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Protein

Cation-transporting ATPase

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, MagnesiumUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cation-transporting ATPaseUniRule annotation (EC:3.6.3.-UniRule annotation)
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei90 – 111HelicalUniRule annotationAdd BLAST22
Transmembranei123 – 146HelicalUniRule annotationAdd BLAST24
Transmembranei598 – 617HelicalUniRule annotationAdd BLAST20
Transmembranei661 – 684HelicalUniRule annotationAdd BLAST24
Transmembranei711 – 728HelicalUniRule annotationAdd BLAST18
Transmembranei740 – 760HelicalUniRule annotationAdd BLAST21
Transmembranei780 – 800HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ8NBS1.
PeptideAtlasiQ8NBS1.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000327214.

Structurei

3D structure databases

ProteinModelPortaliQ8NBS1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 159E1-E2_ATPaseInterPro annotationAdd BLAST158

Sequence similaritiesi

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG0208. Eukaryota.
ENOG410XRCA. LUCA.
HOVERGENiHBG065757.

Family and domain databases

Gene3Di2.70.150.10. 1 hit.
3.40.1110.10. 2 hits.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006544. P-type_TPase_V.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 2 hits.
TIGRFAMsiTIGR01494. ATPase_P-type. 2 hits.
TIGR01657. P-ATPase-V. 1 hit.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NBS1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVNESSLTGE SIPVLKTALP EGLGPYCAET HRRHTLFCGT LILQARAYVG
60 70 80 90 100
PHVLAVVTRT GFCTAKGGLV SSILHPRPIN FKFYKHSMKF VAALSVLALL
110 120 130 140 150
GTIYSIFILY RNRVPLNEIV IRALDLVTVV VPPALPAAMT VCTLYAQSRL
160 170 180 190 200
RRQGIFCIHP LRINLGGKLQ LVCFDKTGTL TEDGLDVMGV VPLKGQAFLP
210 220 230 240 250
LVPEPRRLPV GPLLRALATC HALSRLQDTP VGDPMDLKMV ESTGWVLEEE
260 270 280 290 300
PAADSAFGTQ VLAVMRPPLW EPQLQAMEEP PVPVSVLHRF PFSSALQRMS
310 320 330 340 350
VVVAWPGATQ PEAYVKGSPE LVAGLCNPET VPTDFAQMLQ SYTAAGYRVV
360 370 380 390 400
ALASKPLPTV PSLEAAQQLT RDTVEGDLSL LGLLVMRNLL KPQTTPVIQA
410 420 430 440 450
LRRTRIRAVM VTGDNLQTAV TVARGCGMVA PQEHLIIVHA THPERGQPAS
460 470 480 490 500
LEFLPMESPT AVNGVKDPDQ AASYTVEPDP RSRHLALSGP TFGIIVKHFP
510 520 530 540 550
KLLPKVLVQG TVFARMAPEQ KTELVCELQK LQYCVGMCGD GANGCGALKA
560 570 580 590 600
ADVGISLSQA EASVVSPFTS SMASIECVPM VIREGRCSLD TSFSVFKYMA
610 620 630 640 650
LYSLTQFISV LILYTINTNL GDLQFLAIDL VITTTVAVLM SRTGPALVLG
660 670 680 690 700
RVRPPGALLS VPVLSSLLLQ MVLVTGVQLG GYFLTLAQPW FVPLNRTVAA
710 720 730 740 750
PDNLPNYENT VVFSLSSFQY LILAAAVSKG APFRRPLYTN VPFLVALALL
760 770 780 790 800
SSVLVGLVLV PGLLQGPLAL RNITDTGFKL LLLGLVTLNF VGAFMLESVL
810 820 830 840
DQCLPACLRR LRPKRASKKR FKQLERELAE QPWPPLPAGP LR
Length:842
Mass (Da):91,124
Last modified:October 1, 2002 - v1
Checksum:i252EC3E293711E57
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK075310 mRNA. Translation: BAC11539.1.
RefSeqiNP_001135446.1. NM_001141974.2.
UniGeneiHs.128866.

Genome annotation databases

GeneIDi23400.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK075310 mRNA. Translation: BAC11539.1.
RefSeqiNP_001135446.1. NM_001141974.2.
UniGeneiHs.128866.

3D structure databases

ProteinModelPortaliQ8NBS1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000327214.

Proteomic databases

PaxDbiQ8NBS1.
PeptideAtlasiQ8NBS1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi23400.

Organism-specific databases

CTDi23400.

Phylogenomic databases

eggNOGiKOG0208. Eukaryota.
ENOG410XRCA. LUCA.
HOVERGENiHBG065757.

Miscellaneous databases

GenomeRNAii23400.

Family and domain databases

Gene3Di2.70.150.10. 1 hit.
3.40.1110.10. 2 hits.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006544. P-type_TPase_V.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 2 hits.
TIGRFAMsiTIGR01494. ATPase_P-type. 2 hits.
TIGR01657. P-ATPase-V. 1 hit.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ8NBS1_HUMAN
AccessioniPrimary (citable) accession number: Q8NBS1
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: July 6, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.