Q8NBZ0 (IN80E_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
INO80 complex subunit E

Alternative name(s):
Coiled-coil domain-containing protein 95

Gene names

Name:	INO80E
Synonyms:	CCDC95

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	244 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.
Subunit structure	Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the N-terminus of INO80. Ref.3 Ref.4 Ref.5
Subcellular location	Nucleus Ref.4.

Ontologies

Keywords
Biological process	DNA damage DNA recombination DNA repair Transcription Transcription regulation
Cellular component	Nucleus
Domain	Coiled coil
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA recombination Inferred from electronic annotation. Source: UniProtKB-KW DNA repair Inferred from electronic annotation. Source: UniProtKB-KW DNA replication Inferred from electronic annotation. Source: InterPro regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	Ino80 complex Inferred from direct assay Ref.5. Source: UniProtKB nucleolus Inferred from direct assay. Source: HPA
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
UCHL5	Q9Y5K5	7	EBI-769401,EBI-1051183

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 244	244	INO80 complex subunit E		PRO_0000234292
Regions
	Coiled coil	10 – 54	45	Potential
	Compositional bias	91 – 211	121	Pro-rich

Sequences

	Sequence		Length	Mass (Da)
	Q8NBZ0 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: F329B39D0F3EB253	FASTA	244	26,478
	10 20 30 40 50 60 MNGPADGEVD YKKKYRNLKR KLKFLIYEHE CFQEELRKAQ RKLLKVSRDK SFLLDRLLQY 70 80 90 100 110 120 ENVDEDSSDS DATASSDNSE TEGTPKLSDT PAPKRKRSPP LGGAPSPSSL SLPPSTGFPL 130 140 150 160 170 180 QASGVPSPYL SSLASSRYPP FPSDYLALQL PEPSPLRPKR EKRPRLPRKL KMAVGPPDCP 190 200 210 220 230 240 VGGPLTFPGR GSGAGVGTTL TPLPPPKMPP PTILSTVPRQ MFSDAGSGDD ALDGDDDLVI DIPE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Uterus.
[3]	"A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex." Jin J., Cai Y., Yao T., Gottschalk A.J., Florens L., Swanson S.K., Gutierrez J.L., Coleman M.K., Workman J.L., Mushegian A., Washburn M.P., Conaway R.C., Conaway J.W. J. Biol. Chem. 280:41207-41212(2005) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION IN INO80 COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
[4]	"Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex." Yao T., Song L., Jin J., Cai Y., Takahashi H., Swanson S.K., Washburn M.P., Florens L., Conaway R.C., Cohen R.E., Conaway J.W. Mol. Cell 31:909-917(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION IN THE INO80 COMPLEX, SUBCELLULAR LOCATION, MASS SPECTROMETRY.
[5]	"Subunit organization of the human INO80 chromatin remodeling complex: An evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling." Chen L., Cai Y., Jin J., Florens L., Swanson S.K., Washburn M.P., Conaway J.W., Conaway R.C. J. Biol. Chem. 286:11283-11289(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION IN THE INO80 COMPLEX.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK075133 mRNA. Translation: BAC11424.1. BC047712 mRNA. Translation: AAH47712.1.
IPI	IPI00168357.
RefSeq	NP_775889.1. NM_173618.1.
UniGene	Hs.434864.
3D structure databases
ProteinModelPortal	Q8NBZ0.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8NBZ0. 17 interactions.
MINT	MINT-7034551.
STRING	9606.ENSP00000303977.
PTM databases
PhosphoSite	Q8NBZ0.
Polymorphism databases
DMDM	74730149.
Proteomic databases
PaxDb	Q8NBZ0.
PRIDE	Q8NBZ0.
Protocols and materials databases
DNASU	283899.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000563197; ENSP00000457016; ENSG00000169592.
GeneID	283899.
KEGG	hsa:283899.
UCSC	uc002dvg.1. human.
Organism-specific databases
CTD	283899.
GeneCards	GC16P030007.
HGNC	HGNC:26905. INO80E.
HPA	HPA043146.
neXtProt	NX_Q8NBZ0.
PharmGKB	PA162392174.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG84096.
HOGENOM	HOG000047138.
HOVERGEN	HBG063770.
InParanoid	Q8NBZ0.
KO	K11669.
OMA	MPPHTIL.
OrthoDB	EOG447FVW.
PhylomeDB	Q8NBZ0.
Gene expression databases
ArrayExpress	Q8NBZ0.
Bgee	Q8NBZ0.
CleanEx	HS_INO80E.
Genevestigator	Q8NBZ0.
GermOnline	ENSG00000169592. Homo sapiens.
Family and domain databases
InterPro	IPR026678. INO80E. [Graphical view]
PANTHER	PTHR21812. PTHR21812. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	283899.
NextBio	94346.

Entry information

Entry name

IN80E_HUMAN

Accession

Primary (citable) accession number: Q8NBZ0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 16, 2006
Last sequence update:	October 1, 2002
Last modified:	April 3, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.