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Protein

POC1 centriolar protein homolog A

Gene

POC1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays an important role in centriole assembly and/or stability and ciliogenesis. Involved in early steps of centriole duplication, as well as in the later steps of centriole length control. Acts in concert with POC1B to ensure centriole integrity and proper mitotic spindle formation.2 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cilium biogenesis/degradation

Enzyme and pathway databases

SignaLinkiQ8NBT0.

Names & Taxonomyi

Protein namesi
Recommended name:
POC1 centriolar protein homolog A
Alternative name(s):
Pix2
Proteome of centriole protein 1A
WD repeat-containing protein 51A
Gene namesi
Name:POC1A
Synonyms:WDR51A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:24488. POC1A.

Subcellular locationi

GO - Cellular componenti

  • centriole Source: UniProtKB
  • centrosome Source: UniProtKB
  • ciliary basal body Source: UniProtKB
  • spindle pole Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

Pathology & Biotechi

Involvement in diseasei

Short stature, onychodysplasia, facial dysmorphism, and hypotrichosis (SOFT)2 Publications
The disease is caused by mutations affecting the gene represented in this entry. Cells derived from affected individuals have abnormal mitotic mechanics with multipolar spindles, in addition to clearly impaired ciliogenesis.
Disease descriptionA syndrome characterized by severely short long bones, peculiar facies associated with paucity of hair, and nail anomalies. Growth retardation is evident on prenatal ultrasound as early as the second trimester of pregnancy, and affected individuals reach a final stature consistent with a height age of 6 years to 8 years. Relative macrocephaly is present during early childhood but head circumference is markedly low by adulthood. Psychomotor development is normal. Facial dysmorphism includes a long, triangular face with prominent nose and small ears, and affected individuals have an unusual high-pitched voice. Clinodactyly, brachydactyly, and hypoplastic distal phalanges and fingernails are present in association with postpubertal sparse and short hair. Typical skeletal findings include short and thick long bones with mild irregular metaphyseal changes, short femoral necks, and hypoplastic pelvis and sacrum. All long bones of the hand are short, with major delay of carpal ossification and cone-shaped epiphyses. Vertebral body ossification is also delayed.
See also OMIM:614813
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti171 – 1711L → P in SOFT. 1 Publication
VAR_068884

Keywords - Diseasei

Ciliopathy, Disease mutation, Dwarfism, Hypotrichosis

Organism-specific databases

MalaCardsiPOC1A.
MIMi614813. phenotype.
Orphaneti314394. Short stature-onychodysplasia-facial dysmorphism-hypotrichosis syndrome.
PharmGKBiPA165698089.

Polymorphism and mutation databases

BioMutaiPOC1A.
DMDMi91207986.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 407407POC1 centriolar protein homolog APRO_0000231522Add
BLAST

Proteomic databases

EPDiQ8NBT0.
MaxQBiQ8NBT0.
PaxDbiQ8NBT0.
PRIDEiQ8NBT0.

PTM databases

iPTMnetiQ8NBT0.

Expressioni

Gene expression databases

BgeeiQ8NBT0.
CleanExiHS_WDR51A.
GenevisibleiQ8NBT0. HS.

Organism-specific databases

HPAiHPA040600.

Interactioni

Subunit structurei

Interacts with POC1B.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
NUDCQ9Y2662EBI-2557132,EBI-357298

Protein-protein interaction databases

BioGridi117397. 99 interactions.
IntActiQ8NBT0. 79 interactions.
STRINGi9606.ENSP00000296484.

Structurei

3D structure databases

ProteinModelPortaliQ8NBT0.
SMRiQ8NBT0. Positions 11-336.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati17 – 5640WD 1Add
BLAST
Repeati59 – 9840WD 2Add
BLAST
Repeati101 – 14040WD 3Add
BLAST
Repeati143 – 18240WD 4Add
BLAST
Repeati185 – 22440WD 5Add
BLAST
Repeati227 – 26640WD 6Add
BLAST
Repeati269 – 30840WD 7Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili369 – 39729Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the WD repeat POC1 family.Curated
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat, WD repeat

Phylogenomic databases

eggNOGiENOG410IF90. Eukaryota.
ENOG410XR4H. LUCA.
GeneTreeiENSGT00810000125363.
HOGENOMiHOG000036743.
HOVERGENiHBG057502.
InParanoidiQ8NBT0.
KOiK16482.
OMAiYRFIGHK.
OrthoDBiEOG712TWD.
PhylomeDBiQ8NBT0.
TreeFamiTF324210.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 7 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 7 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NBT0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAPCAEDPS LERHFKGHRD AVTCVDFSIN TKQLASGSMD SCLMVWHMKP
60 70 80 90 100
QSRAYRFTGH KDAVTCVNFS PSGHLLASGS RDKTVRIWVP NVKGESTVFR
110 120 130 140 150
AHTATVRSVH FCSDGQSFVT ASDDKTVKVW ATHRQKFLFS LSQHINWVRC
160 170 180 190 200
AKFSPDGRLI VSASDDKTVK LWDKSSRECV HSYCEHGGFV TYVDFHPSGT
210 220 230 240 250
CIAAAGMDNT VKVWDVRTHR LLQHYQLHSA AVNGLSFHPS GNYLITASSD
260 270 280 290 300
STLKILDLME GRLLYTLHGH QGPATTVAFS RTGEYFASGG SDEQVMVWKS
310 320 330 340 350
NFDIVDHGEV TKVPRPPATL ASSMGNLPEV DFPVPPGRGR SVESVQSQPQ
360 370 380 390 400
EPVSVPQTLT STLEHIVGQL DVLTQTVSIL EQRLTLTEDK LKQCLENQQL

IMQRATP
Length:407
Mass (Da):45,009
Last modified:April 4, 2006 - v2
Checksum:iA5BF28F024DCCC98
GO
Isoform 2 (identifier: Q8NBT0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     328-375: Missing.

Note: No experimental confirmation available.
Show »
Length:359
Mass (Da):39,847
Checksum:iBB89016A021611C0
GO
Isoform 3 (identifier: Q8NBT0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-38: Missing.

Note: No experimental confirmation available.
Show »
Length:369
Mass (Da):40,936
Checksum:iB4C01336033853E4
GO

Sequence cautioni

The sequence AAI19694.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAB56021.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti219 – 2191H → Y in BAC11525 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti79 – 791G → S.
Corresponds to variant rs35249554 [ dbSNP | Ensembl ].
VAR_057627
Natural varianti171 – 1711L → P in SOFT. 1 Publication
VAR_068884
Natural varianti348 – 3481Q → H.
Corresponds to variant rs35898691 [ dbSNP | Ensembl ].
VAR_057628

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3838Missing in isoform 3. 1 PublicationVSP_046398Add
BLAST
Alternative sequencei328 – 37548Missing in isoform 2. 2 PublicationsVSP_017836Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK075289 mRNA. Translation: BAC11525.1.
AC097637 Genomic DNA. No translation available.
AC115284 Genomic DNA. No translation available.
BC007417 mRNA. Translation: AAH07417.2.
BC110877 mRNA. Translation: AAI10878.1.
BC119692 mRNA. Translation: AAI19693.1.
BC119693 mRNA. Translation: AAI19694.1. Different initiation.
AL117629 mRNA. Translation: CAB56021.1. Different initiation.
CCDSiCCDS2846.1. [Q8NBT0-1]
CCDS54591.1. [Q8NBT0-3]
CCDS54592.1. [Q8NBT0-2]
PIRiT17331.
RefSeqiNP_001155052.1. NM_001161580.1. [Q8NBT0-2]
NP_001155053.1. NM_001161581.1. [Q8NBT0-3]
NP_056241.3. NM_015426.4. [Q8NBT0-1]
UniGeneiHs.476306.

Genome annotation databases

EnsembliENST00000296484; ENSP00000296484; ENSG00000164087. [Q8NBT0-1]
ENST00000394970; ENSP00000378421; ENSG00000164087. [Q8NBT0-2]
ENST00000474012; ENSP00000418968; ENSG00000164087. [Q8NBT0-3]
GeneIDi25886.
KEGGihsa:25886.
UCSCiuc003dcu.4. human. [Q8NBT0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK075289 mRNA. Translation: BAC11525.1.
AC097637 Genomic DNA. No translation available.
AC115284 Genomic DNA. No translation available.
BC007417 mRNA. Translation: AAH07417.2.
BC110877 mRNA. Translation: AAI10878.1.
BC119692 mRNA. Translation: AAI19693.1.
BC119693 mRNA. Translation: AAI19694.1. Different initiation.
AL117629 mRNA. Translation: CAB56021.1. Different initiation.
CCDSiCCDS2846.1. [Q8NBT0-1]
CCDS54591.1. [Q8NBT0-3]
CCDS54592.1. [Q8NBT0-2]
PIRiT17331.
RefSeqiNP_001155052.1. NM_001161580.1. [Q8NBT0-2]
NP_001155053.1. NM_001161581.1. [Q8NBT0-3]
NP_056241.3. NM_015426.4. [Q8NBT0-1]
UniGeneiHs.476306.

3D structure databases

ProteinModelPortaliQ8NBT0.
SMRiQ8NBT0. Positions 11-336.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117397. 99 interactions.
IntActiQ8NBT0. 79 interactions.
STRINGi9606.ENSP00000296484.

PTM databases

iPTMnetiQ8NBT0.

Polymorphism and mutation databases

BioMutaiPOC1A.
DMDMi91207986.

Proteomic databases

EPDiQ8NBT0.
MaxQBiQ8NBT0.
PaxDbiQ8NBT0.
PRIDEiQ8NBT0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296484; ENSP00000296484; ENSG00000164087. [Q8NBT0-1]
ENST00000394970; ENSP00000378421; ENSG00000164087. [Q8NBT0-2]
ENST00000474012; ENSP00000418968; ENSG00000164087. [Q8NBT0-3]
GeneIDi25886.
KEGGihsa:25886.
UCSCiuc003dcu.4. human. [Q8NBT0-1]

Organism-specific databases

CTDi25886.
GeneCardsiPOC1A.
HGNCiHGNC:24488. POC1A.
HPAiHPA040600.
MalaCardsiPOC1A.
MIMi614783. gene.
614813. phenotype.
neXtProtiNX_Q8NBT0.
Orphaneti314394. Short stature-onychodysplasia-facial dysmorphism-hypotrichosis syndrome.
PharmGKBiPA165698089.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF90. Eukaryota.
ENOG410XR4H. LUCA.
GeneTreeiENSGT00810000125363.
HOGENOMiHOG000036743.
HOVERGENiHBG057502.
InParanoidiQ8NBT0.
KOiK16482.
OMAiYRFIGHK.
OrthoDBiEOG712TWD.
PhylomeDBiQ8NBT0.
TreeFamiTF324210.

Enzyme and pathway databases

SignaLinkiQ8NBT0.

Miscellaneous databases

ChiTaRSiPOC1A. human.
GenomeRNAii25886.
PROiQ8NBT0.
SOURCEiSearch...

Gene expression databases

BgeeiQ8NBT0.
CleanExiHS_WDR51A.
GenevisibleiQ8NBT0. HS.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 7 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 7 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 7 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Retinoblastoma.
  2. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
    Tissue: Ovary.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 219-407 (ISOFORM 2).
    Tissue: Testis.
  5. "Pix1 and Pix2 are novel WD40 microtubule-associated proteins that colocalize with mitochondria in Xenopus germ plasm and centrosomes in human cells."
    Hames R.S., Hames R., Prosser S.L., Euteneuer U., Lopes C.A., Moore W., Woodland H.R., Fry A.M.
    Exp. Cell Res. 314:574-589(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  6. "Basal body stability and ciliogenesis requires the conserved component Poc1."
    Pearson C.G., Osborn D.P., Giddings T.H. Jr., Beales P.L., Winey M.
    J. Cell Biol. 187:905-920(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  7. "Molecular architecture of the centriole proteome: the conserved WD40 domain protein POC1 is required for centriole duplication and length control."
    Keller L.C., Geimer S., Romijn E., Yates J. III, Zamora I., Marshall W.F.
    Mol. Biol. Cell 20:1150-1166(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  8. Cited for: INVOLVEMENT IN SOFT.
  9. "Poc1A and Poc1B act together in human cells to ensure centriole integrity."
    Venoux M., Tait X., Hames R.S., Straatman K.R., Woodland H.R., Fry A.M.
    J. Cell Sci. 126:163-175(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH POC1B.
  10. Cited for: VARIANT SOFT PRO-171.

Entry informationi

Entry nameiPOC1A_HUMAN
AccessioniPrimary (citable) accession number: Q8NBT0
Secondary accession number(s): A4FUW4
, E9PFC6, Q0VDF8, Q2TAK6, Q96IK6, Q9UFJ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: April 4, 2006
Last modified: June 8, 2016
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.