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Protein

Thioredoxin domain-containing protein 5

Gene

TXNDC5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Possesses thioredoxin activity. Has been shown to reduce insulin disulfide bonds. Also complements protein disulfide-isomerase deficiency in yeast (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:G66-32729-MONOMER.
BRENDAi5.3.4.1. 2681.
ReactomeiR-HSA-432720. Lysosome Vesicle Biogenesis.
R-HSA-432722. Golgi Associated Vesicle Biogenesis.
R-HSA-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin domain-containing protein 5
Alternative name(s):
Endoplasmic reticulum resident protein 46
Short name:
ER protein 46
Short name:
ERp46
Thioredoxin-like protein p46
Gene namesi
Name:TXNDC5
Synonyms:TLP46
ORF Names:UNQ364/PRO700
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:21073. TXNDC5.

Subcellular locationi

  • Endoplasmic reticulum lumen PROSITE-ProRule annotation

GO - Cellular componenti

  • endoplasmic reticulum Source: UniProtKB
  • endoplasmic reticulum lumen Source: UniProtKB-SubCell
  • extracellular exosome Source: UniProtKB
  • lysosomal lumen Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

Pathology & Biotechi

Organism-specific databases

DisGeNETi81567.
OpenTargetsiENSG00000239264.
PharmGKBiPA134992492.

Polymorphism and mutation databases

BioMutaiTXNDC5.
DMDMi29839560.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 32Sequence analysisAdd BLAST32
ChainiPRO_000003418333 – 432Thioredoxin domain-containing protein 5Add BLAST400

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi89 ↔ 92Redox-activePROSITE-ProRule annotation
Disulfide bondi217 ↔ 220Redox-activePROSITE-ProRule annotation
Disulfide bondi350 ↔ 353Redox-activePROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiQ8NBS9.
MaxQBiQ8NBS9.
PaxDbiQ8NBS9.
PeptideAtlasiQ8NBS9.
PRIDEiQ8NBS9.

PTM databases

iPTMnetiQ8NBS9.
PhosphoSitePlusiQ8NBS9.
SwissPalmiQ8NBS9.

Expressioni

Gene expression databases

BgeeiENSG00000239264.
CleanExiHS_TXNDC5.
ExpressionAtlasiQ8NBS9. baseline and differential.
GenevisibleiQ8NBS9. HS.

Organism-specific databases

HPAiHPA034677.
HPA034678.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PRDX4Q131622EBI-2510815,EBI-2211957

Protein-protein interaction databases

BioGridi123529. 72 interactors.
DIPiDIP-53700N.
IntActiQ8NBS9. 17 interactors.
MINTiMINT-5006305.
STRINGi9606.ENSP00000369081.

Structurei

Secondary structure

1432
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi68 – 77Combined sources10
Beta strandi78 – 85Combined sources8
Helixi90 – 106Combined sources17
Beta strandi113 – 120Combined sources8
Turni121 – 123Combined sources3
Helixi125 – 130Combined sources6
Beta strandi135 – 142Combined sources8
Beta strandi149 – 151Combined sources3
Helixi157 – 168Combined sources12
Beta strandi191 – 194Combined sources4
Turni196 – 198Combined sources3
Helixi199 – 203Combined sources5
Beta strandi204 – 213Combined sources10
Helixi218 – 233Combined sources16
Turni234 – 236Combined sources3
Beta strandi238 – 246Combined sources9
Turni247 – 249Combined sources3
Helixi251 – 256Combined sources6
Beta strandi261 – 269Combined sources9
Beta strandi272 – 276Combined sources5
Helixi283 – 294Combined sources12
Beta strandi324 – 326Combined sources3
Turni329 – 331Combined sources3
Helixi332 – 336Combined sources5
Beta strandi337 – 346Combined sources10
Helixi351 – 364Combined sources14
Beta strandi374 – 380Combined sources7
Turni381 – 383Combined sources3
Helixi385 – 390Combined sources6
Beta strandi395 – 403Combined sources9
Beta strandi406 – 411Combined sources6
Helixi417 – 427Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DIZNMR-A323-432[»]
3UJ1X-ray2.65A323-432[»]
3UVTX-ray2.00A/B/C/D/E323-428[»]
3WGDX-ray2.50A/B/C/D/E/F/G/H/I62-170[»]
3WGEX-ray0.95A190-298[»]
3WGXX-ray0.92A/B190-298[»]
ProteinModelPortaliQ8NBS9.
SMRiQ8NBS9.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8NBS9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 169Thioredoxin 1PROSITE-ProRule annotationAdd BLAST134
Domaini170 – 295Thioredoxin 2PROSITE-ProRule annotationAdd BLAST126
Domaini304 – 429Thioredoxin 3PROSITE-ProRule annotationAdd BLAST126

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi429 – 432Prevents secretion from ERPROSITE-ProRule annotation4

Sequence similaritiesi

Belongs to the protein disulfide isomerase family.Curated
Contains 3 thioredoxin domains.PROSITE-ProRule annotation

Keywords - Domaini

Redox-active center, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0191. Eukaryota.
COG0526. LUCA.
GeneTreeiENSGT00860000133723.
HOGENOMiHOG000007899.
HOVERGENiHBG058611.
InParanoidiQ8NBS9.
KOiK13984.
OMAiHQVTGYP.
OrthoDBiEOG091G08PT.
PhylomeDBiQ8NBS9.
TreeFamiTF106379.

Family and domain databases

Gene3Di3.40.30.10. 3 hits.
InterProiIPR005788. Disulphide_isomerase.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00085. Thioredoxin. 3 hits.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 3 hits.
TIGRFAMsiTIGR01126. pdi_dom. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00194. THIOREDOXIN_1. 3 hits.
PS51352. THIOREDOXIN_2. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NBS9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPARPGRLLP LLARPAALTA LLLLLLGHGG GGRWGARAQE AAAAAADGPP
60 70 80 90 100
AADGEDGQDP HSKHLYTADM FTHGIQSAAH FVMFFAPWCG HCQRLQPTWN
110 120 130 140 150
DLGDKYNSME DAKVYVAKVD CTAHSDVCSA QGVRGYPTLK LFKPGQEAVK
160 170 180 190 200
YQGPRDFQTL ENWMLQTLNE EPVTPEPEVE PPSAPELKQG LYELSASNFE
210 220 230 240 250
LHVAQGDHFI KFFAPWCGHC KALAPTWEQL ALGLEHSETV KIGKVDCTQH
260 270 280 290 300
YELCSGNQVR GYPTLLWFRD GKKVDQYKGK RDLESLREYV ESQLQRTETG
310 320 330 340 350
ATETVTPSEA PVLAAEPEAD KGTVLALTEN NFDDTIAEGI TFIKFYAPWC
360 370 380 390 400
GHCKTLAPTW EELSKKEFPG LAGVKIAEVD CTAERNICSK YSVRGYPTLL
410 420 430
LFRGGKKVSE HSGGRDLDSL HRFVLSQAKD EL
Length:432
Mass (Da):47,629
Last modified:April 11, 2003 - v2
Checksum:i85E398008D6DB98C
GO
Isoform 2 (identifier: Q8NBS9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-108: Missing.

Note: No experimental confirmation available.
Show »
Length:324
Mass (Da):36,178
Checksum:i93FE17E484F5EFC9
GO

Sequence cautioni

The sequence AAH01199 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti354K → R in BAC11526 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0451811 – 108Missing in isoform 2. 1 PublicationAdd BLAST108

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358646 mRNA. Translation: AAQ89009.1.
AK075291 mRNA. Translation: BAC11526.1.
AK315598 mRNA. Translation: BAG37969.1.
AL023694 Genomic DNA. No translation available.
AL096800 Genomic DNA. No translation available.
AL133541 Genomic DNA. Translation: CAI19473.1.
CH471087 Genomic DNA. Translation: EAW55221.1.
AJ440721 mRNA. Translation: CAD29430.1.
BC001199 mRNA. Translation: AAH01199.1. Different initiation.
AL834423 mRNA. Translation: CAD39084.1.
CCDSiCCDS4505.1. [Q8NBS9-1]
CCDS47369.1. [Q8NBS9-2]
RefSeqiNP_001139021.1. NM_001145549.2. [Q8NBS9-2]
NP_110437.2. NM_030810.3. [Q8NBS9-1]
UniGeneiHs.150837.

Genome annotation databases

EnsembliENST00000379757; ENSP00000369081; ENSG00000239264. [Q8NBS9-1]
ENST00000473453; ENSP00000420784; ENSG00000239264. [Q8NBS9-2]
GeneIDi81567.
KEGGihsa:81567.
UCSCiuc003mxv.4. human. [Q8NBS9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358646 mRNA. Translation: AAQ89009.1.
AK075291 mRNA. Translation: BAC11526.1.
AK315598 mRNA. Translation: BAG37969.1.
AL023694 Genomic DNA. No translation available.
AL096800 Genomic DNA. No translation available.
AL133541 Genomic DNA. Translation: CAI19473.1.
CH471087 Genomic DNA. Translation: EAW55221.1.
AJ440721 mRNA. Translation: CAD29430.1.
BC001199 mRNA. Translation: AAH01199.1. Different initiation.
AL834423 mRNA. Translation: CAD39084.1.
CCDSiCCDS4505.1. [Q8NBS9-1]
CCDS47369.1. [Q8NBS9-2]
RefSeqiNP_001139021.1. NM_001145549.2. [Q8NBS9-2]
NP_110437.2. NM_030810.3. [Q8NBS9-1]
UniGeneiHs.150837.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DIZNMR-A323-432[»]
3UJ1X-ray2.65A323-432[»]
3UVTX-ray2.00A/B/C/D/E323-428[»]
3WGDX-ray2.50A/B/C/D/E/F/G/H/I62-170[»]
3WGEX-ray0.95A190-298[»]
3WGXX-ray0.92A/B190-298[»]
ProteinModelPortaliQ8NBS9.
SMRiQ8NBS9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123529. 72 interactors.
DIPiDIP-53700N.
IntActiQ8NBS9. 17 interactors.
MINTiMINT-5006305.
STRINGi9606.ENSP00000369081.

PTM databases

iPTMnetiQ8NBS9.
PhosphoSitePlusiQ8NBS9.
SwissPalmiQ8NBS9.

Polymorphism and mutation databases

BioMutaiTXNDC5.
DMDMi29839560.

Proteomic databases

EPDiQ8NBS9.
MaxQBiQ8NBS9.
PaxDbiQ8NBS9.
PeptideAtlasiQ8NBS9.
PRIDEiQ8NBS9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379757; ENSP00000369081; ENSG00000239264. [Q8NBS9-1]
ENST00000473453; ENSP00000420784; ENSG00000239264. [Q8NBS9-2]
GeneIDi81567.
KEGGihsa:81567.
UCSCiuc003mxv.4. human. [Q8NBS9-1]

Organism-specific databases

CTDi81567.
DisGeNETi81567.
GeneCardsiTXNDC5.
HGNCiHGNC:21073. TXNDC5.
HPAiHPA034677.
HPA034678.
MIMi616412. gene.
neXtProtiNX_Q8NBS9.
OpenTargetsiENSG00000239264.
PharmGKBiPA134992492.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0191. Eukaryota.
COG0526. LUCA.
GeneTreeiENSGT00860000133723.
HOGENOMiHOG000007899.
HOVERGENiHBG058611.
InParanoidiQ8NBS9.
KOiK13984.
OMAiHQVTGYP.
OrthoDBiEOG091G08PT.
PhylomeDBiQ8NBS9.
TreeFamiTF106379.

Enzyme and pathway databases

BioCyciZFISH:G66-32729-MONOMER.
BRENDAi5.3.4.1. 2681.
ReactomeiR-HSA-432720. Lysosome Vesicle Biogenesis.
R-HSA-432722. Golgi Associated Vesicle Biogenesis.
R-HSA-6798695. Neutrophil degranulation.

Miscellaneous databases

ChiTaRSiTXNDC5. human.
EvolutionaryTraceiQ8NBS9.
GeneWikiiTXNDC5.
GenomeRNAii81567.
PROiQ8NBS9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000239264.
CleanExiHS_TXNDC5.
ExpressionAtlasiQ8NBS9. baseline and differential.
GenevisibleiQ8NBS9. HS.

Family and domain databases

Gene3Di3.40.30.10. 3 hits.
InterProiIPR005788. Disulphide_isomerase.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00085. Thioredoxin. 3 hits.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 3 hits.
TIGRFAMsiTIGR01126. pdi_dom. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00194. THIOREDOXIN_1. 3 hits.
PS51352. THIOREDOXIN_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTXND5_HUMAN
AccessioniPrimary (citable) accession number: Q8NBS9
Secondary accession number(s): B2RDM2
, Q5TCQ0, Q8ND33, Q8TCT2, Q9BVH9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: April 11, 2003
Last modified: November 30, 2016
This is version 154 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.