Q8NBQ7 (AQP11_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aquaporin-11
Short name=AQP-11

Gene names

Name:	AQP11
Synonyms:	AQPX1
ORF Names:	PSEC0027

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	271 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Aquaporins facilitate the transport of water and small neutral solutes across cell membranes By similarity.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Domain	Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
Sequence similarities	Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily. [View classification]

Ontologies

Keywords
Biological process	Transport
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Repeat Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	endosomal lumen acidification Inferred from electronic annotation. Source: Compara kidney development Inferred from electronic annotation. Source: Compara protein homooligomerization Inferred from electronic annotation. Source: Compara
Cellular_component	cell surface Inferred from direct assay PubMed 16650285. Source: UniProtKB cytosol Inferred from electronic annotation. Source: Compara dendrite Inferred from electronic annotation. Source: Compara endoplasmic reticulum Inferred from electronic annotation. Source: Compara integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: Compara
Molecular_function	transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 271	271	Aquaporin-11		PRO_0000063968
Regions
	Transmembrane	15 – 35	21	Helical; Name=1; Potential
	Transmembrane	42 – 62	21	Helical; Name=2; Potential
	Transmembrane	75 – 95	21	Helical; Name=3; Potential
	Transmembrane	164 – 184	21	Helical; Name=4; Potential
	Transmembrane	195 – 215	21	Helical; Name=5; Potential
	Transmembrane	235 – 255	21	Helical; Name=6; Potential
	Motif	99 – 101	3	NPA 1
	Motif	216 – 218	3	NPA 2
Amino acid modifications
	Glycosylation	264	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	102	1	G → S. Corresponds to variant rs2276415 [ dbSNP | Ensembl ].		VAR_020446

Sequences

	Sequence		Length	Mass (Da)
	Q8NBQ7 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: C4CB292B544C5A40	FASTA	271	30,203
	10 20 30 40 50 60 MSPLLGLRSE LQDTCTSLGL MLSVVLLMGL ARVVARQQLH RPVAHAFVLE FLATFQLCCC 70 80 90 100 110 120 THELQLLSEQ HPAHPTWTLT LVYFFSLVHG LTLVGTSSNP CGVMMQMMLG GMSPETGAVR 130 140 150 160 170 180 LLAQLVSALC SRYCTSALWS LGLTQYHVSE RSFACKNPIR VDLLKAVITE AVCSFLFHSA 190 200 210 220 230 240 LLHFQEVRTK LRIHLLAALI TFLVYAGGSL TGAVFNPALA LSLHFMCFDE AFPQFFIVYW 250 260 270 LAPSLGILLM ILMFSFFLPW LHNNHTINKK E

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of a new superfamily of aquaporin." Ishibashi K. Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries." Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y. , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T. DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Teratocarcinoma.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB028147 mRNA. Translation: BAC45004.1. AK075346 mRNA. Translation: BAC11558.1. BC040443 mRNA. Translation: AAH40443.1.
IPI	IPI00168299.
RefSeq	NP_766627.1. NM_173039.2.
UniGene	Hs.503345.
3D structure databases
ProteinModelPortal	Q8NBQ7.
SMR	Q8NBQ7. Positions 197-258.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8NBQ7. 1 interaction.
STRING	9606.ENSP00000318770.
Protein family/group databases
TCDB	1.A.8.17.1. major intrinsic protein (MIP) family.
Polymorphism databases
DMDM	47115841.
Proteomic databases
PaxDb	Q8NBQ7.
PRIDE	Q8NBQ7.
Protocols and materials databases
DNASU	282679.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000313578; ENSP00000318770; ENSG00000178301.
GeneID	282679.
KEGG	hsa:282679.
UCSC	uc001oyj.3. human.
Organism-specific databases
CTD	282679.
GeneCards	GC11P077300.
HGNC	HGNC:19940. AQP11.
HPA	HPA042879.
MIM	609914. gene.
neXtProt	NX_Q8NBQ7.
PharmGKB	PA134949682.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG41656.
HOGENOM	HOG000034024.
HOVERGEN	HBG050556.
InParanoid	Q8NBQ7.
KO	K09870.
OMA	CCTHELQ.
OrthoDB	EOG4FFD38.
PhylomeDB	Q8NBQ7.
Gene expression databases
Bgee	Q8NBQ7.
CleanEx	HS_AQP11.
Genevestigator	Q8NBQ7.
GermOnline	ENSG00000178301. Homo sapiens.
Family and domain databases
Gene3D	1.20.1080.10. 1 hit.
InterPro	IPR023271. Aquaporin-like. IPR023266. Aquaporin_11. IPR016697. Aquaporin_11/12. IPR000425. MIP. [Graphical view]
PANTHER	PTHR21191:SF7. PTHR21191:SF7. 1 hit.
Pfam	PF00230. MIP. 1 hit. [Graphical view]
PIRSF	PIRSF017529. Aquaporin_11/12. 1 hit.
PRINTS	PR02024. AQUAPORIN11. PR00783. MINTRINSICP.
SUPFAM	SSF81338. MIP. 1 hit.
PROSITE	PS00221. MIP. False negative. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	282679.
NextBio	93479.
SOURCE	Search...

Entry information

Entry name

AQP11_HUMAN

Accession

Primary (citable) accession number: Q8NBQ7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2004
Last sequence update:	October 1, 2002
Last modified:	May 1, 2013
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.