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Q8NBR6

- FA63B_HUMAN

UniProt

Q8NBR6 - FA63B_HUMAN

Protein

Protein FAM63B

Gene

FAM63B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 2 (22 Jul 2008)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein FAM63B
    Gene namesi
    Name:FAM63B
    Synonyms:KIAA1164
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:26954. FAM63B.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142671873.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 621621Protein FAM63BPRO_0000344042Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei94 – 941Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8NBR6.
    PaxDbiQ8NBR6.
    PRIDEiQ8NBR6.

    PTM databases

    PhosphoSiteiQ8NBR6.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8NBR6.
    BgeeiQ8NBR6.
    CleanExiHS_FAM63B.
    GenevestigatoriQ8NBR6.

    Organism-specific databases

    HPAiHPA051103.

    Interactioni

    Protein-protein interaction databases

    BioGridi120085. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NBR6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi508 – 58578Gln-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the FAM63 family.Curated

    Phylogenomic databases

    eggNOGiNOG307988.
    HOGENOMiHOG000060219.
    HOVERGENiHBG102840.
    InParanoidiQ8NBR6.
    OMAiRGQYKVT.
    OrthoDBiEOG7Q5HD8.
    PhylomeDBiQ8NBR6.
    TreeFamiTF314589.

    Family and domain databases

    InterProiIPR007518. DUF544.
    [Graphical view]
    PANTHERiPTHR18063. PTHR18063. 1 hit.
    PfamiPF04424. DUF544. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8NBR6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MESSPESLQP LEHGVAAGPA SGTGSSQEGL QETRLAAGDG PGVWAAETSG    50
    GNGLGAAAAR RSLPDSASPA GSPEVPGPCS SSAGLDLKDS GLESPAAAEA 100
    PLRGQYKVTA SPETAVAGVG HELGTAGDAG ARPDLAGTCQ AELTAAGSEE 150
    PSSAGGLSSS CSDPSPPGES PSLDSLESFS NLHSFPSSCE FNSEEGAENR 200
    VPEEEEGAAV LPGAVPLCKE EEGEETAQVL AASKERFPGQ SVYHIKWIQW 250
    KEENTPIITQ NENGPCPLLA ILNVLLLAWK VKLPPMMEII TAEQLMEYLG 300
    DYMLDAKPKE ISEIQRLNYE QNMSDAMAIL HKLQTGLDVN VRFTGVRVFE 350
    YTPECIVFDL LDIPLYHGWL VDPQIDDIVK AVGNCSYNQL VEKIISCKQS 400
    DNSELVSEGF VAEQFLNNTA TQLTYHGLCE LTSTVQEGEL CVFFRNNHFS 450
    TMTKYKGQLY LLVTDQGFLT EEKVVWESLH NVDGDGNFCD SEFHLRPPSD 500
    PETVYKGQQD QIDQDYLMAL SLQQEQQSQE INWEQIPEGI SDLELAKKLQ 550
    EEEDRRASQY YQEQEQAAAA AAAASTQAQQ GQPAQASPSS GRQSGNSERK 600
    RKEPREKDKE KEKEKNSCVI L 621
    Length:621
    Mass (Da):67,106
    Last modified:July 22, 2008 - v2
    Checksum:iED97D0BBCA6DC421
    GO
    Isoform 2 (identifier: Q8NBR6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         580-580: Missing.

    Show »
    Length:620
    Mass (Da):66,978
    Checksum:iC74C054E51FE3F3D
    GO

    Sequence cautioni

    The sequence EAW77545.1 differs from that shown. Reason: Erroneous gene model prediction.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei580 – 5801Missing in isoform 2. 2 PublicationsVSP_034719

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH471082 Genomic DNA. Translation: EAW77545.1. Sequence problems.
    CH471082 Genomic DNA. Translation: EAW77546.1.
    BC140811 mRNA. Translation: AAI40812.1.
    BC144616 mRNA. Translation: AAI44617.1.
    AK075319 mRNA. Translation: BAC11545.1.
    AB032990 mRNA. Translation: BAA86478.1.
    CCDSiCCDS42046.1. [Q8NBR6-1]
    CCDS45268.1. [Q8NBR6-2]
    RefSeqiNP_001035540.1. NM_001040450.1. [Q8NBR6-1]
    NP_001035543.1. NM_001040453.1. [Q8NBR6-2]
    UniGeneiHs.591122.

    Genome annotation databases

    EnsembliENST00000450403; ENSP00000393231; ENSG00000128923. [Q8NBR6-2]
    ENST00000559228; ENSP00000452885; ENSG00000128923. [Q8NBR6-1]
    GeneIDi54629.
    KEGGihsa:54629.
    UCSCiuc002afi.3. human. [Q8NBR6-2]
    uc002afj.3. human. [Q8NBR6-1]

    Polymorphism databases

    DMDMi205831477.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH471082 Genomic DNA. Translation: EAW77545.1 . Sequence problems.
    CH471082 Genomic DNA. Translation: EAW77546.1 .
    BC140811 mRNA. Translation: AAI40812.1 .
    BC144616 mRNA. Translation: AAI44617.1 .
    AK075319 mRNA. Translation: BAC11545.1 .
    AB032990 mRNA. Translation: BAA86478.1 .
    CCDSi CCDS42046.1. [Q8NBR6-1 ]
    CCDS45268.1. [Q8NBR6-2 ]
    RefSeqi NP_001035540.1. NM_001040450.1. [Q8NBR6-1 ]
    NP_001035543.1. NM_001040453.1. [Q8NBR6-2 ]
    UniGenei Hs.591122.

    3D structure databases

    ProteinModelPortali Q8NBR6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120085. 2 interactions.

    PTM databases

    PhosphoSitei Q8NBR6.

    Polymorphism databases

    DMDMi 205831477.

    Proteomic databases

    MaxQBi Q8NBR6.
    PaxDbi Q8NBR6.
    PRIDEi Q8NBR6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000450403 ; ENSP00000393231 ; ENSG00000128923 . [Q8NBR6-2 ]
    ENST00000559228 ; ENSP00000452885 ; ENSG00000128923 . [Q8NBR6-1 ]
    GeneIDi 54629.
    KEGGi hsa:54629.
    UCSCi uc002afi.3. human. [Q8NBR6-2 ]
    uc002afj.3. human. [Q8NBR6-1 ]

    Organism-specific databases

    CTDi 54629.
    GeneCardsi GC15P059063.
    H-InvDB HIX0012284.
    HGNCi HGNC:26954. FAM63B.
    HPAi HPA051103.
    neXtProti NX_Q8NBR6.
    PharmGKBi PA142671873.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG307988.
    HOGENOMi HOG000060219.
    HOVERGENi HBG102840.
    InParanoidi Q8NBR6.
    OMAi RGQYKVT.
    OrthoDBi EOG7Q5HD8.
    PhylomeDBi Q8NBR6.
    TreeFami TF314589.

    Miscellaneous databases

    ChiTaRSi FAM63B. human.
    GenomeRNAii 54629.
    NextBioi 57178.
    PROi Q8NBR6.

    Gene expression databases

    ArrayExpressi Q8NBR6.
    Bgeei Q8NBR6.
    CleanExi HS_FAM63B.
    Genevestigatori Q8NBR6.

    Family and domain databases

    InterProi IPR007518. DUF544.
    [Graphical view ]
    PANTHERi PTHR18063. PTHR18063. 1 hit.
    Pfami PF04424. DUF544. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-605 (ISOFORM 1).
    4. "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain."
      Hirosawa M., Nagase T., Ishikawa K., Kikuno R., Nomura N., Ohara O.
      DNA Res. 6:329-336(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 231-621 (ISOFORM 2).
      Tissue: Brain.
    5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-94, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiFA63B_HUMAN
    AccessioniPrimary (citable) accession number: Q8NBR6
    Secondary accession number(s): B2RTT8, Q9ULQ6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 22, 2008
    Last sequence update: July 22, 2008
    Last modified: October 1, 2014
    This is version 80 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3