##gff-version 3 Q8NBQ7 UniProtKB Chain 1 271 . . . ID=PRO_0000063968;Note=Aquaporin-11 Q8NBQ7 UniProtKB Topological domain 1 14 . . . Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:31546170;Dbxref=PMID:31546170 Q8NBQ7 UniProtKB Transmembrane 15 35 . . . Note=Helical%3B Name%3D1;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q8NBQ7 UniProtKB Topological domain 36 41 . . . Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:31546170;Dbxref=PMID:31546170 Q8NBQ7 UniProtKB Transmembrane 42 62 . . . Note=Helical%3B Name%3D2;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q8NBQ7 UniProtKB Topological domain 63 74 . . . Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:31546170;Dbxref=PMID:31546170 Q8NBQ7 UniProtKB Transmembrane 75 95 . . . Note=Helical%3B Name%3D3;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q8NBQ7 UniProtKB Topological domain 96 163 . . . Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:31546170;Dbxref=PMID:31546170 Q8NBQ7 UniProtKB Transmembrane 164 184 . . . Note=Helical%3B Name%3D4;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q8NBQ7 UniProtKB Topological domain 185 194 . . . Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:31546170;Dbxref=PMID:31546170 Q8NBQ7 UniProtKB Transmembrane 195 215 . . . Note=Helical%3B Name%3D5;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q8NBQ7 UniProtKB Topological domain 216 234 . . . Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:31546170;Dbxref=PMID:31546170 Q8NBQ7 UniProtKB Transmembrane 235 255 . . . Note=Helical%3B Name%3D6;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q8NBQ7 UniProtKB Topological domain 256 271 . . . Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:31546170;Dbxref=PMID:31546170 Q8NBQ7 UniProtKB Motif 99 101 . . . Note=NPC;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q96PS8 Q8NBQ7 UniProtKB Motif 216 218 . . . Note=NPA;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q96PS8 Q8NBQ7 UniProtKB Natural variant 102 102 . . . ID=VAR_020446;Note=G->S;Dbxref=dbSNP:rs2276415 Q8NBQ7 UniProtKB Mutagenesis 227 227 . . . Note=Does not affect endoplasmic reticulum localization. Does not affect trafficking to the plasma membrane. Increases osmotic water permeability. Decreases homomultimerization. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24918044;Dbxref=PMID:24918044 Q8NBQ7 UniProtKB Mutagenesis 227 227 . . . Note=Does not affect endoplasmic reticulum localization. Does not affect trafficking to the plasma membrane. Reduces protein expression. Increases osmotic water permeability. C->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24918044;Dbxref=PMID:24918044