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Protein

Transmembrane protein 145

Gene

TMEM145

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000167619-MONOMER.
SignaLinkiQ8NBT3.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 145
Gene namesi
Name:TMEM145
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:26912. TMEM145.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei9 – 29HelicalSequence analysisAdd BLAST21
Transmembranei175 – 195HelicalSequence analysisAdd BLAST21
Transmembranei207 – 227HelicalSequence analysisAdd BLAST21
Transmembranei241 – 261HelicalSequence analysisAdd BLAST21
Transmembranei282 – 302HelicalSequence analysisAdd BLAST21
Transmembranei318 – 338HelicalSequence analysisAdd BLAST21
Transmembranei349 – 369HelicalSequence analysisAdd BLAST21
Transmembranei381 – 401HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000167619.
PharmGKBiPA144596253.

Polymorphism and mutation databases

BioMutaiTMEM145.
DMDMi296452935.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002803551 – 493Transmembrane protein 145Add BLAST493

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi35N-linked (GlcNAc...)Sequence analysis1
Glycosylationi444N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8NBT3.
PeptideAtlasiQ8NBT3.
PRIDEiQ8NBT3.

PTM databases

iPTMnetiQ8NBT3.
PhosphoSitePlusiQ8NBT3.

Expressioni

Gene expression databases

BgeeiENSG00000167619.
CleanExiHS_TMEM145.
ExpressionAtlasiQ8NBT3. baseline and differential.
GenevisibleiQ8NBT3. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000301204.

Structurei

3D structure databases

ProteinModelPortaliQ8NBT3.
SMRiQ8NBT3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4290. Eukaryota.
ENOG410XRGS. LUCA.
GeneTreeiENSGT00730000111228.
HOGENOMiHOG000074087.
HOVERGENiHBG094058.
InParanoidiQ8NBT3.
OMAiNTKEDWV.
OrthoDBiEOG091G06OX.
PhylomeDBiQ8NBT3.
TreeFamiTF314975.

Family and domain databases

InterProiIPR019336. Intimal_thickness-rel_rcpt.
[Graphical view]
PfamiPF10192. GpcrRhopsn4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NBT3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPLRAPALR RLLPPLLLLL LSLPPRARAK YVRGNLSSKE DWVFLTRFCF
60 70 80 90 100
LSDYGRLDFR FRYPEAKCCQ NILLYFDDPS QWPAVYKAGD KDCLAKESVI
110 120 130 140 150
RPENNQVINL TTQYAWSGCQ VVSEEGTRYL SCSSGRSFRS GDGLQLEYEM
160 170 180 190 200
VLTNGKSFWT RHFSADEFGI LETDVTFLLI FILIFFLSCY FGYLLKGRQL
210 220 230 240 250
LHTTYKMFMA AAGVEVLSLL FFCIYWGQYA TDGIGNESVK ILAKLLFSSS
260 270 280 290 300
FLIFLLMLIL LGKGFTVTRG RISHAGSVKL SVYMTLYTLT HVVLLIYEAE
310 320 330 340 350
FFDPGQVLYT YESPAGYGLI GLQVAAYVWF CYAVLVSLRH FPEKQPFYVP
360 370 380 390 400
FFAAYTLWFF AVPVMALIAN FGIPKWAREK IVNGIQLGIH LYAHGVFLIM
410 420 430 440 450
TRPSAANKNF PYHVRTSQIA SAGVPGPGGS QSADKAFPQH VYGNVTFISD
460 470 480 490
SVPNFTELFS IPPPATSPLP RAAPDSGLPL FRDLRPPGPL RDL
Length:493
Mass (Da):55,534
Last modified:May 18, 2010 - v2
Checksum:i316BB050EAC5285A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti281S → P in BAC11522 (PubMed:14702039).Curated1
Sequence conflicti467S → F in BAC11522 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_060400256L → M.Corresponds to variant rs7254227dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK075286 mRNA. Translation: BAC11522.1.
AC024078 Genomic DNA. No translation available.
CCDSiCCDS12603.1.
RefSeqiNP_775904.2. NM_173633.2.
UniGeneiHs.382075.

Genome annotation databases

EnsembliENST00000301204; ENSP00000301204; ENSG00000167619.
GeneIDi284339.
KEGGihsa:284339.
UCSCiuc002otk.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK075286 mRNA. Translation: BAC11522.1.
AC024078 Genomic DNA. No translation available.
CCDSiCCDS12603.1.
RefSeqiNP_775904.2. NM_173633.2.
UniGeneiHs.382075.

3D structure databases

ProteinModelPortaliQ8NBT3.
SMRiQ8NBT3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000301204.

PTM databases

iPTMnetiQ8NBT3.
PhosphoSitePlusiQ8NBT3.

Polymorphism and mutation databases

BioMutaiTMEM145.
DMDMi296452935.

Proteomic databases

PaxDbiQ8NBT3.
PeptideAtlasiQ8NBT3.
PRIDEiQ8NBT3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301204; ENSP00000301204; ENSG00000167619.
GeneIDi284339.
KEGGihsa:284339.
UCSCiuc002otk.2. human.

Organism-specific databases

CTDi284339.
GeneCardsiTMEM145.
HGNCiHGNC:26912. TMEM145.
neXtProtiNX_Q8NBT3.
OpenTargetsiENSG00000167619.
PharmGKBiPA144596253.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4290. Eukaryota.
ENOG410XRGS. LUCA.
GeneTreeiENSGT00730000111228.
HOGENOMiHOG000074087.
HOVERGENiHBG094058.
InParanoidiQ8NBT3.
OMAiNTKEDWV.
OrthoDBiEOG091G06OX.
PhylomeDBiQ8NBT3.
TreeFamiTF314975.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000167619-MONOMER.
SignaLinkiQ8NBT3.

Miscellaneous databases

GenomeRNAii284339.
PROiQ8NBT3.

Gene expression databases

BgeeiENSG00000167619.
CleanExiHS_TMEM145.
ExpressionAtlasiQ8NBT3. baseline and differential.
GenevisibleiQ8NBT3. HS.

Family and domain databases

InterProiIPR019336. Intimal_thickness-rel_rcpt.
[Graphical view]
PfamiPF10192. GpcrRhopsn4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTM145_HUMAN
AccessioniPrimary (citable) accession number: Q8NBT3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: May 18, 2010
Last modified: November 2, 2016
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.