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Protein

Aquaporin-11

Gene

AQP11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000178301-MONOMER.
ReactomeiR-HSA-432047. Passive transport by Aquaporins.

Protein family/group databases

TCDBi1.A.8.17.1. the major intrinsic protein (mip) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Aquaporin-11
Short name:
AQP-11
Gene namesi
Name:AQP11
Synonyms:AQPX1
ORF Names:PSEC0027
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:19940. AQP11.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei15 – 35Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei42 – 62Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei75 – 95Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei164 – 184Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei195 – 215Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei235 – 255Helical; Name=6Sequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000178301.
PharmGKBiPA134949682.

Polymorphism and mutation databases

BioMutaiAQP11.
DMDMi47115841.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000639681 – 271Aquaporin-11Add BLAST271

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi264N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8NBQ7.
PaxDbiQ8NBQ7.
PeptideAtlasiQ8NBQ7.
PRIDEiQ8NBQ7.

Expressioni

Gene expression databases

BgeeiENSG00000178301.
CleanExiHS_AQP11.
GenevisibleiQ8NBQ7. HS.

Organism-specific databases

HPAiHPA042879.

Interactioni

Protein-protein interaction databases

BioGridi129399. 1 interactor.
IntActiQ8NBQ7. 1 interactor.
STRINGi9606.ENSP00000318770.

Structurei

3D structure databases

ProteinModelPortaliQ8NBQ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi99 – 101NPA 13
Motifi216 – 218NPA 23

Domaini

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHUS. Eukaryota.
ENOG4111GCP. LUCA.
GeneTreeiENSGT00530000063816.
HOGENOMiHOG000034024.
HOVERGENiHBG050556.
InParanoidiQ8NBQ7.
KOiK09870.
OMAiCCTHELQ.
OrthoDBiEOG091G0JBQ.
PhylomeDBiQ8NBQ7.
TreeFamiTF320251.

Family and domain databases

Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR023266. Aquaporin_11.
IPR016697. Aquaporin_11/12.
IPR000425. MIP.
[Graphical view]
PANTHERiPTHR21191:SF7. PTHR21191:SF7. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PIRSFiPIRSF017529. Aquaporin_11/12. 1 hit.
PRINTSiPR02024. AQUAPORIN11.
PR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8NBQ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPLLGLRSE LQDTCTSLGL MLSVVLLMGL ARVVARQQLH RPVAHAFVLE
60 70 80 90 100
FLATFQLCCC THELQLLSEQ HPAHPTWTLT LVYFFSLVHG LTLVGTSSNP
110 120 130 140 150
CGVMMQMMLG GMSPETGAVR LLAQLVSALC SRYCTSALWS LGLTQYHVSE
160 170 180 190 200
RSFACKNPIR VDLLKAVITE AVCSFLFHSA LLHFQEVRTK LRIHLLAALI
210 220 230 240 250
TFLVYAGGSL TGAVFNPALA LSLHFMCFDE AFPQFFIVYW LAPSLGILLM
260 270
ILMFSFFLPW LHNNHTINKK E
Length:271
Mass (Da):30,203
Last modified:October 1, 2002 - v1
Checksum:iC4CB292B544C5A40
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_020446102G → S.Corresponds to variant rs2276415dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028147 mRNA. Translation: BAC45004.1.
AK075346 mRNA. Translation: BAC11558.1.
BC040443 mRNA. Translation: AAH40443.1.
CCDSiCCDS8251.1.
RefSeqiNP_766627.1. NM_173039.2.
UniGeneiHs.503345.

Genome annotation databases

EnsembliENST00000313578; ENSP00000318770; ENSG00000178301.
GeneIDi282679.
KEGGihsa:282679.
UCSCiuc001oyj.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028147 mRNA. Translation: BAC45004.1.
AK075346 mRNA. Translation: BAC11558.1.
BC040443 mRNA. Translation: AAH40443.1.
CCDSiCCDS8251.1.
RefSeqiNP_766627.1. NM_173039.2.
UniGeneiHs.503345.

3D structure databases

ProteinModelPortaliQ8NBQ7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129399. 1 interactor.
IntActiQ8NBQ7. 1 interactor.
STRINGi9606.ENSP00000318770.

Protein family/group databases

TCDBi1.A.8.17.1. the major intrinsic protein (mip) family.

Polymorphism and mutation databases

BioMutaiAQP11.
DMDMi47115841.

Proteomic databases

MaxQBiQ8NBQ7.
PaxDbiQ8NBQ7.
PeptideAtlasiQ8NBQ7.
PRIDEiQ8NBQ7.

Protocols and materials databases

DNASUi282679.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000313578; ENSP00000318770; ENSG00000178301.
GeneIDi282679.
KEGGihsa:282679.
UCSCiuc001oyj.4. human.

Organism-specific databases

CTDi282679.
GeneCardsiAQP11.
HGNCiHGNC:19940. AQP11.
HPAiHPA042879.
MIMi609914. gene.
neXtProtiNX_Q8NBQ7.
OpenTargetsiENSG00000178301.
PharmGKBiPA134949682.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHUS. Eukaryota.
ENOG4111GCP. LUCA.
GeneTreeiENSGT00530000063816.
HOGENOMiHOG000034024.
HOVERGENiHBG050556.
InParanoidiQ8NBQ7.
KOiK09870.
OMAiCCTHELQ.
OrthoDBiEOG091G0JBQ.
PhylomeDBiQ8NBQ7.
TreeFamiTF320251.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000178301-MONOMER.
ReactomeiR-HSA-432047. Passive transport by Aquaporins.

Miscellaneous databases

GenomeRNAii282679.
PROiQ8NBQ7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000178301.
CleanExiHS_AQP11.
GenevisibleiQ8NBQ7. HS.

Family and domain databases

Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR023266. Aquaporin_11.
IPR016697. Aquaporin_11/12.
IPR000425. MIP.
[Graphical view]
PANTHERiPTHR21191:SF7. PTHR21191:SF7. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PIRSFiPIRSF017529. Aquaporin_11/12. 1 hit.
PRINTSiPR02024. AQUAPORIN11.
PR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiAQP11_HUMAN
AccessioniPrimary (citable) accession number: Q8NBQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.