Reviewed,
UniProtKB/Swiss-Prot Q8NBQ7 (AQP11_HUMAN)
Last modified
December 15, 2009.
Version 60.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin
| Protein names | Recommended name: Aquaporin-11 Short name=AQP-11 | ||||||
| Gene names |
| ||||||
| Organism | Homo sapiens (Human) [Complete proteome] | ||||||
| Taxonomic identifier | 9606 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 271 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Aquaporins facilitate the transport of water and small neutral solutes across cell membranes By similarity. |
| Subcellular location | Membrane; Multi-pass membrane protein Potential. |
| Tissue specificity | Expressed at low levels in roots and leaves. |
| Domain | Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA). |
| Sequence similarities | Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily. [View classification] |
Ontologies
| Keywords | |
|---|---|
| Biological process | Transport |
| Cellular component | Membrane |
| Coding sequence diversity | Polymorphism |
| Domain | Repeat Transmembrane |
| PTM | Glycoprotein |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | transport Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cell surface Inferred from direct assay. Source: UniProtKB integral to membraneInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | transporter activity Inferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 271 | 271 | Aquaporin-11 | PRO_0000063968 | |||||
Regions | |||||||||
| Transmembrane | 15 – 35 | 21 | 1 Potential | ||||||
| Transmembrane | 42 – 62 | 21 | 2 Potential | ||||||
| Transmembrane | 75 – 95 | 21 | 3 Potential | ||||||
| Transmembrane | 164 – 184 | 21 | 4 Potential | ||||||
| Transmembrane | 195 – 215 | 21 | 5 Potential | ||||||
| Transmembrane | 235 – 255 | 21 | 6 Potential | ||||||
| Motif | 99 – 101 | 3 | NPA 1 | ||||||
| Motif | 216 – 218 | 3 | NPA 2 | ||||||
Amino acid modifications | |||||||||
| Glycosylation | 264 | 1 | N-linked (GlcNAc...) Potential | ||||||
Natural variations | |||||||||
| Natural variant | 102 | 1 | G → S: dbSNP rs2276415. | VAR_020446 | |||||
Sequences
| ||||||||||||||||||
References
| « Hide 'large scale' references | |
| [1] | "Cloning of a new superfamily of aquaporin." Ishibashi K. Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries." Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y. Isogai T.DNA Res. 12:117-126(2005) [PubMed: 16303743] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Teratocarcinoma. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain. |
Cross-references
Sequence databases | |
|---|---|
| AB028147 mRNA. Translation: BAC45004.1. AK075346 mRNA. Translation: BAC11558.1. BC040443 mRNA. Translation: AAH40443.1. | |
| IPI | IPI00168299. |
| RefSeq | NP_766627.1. |
| UniGene | Hs.503345 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q8NBQ7. |
Protein family/group databases | |
| TCDB | 1.A.8.17.1. major intrinsic protein (MIP) family. |
Proteomic databases | |
| PRIDE | Q8NBQ7. |
Genome annotation databases | |
| Ensembl | ENST00000313578; ENSP00000318770; ENSG00000178301; Homo sapiens. [Genome view] |
| GeneID | 282679. |
| KEGG | hsa:282679. |
| UCSC | uc001oyj.1. human. |
Organism-specific databases | |
| CTD | 282679. |
| GeneCards | GC11P076978. |
| HGNC | HGNC:19940. AQP11. |
| MIM | 609914. gene. |
| PharmGKB | PA134949682. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | HBG126741. |
| HOVERGEN | Q8NBQ7. |
| InParanoid | Q8NBQ7. |
| OMA | AFVLEFL. |
| OrthoDB | EOG9KM1NG. |
Gene expression databases | |
| ArrayExpress | Q8NBQ7. |
| Bgee | Q8NBQ7. |
| CleanEx | HS_AQP11. |
| Genevestigator | Q8NBQ7. |
| GermOnline | ENSG00000178301. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR016697. Aquaporin_11/12. IPR000425. MIP. [Graphical view] |
| PIRSF | PIRSF017529. Aquaporin_11/12. 1 hit. |
| PRINTS | PR00783. MINTRINSICP. |
| PROSITE | PS00221. MIP. False negative. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 93479. |
| SOURCE | Search... |
Entry information
| Entry name | AQP11_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q8NBQ7 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 11 Human chromosome 11: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


