHENFEL INHDVVEPLY 150
IEVDQIYHLA SPASPPNYMY NPIKTLKTNT IGTLNMLGLA KRVGARLLLA 200
STSEVYGDPE VHPQSEDYWG HVNPIGPRAC YDEGKRVAET MCYAYMKQEG 250
VEVRVARIFN TFGPRMHMND GRVVSNFILQ ALQGEPLTVY GSGSQTRAFQ 300
YVSDLVNGLV ALMNSNVSSP VNLGNPEEHT ILEFAQLIKN LVGSGSEIQF 350
LSEAQDDPQK RKPDIKKAKL MLGWEPVVPL EEGLNKAIHY FRKELEYQAN 400
NQYIPKPKPA RIKKGRTRHS 420
Length:420
Mass (Da):47,577
Last modified:October 1, 2002 - v1
Checksum:iFD7DC0E1B1D02157
GO
Isoform 2 (identifier: Q8NBZ7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     40-40: M → MSFLLN

Show »
Length:425
Mass (Da):48,151
Checksum:i155C013E0C58C159
GO
Isoform 3 (identifier: Q8NBZ7-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-168: Missing.

Show »
Length:252
Mass (Da):28,275
Checksum:iA4A1687AED8AF62D
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 168168Missing in isoform 3. VSP_016756Add
BLAST
Alternative sequencei40 – 401M → MSFLLN in isoform 2. VSP_016757

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY147934 mRNA. Translation: AAN39844.1.
AY358541 mRNA. Translation: AAQ88905.1.
AK027244 mRNA. Translation: BAB15705.1.
AK075120 mRNA. Translation: BAC11415.1.
AK075170 mRNA. Translation: BAC11448.1.
AC018878 Genomic DNA. Translation: AAY15085.1.
BC009819 mRNA. Translation: AAH09819.2.
CCDSiCCDS46378.1. [Q8NBZ7-1]
CCDS58720.1. [Q8NBZ7-3]
CCDS58721.1. [Q8NBZ7-2]
RefSeqiNP_001240804.1. NM_001253875.1. [Q8NBZ7-2]
NP_001240805.1. NM_001253876.1. [Q8NBZ7-3]
NP_079352.2. NM_025076.4. [Q8NBZ7-1]
UniGeneiHs.469561.
Hs.743389.

Genome annotation databases

EnsembliENST00000283148; ENSP00000283148; ENSG00000115652. [Q8NBZ7-2]
ENST00000409032; ENSP00000387096; ENSG00000115652. [Q8NBZ7-3]
ENST00000409501; ENSP00000387019; ENSG00000115652. [Q8NBZ7-1]
GeneIDi80146.
KEGGihsa:80146.
UCSCiuc002tdl.3. human. [Q8NBZ7-1]
uc002tdn.3. human. [Q8NBZ7-2]

Polymorphism databases

DMDMi74730150.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY147934 mRNA. Translation: AAN39844.1 .
AY358541 mRNA. Translation: AAQ88905.1 .
AK027244 mRNA. Translation: BAB15705.1 .
AK075120 mRNA. Translation: BAC11415.1 .
AK075170 mRNA. Translation: BAC11448.1 .
AC018878 Genomic DNA. Translation: AAY15085.1 .
BC009819 mRNA. Translation: AAH09819.2 .
CCDSi CCDS46378.1. [Q8NBZ7-1 ]
CCDS58720.1. [Q8NBZ7-3 ]
CCDS58721.1. [Q8NBZ7-2 ]
RefSeqi NP_001240804.1. NM_001253875.1. [Q8NBZ7-2 ]
NP_001240805.1. NM_001253876.1. [Q8NBZ7-3 ]
NP_079352.2. NM_025076.4. [Q8NBZ7-1 ]
UniGenei Hs.469561.
Hs.743389.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2B69 X-ray 1.21 A 85-402 [» ]
4GLL X-ray 2.50 A/B 85-420 [» ]
4LK3 X-ray 2.64 A/B/C/D/E/F 85-420 [» ]
4M55 X-ray 2.86 A/B/C/D/E/F 85-420 [» ]
ProteinModelPortali Q8NBZ7.
SMRi Q8NBZ7. Positions 88-399.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 123139. 1 interaction.
IntActi Q8NBZ7. 1 interaction.
STRINGi 9606.ENSP00000387019.

PTM databases

PhosphoSitei Q8NBZ7.

Polymorphism databases

DMDMi 74730150.

Proteomic databases

MaxQBi Q8NBZ7.
PaxDbi Q8NBZ7.
PRIDEi Q8NBZ7.

Protocols and materials databases

DNASUi 80146.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000283148 ; ENSP00000283148 ; ENSG00000115652 . [Q8NBZ7-2 ]
ENST00000409032 ; ENSP00000387096 ; ENSG00000115652 . [Q8NBZ7-3 ]
ENST00000409501 ; ENSP00000387019 ; ENSG00000115652 . [Q8NBZ7-1 ]
GeneIDi 80146.
KEGGi hsa:80146.
UCSCi uc002tdl.3. human. [Q8NBZ7-1 ]
uc002tdn.3. human. [Q8NBZ7-2 ]

Organism-specific databases

CTDi 80146.
GeneCardsi GC02M106709.
H-InvDB HIX0030285.
HGNCi HGNC:17729. UXS1.
HPAi HPA008825.
MIMi 609749. gene.
neXtProti NX_Q8NBZ7.
PharmGKBi PA38465.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0451.
HOGENOMi HOG000168004.
HOVERGENi HBG094144.
KOi K08678.
OMAi EMVEPLR.
OrthoDBi EOG73FQMK.
PhylomeDBi Q8NBZ7.
TreeFami TF105736.

Enzyme and pathway databases

UniPathwayi UPA00796 ; UER00771 .

Miscellaneous databases

EvolutionaryTracei Q8NBZ7.
GeneWikii UXS1.
GenomeRNAii 80146.
NextBioi 70422.
PROi Q8NBZ7.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8NBZ7.
Bgeei Q8NBZ7.
CleanExi HS_UXS1.
Genevestigatori Q8NBZ7.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR001509. Epimerase_deHydtase.
IPR016040. NAD(P)-bd_dom.
IPR021761. UXS1_N.
[Graphical view ]
Pfami PF01370. Epimerase. 1 hit.
PF11803. UXS1_N. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The SQV-1 UDP-glucuronic acid decarboxylase and the SQV-7 nucleotide-sugar transporter may act in the Golgi apparatus to affect Caenorhabditis elegans vulval morphogenesis and embryonic development."
    Hwang H.-Y., Horvitz H.R.
    Proc. Natl. Acad. Sci. U.S.A. 99:14218-14223(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
    Tissue: Placenta.
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Placenta.
  6. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-94; SER-102 AND THR-105, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Crystal structure of human UDP-glucoronic acid decarboxylase."
    Structural genomics consortium (SGC)
    Submitted (OCT-2005) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.21 ANGSTROMS) OF 85-402 IN COMPLEX WITH NAD AND UDP.

Entry informationi

Entry nameiUXS1_HUMAN
AccessioniPrimary (citable) accession number: Q8NBZ7
Secondary accession number(s): Q8NBX3, Q9H5C2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi