Q8NBW4 (S38A9_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative sodium-coupled neutral amino acid transporter 9

Gene names

Name:

SLC38A9

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	561 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Putative sodium-dependent amino acid/proton antiporter By similarity.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the amino acid/polyamine transporter 2 family.

Ontologies

Keywords
Biological process	Amino-acid transport Ion transport Sodium transport Transport
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
Ligand	Sodium
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	amino acid transport Inferred from electronic annotation. Source: UniProtKB-KW sodium ion transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8NBW4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8NBW4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     428-561: NFLDNFPSSD...VANLIVQFFM → VRHRVPSLCDCVHFHVFIVGRVIQWQDITSDRPGF

Note: No experimental confirmation available.

Isoform 3 (identifier: Q8NBW4-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-37: MANMNSDSRHLGTSEVDHERDPGPMNIQFEPSDLRSK → MAICILTWRI
     318-353: Missing.

Isoform 4 (identifier: Q8NBW4-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-63: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 561	561	Putative sodium-coupled neutral amino acid transporter 9		PRO_0000328840
Regions
	Transmembrane	120 – 140	21	Helical; Potential
	Transmembrane	145 – 165	21	Helical; Potential
	Transmembrane	199 – 219	21	Helical; Potential
	Transmembrane	291 – 311	21	Helical; Potential
	Transmembrane	314 – 334	21	Helical; Potential
	Transmembrane	359 – 379	21	Helical; Potential
	Transmembrane	393 – 413	21	Helical; Potential
	Transmembrane	441 – 461	21	Helical; Potential
	Transmembrane	478 – 498	21	Helical; Potential
	Transmembrane	510 – 530	21	Helical; Potential
	Transmembrane	541 – 561	21	Helical; Potential
Natural variations
	Alternative sequence	1 – 63	63	Missing in isoform 4.		VSP_045110
	Alternative sequence	1 – 37	37	MANMN…DLRSK → MAICILTWRI in isoform 3.		VSP_045111
	Alternative sequence	318 – 353	36	Missing in isoform 3.		VSP_045112
	Alternative sequence	428 – 561	134	NFLDN…VQFFM → VRHRVPSLCDCVHFHVFIVG RVIQWQDITSDRPGF in isoform 2.		VSP_032815
	Natural variant	182	1	S → T. Ref.1 Ref.4 Ref.5 Corresponds to variant rs4865615 [ dbSNP | Ensembl ].		VAR_042546
Experimental info
	Sequence conflict	84	1	A → P in AAH66891. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 18, 2010. Version 2. Checksum: 0C1A3A136158168A	FASTA	561	63,776
	10 20 30 40 50 60 MANMNSDSRH LGTSEVDHER DPGPMNIQFE PSDLRSKRPF CIEPTNIVNV NHVIQRVSDH 70 80 90 100 110 120 ASAMNKRIHY YSRLTTPADK ALIAPDHVVP APEECYVYSP LGSAYKLQSY TEGYGKNTSL 130 140 150 160 170 180 VTIFMIWNTM MGTSILSIPW GIKQAGFTTG MCVIILMGLL TLYCCYRVVK SRTMMFSLDT 190 200 210 220 230 240 TSWEYPDVCR HYFGSFGQWS SLLFSLVSLI GAMIVYWVLM SNFLFNTGKF IFNFIHHIND 250 260 270 280 290 300 TDTILSTNNS NPVICPSAGS GGHPDNSSMI FYANDTGAQQ FEKWWDKSRT VPFYLVGLLL 310 320 330 340 350 360 PLLNFKSPSF FSKFNILGTV SVLYLIFLVT FKAVRLGFHL EFHWFIPTEF FVPEIRFQFP 370 380 390 400 410 420 QLTGVLTLAF FIHNCIITLL KNNKKQENNV RDLCIAYMLV TLTYLYIGVL VFASFPSPPL 430 440 450 460 470 480 SKDCIEQNFL DNFPSSDTLS FIARIFLLFQ MMTVYPLLGY LARVQLLGHI FGDIYPSIFH 490 500 510 520 530 540 VLILNLIIVG AGVIMACFYP NIGGIIRYSG AACGLAFVFI YPSLIYIISL HQEERLTWPK 550 560 LIFHVFIIIL GVANLIVQFF M
	Isoform 2 [UniParc]. Checksum: FB8344A9CFD7392F	FASTA	462	52,717
	10 20 30 40 50 60 MANMNSDSRH LGTSEVDHER DPGPMNIQFE PSDLRSKRPF CIEPTNIVNV NHVIQRVSDH 70 80 90 100 110 120 ASAMNKRIHY YSRLTTPADK ALIAPDHVVP APEECYVYSP LGSAYKLQSY TEGYGKNTSL 130 140 150 160 170 180 VTIFMIWNTM MGTSILSIPW GIKQAGFTTG MCVIILMGLL TLYCCYRVVK SRTMMFSLDT 190 200 210 220 230 240 TSWEYPDVCR HYFGSFGQWS SLLFSLVSLI GAMIVYWVLM SNFLFNTGKF IFNFIHHIND 250 260 270 280 290 300 TDTILSTNNS NPVICPSAGS GGHPDNSSMI FYANDTGAQQ FEKWWDKSRT VPFYLVGLLL 310 320 330 340 350 360 PLLNFKSPSF FSKFNILGTV SVLYLIFLVT FKAVRLGFHL EFHWFIPTEF FVPEIRFQFP 370 380 390 400 410 420 QLTGVLTLAF FIHNCIITLL KNNKKQENNV RDLCIAYMLV TLTYLYIGVL VFASFPSPPL 430 440 450 460 SKDCIEQVRH RVPSLCDCVH FHVFIVGRVI QWQDITSDRP GF
	Isoform 3 [UniParc]. Checksum: A54A4DA31CC0B696	FASTA	498	56,542
	10 20 30 40 50 60 MAICILTWRI RPFCIEPTNI VNVNHVIQRV SDHASAMNKR IHYYSRLTTP ADKALIAPDH 70 80 90 100 110 120 VVPAPEECYV YSPLGSAYKL QSYTEGYGKN TSLVTIFMIW NTMMGTSILS IPWGIKQAGF 130 140 150 160 170 180 TTGMCVIILM GLLTLYCCYR VVKSRTMMFS LDTTSWEYPD VCRHYFGSFG QWSSLLFSLV 190 200 210 220 230 240 SLIGAMIVYW VLMSNFLFNT GKFIFNFIHH INDTDTILST NNSNPVICPS AGSGGHPDNS 250 260 270 280 290 300 SMIFYANDTG AQQFEKWWDK SRTVPFYLVG LLLPLLNFKS PSFFSKFNIL EIRFQFPQLT 310 320 330 340 350 360 GVLTLAFFIH NCIITLLKNN KKQENNVRDL CIAYMLVTLT YLYIGVLVFA SFPSPPLSKD 370 380 390 400 410 420 CIEQNFLDNF PSSDTLSFIA RIFLLFQMMT VYPLLGYLAR VQLLGHIFGD IYPSIFHVLI 430 440 450 460 470 480 LNLIIVGAGV IMACFYPNIG GIIRYSGAAC GLAFVFIYPS LIYIISLHQE ERLTWPKLIF 490 HVFIIILGVA NLIVQFFM
	Isoform 4 [UniParc]. Checksum: D213355DA1CD5C13	FASTA	498	56,695
	10 20 30 40 50 60 MNKRIHYYSR LTTPADKALI APDHVVPAPE ECYVYSPLGS AYKLQSYTEG YGKNTSLVTI 70 80 90 100 110 120 FMIWNTMMGT SILSIPWGIK QAGFTTGMCV IILMGLLTLY CCYRVVKSRT MMFSLDTTSW 130 140 150 160 170 180 EYPDVCRHYF GSFGQWSSLL FSLVSLIGAM IVYWVLMSNF LFNTGKFIFN FIHHINDTDT 190 200 210 220 230 240 ILSTNNSNPV ICPSAGSGGH PDNSSMIFYA NDTGAQQFEK WWDKSRTVPF YLVGLLLPLL 250 260 270 280 290 300 NFKSPSFFSK FNILGTVSVL YLIFLVTFKA VRLGFHLEFH WFIPTEFFVP EIRFQFPQLT 310 320 330 340 350 360 GVLTLAFFIH NCIITLLKNN KKQENNVRDL CIAYMLVTLT YLYIGVLVFA SFPSPPLSKD 370 380 390 400 410 420 CIEQNFLDNF PSSDTLSFIA RIFLLFQMMT VYPLLGYLAR VQLLGHIFGD IYPSIFHVLI 430 440 450 460 470 480 LNLIIVGAGV IMACFYPNIG GIIRYSGAAC GLAFVFIYPS LIYIISLHQE ERLTWPKLIF 490 HVFIIILGVA NLIVQFFM

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4), VARIANT THR-182. Tissue: Placenta and Testis.
[2]	"The DNA sequence and comparative analysis of human chromosome 5." Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M. Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT THR-182. Tissue: Testis.
[5]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 173-561 (ISOFORM 2), VARIANT THR-182. Tissue: Fetal kidney.
[6]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK075190 mRNA. Translation: BAC11460.1. AK127988 mRNA. Translation: BAG54613.1. AK301850 mRNA. Translation: BAH13566.1. AC008784 Genomic DNA. No translation available. AC016632 Genomic DNA. No translation available. CH471123 Genomic DNA. Translation: EAW54926.1. BC066891 mRNA. Translation: AAH66891.1. BC101362 mRNA. Translation: AAI01363.1. BX641065 mRNA. Translation: CAE46032.1.
IPI	IPI00168340. IPI00889635.
RefSeq	NP_001245215.1. NM_001258286.1. NP_001245216.1. NM_001258287.1. NP_775785.2. NM_173514.3.
UniGene	Hs.649685.
3D structure databases
ProteinModelPortal	Q8NBW4.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000316596.
Protein family/group databases
TCDB	2.A.18.9.1. amino acid/auxin permease (AAAP) family.
PTM databases
PhosphoSite	Q8NBW4.
Polymorphism databases
DMDM	296452888.
Proteomic databases
PaxDb	Q8NBW4.
PeptideAtlas	Q0P5S0.
PRIDE	Q8NBW4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000318672; ENSP00000316596; ENSG00000177058. ENST00000396865; ENSP00000380074; ENSG00000177058. ENST00000512595; ENSP00000427335; ENSG00000177058. ENST00000515629; ENSP00000420934; ENSG00000177058. ENST00000539768; ENSP00000437771; ENSG00000177058.
GeneID	153129.
KEGG	hsa:153129.
UCSC	uc003jqd.2. human. uc010ivx.2. human.
Organism-specific databases
CTD	153129.
GeneCards	GC05M054958.
HGNC	HGNC:26907. SLC38A9.
HPA	HPA043785.
neXtProt	NX_Q8NBW4.
PharmGKB	PA162403774.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG294315.
HOGENOM	HOG000294102.
HOVERGEN	HBG106242.
InParanoid	Q8NBW4.
KO	K14995.
OMA	RYSGAAC.
OrthoDB	EOG469QTD.
PhylomeDB	Q8NBW4.
Gene expression databases
ArrayExpress	Q8NBW4.
Bgee	Q8NBW4.
CleanEx	HS_SLC38A9.
Genevestigator	Q8NBW4.
Family and domain databases
InterPro	IPR013057. AA_transpt_TM. [Graphical view]
Pfam	PF01490. Aa_trans. 2 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	153129.
NextBio	87078.

Entry information

Entry name

S38A9_HUMAN

Accession

Primary (citable) accession number: Q8NBW4
Secondary accession number(s): B3KXV1 , B7Z7D0, Q0P5S0, Q6MZJ8

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	May 18, 2010
Last modified:	May 29, 2013
This is version 79 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.