SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8NBX0

- SCPDL_HUMAN

UniProt

Q8NBX0 - SCPDL_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Saccharopine dehydrogenase-like oxidoreductase
Gene
SCCPDH, CGI-49
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. oxidoreductase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Saccharopine dehydrogenase-like oxidoreductase (EC:1.-.-.-)
Gene namesi
Name:SCCPDH
ORF Names:CGI-49
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:24275. SCCPDH.

Subcellular locationi

GO - Cellular componenti

  1. lipid particle Source: UniProtKB
  2. midbody Source: UniProtKB
  3. mitochondrion Source: UniProt
  4. nucleus Source: UniProt
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670949.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 429428Saccharopine dehydrogenase-like oxidoreductase
PRO_0000212840Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ8NBX0.
PaxDbiQ8NBX0.
PeptideAtlasiQ8NBX0.
PRIDEiQ8NBX0.

PTM databases

PhosphoSiteiQ8NBX0.

Expressioni

Gene expression databases

BgeeiQ8NBX0.
CleanExiHS_SCCPDH.
GenevestigatoriQ8NBX0.

Organism-specific databases

HPAiHPA050775.

Interactioni

Protein-protein interaction databases

BioGridi119286. 2 interactions.
IntActiQ8NBX0. 1 interaction.
MINTiMINT-5003371.
STRINGi9606.ENSP00000355467.

Structurei

3D structure databases

ProteinModelPortaliQ8NBX0.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG3268.
HOGENOMiHOG000251397.
HOVERGENiHBG057028.
InParanoidiQ8NBX0.
OMAiMTFFGQG.
OrthoDBiEOG7B31MZ.
PhylomeDBiQ8NBX0.
TreeFamiTF314904.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR005097. Saccharopine_DH/HSpermid_syn.
[Graphical view]
PfamiPF03435. Saccharop_dh. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8NBX0-1 [UniParc]FASTAAdd to Basket

« Hide

MATEQRPFHL VVFGASGFTG QFVTEEVARE QVDPERSSRL PWAVAGRSRE    50
KLQRVLEKAA LKLGRPTLSS EVGIIICDIA NPASLDEMAK QATVVLNCVG 100
PYRFYGEPVI KACIENGASC IDISGEPQFL ELMQLKYHEK AADKGVYIIG 150
SSGFDSIPAD LGVIYTRNKM NGTLTAVESF LTIHSGPEGL SIHDGTWKSA 200
IYGFGDQSNL RKLRNVSNLK PVPLIGPKLK RRWPISYCRE LKGYSIPFMG 250
SDVSVVRRTQ RYLYENLEES PVQYAAYVTV GGITSVIKLM FAGLFFLFFV 300
RFGIGRQLLI KFPWFFSFGY FSKQGPTQKQ IDAASFTLTF FGQGYSQGTG 350
TDKNKPNIKI CTQVKGPEAG YVATPIAMVQ AAMTLLSDAS HLPKAGGVFT 400
PGAAFSKTKL IDRLNKHGIE FSVISSSEV 429
Length:429
Mass (Da):47,151
Last modified:October 1, 2002 - v1
Checksum:iA93EBEDDF128A548
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti418 – 4181G → R.
Corresponds to variant rs7779 [ dbSNP | Ensembl ].
VAR_034486

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti37 – 437SSRLPWA → TQPALG in AAD34044. 1 Publication
Sequence conflicti187 – 1871P → H in AAH26185. 1 Publication
Sequence conflicti347 – 3471Q → R in AAH26185. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF151807 mRNA. Translation: AAD34044.1.
AK075178 mRNA. Translation: BAC11453.1.
AL591848 Genomic DNA. Translation: CAH73844.1.
BC026185 mRNA. Translation: AAH26185.1.
CCDSiCCDS31084.1.
RefSeqiNP_057086.2. NM_016002.2.
UniGeneiHs.498397.

Genome annotation databases

EnsembliENST00000366510; ENSP00000355467; ENSG00000143653.
GeneIDi51097.
KEGGihsa:51097.
UCSCiuc001ibr.3. human.

Polymorphism databases

DMDMi73919294.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF151807 mRNA. Translation: AAD34044.1 .
AK075178 mRNA. Translation: BAC11453.1 .
AL591848 Genomic DNA. Translation: CAH73844.1 .
BC026185 mRNA. Translation: AAH26185.1 .
CCDSi CCDS31084.1.
RefSeqi NP_057086.2. NM_016002.2.
UniGenei Hs.498397.

3D structure databases

ProteinModelPortali Q8NBX0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119286. 2 interactions.
IntActi Q8NBX0. 1 interaction.
MINTi MINT-5003371.
STRINGi 9606.ENSP00000355467.

PTM databases

PhosphoSitei Q8NBX0.

Polymorphism databases

DMDMi 73919294.

Proteomic databases

MaxQBi Q8NBX0.
PaxDbi Q8NBX0.
PeptideAtlasi Q8NBX0.
PRIDEi Q8NBX0.

Protocols and materials databases

DNASUi 51097.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000366510 ; ENSP00000355467 ; ENSG00000143653 .
GeneIDi 51097.
KEGGi hsa:51097.
UCSCi uc001ibr.3. human.

Organism-specific databases

CTDi 51097.
GeneCardsi GC01P246887.
HGNCi HGNC:24275. SCCPDH.
HPAi HPA050775.
neXtProti NX_Q8NBX0.
PharmGKBi PA142670949.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG3268.
HOGENOMi HOG000251397.
HOVERGENi HBG057028.
InParanoidi Q8NBX0.
OMAi MTFFGQG.
OrthoDBi EOG7B31MZ.
PhylomeDBi Q8NBX0.
TreeFami TF314904.

Miscellaneous databases

ChiTaRSi SCCPDH. human.
GenomeRNAii 51097.
NextBioi 53797.
PROi Q8NBX0.

Gene expression databases

Bgeei Q8NBX0.
CleanExi HS_SCCPDH.
Genevestigatori Q8NBX0.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR016040. NAD(P)-bd_dom.
IPR005097. Saccharopine_DH/HSpermid_syn.
[Graphical view ]
Pfami PF03435. Saccharop_dh. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
    Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
    Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. Bienvenut W.V.
    Submitted (JAN-2010) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 2-29; 63-103; 141-167; 199-211; 215-228; 243-257; 330-353; 366-394 AND 417-429, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Ovarian carcinoma.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSCPDL_HUMAN
AccessioniPrimary (citable) accession number: Q8NBX0
Secondary accession number(s): Q8TAR0, Q9Y363
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi