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Q8NBQ7

- AQP11_HUMAN

UniProt

Q8NBQ7 - AQP11_HUMAN

Protein

Aquaporin-11

Gene

AQP11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.By similarity

    GO - Molecular functioni

    1. transporter activity Source: InterPro

    GO - Biological processi

    1. endosomal lumen acidification Source: Ensembl
    2. protein homooligomerization Source: Ensembl
    3. proximal tubule development Source: Ensembl
    4. transmembrane transport Source: Reactome
    5. water transport Source: Reactome

    Keywords - Biological processi

    Transport

    Enzyme and pathway databases

    ReactomeiREACT_23826. Passive transport by Aquaporins.

    Protein family/group databases

    TCDBi1.A.8.17.1. the major intrinsic protein (mip) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aquaporin-11
    Short name:
    AQP-11
    Gene namesi
    Name:AQP11
    Synonyms:AQPX1
    ORF Names:PSEC0027
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:19940. AQP11.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: UniProtKB
    2. cytosol Source: Ensembl
    3. dendrite Source: Ensembl
    4. endoplasmic reticulum Source: Ensembl
    5. integral component of membrane Source: UniProtKB-KW
    6. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134949682.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 271271Aquaporin-11PRO_0000063968Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi264 – 2641N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ8NBQ7.
    PaxDbiQ8NBQ7.
    PRIDEiQ8NBQ7.

    Expressioni

    Gene expression databases

    BgeeiQ8NBQ7.
    CleanExiHS_AQP11.
    GenevestigatoriQ8NBQ7.

    Organism-specific databases

    HPAiHPA042879.

    Interactioni

    Protein-protein interaction databases

    BioGridi129399. 2 interactions.
    IntActiQ8NBQ7. 1 interaction.
    STRINGi9606.ENSP00000318770.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NBQ7.
    SMRiQ8NBQ7. Positions 42-139, 161-263.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei15 – 3521Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei42 – 6221Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei75 – 9521Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei164 – 18421Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei195 – 21521Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei235 – 25521Helical; Name=6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi99 – 1013NPA 1
    Motifi216 – 2183NPA 2

    Domaini

    Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

    Sequence similaritiesi

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG41656.
    HOGENOMiHOG000034024.
    HOVERGENiHBG050556.
    InParanoidiQ8NBQ7.
    KOiK09870.
    OMAiCCTHELQ.
    OrthoDBiEOG7327QH.
    PhylomeDBiQ8NBQ7.
    TreeFamiTF320251.

    Family and domain databases

    Gene3Di1.20.1080.10. 1 hit.
    InterProiIPR023271. Aquaporin-like.
    IPR023266. Aquaporin_11.
    IPR016697. Aquaporin_11/12.
    IPR000425. MIP.
    [Graphical view]
    PANTHERiPTHR21191:SF7. PTHR21191:SF7. 1 hit.
    PfamiPF00230. MIP. 1 hit.
    [Graphical view]
    PIRSFiPIRSF017529. Aquaporin_11/12. 1 hit.
    PRINTSiPR02024. AQUAPORIN11.
    PR00783. MINTRINSICP.
    SUPFAMiSSF81338. SSF81338. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8NBQ7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSPLLGLRSE LQDTCTSLGL MLSVVLLMGL ARVVARQQLH RPVAHAFVLE    50
    FLATFQLCCC THELQLLSEQ HPAHPTWTLT LVYFFSLVHG LTLVGTSSNP 100
    CGVMMQMMLG GMSPETGAVR LLAQLVSALC SRYCTSALWS LGLTQYHVSE 150
    RSFACKNPIR VDLLKAVITE AVCSFLFHSA LLHFQEVRTK LRIHLLAALI 200
    TFLVYAGGSL TGAVFNPALA LSLHFMCFDE AFPQFFIVYW LAPSLGILLM 250
    ILMFSFFLPW LHNNHTINKK E 271
    Length:271
    Mass (Da):30,203
    Last modified:October 1, 2002 - v1
    Checksum:iC4CB292B544C5A40
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti102 – 1021G → S.
    Corresponds to variant rs2276415 [ dbSNP | Ensembl ].
    VAR_020446

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB028147 mRNA. Translation: BAC45004.1.
    AK075346 mRNA. Translation: BAC11558.1.
    BC040443 mRNA. Translation: AAH40443.1.
    CCDSiCCDS8251.1.
    RefSeqiNP_766627.1. NM_173039.2.
    UniGeneiHs.503345.

    Genome annotation databases

    EnsembliENST00000313578; ENSP00000318770; ENSG00000178301.
    GeneIDi282679.
    KEGGihsa:282679.
    UCSCiuc001oyj.3. human.

    Polymorphism databases

    DMDMi47115841.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB028147 mRNA. Translation: BAC45004.1 .
    AK075346 mRNA. Translation: BAC11558.1 .
    BC040443 mRNA. Translation: AAH40443.1 .
    CCDSi CCDS8251.1.
    RefSeqi NP_766627.1. NM_173039.2.
    UniGenei Hs.503345.

    3D structure databases

    ProteinModelPortali Q8NBQ7.
    SMRi Q8NBQ7. Positions 42-139, 161-263.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 129399. 2 interactions.
    IntActi Q8NBQ7. 1 interaction.
    STRINGi 9606.ENSP00000318770.

    Protein family/group databases

    TCDBi 1.A.8.17.1. the major intrinsic protein (mip) family.

    Polymorphism databases

    DMDMi 47115841.

    Proteomic databases

    MaxQBi Q8NBQ7.
    PaxDbi Q8NBQ7.
    PRIDEi Q8NBQ7.

    Protocols and materials databases

    DNASUi 282679.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000313578 ; ENSP00000318770 ; ENSG00000178301 .
    GeneIDi 282679.
    KEGGi hsa:282679.
    UCSCi uc001oyj.3. human.

    Organism-specific databases

    CTDi 282679.
    GeneCardsi GC11P077300.
    HGNCi HGNC:19940. AQP11.
    HPAi HPA042879.
    MIMi 609914. gene.
    neXtProti NX_Q8NBQ7.
    PharmGKBi PA134949682.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG41656.
    HOGENOMi HOG000034024.
    HOVERGENi HBG050556.
    InParanoidi Q8NBQ7.
    KOi K09870.
    OMAi CCTHELQ.
    OrthoDBi EOG7327QH.
    PhylomeDBi Q8NBQ7.
    TreeFami TF320251.

    Enzyme and pathway databases

    Reactomei REACT_23826. Passive transport by Aquaporins.

    Miscellaneous databases

    GenomeRNAii 282679.
    NextBioi 93479.
    PROi Q8NBQ7.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8NBQ7.
    CleanExi HS_AQP11.
    Genevestigatori Q8NBQ7.

    Family and domain databases

    Gene3Di 1.20.1080.10. 1 hit.
    InterProi IPR023271. Aquaporin-like.
    IPR023266. Aquaporin_11.
    IPR016697. Aquaporin_11/12.
    IPR000425. MIP.
    [Graphical view ]
    PANTHERi PTHR21191:SF7. PTHR21191:SF7. 1 hit.
    Pfami PF00230. MIP. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF017529. Aquaporin_11/12. 1 hit.
    PRINTSi PR02024. AQUAPORIN11.
    PR00783. MINTRINSICP.
    SUPFAMi SSF81338. SSF81338. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of a new superfamily of aquaporin."
      Ishibashi K.
      Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
      Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
      , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
      DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Teratocarcinoma.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiAQP11_HUMAN
    AccessioniPrimary (citable) accession number: Q8NBQ7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2004
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3