Reviewed, UniProtKB/Swiss-Prot Q8NBQ7 (AQP11_HUMAN)

Names and origin

Protein names

Recommended name:
    Aquaporin-11
      Short name=AQP-11

Gene names

Name:	AQP11
Synonyms:	AQPX1
ORF Names:	PSEC0027

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	271 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Aquaporins facilitate the transport of water and small neutral solutes across cell membranes By similarity.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Tissue specificity	Expressed at low levels in roots and leaves.
Domain	Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
Sequence similarities	Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily. [View classification]

Ontologies

Keywords
Biological process	Transport
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Repeat Transmembrane
PTM	Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cell surface Inferred from direct assay. Source: UniProtKB integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 271	271	Aquaporin-11		PRO_0000063968
Regions
	Transmembrane	15 – 35	21	1 Potential
	Transmembrane	42 – 62	21	2 Potential
	Transmembrane	75 – 95	21	3 Potential
	Transmembrane	164 – 184	21	4 Potential
	Transmembrane	195 – 215	21	5 Potential
	Transmembrane	235 – 255	21	6 Potential
	Motif	99 – 101	3	NPA 1
	Motif	216 – 218	3	NPA 2
Amino acid modifications
	Glycosylation	264	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	102	1	G → S: dbSNP rs2276415.		VAR_020446

Sequences

	Sequence		Length	Mass (Da)
	Q8NBQ7-1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: C4CB292B544C5A40	FASTA	271	30,203
	10 20 30 40 50 60 MSPLLGLRSE LQDTCTSLGL MLSVVLLMGL ARVVARQQLH RPVAHAFVLE FLATFQLCCC 70 80 90 100 110 120 THELQLLSEQ HPAHPTWTLT LVYFFSLVHG LTLVGTSSNP CGVMMQMMLG GMSPETGAVR 130 140 150 160 170 180 LLAQLVSALC SRYCTSALWS LGLTQYHVSE RSFACKNPIR VDLLKAVITE AVCSFLFHSA 190 200 210 220 230 240 LLHFQEVRTK LRIHLLAALI TFLVYAGGSL TGAVFNPALA LSLHFMCFDE AFPQFFIVYW 250 260 270 LAPSLGILLM ILMFSFFLPW LHNNHTINKK E

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of a new superfamily of aquaporin." Ishibashi K. Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries." Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y. , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T. DNA Res. 12:117-126(2005) [PubMed: 16303743] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Teratocarcinoma.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB028147 mRNA. Translation: BAC45004.1. AK075346 mRNA. Translation: BAC11558.1. BC040443 mRNA. Translation: AAH40443.1.
IPI	IPI00168299.
RefSeq	NP_766627.1.
UniGene	Hs.503345
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q8NBQ7.
Protein family/group databases
TCDB	1.A.8.17.1. major intrinsic protein (MIP) family.
Proteomic databases
PRIDE	Q8NBQ7.
Genome annotation databases
Ensembl	ENST00000313578; ENSP00000318770; ENSG00000178301; Homo sapiens. [Genome view]
GeneID	282679.
KEGG	hsa:282679.
UCSC	uc001oyj.1. human.
Organism-specific databases
CTD	282679.
GeneCards	GC11P076978.
HGNC	HGNC:19940. AQP11.
MIM	609914. gene.
PharmGKB	PA134949682.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HBG126741.
HOVERGEN	Q8NBQ7.
InParanoid	Q8NBQ7.
OMA	AFVLEFL.
OrthoDB	EOG9KM1NG.
Gene expression databases
ArrayExpress	Q8NBQ7.
Bgee	Q8NBQ7.
CleanEx	HS_AQP11.
Genevestigator	Q8NBQ7.
GermOnline	ENSG00000178301. Homo sapiens.
Family and domain databases
InterPro	IPR016697. Aquaporin_11/12. IPR000425. MIP. [Graphical view]
PIRSF	PIRSF017529. Aquaporin_11/12. 1 hit.
PRINTS	PR00783. MINTRINSICP.
PROSITE	PS00221. MIP. False negative. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	93479.
SOURCE	Search...

Entry information

Entry name

AQP11_HUMAN

Accession

Primary (citable) accession number: Q8NBQ7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2004
Last sequence update:	October 1, 2002
Last modified:	December 15, 2009
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.