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Q8NBR6

- FA63B_HUMAN

UniProt

Q8NBR6 - FA63B_HUMAN

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Protein
Protein FAM63B
Gene
FAM63B, KIAA1164
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM63B
Gene namesi
Name:FAM63B
Synonyms:KIAA1164
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:26954. FAM63B.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671873.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 621621Protein FAM63B
PRO_0000344042Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei94 – 941Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8NBR6.
PaxDbiQ8NBR6.
PRIDEiQ8NBR6.

PTM databases

PhosphoSiteiQ8NBR6.

Expressioni

Gene expression databases

ArrayExpressiQ8NBR6.
BgeeiQ8NBR6.
CleanExiHS_FAM63B.
GenevestigatoriQ8NBR6.

Organism-specific databases

HPAiHPA051103.

Interactioni

Protein-protein interaction databases

BioGridi120085. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ8NBR6.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi508 – 58578Gln-rich
Add
BLAST

Sequence similaritiesi

Belongs to the FAM63 family.

Phylogenomic databases

eggNOGiNOG307988.
HOGENOMiHOG000060219.
HOVERGENiHBG102840.
InParanoidiQ8NBR6.
OMAiRGQYKVT.
OrthoDBiEOG7Q5HD8.
PhylomeDBiQ8NBR6.
TreeFamiTF314589.

Family and domain databases

InterProiIPR007518. DUF544.
[Graphical view]
PANTHERiPTHR18063. PTHR18063. 1 hit.
PfamiPF04424. DUF544. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8NBR6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MESSPESLQP LEHGVAAGPA SGTGSSQEGL QETRLAAGDG PGVWAAETSG    50
GNGLGAAAAR RSLPDSASPA GSPEVPGPCS SSAGLDLKDS GLESPAAAEA 100
PLRGQYKVTA SPETAVAGVG HELGTAGDAG ARPDLAGTCQ AELTAAGSEE 150
PSSAGGLSSS CSDPSPPGES PSLDSLESFS NLHSFPSSCE FNSEEGAENR 200
VPEEEEGAAV LPGAVPLCKE EEGEETAQVL AASKERFPGQ SVYHIKWIQW 250
KEENTPIITQ NENGPCPLLA ILNVLLLAWK VKLPPMMEII TAEQLMEYLG 300
DYMLDAKPKE ISEIQRLNYE QNMSDAMAIL HKLQTGLDVN VRFTGVRVFE 350
YTPECIVFDL LDIPLYHGWL VDPQIDDIVK AVGNCSYNQL VEKIISCKQS 400
DNSELVSEGF VAEQFLNNTA TQLTYHGLCE LTSTVQEGEL CVFFRNNHFS 450
TMTKYKGQLY LLVTDQGFLT EEKVVWESLH NVDGDGNFCD SEFHLRPPSD 500
PETVYKGQQD QIDQDYLMAL SLQQEQQSQE INWEQIPEGI SDLELAKKLQ 550
EEEDRRASQY YQEQEQAAAA AAAASTQAQQ GQPAQASPSS GRQSGNSERK 600
RKEPREKDKE KEKEKNSCVI L 621
Length:621
Mass (Da):67,106
Last modified:July 22, 2008 - v2
Checksum:iED97D0BBCA6DC421
GO
Isoform 2 (identifier: Q8NBR6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     580-580: Missing.

Show »
Length:620
Mass (Da):66,978
Checksum:iC74C054E51FE3F3D
GO

Sequence cautioni

The sequence EAW77545.1 differs from that shown. Reason: Erroneous gene model prediction.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei580 – 5801Missing in isoform 2.
VSP_034719

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH471082 Genomic DNA. Translation: EAW77545.1. Sequence problems.
CH471082 Genomic DNA. Translation: EAW77546.1.
BC140811 mRNA. Translation: AAI40812.1.
BC144616 mRNA. Translation: AAI44617.1.
AK075319 mRNA. Translation: BAC11545.1.
AB032990 mRNA. Translation: BAA86478.1.
CCDSiCCDS42046.1. [Q8NBR6-1]
CCDS45268.1. [Q8NBR6-2]
RefSeqiNP_001035540.1. NM_001040450.1. [Q8NBR6-1]
NP_001035543.1. NM_001040453.1. [Q8NBR6-2]
UniGeneiHs.591122.

Genome annotation databases

EnsembliENST00000450403; ENSP00000393231; ENSG00000128923. [Q8NBR6-2]
ENST00000559228; ENSP00000452885; ENSG00000128923. [Q8NBR6-1]
GeneIDi54629.
KEGGihsa:54629.
UCSCiuc002afi.3. human. [Q8NBR6-2]
uc002afj.3. human. [Q8NBR6-1]

Polymorphism databases

DMDMi205831477.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH471082 Genomic DNA. Translation: EAW77545.1 . Sequence problems.
CH471082 Genomic DNA. Translation: EAW77546.1 .
BC140811 mRNA. Translation: AAI40812.1 .
BC144616 mRNA. Translation: AAI44617.1 .
AK075319 mRNA. Translation: BAC11545.1 .
AB032990 mRNA. Translation: BAA86478.1 .
CCDSi CCDS42046.1. [Q8NBR6-1 ]
CCDS45268.1. [Q8NBR6-2 ]
RefSeqi NP_001035540.1. NM_001040450.1. [Q8NBR6-1 ]
NP_001035543.1. NM_001040453.1. [Q8NBR6-2 ]
UniGenei Hs.591122.

3D structure databases

ProteinModelPortali Q8NBR6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120085. 2 interactions.

PTM databases

PhosphoSitei Q8NBR6.

Polymorphism databases

DMDMi 205831477.

Proteomic databases

MaxQBi Q8NBR6.
PaxDbi Q8NBR6.
PRIDEi Q8NBR6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000450403 ; ENSP00000393231 ; ENSG00000128923 . [Q8NBR6-2 ]
ENST00000559228 ; ENSP00000452885 ; ENSG00000128923 . [Q8NBR6-1 ]
GeneIDi 54629.
KEGGi hsa:54629.
UCSCi uc002afi.3. human. [Q8NBR6-2 ]
uc002afj.3. human. [Q8NBR6-1 ]

Organism-specific databases

CTDi 54629.
GeneCardsi GC15P059063.
H-InvDB HIX0012284.
HGNCi HGNC:26954. FAM63B.
HPAi HPA051103.
neXtProti NX_Q8NBR6.
PharmGKBi PA142671873.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG307988.
HOGENOMi HOG000060219.
HOVERGENi HBG102840.
InParanoidi Q8NBR6.
OMAi RGQYKVT.
OrthoDBi EOG7Q5HD8.
PhylomeDBi Q8NBR6.
TreeFami TF314589.

Miscellaneous databases

ChiTaRSi FAM63B. human.
GenomeRNAii 54629.
NextBioi 57178.
PROi Q8NBR6.

Gene expression databases

ArrayExpressi Q8NBR6.
Bgeei Q8NBR6.
CleanExi HS_FAM63B.
Genevestigatori Q8NBR6.

Family and domain databases

InterProi IPR007518. DUF544.
[Graphical view ]
PANTHERi PTHR18063. PTHR18063. 1 hit.
Pfami PF04424. DUF544. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-605 (ISOFORM 1).
  4. "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain."
    Hirosawa M., Nagase T., Ishikawa K., Kikuno R., Nomura N., Ohara O.
    DNA Res. 6:329-336(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 231-621 (ISOFORM 2).
    Tissue: Brain.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-94, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiFA63B_HUMAN
AccessioniPrimary (citable) accession number: Q8NBR6
Secondary accession number(s): B2RTT8, Q9ULQ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 22, 2008
Last modified: July 9, 2014
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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