POC1A

Functionⁱ

Plays an important role in centriole assembly and/or stability and ciliogenesis. Involved in early steps of centriole duplication, as well as in the later steps of centriole length control. Acts in concert with POC1B to ensure centriole integrity and proper mitotic spindle formation.2 Publications

GO - Biological processⁱ

growth plate cartilage chondrocyte development Source: Ensembl
mitotic spindle organization Source: Ensembl
non-motile cilium assembly Source: Ensembl
positive regulation of centrosome duplication Source: Ensembl
spermatogenesis Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Cilium biogenesis/degradation

Biological process

Cilium biogenesis/degradation

Enzyme and pathway databases

SignaLinkⁱ	Q8NBT0

SignaLinkⁱ

Q8NBT0

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: POC1 centriolar protein homolog A Alternative name(s): Pix2 Proteome of centriole protein 1A WD repeat-containing protein 51A
Gene namesⁱ	Name:POC1A Synonyms:WDR51A
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 3

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000164087.7
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:24488 POC1A
MIMⁱ	614783 gene
neXtProtⁱ	NX_Q8NBT0

Keywords - Cellular componentⁱ

Cell projection, Cytoplasm, Cytoskeleton

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Short stature, onychodysplasia, facial dysmorphism, and hypotrichosis (SOFT)2 Publications

The disease is caused by mutations affecting the gene represented in this entry. Cells derived from affected individuals have abnormal mitotic mechanics with multipolar spindles, in addition to clearly impaired ciliogenesis.

Disease descriptionA syndrome characterized by severely short long bones, peculiar facies associated with paucity of hair, and nail anomalies. Growth retardation is evident on prenatal ultrasound as early as the second trimester of pregnancy, and affected individuals reach a final stature consistent with a height age of 6 years to 8 years. Relative macrocephaly is present during early childhood but head circumference is markedly low by adulthood. Psychomotor development is normal. Facial dysmorphism includes a long, triangular face with prominent nose and small ears, and affected individuals have an unusual high-pitched voice. Clinodactyly, brachydactyly, and hypoplastic distal phalanges and fingernails are present in association with postpubertal sparse and short hair. Typical skeletal findings include short and thick long bones with mild irregular metaphyseal changes, short femoral necks, and hypoplastic pelvis and sacrum. All long bones of the hand are short, with major delay of carpal ossification and cone-shaped epiphyses. Vertebral body ossification is also delayed.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_068884	171	L → P in SOFT. 1 PublicationCorresponds to variant dbSNP:rs397514488Ensembl.		1

Keywords - Diseaseⁱ

Ciliopathy, Disease mutation, Dwarfism, Hypotrichosis

Organism-specific databases

DisGeNET More...DisGeNETⁱ	25886
MalaCards human disease database More...MalaCardsⁱ	POC1A
MIMⁱ	614813 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000164087
Orphanetⁱ	314394 Short stature-onychodysplasia-facial dysmorphism-hypotrichosis syndrome
PharmGKBⁱ	PA165698089

Polymorphism and mutation databases

BioMutaⁱ	POC1A
DMDMⁱ	91207986

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000231522	1 – 407	POC1 centriolar protein homolog AAdd BLAST		407

Proteomic databases

EPDⁱ	Q8NBT0
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8NBT0
PaxDbⁱ	Q8NBT0
PeptideAtlas More...PeptideAtlasⁱ	Q8NBT0
PRIDEⁱ	Q8NBT0
ProteomicsDBⁱ	72818 72819 [Q8NBT0-2]

PTM databases

iPTMnetⁱ	Q8NBT0
PhosphoSitePlusⁱ	Q8NBT0

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000164087
CleanExⁱ	HS_WDR51A
Genevisibleⁱ	Q8NBT0 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA040600

HPAⁱ

HPA040600

Interactionⁱ

Subunit structureⁱ

Interacts with POC1B.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
NUDC	Q9Y266	2	EBI-2557132,EBI-357298

With

Entry

#Exp.

IntAct

Notes

NUDC

Q9Y266

2

EBI-2557132,EBI-357298

Protein-protein interaction databases

BioGridⁱ	117397, 106 interactors
IntActⁱ	Q8NBT0, 79 interactors
STRINGⁱ	9606.ENSP00000296484

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8NBT0
SMRⁱ	Q8NBT0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	17 – 56	WD 1Add BLAST	40
Repeatⁱ	59 – 98	WD 2Add BLAST	40
Repeatⁱ	101 – 140	WD 3Add BLAST	40
Repeatⁱ	143 – 182	WD 4Add BLAST	40
Repeatⁱ	185 – 224	WD 5Add BLAST	40
Repeatⁱ	227 – 266	WD 6Add BLAST	40
Repeatⁱ	269 – 308	WD 7Add BLAST	40

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	369 – 397	Sequence analysisAdd BLAST		29

Sequence similaritiesⁱ

Belongs to the WD repeat POC1 family.Curated

Keywords - Domainⁱ

Coiled coil, Repeat, WD repeat

Phylogenomic databases

eggNOGⁱ	ENOG410IF90 Eukaryota ENOG410XR4H LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00810000125363
HOGENOMⁱ	HOG000036743
HOVERGENⁱ	HBG057502
InParanoidⁱ	Q8NBT0
KEGG Orthology (KO) More...KOⁱ	K16482
OMAⁱ	CLENQQL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G07ES
PhylomeDBⁱ	Q8NBT0
TreeFamⁱ	TF324210

Family and domain databases

Gene3Dⁱ	2.130.10.10, 4 hits
InterProⁱ	View protein in InterPro IPR020472 G-protein_beta_WD-40_rep IPR015943 WD40/YVTN_repeat-like_dom_sf IPR001680 WD40_repeat IPR019775 WD40_repeat_CS IPR017986 WD40_repeat_dom IPR036322 WD40_repeat_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00400 WD40, 7 hits
PRINTSⁱ	PR00320 GPROTEINBRPT
SMARTⁱ	View protein in SMART SM00320 WD40, 7 hits
SUPFAMⁱ	SSF50978 SSF50978, 1 hit
PROSITEⁱ	View protein in PROSITE PS00678 WD_REPEATS_1, 1 hit PS50082 WD_REPEATS_2, 7 hits PS50294 WD_REPEATS_REGION, 1 hit

Sequences (3)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: Q8NBT0-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAPCAEDPS LERHFKGHRD AVTCVDFSIN TKQLASGSMD SCLMVWHMKP 
        60         70         80         90        100
QSRAYRFTGH KDAVTCVNFS PSGHLLASGS RDKTVRIWVP NVKGESTVFR 
       110        120        130        140        150
AHTATVRSVH FCSDGQSFVT ASDDKTVKVW ATHRQKFLFS LSQHINWVRC 
       160        170        180        190        200
AKFSPDGRLI VSASDDKTVK LWDKSSRECV HSYCEHGGFV TYVDFHPSGT 
       210        220        230        240        250
CIAAAGMDNT VKVWDVRTHR LLQHYQLHSA AVNGLSFHPS GNYLITASSD 
       260        270        280        290        300
STLKILDLME GRLLYTLHGH QGPATTVAFS RTGEYFASGG SDEQVMVWKS 
       310        320        330        340        350
NFDIVDHGEV TKVPRPPATL ASSMGNLPEV DFPVPPGRGR SVESVQSQPQ 
       360        370        380        390        400
EPVSVPQTLT STLEHIVGQL DVLTQTVSIL EQRLTLTEDK LKQCLENQQL 

IMQRATP

Length:407

Mass (Da):45,009

Last modified:April 4, 2006 - v2

Checksum:ⁱA5BF28F024DCCC98

GO

Isoform 2 (identifier: Q8NBT0-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
328-375: Missing.

« Hide

        10         20         30         40         50
MAAPCAEDPS LERHFKGHRD AVTCVDFSIN TKQLASGSMD SCLMVWHMKP 
        60         70         80         90        100
QSRAYRFTGH KDAVTCVNFS PSGHLLASGS RDKTVRIWVP NVKGESTVFR 
       110        120        130        140        150
AHTATVRSVH FCSDGQSFVT ASDDKTVKVW ATHRQKFLFS LSQHINWVRC 
       160        170        180        190        200
AKFSPDGRLI VSASDDKTVK LWDKSSRECV HSYCEHGGFV TYVDFHPSGT 
       210        220        230        240        250
CIAAAGMDNT VKVWDVRTHR LLQHYQLHSA AVNGLSFHPS GNYLITASSD 
       260        270        280        290        300
STLKILDLME GRLLYTLHGH QGPATTVAFS RTGEYFASGG SDEQVMVWKS 
       310        320        330        340        350
NFDIVDHGEV TKVPRPPATL ASSMGNLTVS ILEQRLTLTE DKLKQCLENQ 

QLIMQRATP

Note: No experimental confirmation available.

Show »

Length:359

Mass (Da):39,847

Checksum:ⁱBB89016A021611C0

GO

Isoform 3 (identifier: Q8NBT0-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-38: Missing.

« Hide

        10         20         30         40         50
MDSCLMVWHM KPQSRAYRFT GHKDAVTCVN FSPSGHLLAS GSRDKTVRIW 
        60         70         80         90        100
VPNVKGESTV FRAHTATVRS VHFCSDGQSF VTASDDKTVK VWATHRQKFL 
       110        120        130        140        150
FSLSQHINWV RCAKFSPDGR LIVSASDDKT VKLWDKSSRE CVHSYCEHGG 
       160        170        180        190        200
FVTYVDFHPS GTCIAAAGMD NTVKVWDVRT HRLLQHYQLH SAAVNGLSFH 
       210        220        230        240        250
PSGNYLITAS SDSTLKILDL MEGRLLYTLH GHQGPATTVA FSRTGEYFAS 
       260        270        280        290        300
GGSDEQVMVW KSNFDIVDHG EVTKVPRPPA TLASSMGNLP EVDFPVPPGR 
       310        320        330        340        350
GRSVESVQSQ PQEPVSVPQT LTSTLEHIVG QLDVLTQTVS ILEQRLTLTE 
       360 
DKLKQCLENQ QLIMQRATP

Note: No experimental confirmation available.

Show »

Length:369

Mass (Da):40,936

Checksum:ⁱB4C01336033853E4

GO

Sequence cautionⁱ

The sequence AAI19694 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

The sequence CAB56021 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	219	H → Y in BAC11525 (PubMed:14702039).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_057627	79	G → S. Corresponds to variant dbSNP:rs35249554Ensembl.	1
Natural variantⁱVAR_068884	171	L → P in SOFT. 1 PublicationCorresponds to variant dbSNP:rs397514488Ensembl.	1
Natural variantⁱVAR_057628	348	Q → H. Corresponds to variant dbSNP:rs35898691EnsemblClinVar.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_046398	1 – 38	Missing in isoform 3. 1 PublicationAdd BLAST		38
Alternative sequenceⁱVSP_017836	328 – 375	Missing in isoform 2. 2 PublicationsAdd BLAST		48

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK075289 mRNA Translation: BAC11525.1 AC097637 Genomic DNA No translation available. AC115284 Genomic DNA No translation available. BC007417 mRNA Translation: AAH07417.2 BC110877 mRNA Translation: AAI10878.1 BC119692 mRNA Translation: AAI19693.1 BC119693 mRNA Translation: AAI19694.1 Different initiation. AL117629 mRNA Translation: CAB56021.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2846.1 [Q8NBT0-1] CCDS54591.1 [Q8NBT0-3] CCDS54592.1 [Q8NBT0-2]
PIRⁱ	T17331
NCBI Reference Sequences More...RefSeqⁱ	NP_001155052.1, NM_001161580.1 [Q8NBT0-2] NP_001155053.1, NM_001161581.1 [Q8NBT0-3] NP_056241.3, NM_015426.4 [Q8NBT0-1]
UniGeneⁱ	Hs.476306

Genome annotation databases

Ensemblⁱ	ENST00000296484; ENSP00000296484; ENSG00000164087 [Q8NBT0-1] ENST00000394970; ENSP00000378421; ENSG00000164087 [Q8NBT0-2] ENST00000474012; ENSP00000418968; ENSG00000164087 [Q8NBT0-3]
GeneIDⁱ	25886
KEGGⁱ	hsa:25886
UCSC genome browser More...UCSCⁱ	uc003dcu.4 human [Q8NBT0-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q8NBT0	POC1 centriolar protein homolog A		PANTR		407
cDNA, FLJ96786		HUMAN		364
UPI00045DACF7		CHLSB		448
POC1 centriolar protein A		HORSE		426
POC1 centriolar protein A		SHEEP		425
+118
Q8NBT0-2	POC1 centriolar protein A		PANTR		359
POC1 centriolar protein A		PANPA		359
UPI000511BBBE		HUMAN		321
UPI00045DA02E		CHLSB		445
UPI000C2A7C88		Ugandan red Colobus		375
+15

Protein	Similar proteins		Species	Score	Length
Q8NBT0	POC1 centriolar protein homolog A		PANTR		407
cDNA, FLJ96786		HUMAN		364
UPI00045DACF7		CHLSB		448
POC1 centriolar protein A		HORSE		426
POC1 centriolar protein A		SHEEP		425
+267
Q8NBT0-2	POC1 centriolar protein A		FICAL		405
UPI000719F3B9		STUVU		405
UPI0002B48410		TAEGU		405
POC1 centriolar A		Bengalese finch		405
UPI000534F350		Corvus cornix cornix		405
+127

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK075289 mRNA Translation: BAC11525.1 AC097637 Genomic DNA No translation available. AC115284 Genomic DNA No translation available. BC007417 mRNA Translation: AAH07417.2 BC110877 mRNA Translation: AAI10878.1 BC119692 mRNA Translation: AAI19693.1 BC119693 mRNA Translation: AAI19694.1 Different initiation. AL117629 mRNA Translation: CAB56021.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2846.1 [Q8NBT0-1] CCDS54591.1 [Q8NBT0-3] CCDS54592.1 [Q8NBT0-2]
PIRⁱ	T17331
NCBI Reference Sequences More...RefSeqⁱ	NP_001155052.1, NM_001161580.1 [Q8NBT0-2] NP_001155053.1, NM_001161581.1 [Q8NBT0-3] NP_056241.3, NM_015426.4 [Q8NBT0-1]
UniGeneⁱ	Hs.476306

3D structure databases

ProteinModelPortalⁱ	Q8NBT0
SMRⁱ	Q8NBT0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	117397, 106 interactors
IntActⁱ	Q8NBT0, 79 interactors
STRINGⁱ	9606.ENSP00000296484

PTM databases

iPTMnetⁱ	Q8NBT0
PhosphoSitePlusⁱ	Q8NBT0

Polymorphism and mutation databases

BioMutaⁱ	POC1A
DMDMⁱ	91207986

Proteomic databases

EPDⁱ	Q8NBT0
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8NBT0
PaxDbⁱ	Q8NBT0
PeptideAtlas More...PeptideAtlasⁱ	Q8NBT0
PRIDEⁱ	Q8NBT0
ProteomicsDBⁱ	72818 72819 [Q8NBT0-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000296484; ENSP00000296484; ENSG00000164087 [Q8NBT0-1] ENST00000394970; ENSP00000378421; ENSG00000164087 [Q8NBT0-2] ENST00000474012; ENSP00000418968; ENSG00000164087 [Q8NBT0-3]
GeneIDⁱ	25886
KEGGⁱ	hsa:25886
UCSC genome browser More...UCSCⁱ	uc003dcu.4 human [Q8NBT0-1]

Organism-specific databases

CTDⁱ	25886
DisGeNET More...DisGeNETⁱ	25886
EuPathDBⁱ	HostDB:ENSG00000164087.7
GeneCardsⁱ	POC1A
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:24488 POC1A
Human Protein Atlas More...HPAⁱ	HPA040600
MalaCards human disease database More...MalaCardsⁱ	POC1A
MIMⁱ	614783 gene 614813 phenotype
neXtProtⁱ	NX_Q8NBT0
Open Targets More...OpenTargetsⁱ	ENSG00000164087
Orphanetⁱ	314394 Short stature-onychodysplasia-facial dysmorphism-hypotrichosis syndrome
PharmGKBⁱ	PA165698089
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IF90 Eukaryota ENOG410XR4H LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00810000125363
HOGENOMⁱ	HOG000036743
HOVERGENⁱ	HBG057502
InParanoidⁱ	Q8NBT0
KEGG Orthology (KO) More...KOⁱ	K16482
OMAⁱ	CLENQQL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G07ES
PhylomeDBⁱ	Q8NBT0
TreeFamⁱ	TF324210

Enzyme and pathway databases

SignaLinkⁱ	Q8NBT0

SignaLinkⁱ

Q8NBT0

Miscellaneous databases

ChiTaRSⁱ	POC1A human
GenomeRNAiⁱ	25886
Protein Ontology More...PROⁱ	PR:Q8NBT0
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000164087
CleanExⁱ	HS_WDR51A
Genevisibleⁱ	Q8NBT0 HS

Family and domain databases

Gene3Dⁱ	2.130.10.10, 4 hits
InterProⁱ	View protein in InterPro IPR020472 G-protein_beta_WD-40_rep IPR015943 WD40/YVTN_repeat-like_dom_sf IPR001680 WD40_repeat IPR019775 WD40_repeat_CS IPR017986 WD40_repeat_dom IPR036322 WD40_repeat_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00400 WD40, 7 hits
PRINTSⁱ	PR00320 GPROTEINBRPT
SMARTⁱ	View protein in SMART SM00320 WD40, 7 hits
SUPFAMⁱ	SSF50978 SSF50978, 1 hit
PROSITEⁱ	View protein in PROSITE PS00678 WD_REPEATS_1, 1 hit PS50082 WD_REPEATS_2, 7 hits PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	POC1A_HUMAN
Accessionⁱ	Q8NBT0Primary (citable) accession number: Q8NBT0 Secondary accession number(s): A4FUW4 , E9PFC6, Q0VDF8, Q2TAK6, Q96IK6, Q9UFJ8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
	Last sequence update:	April 4, 2006
	Last modified:	June 20, 2018
	This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

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UniProtKB - Q8NBT0 (POC1A_HUMAN)

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POC1 centriolar protein homolog A

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ