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Protein

Ubiquitin carboxyl-terminal hydrolase MINDY-2

Gene

FAM63B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. May play a regulatory role at the level of protein turnover.1 Publication

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei266NucleophileBy similarity1
Active sitei448Proton acceptorBy similarity1

GO - Molecular functioni

  • cysteine-type carboxypeptidase activity Source: UniProtKB
  • Lys48-specific deubiquitinase activity Source: UniProtKB
  • thiol-dependent ubiquitin-specific protease activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase MINDY-21 Publication (EC:3.4.19.121 Publication)
Alternative name(s):
Deubiquitinating enzyme MINDY-21 Publication
Protein FAM63B
Gene namesi
Name:FAM63B
Synonyms:KIAA1164
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:26954. FAM63B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000128923.
PharmGKBiPA142671873.

Polymorphism and mutation databases

BioMutaiFAM63B.
DMDMi205831477.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003440421 – 621Ubiquitin carboxyl-terminal hydrolase MINDY-2Add BLAST621

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei94PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8NBR6.
MaxQBiQ8NBR6.
PaxDbiQ8NBR6.
PeptideAtlasiQ8NBR6.
PRIDEiQ8NBR6.

PTM databases

iPTMnetiQ8NBR6.
PhosphoSitePlusiQ8NBR6.

Expressioni

Gene expression databases

BgeeiENSG00000128923.
CleanExiHS_FAM63B.
ExpressionAtlasiQ8NBR6. baseline and differential.
GenevisibleiQ8NBR6. HS.

Organism-specific databases

HPAiHPA051103.
HPA063669.

Interactioni

Protein-protein interaction databases

BioGridi120085. 24 interactors.
STRINGi9606.ENSP00000452885.

Structurei

3D structure databases

ProteinModelPortaliQ8NBR6.
SMRiQ8NBR6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni507 – 559Ubiquitin-binding domain (UBD)1 PublicationAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi508 – 585Gln-richAdd BLAST78

Sequence similaritiesi

Belongs to the peptidase MINDY family. FAM63 subfamily.Curated

Phylogenomic databases

eggNOGiKOG2427. Eukaryota.
ENOG41102GM. LUCA.
GeneTreeiENSGT00390000016607.
HOGENOMiHOG000060219.
HOVERGENiHBG102840.
InParanoidiQ8NBR6.
OMAiRGQYKVT.
OrthoDBiEOG091G0C4Y.
PhylomeDBiQ8NBR6.
TreeFamiTF314589.

Family and domain databases

InterProiIPR007518. MINDY.
IPR033979. MINDY_domain.
[Graphical view]
PANTHERiPTHR18063. PTHR18063. 1 hit.
PfamiPF04424. DUF544. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NBR6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESSPESLQP LEHGVAAGPA SGTGSSQEGL QETRLAAGDG PGVWAAETSG
60 70 80 90 100
GNGLGAAAAR RSLPDSASPA GSPEVPGPCS SSAGLDLKDS GLESPAAAEA
110 120 130 140 150
PLRGQYKVTA SPETAVAGVG HELGTAGDAG ARPDLAGTCQ AELTAAGSEE
160 170 180 190 200
PSSAGGLSSS CSDPSPPGES PSLDSLESFS NLHSFPSSCE FNSEEGAENR
210 220 230 240 250
VPEEEEGAAV LPGAVPLCKE EEGEETAQVL AASKERFPGQ SVYHIKWIQW
260 270 280 290 300
KEENTPIITQ NENGPCPLLA ILNVLLLAWK VKLPPMMEII TAEQLMEYLG
310 320 330 340 350
DYMLDAKPKE ISEIQRLNYE QNMSDAMAIL HKLQTGLDVN VRFTGVRVFE
360 370 380 390 400
YTPECIVFDL LDIPLYHGWL VDPQIDDIVK AVGNCSYNQL VEKIISCKQS
410 420 430 440 450
DNSELVSEGF VAEQFLNNTA TQLTYHGLCE LTSTVQEGEL CVFFRNNHFS
460 470 480 490 500
TMTKYKGQLY LLVTDQGFLT EEKVVWESLH NVDGDGNFCD SEFHLRPPSD
510 520 530 540 550
PETVYKGQQD QIDQDYLMAL SLQQEQQSQE INWEQIPEGI SDLELAKKLQ
560 570 580 590 600
EEEDRRASQY YQEQEQAAAA AAAASTQAQQ GQPAQASPSS GRQSGNSERK
610 620
RKEPREKDKE KEKEKNSCVI L
Length:621
Mass (Da):67,106
Last modified:July 22, 2008 - v2
Checksum:iED97D0BBCA6DC421
GO
Isoform 2 (identifier: Q8NBR6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     580-580: Missing.

Show »
Length:620
Mass (Da):66,978
Checksum:iC74C054E51FE3F3D
GO

Sequence cautioni

The sequence EAW77545 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_034719580Missing in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471082 Genomic DNA. Translation: EAW77545.1. Sequence problems.
CH471082 Genomic DNA. Translation: EAW77546.1.
BC140811 mRNA. Translation: AAI40812.1.
BC144616 mRNA. Translation: AAI44617.1.
AK075319 mRNA. Translation: BAC11545.1.
AB032990 mRNA. Translation: BAA86478.1.
CCDSiCCDS42046.1. [Q8NBR6-1]
CCDS45268.1. [Q8NBR6-2]
RefSeqiNP_001035540.1. NM_001040450.2. [Q8NBR6-1]
NP_001035543.1. NM_001040453.2. [Q8NBR6-2]
UniGeneiHs.591122.
Hs.595286.

Genome annotation databases

EnsembliENST00000450403; ENSP00000393231; ENSG00000128923. [Q8NBR6-2]
ENST00000559228; ENSP00000452885; ENSG00000128923. [Q8NBR6-1]
GeneIDi54629.
KEGGihsa:54629.
UCSCiuc002afi.4. human. [Q8NBR6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471082 Genomic DNA. Translation: EAW77545.1. Sequence problems.
CH471082 Genomic DNA. Translation: EAW77546.1.
BC140811 mRNA. Translation: AAI40812.1.
BC144616 mRNA. Translation: AAI44617.1.
AK075319 mRNA. Translation: BAC11545.1.
AB032990 mRNA. Translation: BAA86478.1.
CCDSiCCDS42046.1. [Q8NBR6-1]
CCDS45268.1. [Q8NBR6-2]
RefSeqiNP_001035540.1. NM_001040450.2. [Q8NBR6-1]
NP_001035543.1. NM_001040453.2. [Q8NBR6-2]
UniGeneiHs.591122.
Hs.595286.

3D structure databases

ProteinModelPortaliQ8NBR6.
SMRiQ8NBR6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120085. 24 interactors.
STRINGi9606.ENSP00000452885.

PTM databases

iPTMnetiQ8NBR6.
PhosphoSitePlusiQ8NBR6.

Polymorphism and mutation databases

BioMutaiFAM63B.
DMDMi205831477.

Proteomic databases

EPDiQ8NBR6.
MaxQBiQ8NBR6.
PaxDbiQ8NBR6.
PeptideAtlasiQ8NBR6.
PRIDEiQ8NBR6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000450403; ENSP00000393231; ENSG00000128923. [Q8NBR6-2]
ENST00000559228; ENSP00000452885; ENSG00000128923. [Q8NBR6-1]
GeneIDi54629.
KEGGihsa:54629.
UCSCiuc002afi.4. human. [Q8NBR6-1]

Organism-specific databases

CTDi54629.
GeneCardsiFAM63B.
H-InvDBHIX0012284.
HGNCiHGNC:26954. FAM63B.
HPAiHPA051103.
HPA063669.
neXtProtiNX_Q8NBR6.
OpenTargetsiENSG00000128923.
PharmGKBiPA142671873.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2427. Eukaryota.
ENOG41102GM. LUCA.
GeneTreeiENSGT00390000016607.
HOGENOMiHOG000060219.
HOVERGENiHBG102840.
InParanoidiQ8NBR6.
OMAiRGQYKVT.
OrthoDBiEOG091G0C4Y.
PhylomeDBiQ8NBR6.
TreeFamiTF314589.

Miscellaneous databases

ChiTaRSiFAM63B. human.
GenomeRNAii54629.
PROiQ8NBR6.

Gene expression databases

BgeeiENSG00000128923.
CleanExiHS_FAM63B.
ExpressionAtlasiQ8NBR6. baseline and differential.
GenevisibleiQ8NBR6. HS.

Family and domain databases

InterProiIPR007518. MINDY.
IPR033979. MINDY_domain.
[Graphical view]
PANTHERiPTHR18063. PTHR18063. 1 hit.
PfamiPF04424. DUF544. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFA63B_HUMAN
AccessioniPrimary (citable) accession number: Q8NBR6
Secondary accession number(s): B2RTT8, Q9ULQ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 22, 2008
Last modified: November 30, 2016
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.