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Q8NBX0

- SCPDL_HUMAN

UniProt

Q8NBX0 - SCPDL_HUMAN

Protein

Saccharopine dehydrogenase-like oxidoreductase

Gene

SCCPDH

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. oxidoreductase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Saccharopine dehydrogenase-like oxidoreductase (EC:1.-.-.-)
    Gene namesi
    Name:SCCPDH
    ORF Names:CGI-49
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:24275. SCCPDH.

    Subcellular locationi

    GO - Cellular componenti

    1. lipid particle Source: UniProtKB
    2. membrane Source: UniProtKB
    3. midbody Source: UniProtKB
    4. mitochondrion Source: UniProt
    5. nucleus Source: UniProt

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142670949.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 429428Saccharopine dehydrogenase-like oxidoreductasePRO_0000212840Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ8NBX0.
    PaxDbiQ8NBX0.
    PeptideAtlasiQ8NBX0.
    PRIDEiQ8NBX0.

    PTM databases

    PhosphoSiteiQ8NBX0.

    Expressioni

    Gene expression databases

    BgeeiQ8NBX0.
    CleanExiHS_SCCPDH.
    GenevestigatoriQ8NBX0.

    Organism-specific databases

    HPAiHPA050775.

    Interactioni

    Protein-protein interaction databases

    BioGridi119286. 2 interactions.
    IntActiQ8NBX0. 1 interaction.
    MINTiMINT-5003371.
    STRINGi9606.ENSP00000355467.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NBX0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the saccharopine dehydrogenase family.Curated

    Phylogenomic databases

    eggNOGiCOG3268.
    HOGENOMiHOG000251397.
    HOVERGENiHBG057028.
    InParanoidiQ8NBX0.
    OMAiMTFFGQG.
    OrthoDBiEOG7B31MZ.
    PhylomeDBiQ8NBX0.
    TreeFamiTF314904.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR016040. NAD(P)-bd_dom.
    IPR005097. Saccharopine_DH/HSpermid_syn.
    [Graphical view]
    PfamiPF03435. Saccharop_dh. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8NBX0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATEQRPFHL VVFGASGFTG QFVTEEVARE QVDPERSSRL PWAVAGRSRE    50
    KLQRVLEKAA LKLGRPTLSS EVGIIICDIA NPASLDEMAK QATVVLNCVG 100
    PYRFYGEPVI KACIENGASC IDISGEPQFL ELMQLKYHEK AADKGVYIIG 150
    SSGFDSIPAD LGVIYTRNKM NGTLTAVESF LTIHSGPEGL SIHDGTWKSA 200
    IYGFGDQSNL RKLRNVSNLK PVPLIGPKLK RRWPISYCRE LKGYSIPFMG 250
    SDVSVVRRTQ RYLYENLEES PVQYAAYVTV GGITSVIKLM FAGLFFLFFV 300
    RFGIGRQLLI KFPWFFSFGY FSKQGPTQKQ IDAASFTLTF FGQGYSQGTG 350
    TDKNKPNIKI CTQVKGPEAG YVATPIAMVQ AAMTLLSDAS HLPKAGGVFT 400
    PGAAFSKTKL IDRLNKHGIE FSVISSSEV 429
    Length:429
    Mass (Da):47,151
    Last modified:October 1, 2002 - v1
    Checksum:iA93EBEDDF128A548
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti37 – 437SSRLPWA → TQPALG in AAD34044. (PubMed:10810093)Curated
    Sequence conflicti187 – 1871P → H in AAH26185. (PubMed:15489334)Curated
    Sequence conflicti347 – 3471Q → R in AAH26185. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti418 – 4181G → R.
    Corresponds to variant rs7779 [ dbSNP | Ensembl ].
    VAR_034486

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF151807 mRNA. Translation: AAD34044.1.
    AK075178 mRNA. Translation: BAC11453.1.
    AL591848 Genomic DNA. Translation: CAH73844.1.
    BC026185 mRNA. Translation: AAH26185.1.
    CCDSiCCDS31084.1.
    RefSeqiNP_057086.2. NM_016002.2.
    UniGeneiHs.498397.

    Genome annotation databases

    EnsembliENST00000366510; ENSP00000355467; ENSG00000143653.
    GeneIDi51097.
    KEGGihsa:51097.
    UCSCiuc001ibr.3. human.

    Polymorphism databases

    DMDMi73919294.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF151807 mRNA. Translation: AAD34044.1 .
    AK075178 mRNA. Translation: BAC11453.1 .
    AL591848 Genomic DNA. Translation: CAH73844.1 .
    BC026185 mRNA. Translation: AAH26185.1 .
    CCDSi CCDS31084.1.
    RefSeqi NP_057086.2. NM_016002.2.
    UniGenei Hs.498397.

    3D structure databases

    ProteinModelPortali Q8NBX0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119286. 2 interactions.
    IntActi Q8NBX0. 1 interaction.
    MINTi MINT-5003371.
    STRINGi 9606.ENSP00000355467.

    PTM databases

    PhosphoSitei Q8NBX0.

    Polymorphism databases

    DMDMi 73919294.

    Proteomic databases

    MaxQBi Q8NBX0.
    PaxDbi Q8NBX0.
    PeptideAtlasi Q8NBX0.
    PRIDEi Q8NBX0.

    Protocols and materials databases

    DNASUi 51097.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000366510 ; ENSP00000355467 ; ENSG00000143653 .
    GeneIDi 51097.
    KEGGi hsa:51097.
    UCSCi uc001ibr.3. human.

    Organism-specific databases

    CTDi 51097.
    GeneCardsi GC01P246887.
    HGNCi HGNC:24275. SCCPDH.
    HPAi HPA050775.
    neXtProti NX_Q8NBX0.
    PharmGKBi PA142670949.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG3268.
    HOGENOMi HOG000251397.
    HOVERGENi HBG057028.
    InParanoidi Q8NBX0.
    OMAi MTFFGQG.
    OrthoDBi EOG7B31MZ.
    PhylomeDBi Q8NBX0.
    TreeFami TF314904.

    Miscellaneous databases

    ChiTaRSi SCCPDH. human.
    GenomeRNAii 51097.
    NextBioi 53797.
    PROi Q8NBX0.

    Gene expression databases

    Bgeei Q8NBX0.
    CleanExi HS_SCCPDH.
    Genevestigatori Q8NBX0.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR016040. NAD(P)-bd_dom.
    IPR005097. Saccharopine_DH/HSpermid_syn.
    [Graphical view ]
    Pfami PF03435. Saccharop_dh. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
      Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
      Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    5. Bienvenut W.V.
      Submitted (JAN-2010) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 2-29; 63-103; 141-167; 199-211; 215-228; 243-257; 330-353; 366-394 AND 417-429, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Ovarian carcinoma.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSCPDL_HUMAN
    AccessioniPrimary (citable) accession number: Q8NBX0
    Secondary accession number(s): Q8TAR0, Q9Y363
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 30, 2005
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3