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Protein

Cation-transporting ATPase

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotation
LigandATP-bindingUniRule annotation, MagnesiumUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cation-transporting ATPaseUniRule annotation (EC:3.6.3.-UniRule annotation)
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei90 – 111HelicalUniRule annotationAdd BLAST22
Transmembranei123 – 146HelicalUniRule annotationAdd BLAST24
Transmembranei598 – 617HelicalUniRule annotationAdd BLAST20
Transmembranei661 – 684HelicalUniRule annotationAdd BLAST24
Transmembranei711 – 728HelicalUniRule annotationAdd BLAST18
Transmembranei740 – 760HelicalUniRule annotationAdd BLAST21
Transmembranei780 – 800HelicalUniRule annotationAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ8NBS1.
PeptideAtlasiQ8NBS1.

Structurei

3D structure databases

ProteinModelPortaliQ8NBS1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG0208. Eukaryota.
ENOG410XRCA. LUCA.
HOVERGENiHBG065757.

Family and domain databases

Gene3Di3.40.1110.10. 1 hit.
InterProiView protein in InterPro
IPR023299. ATPase_P-typ_cyto_dom_N.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom_sf.
IPR008250. ATPase_P-typ_transduc_dom_A_sf.
IPR036412. HAD-like_sf.
IPR006544. P-type_TPase_V.
IPR001757. P_typ_ATPase.
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81653. SSF81653. 1 hit.
SSF81660. SSF81660. 2 hits.
SSF81665. SSF81665. 2 hits.
TIGRFAMsiTIGR01494. ATPase_P-type. 2 hits.
TIGR01657. P-ATPase-V. 1 hit.
PROSITEiView protein in PROSITE
PS00154. ATPASE_E1_E2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8NBS1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVNESSLTGE SIPVLKTALP EGLGPYCAET HRRHTLFCGT LILQARAYVG
60 70 80 90 100
PHVLAVVTRT GFCTAKGGLV SSILHPRPIN FKFYKHSMKF VAALSVLALL
110 120 130 140 150
GTIYSIFILY RNRVPLNEIV IRALDLVTVV VPPALPAAMT VCTLYAQSRL
160 170 180 190 200
RRQGIFCIHP LRINLGGKLQ LVCFDKTGTL TEDGLDVMGV VPLKGQAFLP
210 220 230 240 250
LVPEPRRLPV GPLLRALATC HALSRLQDTP VGDPMDLKMV ESTGWVLEEE
260 270 280 290 300
PAADSAFGTQ VLAVMRPPLW EPQLQAMEEP PVPVSVLHRF PFSSALQRMS
310 320 330 340 350
VVVAWPGATQ PEAYVKGSPE LVAGLCNPET VPTDFAQMLQ SYTAAGYRVV
360 370 380 390 400
ALASKPLPTV PSLEAAQQLT RDTVEGDLSL LGLLVMRNLL KPQTTPVIQA
410 420 430 440 450
LRRTRIRAVM VTGDNLQTAV TVARGCGMVA PQEHLIIVHA THPERGQPAS
460 470 480 490 500
LEFLPMESPT AVNGVKDPDQ AASYTVEPDP RSRHLALSGP TFGIIVKHFP
510 520 530 540 550
KLLPKVLVQG TVFARMAPEQ KTELVCELQK LQYCVGMCGD GANGCGALKA
560 570 580 590 600
ADVGISLSQA EASVVSPFTS SMASIECVPM VIREGRCSLD TSFSVFKYMA
610 620 630 640 650
LYSLTQFISV LILYTINTNL GDLQFLAIDL VITTTVAVLM SRTGPALVLG
660 670 680 690 700
RVRPPGALLS VPVLSSLLLQ MVLVTGVQLG GYFLTLAQPW FVPLNRTVAA
710 720 730 740 750
PDNLPNYENT VVFSLSSFQY LILAAAVSKG APFRRPLYTN VPFLVALALL
760 770 780 790 800
SSVLVGLVLV PGLLQGPLAL RNITDTGFKL LLLGLVTLNF VGAFMLESVL
810 820 830 840
DQCLPACLRR LRPKRASKKR FKQLERELAE QPWPPLPAGP LR
Length:842
Mass (Da):91,124
Last modified:October 1, 2002 - v1
Checksum:i252EC3E293711E57
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK075310 mRNA. Translation: BAC11539.1.
RefSeqiNP_001135446.1. NM_001141974.2.
UniGeneiHs.128866.

Genome annotation databases

GeneIDi23400.

Similar proteinsi

Entry informationi

Entry nameiQ8NBS1_HUMAN
AccessioniPrimary (citable) accession number: Q8NBS1
Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: November 22, 2017
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation