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Protein

ATPase family AAA domain-containing protein 1

Gene

ATAD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

ATPase that plays a critical role in regulating the surface expression of AMPA receptors (AMPAR), thereby regulating synaptic plasticity and learning and memory. Required for NMDA-stimulated AMPAR internalization and inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane; these activities are ATPase-dependent (By similarity).By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi133 – 1408ATPSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATPase family AAA domain-containing protein 1 (EC:3.6.1.3)
Alternative name(s):
Thorase
Gene namesi
Name:ATAD1
ORF Names:FNP001
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componentsi: Chromosome 10, Chromosome 4

Organism-specific databases

HGNCiHGNC:25903. ATAD1.

Subcellular locationi

  • Peroxisome By similarity
  • Cell junctionsynapsepostsynaptic cell membrane By similarity

GO - Cellular componenti

  • cell junction Source: UniProtKB-KW
  • membrane Source: UniProtKB
  • mitochondrion Source: Ensembl
  • nucleus Source: GO_Central
  • peroxisomal membrane Source: UniProtKB
  • postsynaptic membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Peroxisome, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134914940.

Polymorphism and mutation databases

BioMutaiATAD1.
DMDMi74762551.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 361361ATPase family AAA domain-containing protein 1PRO_0000084791Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki46 – 46Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei322 – 3221PhosphoserineBy similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8NBU5.
MaxQBiQ8NBU5.
PaxDbiQ8NBU5.
PeptideAtlasiQ8NBU5.
PRIDEiQ8NBU5.

PTM databases

iPTMnetiQ8NBU5.
PhosphoSiteiQ8NBU5.
SwissPalmiQ8NBU5.

Expressioni

Gene expression databases

BgeeiENSG00000138138.
CleanExiHS_ATAD1.
GenevisibleiQ8NBU5. HS.

Organism-specific databases

HPAiHPA037569.

Interactioni

Subunit structurei

Interacts with GRIA2 and GRIP1 in an ATP-dependent manner. ATAD1-catalyzed ATP hydrolysis disrupts not only its binding to GRIA2 and GRIP1, but also interaction between GRIP1 and GRIA2, leading to AMPAR complex disassembly (By similarity).By similarity

Protein-protein interaction databases

BioGridi124336. 16 interactions.
IntActiQ8NBU5. 10 interactions.
MINTiMINT-3041854.
STRINGi9606.ENSP00000339016.

Structurei

3D structure databases

ProteinModelPortaliQ8NBU5.
SMRiQ8NBU5. Positions 54-348.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AAA ATPase family.Curated

Phylogenomic databases

eggNOGiKOG0737. Eukaryota.
COG0464. LUCA.
GeneTreeiENSGT00550000074823.
HOVERGENiHBG057074.
InParanoidiQ8NBU5.
OMAiKWMMNQM.
OrthoDBiEOG091G0CJ6.
PhylomeDBiQ8NBU5.
TreeFamiTF105016.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00674. AAA. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NBU5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVHAEAFSRP LSRNEVVGLI FRLTIFGAVT YFTIKWMVDA IDPTRKQKVE
60 70 80 90 100
AQKQAEKLMK QIGVKNVKLS EYEMSIAAHL VDPLNMHVTW SDIAGLDDVI
110 120 130 140 150
TDLKDTVILP IKKKHLFENS RLLQPPKGVL LYGPPGCGKT LIAKATAKEA
160 170 180 190 200
GCRFINLQPS TLTDKWYGES QKLAAAVFSL AIKLQPSIIF IDEIDSFLRN
210 220 230 240 250
RSSSDHEATA MMKAQFMSLW DGLDTDHSCQ VIVMGATNRP QDLDSAIMRR
260 270 280 290 300
MPTRFHINQP ALKQREAILK LILKNENVDR HVDLLEVAQE TDGFSGSDLK
310 320 330 340 350
EMCRDAALLC VREYVNSTSE ESHDEDEIRP VQQQDLHRAI EKMKKSKDAA
360
FQNVLTHVCL D
Length:361
Mass (Da):40,744
Last modified:October 1, 2002 - v1
Checksum:i2FAE88BA7E7140BC
GO
Isoform 2 (identifier: Q8NBU5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     278-361: VDRHVDLLEV...QNVLTHVCLD → LRKLKPREVL

Show »
Length:287
Mass (Da):32,408
Checksum:i9081A083DE9D1FAD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti160 – 1601S → R in AAL57218 (Ref. 1) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti107 – 1071V → I in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035903

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei278 – 36184VDRHV…HVCLD → LRKLKPREVL in isoform 2. 1 PublicationVSP_037304Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF361493 mRNA. Translation: AAL57218.1.
AK027506 mRNA. Translation: BAB55161.1.
AK075223 mRNA. Translation: BAC11482.1.
AL133327, AC022016 Genomic DNA. Translation: CAI16701.1.
CH471066 Genomic DNA. Translation: EAW50180.1.
CH471066 Genomic DNA. Translation: EAW50177.1.
CH471066 Genomic DNA. Translation: EAW50179.1.
BC010868 mRNA. Translation: AAH10868.1.
BC063530 mRNA. Translation: AAH63530.1.
BC073998 mRNA. Translation: AAH73998.1.
AL834370 mRNA. Translation: CAD39033.1.
CCDSiCCDS7386.1. [Q8NBU5-1]
RefSeqiNP_001308896.1. NM_001321967.1. [Q8NBU5-1]
NP_116199.2. NM_032810.3. [Q8NBU5-1]
XP_005270309.1. XM_005270252.4. [Q8NBU5-1]
UniGeneiHs.435948.

Genome annotation databases

EnsembliENST00000308448; ENSP00000339017; ENSG00000138138. [Q8NBU5-1]
ENST00000328142; ENSP00000339016; ENSG00000138138. [Q8NBU5-1]
ENST00000634773; ENSP00000489353; ENSG00000283024. [Q8NBU5-1]
ENST00000634970; ENSP00000489455; ENSG00000283024. [Q8NBU5-1]
GeneIDi84896.
KEGGihsa:84896.
UCSCiuc001key.2. human. [Q8NBU5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF361493 mRNA. Translation: AAL57218.1.
AK027506 mRNA. Translation: BAB55161.1.
AK075223 mRNA. Translation: BAC11482.1.
AL133327, AC022016 Genomic DNA. Translation: CAI16701.1.
CH471066 Genomic DNA. Translation: EAW50180.1.
CH471066 Genomic DNA. Translation: EAW50177.1.
CH471066 Genomic DNA. Translation: EAW50179.1.
BC010868 mRNA. Translation: AAH10868.1.
BC063530 mRNA. Translation: AAH63530.1.
BC073998 mRNA. Translation: AAH73998.1.
AL834370 mRNA. Translation: CAD39033.1.
CCDSiCCDS7386.1. [Q8NBU5-1]
RefSeqiNP_001308896.1. NM_001321967.1. [Q8NBU5-1]
NP_116199.2. NM_032810.3. [Q8NBU5-1]
XP_005270309.1. XM_005270252.4. [Q8NBU5-1]
UniGeneiHs.435948.

3D structure databases

ProteinModelPortaliQ8NBU5.
SMRiQ8NBU5. Positions 54-348.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124336. 16 interactions.
IntActiQ8NBU5. 10 interactions.
MINTiMINT-3041854.
STRINGi9606.ENSP00000339016.

PTM databases

iPTMnetiQ8NBU5.
PhosphoSiteiQ8NBU5.
SwissPalmiQ8NBU5.

Polymorphism and mutation databases

BioMutaiATAD1.
DMDMi74762551.

Proteomic databases

EPDiQ8NBU5.
MaxQBiQ8NBU5.
PaxDbiQ8NBU5.
PeptideAtlasiQ8NBU5.
PRIDEiQ8NBU5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308448; ENSP00000339017; ENSG00000138138. [Q8NBU5-1]
ENST00000328142; ENSP00000339016; ENSG00000138138. [Q8NBU5-1]
ENST00000634773; ENSP00000489353; ENSG00000283024. [Q8NBU5-1]
ENST00000634970; ENSP00000489455; ENSG00000283024. [Q8NBU5-1]
GeneIDi84896.
KEGGihsa:84896.
UCSCiuc001key.2. human. [Q8NBU5-1]

Organism-specific databases

CTDi84896.
GeneCardsiATAD1.
HGNCiHGNC:25903. ATAD1.
HPAiHPA037569.
MIMi614452. gene.
neXtProtiNX_Q8NBU5.
PharmGKBiPA134914940.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0737. Eukaryota.
COG0464. LUCA.
GeneTreeiENSGT00550000074823.
HOVERGENiHBG057074.
InParanoidiQ8NBU5.
OMAiKWMMNQM.
OrthoDBiEOG091G0CJ6.
PhylomeDBiQ8NBU5.
TreeFamiTF105016.

Miscellaneous databases

ChiTaRSiATAD1. human.
GenomeRNAii84896.
PROiQ8NBU5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000138138.
CleanExiHS_ATAD1.
GenevisibleiQ8NBU5. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00674. AAA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATAD1_HUMAN
AccessioniPrimary (citable) accession number: Q8NBU5
Secondary accession number(s): D3DR26
, Q6DKG1, Q6P4B9, Q8N3G1, Q8WYR9, Q969Y3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: October 1, 2002
Last modified: September 7, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.