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Protein

Aquaporin-11

Gene

AQP11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Enzyme and pathway databases

ReactomeiR-HSA-432047 Passive transport by Aquaporins

Protein family/group databases

TCDBi1.A.8.4.1 the major intrinsic protein (mip) family

Names & Taxonomyi

Protein namesi
Recommended name:
Aquaporin-11
Short name:
AQP-11
Gene namesi
Name:AQP11
Synonyms:AQPX1
ORF Names:PSEC0027
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000178301.3
HGNCiHGNC:19940 AQP11
MIMi609914 gene
neXtProtiNX_Q8NBQ7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei15 – 35Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei42 – 62Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei75 – 95Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei164 – 184Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei195 – 215Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei235 – 255Helical; Name=6Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi282679
OpenTargetsiENSG00000178301
PharmGKBiPA134949682

Polymorphism and mutation databases

BioMutaiAQP11
DMDMi47115841

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000639681 – 271Aquaporin-11Add BLAST271

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi264N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8NBQ7
PaxDbiQ8NBQ7
PeptideAtlasiQ8NBQ7
PRIDEiQ8NBQ7

Expressioni

Gene expression databases

BgeeiENSG00000178301
CleanExiHS_AQP11
GenevisibleiQ8NBQ7 HS

Organism-specific databases

HPAiHPA042879

Interactioni

Protein-protein interaction databases

BioGridi129399, 1 interactor
IntActiQ8NBQ7, 1 interactor
STRINGi9606.ENSP00000318770

Structurei

3D structure databases

ProteinModelPortaliQ8NBQ7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi99 – 101NPA 13
Motifi216 – 218NPA 23

Domaini

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHUS Eukaryota
ENOG4111GCP LUCA
GeneTreeiENSGT00530000063816
HOGENOMiHOG000034024
HOVERGENiHBG050556
InParanoidiQ8NBQ7
KOiK09870
OMAiCCTHELQ
OrthoDBiEOG091G0JBQ
PhylomeDBiQ8NBQ7
TreeFamiTF320251

Family and domain databases

Gene3Di1.20.1080.10, 1 hit
InterProiView protein in InterPro
IPR023271 Aquaporin-like
IPR023266 Aquaporin_11
IPR016697 Aquaporin_11/12
IPR000425 MIP
PANTHERiPTHR21191:SF7 PTHR21191:SF7, 1 hit
PfamiView protein in Pfam
PF00230 MIP, 1 hit
PIRSFiPIRSF017529 Aquaporin_11/12, 1 hit
PRINTSiPR02024 AQUAPORIN11
PR00783 MINTRINSICP
SUPFAMiSSF81338 SSF81338, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NBQ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPLLGLRSE LQDTCTSLGL MLSVVLLMGL ARVVARQQLH RPVAHAFVLE
60 70 80 90 100
FLATFQLCCC THELQLLSEQ HPAHPTWTLT LVYFFSLVHG LTLVGTSSNP
110 120 130 140 150
CGVMMQMMLG GMSPETGAVR LLAQLVSALC SRYCTSALWS LGLTQYHVSE
160 170 180 190 200
RSFACKNPIR VDLLKAVITE AVCSFLFHSA LLHFQEVRTK LRIHLLAALI
210 220 230 240 250
TFLVYAGGSL TGAVFNPALA LSLHFMCFDE AFPQFFIVYW LAPSLGILLM
260 270
ILMFSFFLPW LHNNHTINKK E
Length:271
Mass (Da):30,203
Last modified:October 1, 2002 - v1
Checksum:iC4CB292B544C5A40
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_020446102G → S. Corresponds to variant dbSNP:rs2276415Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028147 mRNA Translation: BAC45004.1
AK075346 mRNA Translation: BAC11558.1
BC040443 mRNA Translation: AAH40443.1
CCDSiCCDS8251.1
RefSeqiNP_766627.1, NM_173039.2
UniGeneiHs.503345

Genome annotation databases

EnsembliENST00000313578; ENSP00000318770; ENSG00000178301
GeneIDi282679
KEGGihsa:282679
UCSCiuc001oyj.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiAQP11_HUMAN
AccessioniPrimary (citable) accession number: Q8NBQ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: October 1, 2002
Last modified: January 31, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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