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Protein

Saccharopine dehydrogenase-like oxidoreductase

Gene

SCCPDH

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciZFISH:HS13980-MONOMER.
ReactomeiR-HSA-114608. Platelet degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Saccharopine dehydrogenase-like oxidoreductase (EC:1.-.-.-)
Gene namesi
Name:SCCPDH
ORF Names:CGI-49
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:24275. SCCPDH.

Subcellular locationi

GO - Cellular componenti

  • lipid particle Source: UniProtKB
  • membrane Source: UniProtKB
  • midbody Source: UniProtKB
  • mitochondrion Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000143653.
PharmGKBiPA142670949.

Polymorphism and mutation databases

BioMutaiSCCPDH.
DMDMi73919294.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00002128402 – 429Saccharopine dehydrogenase-like oxidoreductaseAdd BLAST428

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine1 Publication1
Modified residuei217PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8NBX0.
MaxQBiQ8NBX0.
PaxDbiQ8NBX0.
PeptideAtlasiQ8NBX0.
PRIDEiQ8NBX0.
TopDownProteomicsiQ8NBX0.

PTM databases

iPTMnetiQ8NBX0.
PhosphoSitePlusiQ8NBX0.
SwissPalmiQ8NBX0.

Expressioni

Gene expression databases

BgeeiENSG00000143653.
CleanExiHS_SCCPDH.
GenevisibleiQ8NBX0. HS.

Organism-specific databases

HPAiHPA050775.

Interactioni

Protein-protein interaction databases

BioGridi119286. 42 interactors.
IntActiQ8NBX0. 4 interactors.
MINTiMINT-5003371.
STRINGi9606.ENSP00000355467.

Structurei

3D structure databases

ProteinModelPortaliQ8NBX0.
SMRiQ8NBX0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the saccharopine dehydrogenase family.Curated

Phylogenomic databases

eggNOGiKOG2733. Eukaryota.
COG3268. LUCA.
GeneTreeiENSGT00390000004799.
HOGENOMiHOG000251397.
HOVERGENiHBG057028.
InParanoidiQ8NBX0.
OMAiVQYAAYI.
OrthoDBiEOG091G07C9.
PhylomeDBiQ8NBX0.
TreeFamiTF314904.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR005097. Sacchrp_dh_NADP.
[Graphical view]
PfamiPF03435. Sacchrp_dh_NADP. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8NBX0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATEQRPFHL VVFGASGFTG QFVTEEVARE QVDPERSSRL PWAVAGRSRE
60 70 80 90 100
KLQRVLEKAA LKLGRPTLSS EVGIIICDIA NPASLDEMAK QATVVLNCVG
110 120 130 140 150
PYRFYGEPVI KACIENGASC IDISGEPQFL ELMQLKYHEK AADKGVYIIG
160 170 180 190 200
SSGFDSIPAD LGVIYTRNKM NGTLTAVESF LTIHSGPEGL SIHDGTWKSA
210 220 230 240 250
IYGFGDQSNL RKLRNVSNLK PVPLIGPKLK RRWPISYCRE LKGYSIPFMG
260 270 280 290 300
SDVSVVRRTQ RYLYENLEES PVQYAAYVTV GGITSVIKLM FAGLFFLFFV
310 320 330 340 350
RFGIGRQLLI KFPWFFSFGY FSKQGPTQKQ IDAASFTLTF FGQGYSQGTG
360 370 380 390 400
TDKNKPNIKI CTQVKGPEAG YVATPIAMVQ AAMTLLSDAS HLPKAGGVFT
410 420
PGAAFSKTKL IDRLNKHGIE FSVISSSEV
Length:429
Mass (Da):47,151
Last modified:October 1, 2002 - v1
Checksum:iA93EBEDDF128A548
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti37 – 43SSRLPWA → TQPALG in AAD34044 (PubMed:10810093).Curated7
Sequence conflicti187P → H in AAH26185 (PubMed:15489334).Curated1
Sequence conflicti347Q → R in AAH26185 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034486418G → R.Corresponds to variant rs7779dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151807 mRNA. Translation: AAD34044.1.
AK075178 mRNA. Translation: BAC11453.1.
AL591848 Genomic DNA. Translation: CAH73844.1.
BC026185 mRNA. Translation: AAH26185.1.
CCDSiCCDS31084.1.
RefSeqiNP_057086.2. NM_016002.2.
UniGeneiHs.498397.

Genome annotation databases

EnsembliENST00000366510; ENSP00000355467; ENSG00000143653.
GeneIDi51097.
KEGGihsa:51097.
UCSCiuc001ibr.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151807 mRNA. Translation: AAD34044.1.
AK075178 mRNA. Translation: BAC11453.1.
AL591848 Genomic DNA. Translation: CAH73844.1.
BC026185 mRNA. Translation: AAH26185.1.
CCDSiCCDS31084.1.
RefSeqiNP_057086.2. NM_016002.2.
UniGeneiHs.498397.

3D structure databases

ProteinModelPortaliQ8NBX0.
SMRiQ8NBX0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119286. 42 interactors.
IntActiQ8NBX0. 4 interactors.
MINTiMINT-5003371.
STRINGi9606.ENSP00000355467.

PTM databases

iPTMnetiQ8NBX0.
PhosphoSitePlusiQ8NBX0.
SwissPalmiQ8NBX0.

Polymorphism and mutation databases

BioMutaiSCCPDH.
DMDMi73919294.

Proteomic databases

EPDiQ8NBX0.
MaxQBiQ8NBX0.
PaxDbiQ8NBX0.
PeptideAtlasiQ8NBX0.
PRIDEiQ8NBX0.
TopDownProteomicsiQ8NBX0.

Protocols and materials databases

DNASUi51097.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000366510; ENSP00000355467; ENSG00000143653.
GeneIDi51097.
KEGGihsa:51097.
UCSCiuc001ibr.4. human.

Organism-specific databases

CTDi51097.
GeneCardsiSCCPDH.
HGNCiHGNC:24275. SCCPDH.
HPAiHPA050775.
neXtProtiNX_Q8NBX0.
OpenTargetsiENSG00000143653.
PharmGKBiPA142670949.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2733. Eukaryota.
COG3268. LUCA.
GeneTreeiENSGT00390000004799.
HOGENOMiHOG000251397.
HOVERGENiHBG057028.
InParanoidiQ8NBX0.
OMAiVQYAAYI.
OrthoDBiEOG091G07C9.
PhylomeDBiQ8NBX0.
TreeFamiTF314904.

Enzyme and pathway databases

BioCyciZFISH:HS13980-MONOMER.
ReactomeiR-HSA-114608. Platelet degranulation.

Miscellaneous databases

ChiTaRSiSCCPDH. human.
GenomeRNAii51097.
PROiQ8NBX0.

Gene expression databases

BgeeiENSG00000143653.
CleanExiHS_SCCPDH.
GenevisibleiQ8NBX0. HS.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR005097. Sacchrp_dh_NADP.
[Graphical view]
PfamiPF03435. Sacchrp_dh_NADP. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSCPDL_HUMAN
AccessioniPrimary (citable) accession number: Q8NBX0
Secondary accession number(s): Q8TAR0, Q9Y363
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.