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Q8NBU5

- ATAD1_HUMAN

UniProt

Q8NBU5 - ATAD1_HUMAN

Protein

ATPase family AAA domain-containing protein 1

Gene

ATAD1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    ATPase that plays a critical role in regulating the surface expression of AMPA receptors (AMPAR), thereby regulating synaptic plasticity and learning and memory. Required for NMDA-stimulated AMPAR internalization and inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane; these activities are ATPase-dependent By similarity.By similarity

    Catalytic activityi

    ATP + H2O = ADP + phosphate.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi133 – 1408ATPSequence Analysis

    GO - Molecular functioni

    1. ATPase activity Source: UniProtKB
    2. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. learning Source: UniProtKB
    2. memory Source: UniProtKB
    3. negative regulation of synaptic transmission, glutamatergic Source: UniProtKB
    4. positive regulation of receptor internalization Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATPase family AAA domain-containing protein 1 (EC:3.6.1.3)
    Alternative name(s):
    Thorase
    Gene namesi
    Name:ATAD1
    ORF Names:FNP001
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:25903. ATAD1.

    Subcellular locationi

    Peroxisome By similarity. Cell junctionsynapsepostsynaptic cell membrane By similarity

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. membrane Source: UniProtKB
    3. mitochondrion Source: Ensembl
    4. peroxisomal membrane Source: UniProtKB
    5. postsynaptic membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Peroxisome, Postsynaptic cell membrane, Synapse

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134914940.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 361361ATPase family AAA domain-containing protein 1PRO_0000084791Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki46 – 46Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

    Keywords - PTMi

    Isopeptide bond, Ubl conjugation

    Proteomic databases

    MaxQBiQ8NBU5.
    PaxDbiQ8NBU5.
    PeptideAtlasiQ8NBU5.
    PRIDEiQ8NBU5.

    PTM databases

    PhosphoSiteiQ8NBU5.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8NBU5.
    BgeeiQ8NBU5.
    CleanExiHS_ATAD1.
    GenevestigatoriQ8NBU5.

    Organism-specific databases

    HPAiHPA037569.

    Interactioni

    Subunit structurei

    Interacts with GRIA2 and GRIP1 in an ATP-dependent manner. ATAD1-catalyzed ATP hydrolysis disrupts not only its binding to GRIA2 and GRIP1, but also interaction between GRIP1 and GRIA2, leading to AMPAR complex disassembly By similarity.By similarity

    Protein-protein interaction databases

    BioGridi124336. 6 interactions.
    IntActiQ8NBU5. 3 interactions.
    MINTiMINT-3041854.
    STRINGi9606.ENSP00000339016.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NBU5.
    SMRiQ8NBU5. Positions 54-348.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AAA ATPase family.Curated

    Phylogenomic databases

    eggNOGiCOG0464.
    HOVERGENiHBG057074.
    InParanoidiQ8NBU5.
    OMAiYNCQVIV.
    OrthoDBiEOG7SR4MJ.
    PhylomeDBiQ8NBU5.
    TreeFamiTF105016.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR003593. AAA+_ATPase.
    IPR003959. ATPase_AAA_core.
    IPR003960. ATPase_AAA_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00004. AAA. 1 hit.
    [Graphical view]
    SMARTiSM00382. AAA. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00674. AAA. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8NBU5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVHAEAFSRP LSRNEVVGLI FRLTIFGAVT YFTIKWMVDA IDPTRKQKVE    50
    AQKQAEKLMK QIGVKNVKLS EYEMSIAAHL VDPLNMHVTW SDIAGLDDVI 100
    TDLKDTVILP IKKKHLFENS RLLQPPKGVL LYGPPGCGKT LIAKATAKEA 150
    GCRFINLQPS TLTDKWYGES QKLAAAVFSL AIKLQPSIIF IDEIDSFLRN 200
    RSSSDHEATA MMKAQFMSLW DGLDTDHSCQ VIVMGATNRP QDLDSAIMRR 250
    MPTRFHINQP ALKQREAILK LILKNENVDR HVDLLEVAQE TDGFSGSDLK 300
    EMCRDAALLC VREYVNSTSE ESHDEDEIRP VQQQDLHRAI EKMKKSKDAA 350
    FQNVLTHVCL D 361
    Length:361
    Mass (Da):40,744
    Last modified:October 1, 2002 - v1
    Checksum:i2FAE88BA7E7140BC
    GO
    Isoform 2 (identifier: Q8NBU5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         278-361: VDRHVDLLEV...QNVLTHVCLD → LRKLKPREVL

    Show »
    Length:287
    Mass (Da):32,408
    Checksum:i9081A083DE9D1FAD
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti160 – 1601S → R in AAL57218. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti107 – 1071V → I in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_035903

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei278 – 36184VDRHV…HVCLD → LRKLKPREVL in isoform 2. 1 PublicationVSP_037304Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF361493 mRNA. Translation: AAL57218.1.
    AK027506 mRNA. Translation: BAB55161.1.
    AK075223 mRNA. Translation: BAC11482.1.
    AL133327, AC022016 Genomic DNA. Translation: CAI16701.1.
    CH471066 Genomic DNA. Translation: EAW50180.1.
    CH471066 Genomic DNA. Translation: EAW50177.1.
    CH471066 Genomic DNA. Translation: EAW50179.1.
    BC010868 mRNA. Translation: AAH10868.1.
    BC063530 mRNA. Translation: AAH63530.1.
    BC073998 mRNA. Translation: AAH73998.1.
    AL834370 mRNA. Translation: CAD39033.1.
    CCDSiCCDS7386.1. [Q8NBU5-1]
    RefSeqiNP_116199.2. NM_032810.2. [Q8NBU5-1]
    XP_005270308.1. XM_005270251.1. [Q8NBU5-1]
    XP_005270309.1. XM_005270252.2. [Q8NBU5-1]
    UniGeneiHs.435948.

    Genome annotation databases

    EnsembliENST00000308448; ENSP00000339017; ENSG00000138138. [Q8NBU5-1]
    ENST00000328142; ENSP00000339016; ENSG00000138138. [Q8NBU5-1]
    GeneIDi84896.
    KEGGihsa:84896.
    UCSCiuc001key.1. human. [Q8NBU5-1]

    Polymorphism databases

    DMDMi74762551.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF361493 mRNA. Translation: AAL57218.1 .
    AK027506 mRNA. Translation: BAB55161.1 .
    AK075223 mRNA. Translation: BAC11482.1 .
    AL133327 , AC022016 Genomic DNA. Translation: CAI16701.1 .
    CH471066 Genomic DNA. Translation: EAW50180.1 .
    CH471066 Genomic DNA. Translation: EAW50177.1 .
    CH471066 Genomic DNA. Translation: EAW50179.1 .
    BC010868 mRNA. Translation: AAH10868.1 .
    BC063530 mRNA. Translation: AAH63530.1 .
    BC073998 mRNA. Translation: AAH73998.1 .
    AL834370 mRNA. Translation: CAD39033.1 .
    CCDSi CCDS7386.1. [Q8NBU5-1 ]
    RefSeqi NP_116199.2. NM_032810.2. [Q8NBU5-1 ]
    XP_005270308.1. XM_005270251.1. [Q8NBU5-1 ]
    XP_005270309.1. XM_005270252.2. [Q8NBU5-1 ]
    UniGenei Hs.435948.

    3D structure databases

    ProteinModelPortali Q8NBU5.
    SMRi Q8NBU5. Positions 54-348.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124336. 6 interactions.
    IntActi Q8NBU5. 3 interactions.
    MINTi MINT-3041854.
    STRINGi 9606.ENSP00000339016.

    PTM databases

    PhosphoSitei Q8NBU5.

    Polymorphism databases

    DMDMi 74762551.

    Proteomic databases

    MaxQBi Q8NBU5.
    PaxDbi Q8NBU5.
    PeptideAtlasi Q8NBU5.
    PRIDEi Q8NBU5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000308448 ; ENSP00000339017 ; ENSG00000138138 . [Q8NBU5-1 ]
    ENST00000328142 ; ENSP00000339016 ; ENSG00000138138 . [Q8NBU5-1 ]
    GeneIDi 84896.
    KEGGi hsa:84896.
    UCSCi uc001key.1. human. [Q8NBU5-1 ]

    Organism-specific databases

    CTDi 84896.
    GeneCardsi GC10M089502.
    HGNCi HGNC:25903. ATAD1.
    HPAi HPA037569.
    MIMi 614452. gene.
    neXtProti NX_Q8NBU5.
    PharmGKBi PA134914940.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0464.
    HOVERGENi HBG057074.
    InParanoidi Q8NBU5.
    OMAi YNCQVIV.
    OrthoDBi EOG7SR4MJ.
    PhylomeDBi Q8NBU5.
    TreeFami TF105016.

    Miscellaneous databases

    ChiTaRSi ATAD1. human.
    GenomeRNAii 84896.
    NextBioi 75244.
    PROi Q8NBU5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8NBU5.
    Bgeei Q8NBU5.
    CleanExi HS_ATAD1.
    Genevestigatori Q8NBU5.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR003593. AAA+_ATPase.
    IPR003959. ATPase_AAA_core.
    IPR003960. ATPase_AAA_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00004. AAA. 1 hit.
    [Graphical view ]
    SMARTi SM00382. AAA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00674. AAA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel gene expressed in fetal normal pituitary."
      Liu F., Xu X.R., Qian B.Z., Xiao H., Chen Z., Han Z.
      Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Pituitary.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Placenta.
    3. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 32-361 (ISOFORM 1).
      Tissue: Bone, Lung and PNS.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 47-361 (ISOFORM 1).
      Tissue: Melanoma.
    7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. "The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells."
      Vasilescu J., Zweitzig D.R., Denis N.J., Smith J.C., Ethier M., Haines D.S., Figeys D.
      J. Proteome Res. 6:298-305(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-46.
      Tissue: Lung adenocarcinoma.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. Cited for: VARIANT [LARGE SCALE ANALYSIS] ILE-107.

    Entry informationi

    Entry nameiATAD1_HUMAN
    AccessioniPrimary (citable) accession number: Q8NBU5
    Secondary accession number(s): D3DR26
    , Q6DKG1, Q6P4B9, Q8N3G1, Q8WYR9, Q969Y3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 13, 2005
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3