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Q8NBZ0

- IN80E_HUMAN

UniProt

Q8NBZ0 - IN80E_HUMAN

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Protein

INO80 complex subunit E

Gene

INO80E

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.

GO - Biological processi

  1. DNA recombination Source: UniProtKB-KW
  2. DNA repair Source: UniProtKB-KW
  3. DNA replication Source: InterPro
  4. regulation of transcription, DNA-templated Source: UniProtKB-KW
  5. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA recombination, DNA repair, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
INO80 complex subunit E
Alternative name(s):
Coiled-coil domain-containing protein 95
Gene namesi
Name:INO80E
Synonyms:CCDC95
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:26905. INO80E.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. Ino80 complex Source: UniProtKB
  2. nucleolus Source: HPA
  3. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162392174.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 244244INO80 complex subunit EPRO_0000234292Add
BLAST

Proteomic databases

MaxQBiQ8NBZ0.
PaxDbiQ8NBZ0.
PRIDEiQ8NBZ0.

PTM databases

PhosphoSiteiQ8NBZ0.

Expressioni

Gene expression databases

BgeeiQ8NBZ0.
CleanExiHS_INO80E.
ExpressionAtlasiQ8NBZ0. baseline and differential.
GenevestigatoriQ8NBZ0.

Organism-specific databases

HPAiHPA043146.

Interactioni

Subunit structurei

Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the N-terminus of INO80.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
UCHL5Q9Y5K57EBI-769401,EBI-1051183

Protein-protein interaction databases

BioGridi129701. 22 interactions.
IntActiQ8NBZ0. 18 interactions.
MINTiMINT-7034551.
STRINGi9606.ENSP00000303977.

Structurei

3D structure databases

ProteinModelPortaliQ8NBZ0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili10 – 5445Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi91 – 211121Pro-richAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG84096.
GeneTreeiENSGT00390000011918.
HOGENOMiHOG000047138.
HOVERGENiHBG063770.
InParanoidiQ8NBZ0.
KOiK11669.
OMAiMPPHTIL.
PhylomeDBiQ8NBZ0.
TreeFamiTF326931.

Family and domain databases

InterProiIPR026678. INO80E.
[Graphical view]
PANTHERiPTHR21812. PTHR21812. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8NBZ0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNGPADGEVD YKKKYRNLKR KLKFLIYEHE CFQEELRKAQ RKLLKVSRDK
60 70 80 90 100
SFLLDRLLQY ENVDEDSSDS DATASSDNSE TEGTPKLSDT PAPKRKRSPP
110 120 130 140 150
LGGAPSPSSL SLPPSTGFPL QASGVPSPYL SSLASSRYPP FPSDYLALQL
160 170 180 190 200
PEPSPLRPKR EKRPRLPRKL KMAVGPPDCP VGGPLTFPGR GSGAGVGTTL
210 220 230 240
TPLPPPKMPP PTILSTVPRQ MFSDAGSGDD ALDGDDDLVI DIPE
Length:244
Mass (Da):26,478
Last modified:October 1, 2002 - v1
Checksum:iF329B39D0F3EB253
GO
Isoform 2 (identifier: Q8NBZ0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     133-244: LASSRYPPFP...DDDLVIDIPE → ERGQA

Note: No experimental confirmation available.

Show »
Length:137
Mass (Da):15,173
Checksum:i995B139B12265F9A
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei133 – 244112LASSR…IDIPE → ERGQA in isoform 2. 1 PublicationVSP_055984Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY189289 mRNA. Translation: AAO86733.1.
AK075133 mRNA. Translation: BAC11424.1.
AC093512 Genomic DNA. No translation available.
CH471238 Genomic DNA. Translation: EAW79953.1.
CH471238 Genomic DNA. Translation: EAW79956.1.
CH471238 Genomic DNA. Translation: EAW79959.1.
BC047712 mRNA. Translation: AAH47712.1.
CCDSiCCDS10665.1. [Q8NBZ0-1]
RefSeqiNP_775889.1. NM_173618.1. [Q8NBZ0-1]
UniGeneiHs.434864.

Genome annotation databases

EnsembliENST00000562441; ENSP00000456073; ENSG00000169592. [Q8NBZ0-2]
ENST00000563197; ENSP00000457016; ENSG00000169592. [Q8NBZ0-1]
ENST00000567065; ENSP00000454665; ENSG00000169592. [Q8NBZ0-2]
ENST00000620599; ENSP00000484187; ENSG00000169592. [Q8NBZ0-2]
GeneIDi283899.
KEGGihsa:283899.
UCSCiuc002dvg.1. human. [Q8NBZ0-1]

Polymorphism databases

DMDMi74730149.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY189289 mRNA. Translation: AAO86733.1 .
AK075133 mRNA. Translation: BAC11424.1 .
AC093512 Genomic DNA. No translation available.
CH471238 Genomic DNA. Translation: EAW79953.1 .
CH471238 Genomic DNA. Translation: EAW79956.1 .
CH471238 Genomic DNA. Translation: EAW79959.1 .
BC047712 mRNA. Translation: AAH47712.1 .
CCDSi CCDS10665.1. [Q8NBZ0-1 ]
RefSeqi NP_775889.1. NM_173618.1. [Q8NBZ0-1 ]
UniGenei Hs.434864.

3D structure databases

ProteinModelPortali Q8NBZ0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 129701. 22 interactions.
IntActi Q8NBZ0. 18 interactions.
MINTi MINT-7034551.
STRINGi 9606.ENSP00000303977.

PTM databases

PhosphoSitei Q8NBZ0.

Polymorphism databases

DMDMi 74730149.

Proteomic databases

MaxQBi Q8NBZ0.
PaxDbi Q8NBZ0.
PRIDEi Q8NBZ0.

Protocols and materials databases

DNASUi 283899.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000562441 ; ENSP00000456073 ; ENSG00000169592 . [Q8NBZ0-2 ]
ENST00000563197 ; ENSP00000457016 ; ENSG00000169592 . [Q8NBZ0-1 ]
ENST00000567065 ; ENSP00000454665 ; ENSG00000169592 . [Q8NBZ0-2 ]
ENST00000620599 ; ENSP00000484187 ; ENSG00000169592 . [Q8NBZ0-2 ]
GeneIDi 283899.
KEGGi hsa:283899.
UCSCi uc002dvg.1. human. [Q8NBZ0-1 ]

Organism-specific databases

CTDi 283899.
GeneCardsi GC16P030007.
HGNCi HGNC:26905. INO80E.
HPAi HPA043146.
neXtProti NX_Q8NBZ0.
PharmGKBi PA162392174.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG84096.
GeneTreei ENSGT00390000011918.
HOGENOMi HOG000047138.
HOVERGENi HBG063770.
InParanoidi Q8NBZ0.
KOi K11669.
OMAi MPPHTIL.
PhylomeDBi Q8NBZ0.
TreeFami TF326931.

Miscellaneous databases

GenomeRNAii 283899.
NextBioi 94346.
PROi Q8NBZ0.

Gene expression databases

Bgeei Q8NBZ0.
CleanExi HS_INO80E.
ExpressionAtlasi Q8NBZ0. baseline and differential.
Genevestigatori Q8NBZ0.

Family and domain databases

InterProi IPR026678. INO80E.
[Graphical view ]
PANTHERi PTHR21812. PTHR21812. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Novel human cDNA clones with function of inhibiting growth of liver cancer cells."
    Wan D.F., Qin W.X., Zhou X.M., Zhang P.P., Jiang H.Q., Gu J.R.
    Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Placenta.
  3. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Uterus.
  6. Cited for: IDENTIFICATION IN INO80 COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
  7. "Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex."
    Yao T., Song L., Jin J., Cai Y., Takahashi H., Swanson S.K., Washburn M.P., Florens L., Conaway R.C., Cohen R.E., Conaway J.W.
    Mol. Cell 31:909-917(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE INO80 COMPLEX, SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.
  8. "Subunit organization of the human INO80 chromatin remodeling complex: An evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling."
    Chen L., Cai Y., Jin J., Florens L., Swanson S.K., Washburn M.P., Conaway J.W., Conaway R.C.
    J. Biol. Chem. 286:11283-11289(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE INO80 COMPLEX.

Entry informationi

Entry nameiIN80E_HUMAN
AccessioniPrimary (citable) accession number: Q8NBZ0
Secondary accession number(s): Q6Y2K3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: October 1, 2002
Last modified: November 26, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM

External Data

Dasty 3