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Protein

Inactive phospholipid phosphatase 7

Gene

PLPP7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a role as negative regulator of myoblast differentiation, in part through effects on MTOR signaling. Has no detectable enzymatic activity (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Inactive phospholipid phosphatase 7Imported
Alternative name(s):
Phosphatidic acid phosphatase type 2 domain-containing protein 3
Gene namesi
Name:PLPP7Imported
Synonyms:C9orf67, PPAPDC3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:28174. PLPP7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 112112CytoplasmicSequence analysisAdd
BLAST
Transmembranei113 – 13321HelicalSequence analysisAdd
BLAST
Topological domaini134 – 1418ExtracellularSequence analysis
Transmembranei142 – 16221HelicalSequence analysisAdd
BLAST
Topological domaini163 – 20240CytoplasmicSequence analysisAdd
BLAST
Transmembranei203 – 22321HelicalSequence analysisAdd
BLAST
Topological domaini224 – 23916ExtracellularSequence analysisAdd
BLAST
Transmembranei240 – 26021HelicalSequence analysisAdd
BLAST
Topological domaini261 – 27111CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134931886.

Polymorphism and mutation databases

BioMutaiPPAPDC3.
DMDMi74751178.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 271271Inactive phospholipid phosphatase 7PRO_0000239401Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei43 – 431PhosphoserineBy similarity
Modified residuei62 – 621PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8NBV4.
PeptideAtlasiQ8NBV4.
PRIDEiQ8NBV4.

PTM databases

DEPODiQ8NBV4.
iPTMnetiQ8NBV4.
PhosphoSiteiQ8NBV4.

Expressioni

Gene expression databases

BgeeiENSG00000160539.
CleanExiHS_PPAPDC3.
ExpressionAtlasiQ8NBV4. baseline and differential.
GenevisibleiQ8NBV4. HS.

Organism-specific databases

HPAiHPA062514.

Interactioni

Subunit structurei

Homo and heterooligomer. Interacts with MTOR; controls MTOR-dependent IGF2 expression during myoblast differentiation (By similarity).By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000361338.

Structurei

3D structure databases

ProteinModelPortaliQ8NBV4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni70 – 9122Interaction with MTORBy similarityAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410ISHN. Eukaryota.
ENOG4111VXU. LUCA.
GeneTreeiENSGT00390000012789.
HOGENOMiHOG000231931.
HOVERGENiHBG054746.
InParanoidiQ8NBV4.
OMAiYLQFRLV.
OrthoDBiEOG091G0STF.
PhylomeDBiQ8NBV4.
TreeFamiTF323272.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiIPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PfamiPF01569. PAP2. 1 hit.
[Graphical view]
SMARTiSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8NBV4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPASQSRARA RDRNNVLNRA EFLSLNQPPK GGPEPRSSGR KASGPSAQPP
60 70 80 90 100
PAGDGARERR QSQQLPEEDC MQLNPSFKGI AFNSLLAIDI CMSKRLGVCA
110 120 130 140 150
GRAASWASAR SMVKLIGITG HGIPWIGGTI LCLVKSSTLA GQEVLMNLLL
160 170 180 190 200
ALLLDIMTVA GVQKLIKRRG PYETSPSLLD YLTMDIYAFP AGHASRAAMV
210 220 230 240 250
SKFFLSHLVL AVPLRVLLVL WALCVGLSRV MIGRHHVTDV LSGFVIGYLQ
260 270
FRLVELVWMP SSTCQMLISA W
Length:271
Mass (Da):29,448
Last modified:October 1, 2002 - v1
Checksum:i1AE74180CDCD1A11
GO

Sequence cautioni

The sequence CAI16274 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti203 – 2031F → Y in BAB55204 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti174 – 1741T → M.1 Publication
Corresponds to variant rs2966332 [ dbSNP | Ensembl ].
VAR_026646
Natural varianti267 – 2671L → V.
Corresponds to variant rs11244366 [ dbSNP | Ensembl ].
VAR_026647

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027568 mRNA. Translation: BAB55204.1.
AK075207 mRNA. Translation: BAC11472.1.
AL354855 Genomic DNA. Translation: CAI16274.1. Sequence problems.
AL354855 Genomic DNA. Translation: CAI16275.1.
BC006362 mRNA. Translation: AAH06362.2.
CCDSiCCDS6942.1.
RefSeqiNP_116117.3. NM_032728.3.
UniGeneiHs.134292.

Genome annotation databases

EnsembliENST00000372264; ENSP00000361338; ENSG00000160539.
GeneIDi84814.
KEGGihsa:84814.
UCSCiuc004cal.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027568 mRNA. Translation: BAB55204.1.
AK075207 mRNA. Translation: BAC11472.1.
AL354855 Genomic DNA. Translation: CAI16274.1. Sequence problems.
AL354855 Genomic DNA. Translation: CAI16275.1.
BC006362 mRNA. Translation: AAH06362.2.
CCDSiCCDS6942.1.
RefSeqiNP_116117.3. NM_032728.3.
UniGeneiHs.134292.

3D structure databases

ProteinModelPortaliQ8NBV4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000361338.

PTM databases

DEPODiQ8NBV4.
iPTMnetiQ8NBV4.
PhosphoSiteiQ8NBV4.

Polymorphism and mutation databases

BioMutaiPPAPDC3.
DMDMi74751178.

Proteomic databases

PaxDbiQ8NBV4.
PeptideAtlasiQ8NBV4.
PRIDEiQ8NBV4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372264; ENSP00000361338; ENSG00000160539.
GeneIDi84814.
KEGGihsa:84814.
UCSCiuc004cal.2. human.

Organism-specific databases

CTDi84814.
GeneCardsiPPAPDC3.
HGNCiHGNC:28174. PLPP7.
HPAiHPA062514.
neXtProtiNX_Q8NBV4.
PharmGKBiPA134931886.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ISHN. Eukaryota.
ENOG4111VXU. LUCA.
GeneTreeiENSGT00390000012789.
HOGENOMiHOG000231931.
HOVERGENiHBG054746.
InParanoidiQ8NBV4.
OMAiYLQFRLV.
OrthoDBiEOG091G0STF.
PhylomeDBiQ8NBV4.
TreeFamiTF323272.

Miscellaneous databases

ChiTaRSiPPAPDC3. human.
GenomeRNAii84814.
PROiQ8NBV4.

Gene expression databases

BgeeiENSG00000160539.
CleanExiHS_PPAPDC3.
ExpressionAtlasiQ8NBV4. baseline and differential.
GenevisibleiQ8NBV4. HS.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiIPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PfamiPF01569. PAP2. 1 hit.
[Graphical view]
SMARTiSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPLPP7_HUMAN
AccessioniPrimary (citable) accession number: Q8NBV4
Secondary accession number(s): Q5T6P0, Q96SS7, Q9BRC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: October 1, 2002
Last modified: September 7, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.