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Protein

Inactive phospholipid phosphatase 7

Gene

PLPP7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a role as negative regulator of myoblast differentiation, in part through effects on MTOR signaling. Has no detectable enzymatic activity (By similarity).By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Inactive phospholipid phosphatase 7Imported
Alternative name(s):
Phosphatidic acid phosphatase type 2 domain-containing protein 3
Gene namesi
Name:PLPP7Imported
Synonyms:C9orf67, PPAPDC3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000160539.4.
HGNCiHGNC:28174. PLPP7.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 112CytoplasmicSequence analysisAdd BLAST112
Transmembranei113 – 133HelicalSequence analysisAdd BLAST21
Topological domaini134 – 141ExtracellularSequence analysis8
Transmembranei142 – 162HelicalSequence analysisAdd BLAST21
Topological domaini163 – 202CytoplasmicSequence analysisAdd BLAST40
Transmembranei203 – 223HelicalSequence analysisAdd BLAST21
Topological domaini224 – 239ExtracellularSequence analysisAdd BLAST16
Transmembranei240 – 260HelicalSequence analysisAdd BLAST21
Topological domaini261 – 271CytoplasmicSequence analysisAdd BLAST11

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000160539.
PharmGKBiPA134931886.

Polymorphism and mutation databases

BioMutaiPPAPDC3.
DMDMi74751178.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002394011 – 271Inactive phospholipid phosphatase 7Add BLAST271

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei43PhosphoserineBy similarity1
Modified residuei62PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8NBV4.
PeptideAtlasiQ8NBV4.
PRIDEiQ8NBV4.

PTM databases

DEPODiQ8NBV4.
iPTMnetiQ8NBV4.
PhosphoSitePlusiQ8NBV4.

Expressioni

Gene expression databases

BgeeiENSG00000160539.
CleanExiHS_PPAPDC3.
ExpressionAtlasiQ8NBV4. baseline and differential.
GenevisibleiQ8NBV4. HS.

Organism-specific databases

HPAiHPA070252.

Interactioni

Subunit structurei

Homo and heterooligomer. Interacts with MTOR; controls MTOR-dependent IGF2 expression during myoblast differentiation (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ8NBV4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni70 – 91Interaction with MTORBy similarityAdd BLAST22

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410ISHN. Eukaryota.
ENOG4111VXU. LUCA.
GeneTreeiENSGT00390000012789.
HOGENOMiHOG000231931.
HOVERGENiHBG054746.
InParanoidiQ8NBV4.
OMAiHHITDVI.
OrthoDBiEOG091G0STF.
PhylomeDBiQ8NBV4.
TreeFamiTF323272.

Family and domain databases

InterProiView protein in InterPro
IPR036938. P_Acid_Pase_2/haloperoxi_sf.
IPR000326. P_Acid_Pase_2/haloperoxidase.
PfamiView protein in Pfam
PF01569. PAP2. 1 hit.
SMARTiView protein in SMART
SM00014. acidPPc. 1 hit.
SUPFAMiSSF48317. SSF48317. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8NBV4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPASQSRARA RDRNNVLNRA EFLSLNQPPK GGPEPRSSGR KASGPSAQPP
60 70 80 90 100
PAGDGARERR QSQQLPEEDC MQLNPSFKGI AFNSLLAIDI CMSKRLGVCA
110 120 130 140 150
GRAASWASAR SMVKLIGITG HGIPWIGGTI LCLVKSSTLA GQEVLMNLLL
160 170 180 190 200
ALLLDIMTVA GVQKLIKRRG PYETSPSLLD YLTMDIYAFP AGHASRAAMV
210 220 230 240 250
SKFFLSHLVL AVPLRVLLVL WALCVGLSRV MIGRHHVTDV LSGFVIGYLQ
260 270
FRLVELVWMP SSTCQMLISA W
Length:271
Mass (Da):29,448
Last modified:October 1, 2002 - v1
Checksum:i1AE74180CDCD1A11
GO

Sequence cautioni

The sequence CAI16274 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti203F → Y in BAB55204 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_026646174T → M1 PublicationCorresponds to variant dbSNP:rs2966332Ensembl.1
Natural variantiVAR_026647267L → V. Corresponds to variant dbSNP:rs11244366Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027568 mRNA. Translation: BAB55204.1.
AK075207 mRNA. Translation: BAC11472.1.
AL354855 Genomic DNA. Translation: CAI16274.1. Sequence problems.
AL354855 Genomic DNA. Translation: CAI16275.1.
BC006362 mRNA. Translation: AAH06362.2.
CCDSiCCDS6942.1.
RefSeqiNP_116117.3. NM_032728.3.
UniGeneiHs.134292.

Genome annotation databases

EnsembliENST00000372264; ENSP00000361338; ENSG00000160539.
GeneIDi84814.
KEGGihsa:84814.
UCSCiuc004cal.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPLPP7_HUMAN
AccessioniPrimary (citable) accession number: Q8NBV4
Secondary accession number(s): Q5T6P0, Q96SS7, Q9BRC3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: October 1, 2002
Last modified: October 25, 2017
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families