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Q8NBQ7 (AQP11_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aquaporin-11

Short name=AQP-11
Gene names
Name:AQP11
Synonyms:AQPX1
ORF Names:PSEC0027
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length271 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Aquaporins facilitate the transport of water and small neutral solutes across cell membranes By similarity.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Domain

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Sequence similarities

Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 271271Aquaporin-11
PRO_0000063968

Regions

Transmembrane15 – 3521Helical; Name=1; Potential
Transmembrane42 – 6221Helical; Name=2; Potential
Transmembrane75 – 9521Helical; Name=3; Potential
Transmembrane164 – 18421Helical; Name=4; Potential
Transmembrane195 – 21521Helical; Name=5; Potential
Transmembrane235 – 25521Helical; Name=6; Potential
Motif99 – 1013NPA 1
Motif216 – 2183NPA 2

Amino acid modifications

Glycosylation2641N-linked (GlcNAc...) Potential

Natural variations

Natural variant1021G → S.
Corresponds to variant rs2276415 [ dbSNP | Ensembl ].
VAR_020446

Sequences

Sequence LengthMass (Da)Tools
Q8NBQ7 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: C4CB292B544C5A40

FASTA27130,203
        10         20         30         40         50         60 
MSPLLGLRSE LQDTCTSLGL MLSVVLLMGL ARVVARQQLH RPVAHAFVLE FLATFQLCCC 

        70         80         90        100        110        120 
THELQLLSEQ HPAHPTWTLT LVYFFSLVHG LTLVGTSSNP CGVMMQMMLG GMSPETGAVR 

       130        140        150        160        170        180 
LLAQLVSALC SRYCTSALWS LGLTQYHVSE RSFACKNPIR VDLLKAVITE AVCSFLFHSA 

       190        200        210        220        230        240 
LLHFQEVRTK LRIHLLAALI TFLVYAGGSL TGAVFNPALA LSLHFMCFDE AFPQFFIVYW 

       250        260        270 
LAPSLGILLM ILMFSFFLPW LHNNHTINKK E 

« Hide

References

« Hide 'large scale' references
[1]"Cloning of a new superfamily of aquaporin."
Ishibashi K.
Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y. expand/collapse author list , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Teratocarcinoma.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB028147 mRNA. Translation: BAC45004.1.
AK075346 mRNA. Translation: BAC11558.1.
BC040443 mRNA. Translation: AAH40443.1.
RefSeqNP_766627.1. NM_173039.2.
UniGeneHs.503345.

3D structure databases

ProteinModelPortalQ8NBQ7.
SMRQ8NBQ7. Positions 42-139, 161-263.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid129399. 2 interactions.
IntActQ8NBQ7. 1 interaction.
STRING9606.ENSP00000318770.

Protein family/group databases

TCDB1.A.8.17.1. the major intrinsic protein (mip) family.

Polymorphism databases

DMDM47115841.

Proteomic databases

PaxDbQ8NBQ7.
PRIDEQ8NBQ7.

Protocols and materials databases

DNASU282679.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000313578; ENSP00000318770; ENSG00000178301.
GeneID282679.
KEGGhsa:282679.
UCSCuc001oyj.3. human.

Organism-specific databases

CTD282679.
GeneCardsGC11P077300.
HGNCHGNC:19940. AQP11.
HPAHPA042879.
MIM609914. gene.
neXtProtNX_Q8NBQ7.
PharmGKBPA134949682.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG41656.
HOGENOMHOG000034024.
HOVERGENHBG050556.
InParanoidQ8NBQ7.
KOK09870.
OMACCTHELQ.
OrthoDBEOG7327QH.
PhylomeDBQ8NBQ7.
TreeFamTF320251.

Enzyme and pathway databases

ReactomeREACT_15518. Transmembrane transport of small molecules.

Gene expression databases

BgeeQ8NBQ7.
CleanExHS_AQP11.
GenevestigatorQ8NBQ7.

Family and domain databases

Gene3D1.20.1080.10. 1 hit.
InterProIPR023271. Aquaporin-like.
IPR023266. Aquaporin_11.
IPR016697. Aquaporin_11/12.
IPR000425. MIP.
[Graphical view]
PANTHERPTHR21191:SF7. PTHR21191:SF7. 1 hit.
PfamPF00230. MIP. 1 hit.
[Graphical view]
PIRSFPIRSF017529. Aquaporin_11/12. 1 hit.
PRINTSPR02024. AQUAPORIN11.
PR00783. MINTRINSICP.
SUPFAMSSF81338. SSF81338. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi282679.
NextBio93479.
PROQ8NBQ7.
SOURCESearch...

Entry information

Entry nameAQP11_HUMAN
AccessionPrimary (citable) accession number: Q8NBQ7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: October 1, 2002
Last modified: March 19, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM