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Q8NBS9

- TXND5_HUMAN

UniProt

Q8NBS9 - TXND5_HUMAN

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Protein

Thioredoxin domain-containing protein 5

Gene
TXNDC5, TLP46, UNQ364/PRO700
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Possesses thioredoxin activity. Has been shown to reduce insulin disulfide bonds. Also complements protein disulfide-isomerase deficiency in yeast By similarity.

GO - Molecular functioni

  1. protein binding Source: IntAct
  2. protein disulfide isomerase activity Source: RefGenome

GO - Biological processi

  1. apoptotic cell clearance Source: RefGenome
  2. cell redox homeostasis Source: InterPro
  3. membrane organization Source: Reactome
  4. negative regulation of apoptotic process Source: UniProtKB
  5. post-Golgi vesicle-mediated transport Source: Reactome
  6. protein folding Source: RefGenome
  7. response to endoplasmic reticulum stress Source: RefGenome
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_19287. Lysosome Vesicle Biogenesis.
REACT_19400. Golgi Associated Vesicle Biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin domain-containing protein 5
Alternative name(s):
Endoplasmic reticulum resident protein 46
Short name:
ER protein 46
Short name:
ERp46
Thioredoxin-like protein p46
Gene namesi
Name:TXNDC5
Synonyms:TLP46
ORF Names:UNQ364/PRO700
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:21073. TXNDC5.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB
  2. endoplasmic reticulum lumen Source: UniProtKB-SubCell
  3. extracellular vesicular exosome Source: UniProt
  4. lysosomal lumen Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134992492.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3232 Reviewed predictionAdd
BLAST
Chaini33 – 432400Thioredoxin domain-containing protein 5PRO_0000034183Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi89 ↔ 92Redox-active Reviewed prediction
Disulfide bondi217 ↔ 220Redox-active Reviewed prediction
Disulfide bondi350 ↔ 353Redox-active Reviewed prediction

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ8NBS9.
PaxDbiQ8NBS9.
PRIDEiQ8NBS9.

PTM databases

PhosphoSiteiQ8NBS9.

Expressioni

Gene expression databases

BgeeiQ8NBS9.
CleanExiHS_TXNDC5.
GenevestigatoriQ8NBS9.

Organism-specific databases

HPAiHPA034677.
HPA034678.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PRDX4Q131622EBI-2510815,EBI-2211957

Protein-protein interaction databases

BioGridi123529. 37 interactions.
DIPiDIP-53700N.
IntActiQ8NBS9. 9 interactions.
MINTiMINT-5006305.
STRINGi9606.ENSP00000369081.

Structurei

Secondary structure

1
432
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi324 – 3263
Turni329 – 3313
Helixi332 – 3365
Beta strandi337 – 34610
Helixi351 – 36414
Beta strandi374 – 3807
Turni381 – 3833
Helixi385 – 3906
Beta strandi395 – 4039
Beta strandi406 – 4116
Helixi417 – 42711

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DIZNMR-A323-432[»]
3UJ1X-ray2.65A323-432[»]
3UVTX-ray2.00A/B/C/D/E323-428[»]
ProteinModelPortaliQ8NBS9.
SMRiQ8NBS9. Positions 55-428.

Miscellaneous databases

EvolutionaryTraceiQ8NBS9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini36 – 169134Thioredoxin 1Add
BLAST
Domaini170 – 295126Thioredoxin 2Add
BLAST
Domaini304 – 429126Thioredoxin 3Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi429 – 4324Prevents secretion from ER Reviewed prediction

Sequence similaritiesi

Contains 3 thioredoxin domains.

Keywords - Domaini

Redox-active center, Repeat, Signal

Phylogenomic databases

eggNOGiCOG0526.
HOGENOMiHOG000007899.
HOVERGENiHBG058611.
InParanoidiQ8NBS9.
KOiK13984.
OMAiHFVKFFA.
OrthoDBiEOG75F4DK.
PhylomeDBiQ8NBS9.
TreeFamiTF106379.

Family and domain databases

Gene3Di3.40.30.10. 3 hits.
InterProiIPR005788. Disulphide_isomerase.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00085. Thioredoxin. 3 hits.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 3 hits.
TIGRFAMsiTIGR01126. pdi_dom. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00194. THIOREDOXIN_1. 3 hits.
PS51352. THIOREDOXIN_2. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8NBS9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MPARPGRLLP LLARPAALTA LLLLLLGHGG GGRWGARAQE AAAAAADGPP    50
AADGEDGQDP HSKHLYTADM FTHGIQSAAH FVMFFAPWCG HCQRLQPTWN 100
DLGDKYNSME DAKVYVAKVD CTAHSDVCSA QGVRGYPTLK LFKPGQEAVK 150
YQGPRDFQTL ENWMLQTLNE EPVTPEPEVE PPSAPELKQG LYELSASNFE 200
LHVAQGDHFI KFFAPWCGHC KALAPTWEQL ALGLEHSETV KIGKVDCTQH 250
YELCSGNQVR GYPTLLWFRD GKKVDQYKGK RDLESLREYV ESQLQRTETG 300
ATETVTPSEA PVLAAEPEAD KGTVLALTEN NFDDTIAEGI TFIKFYAPWC 350
GHCKTLAPTW EELSKKEFPG LAGVKIAEVD CTAERNICSK YSVRGYPTLL 400
LFRGGKKVSE HSGGRDLDSL HRFVLSQAKD EL 432
Length:432
Mass (Da):47,629
Last modified:April 11, 2003 - v2
Checksum:i85E398008D6DB98C
GO
Isoform 2 (identifier: Q8NBS9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-108: Missing.

Note: No experimental confirmation available.

Show »
Length:324
Mass (Da):36,178
Checksum:i93FE17E484F5EFC9
GO

Sequence cautioni

The sequence AAH01199.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 108108Missing in isoform 2. VSP_045181Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti354 – 3541K → R in BAC11526. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY358646 mRNA. Translation: AAQ89009.1.
AK075291 mRNA. Translation: BAC11526.1.
AK315598 mRNA. Translation: BAG37969.1.
AL023694 Genomic DNA. No translation available.
AL096800 Genomic DNA. No translation available.
AL133541 Genomic DNA. Translation: CAI19473.1.
CH471087 Genomic DNA. Translation: EAW55221.1.
AJ440721 mRNA. Translation: CAD29430.1.
BC001199 mRNA. Translation: AAH01199.1. Different initiation.
AL834423 mRNA. Translation: CAD39084.1.
CCDSiCCDS4505.1. [Q8NBS9-1]
CCDS47369.1. [Q8NBS9-2]
RefSeqiNP_001139021.1. NM_001145549.2. [Q8NBS9-2]
NP_110437.2. NM_030810.3. [Q8NBS9-1]
UniGeneiHs.150837.

Genome annotation databases

EnsembliENST00000379757; ENSP00000369081; ENSG00000239264. [Q8NBS9-1]
ENST00000473453; ENSP00000420784; ENSG00000239264. [Q8NBS9-2]
GeneIDi81567.
KEGGihsa:81567.
UCSCiuc003mxv.3. human. [Q8NBS9-1]
uc010joa.2. human.

Polymorphism databases

DMDMi29839560.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY358646 mRNA. Translation: AAQ89009.1 .
AK075291 mRNA. Translation: BAC11526.1 .
AK315598 mRNA. Translation: BAG37969.1 .
AL023694 Genomic DNA. No translation available.
AL096800 Genomic DNA. No translation available.
AL133541 Genomic DNA. Translation: CAI19473.1 .
CH471087 Genomic DNA. Translation: EAW55221.1 .
AJ440721 mRNA. Translation: CAD29430.1 .
BC001199 mRNA. Translation: AAH01199.1 . Different initiation.
AL834423 mRNA. Translation: CAD39084.1 .
CCDSi CCDS4505.1. [Q8NBS9-1 ]
CCDS47369.1. [Q8NBS9-2 ]
RefSeqi NP_001139021.1. NM_001145549.2. [Q8NBS9-2 ]
NP_110437.2. NM_030810.3. [Q8NBS9-1 ]
UniGenei Hs.150837.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2DIZ NMR - A 323-432 [» ]
3UJ1 X-ray 2.65 A 323-432 [» ]
3UVT X-ray 2.00 A/B/C/D/E 323-428 [» ]
ProteinModelPortali Q8NBS9.
SMRi Q8NBS9. Positions 55-428.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 123529. 37 interactions.
DIPi DIP-53700N.
IntActi Q8NBS9. 9 interactions.
MINTi MINT-5006305.
STRINGi 9606.ENSP00000369081.

PTM databases

PhosphoSitei Q8NBS9.

Polymorphism databases

DMDMi 29839560.

Proteomic databases

MaxQBi Q8NBS9.
PaxDbi Q8NBS9.
PRIDEi Q8NBS9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000379757 ; ENSP00000369081 ; ENSG00000239264 . [Q8NBS9-1 ]
ENST00000473453 ; ENSP00000420784 ; ENSG00000239264 . [Q8NBS9-2 ]
GeneIDi 81567.
KEGGi hsa:81567.
UCSCi uc003mxv.3. human. [Q8NBS9-1 ]
uc010joa.2. human.

Organism-specific databases

CTDi 81567.
GeneCardsi GC06M007826.
HGNCi HGNC:21073. TXNDC5.
HPAi HPA034677.
HPA034678.
neXtProti NX_Q8NBS9.
PharmGKBi PA134992492.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0526.
HOGENOMi HOG000007899.
HOVERGENi HBG058611.
InParanoidi Q8NBS9.
KOi K13984.
OMAi HFVKFFA.
OrthoDBi EOG75F4DK.
PhylomeDBi Q8NBS9.
TreeFami TF106379.

Enzyme and pathway databases

Reactomei REACT_19287. Lysosome Vesicle Biogenesis.
REACT_19400. Golgi Associated Vesicle Biogenesis.

Miscellaneous databases

ChiTaRSi TXNDC5. human.
EvolutionaryTracei Q8NBS9.
GeneWikii TXNDC5.
GenomeRNAii 81567.
NextBioi 71856.
PROi Q8NBS9.

Gene expression databases

Bgeei Q8NBS9.
CleanExi HS_TXNDC5.
Genevestigatori Q8NBS9.

Family and domain databases

Gene3Di 3.40.30.10. 3 hits.
InterProi IPR005788. Disulphide_isomerase.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view ]
Pfami PF00085. Thioredoxin. 3 hits.
[Graphical view ]
SUPFAMi SSF52833. SSF52833. 3 hits.
TIGRFAMsi TIGR01126. pdi_dom. 1 hit.
PROSITEi PS00014. ER_TARGET. 1 hit.
PS00194. THIOREDOXIN_1. 3 hits.
PS51352. THIOREDOXIN_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Lung.
  3. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Lo S.L., Nissom P.M., Ong S.E., Choong M.L., Ng S.S., Lim J.W.E., Liang R.C.M.Y., Ou K., Seow T.K., Chung M.C.M.
    Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 70-432 (ISOFORM 1).
    Tissue: Liver.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 82-432 (ISOFORM 1).
    Tissue: Eye.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 189-432 (ISOFORMS 1/2).
    Tissue: Lymph node.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "The solution structure of the third thioredoxin domain of human thioredoxin domain-containing protein 5."
    RIKEN structural genomics initiative (RSGI)
    Submitted (SEP-2006) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 322-432.

Entry informationi

Entry nameiTXND5_HUMAN
AccessioniPrimary (citable) accession number: Q8NBS9
Secondary accession number(s): B2RDM2
, Q5TCQ0, Q8ND33, Q8TCT2, Q9BVH9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: April 11, 2003
Last modified: September 3, 2014
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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