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Q8NBZ0

- IN80E_HUMAN

UniProt

Q8NBZ0 - IN80E_HUMAN

Protein

INO80 complex subunit E

Gene

INO80E

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. DNA recombination Source: UniProtKB-KW
    2. DNA repair Source: UniProtKB-KW
    3. DNA replication Source: InterPro
    4. regulation of transcription, DNA-templated Source: UniProtKB-KW
    5. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    DNA damage, DNA recombination, DNA repair, Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    INO80 complex subunit E
    Alternative name(s):
    Coiled-coil domain-containing protein 95
    Gene namesi
    Name:INO80E
    Synonyms:CCDC95
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:26905. INO80E.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. Ino80 complex Source: UniProtKB
    2. nucleolus Source: HPA
    3. nucleus Source: HPA

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162392174.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 244244INO80 complex subunit EPRO_0000234292Add
    BLAST

    Proteomic databases

    MaxQBiQ8NBZ0.
    PaxDbiQ8NBZ0.
    PRIDEiQ8NBZ0.

    PTM databases

    PhosphoSiteiQ8NBZ0.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8NBZ0.
    BgeeiQ8NBZ0.
    CleanExiHS_INO80E.
    GenevestigatoriQ8NBZ0.

    Organism-specific databases

    HPAiHPA043146.

    Interactioni

    Subunit structurei

    Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the N-terminus of INO80.3 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    UCHL5Q9Y5K57EBI-769401,EBI-1051183

    Protein-protein interaction databases

    BioGridi129701. 20 interactions.
    IntActiQ8NBZ0. 18 interactions.
    MINTiMINT-7034551.
    STRINGi9606.ENSP00000303977.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NBZ0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili10 – 5445Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi91 – 211121Pro-richAdd
    BLAST

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG84096.
    HOGENOMiHOG000047138.
    HOVERGENiHBG063770.
    InParanoidiQ8NBZ0.
    KOiK11669.
    OMAiMPPHTIL.
    PhylomeDBiQ8NBZ0.
    TreeFamiTF326931.

    Family and domain databases

    InterProiIPR026678. INO80E.
    [Graphical view]
    PANTHERiPTHR21812. PTHR21812. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8NBZ0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNGPADGEVD YKKKYRNLKR KLKFLIYEHE CFQEELRKAQ RKLLKVSRDK    50
    SFLLDRLLQY ENVDEDSSDS DATASSDNSE TEGTPKLSDT PAPKRKRSPP 100
    LGGAPSPSSL SLPPSTGFPL QASGVPSPYL SSLASSRYPP FPSDYLALQL 150
    PEPSPLRPKR EKRPRLPRKL KMAVGPPDCP VGGPLTFPGR GSGAGVGTTL 200
    TPLPPPKMPP PTILSTVPRQ MFSDAGSGDD ALDGDDDLVI DIPE 244
    Length:244
    Mass (Da):26,478
    Last modified:October 1, 2002 - v1
    Checksum:iF329B39D0F3EB253
    GO
    Isoform 2 (identifier: Q8NBZ0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         133-244: LASSRYPPFP...DDDLVIDIPE → ERGQA

    Note: No experimental confirmation available.

    Show »
    Length:137
    Mass (Da):15,173
    Checksum:i995B139B12265F9A
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei133 – 244112LASSR…IDIPE → ERGQA in isoform 2. 1 PublicationVSP_055984Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY189289 mRNA. Translation: AAO86733.1.
    AK075133 mRNA. Translation: BAC11424.1.
    AC093512 Genomic DNA. No translation available.
    CH471238 Genomic DNA. Translation: EAW79953.1.
    CH471238 Genomic DNA. Translation: EAW79956.1.
    CH471238 Genomic DNA. Translation: EAW79959.1.
    BC047712 mRNA. Translation: AAH47712.1.
    CCDSiCCDS10665.1.
    RefSeqiNP_775889.1. NM_173618.1.
    UniGeneiHs.434864.

    Genome annotation databases

    EnsembliENST00000562441; ENSP00000456073; ENSG00000169592.
    ENST00000563197; ENSP00000457016; ENSG00000169592.
    GeneIDi283899.
    KEGGihsa:283899.
    UCSCiuc002dvg.1. human.

    Polymorphism databases

    DMDMi74730149.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY189289 mRNA. Translation: AAO86733.1 .
    AK075133 mRNA. Translation: BAC11424.1 .
    AC093512 Genomic DNA. No translation available.
    CH471238 Genomic DNA. Translation: EAW79953.1 .
    CH471238 Genomic DNA. Translation: EAW79956.1 .
    CH471238 Genomic DNA. Translation: EAW79959.1 .
    BC047712 mRNA. Translation: AAH47712.1 .
    CCDSi CCDS10665.1.
    RefSeqi NP_775889.1. NM_173618.1.
    UniGenei Hs.434864.

    3D structure databases

    ProteinModelPortali Q8NBZ0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 129701. 20 interactions.
    IntActi Q8NBZ0. 18 interactions.
    MINTi MINT-7034551.
    STRINGi 9606.ENSP00000303977.

    PTM databases

    PhosphoSitei Q8NBZ0.

    Polymorphism databases

    DMDMi 74730149.

    Proteomic databases

    MaxQBi Q8NBZ0.
    PaxDbi Q8NBZ0.
    PRIDEi Q8NBZ0.

    Protocols and materials databases

    DNASUi 283899.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000562441 ; ENSP00000456073 ; ENSG00000169592 .
    ENST00000563197 ; ENSP00000457016 ; ENSG00000169592 .
    GeneIDi 283899.
    KEGGi hsa:283899.
    UCSCi uc002dvg.1. human.

    Organism-specific databases

    CTDi 283899.
    GeneCardsi GC16P030007.
    HGNCi HGNC:26905. INO80E.
    HPAi HPA043146.
    neXtProti NX_Q8NBZ0.
    PharmGKBi PA162392174.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG84096.
    HOGENOMi HOG000047138.
    HOVERGENi HBG063770.
    InParanoidi Q8NBZ0.
    KOi K11669.
    OMAi MPPHTIL.
    PhylomeDBi Q8NBZ0.
    TreeFami TF326931.

    Miscellaneous databases

    GenomeRNAii 283899.
    NextBioi 94346.
    PROi Q8NBZ0.

    Gene expression databases

    ArrayExpressi Q8NBZ0.
    Bgeei Q8NBZ0.
    CleanExi HS_INO80E.
    Genevestigatori Q8NBZ0.

    Family and domain databases

    InterProi IPR026678. INO80E.
    [Graphical view ]
    PANTHERi PTHR21812. PTHR21812. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Novel human cDNA clones with function of inhibiting growth of liver cancer cells."
      Wan D.F., Qin W.X., Zhou X.M., Zhang P.P., Jiang H.Q., Gu J.R.
      Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Placenta.
    3. "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
      , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
      Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Uterus.
    6. Cited for: IDENTIFICATION IN INO80 COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
    7. "Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex."
      Yao T., Song L., Jin J., Cai Y., Takahashi H., Swanson S.K., Washburn M.P., Florens L., Conaway R.C., Cohen R.E., Conaway J.W.
      Mol. Cell 31:909-917(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE INO80 COMPLEX, SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.
    8. "Subunit organization of the human INO80 chromatin remodeling complex: An evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling."
      Chen L., Cai Y., Jin J., Florens L., Swanson S.K., Washburn M.P., Conaway J.W., Conaway R.C.
      J. Biol. Chem. 286:11283-11289(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE INO80 COMPLEX.

    Entry informationi

    Entry nameiIN80E_HUMAN
    AccessioniPrimary (citable) accession number: Q8NBZ0
    Secondary accession number(s): Q6Y2K3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 16, 2006
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM

    External Data

    Dasty 3