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Q8NBQ7

- AQP11_HUMAN

UniProt

Q8NBQ7 - AQP11_HUMAN

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Protein

Aquaporin-11

Gene
AQP11, AQPX1, PSEC0027
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Aquaporins facilitate the transport of water and small neutral solutes across cell membranes By similarity.

GO - Molecular functioni

  1. transporter activity Source: InterPro

GO - Biological processi

  1. endosomal lumen acidification Source: Ensembl
  2. protein homooligomerization Source: Ensembl
  3. proximal tubule development Source: Ensembl
  4. transmembrane transport Source: Reactome
  5. water transport Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiREACT_23826. Passive transport by Aquaporins.

Protein family/group databases

TCDBi1.A.8.17.1. the major intrinsic protein (mip) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Aquaporin-11
Short name:
AQP-11
Gene namesi
Name:AQP11
Synonyms:AQPX1
ORF Names:PSEC0027
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:19940. AQP11.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei15 – 3521Helical; Name=1; Reviewed predictionAdd
BLAST
Transmembranei42 – 6221Helical; Name=2; Reviewed predictionAdd
BLAST
Transmembranei75 – 9521Helical; Name=3; Reviewed predictionAdd
BLAST
Transmembranei164 – 18421Helical; Name=4; Reviewed predictionAdd
BLAST
Transmembranei195 – 21521Helical; Name=5; Reviewed predictionAdd
BLAST
Transmembranei235 – 25521Helical; Name=6; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. cell surface Source: UniProtKB
  2. cytosol Source: Ensembl
  3. dendrite Source: Ensembl
  4. endoplasmic reticulum Source: Ensembl
  5. integral component of membrane Source: UniProtKB-KW
  6. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134949682.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 271271Aquaporin-11PRO_0000063968Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi264 – 2641N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8NBQ7.
PaxDbiQ8NBQ7.
PRIDEiQ8NBQ7.

Expressioni

Gene expression databases

BgeeiQ8NBQ7.
CleanExiHS_AQP11.
GenevestigatoriQ8NBQ7.

Organism-specific databases

HPAiHPA042879.

Interactioni

Protein-protein interaction databases

BioGridi129399. 2 interactions.
IntActiQ8NBQ7. 1 interaction.
STRINGi9606.ENSP00000318770.

Structurei

3D structure databases

ProteinModelPortaliQ8NBQ7.
SMRiQ8NBQ7. Positions 42-139, 161-263.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi99 – 1013NPA 1
Motifi216 – 2183NPA 2

Domaini

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG41656.
HOGENOMiHOG000034024.
HOVERGENiHBG050556.
InParanoidiQ8NBQ7.
KOiK09870.
OMAiCCTHELQ.
OrthoDBiEOG7327QH.
PhylomeDBiQ8NBQ7.
TreeFamiTF320251.

Family and domain databases

Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR023266. Aquaporin_11.
IPR016697. Aquaporin_11/12.
IPR000425. MIP.
[Graphical view]
PANTHERiPTHR21191:SF7. PTHR21191:SF7. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PIRSFiPIRSF017529. Aquaporin_11/12. 1 hit.
PRINTSiPR02024. AQUAPORIN11.
PR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8NBQ7-1 [UniParc]FASTAAdd to Basket

« Hide

MSPLLGLRSE LQDTCTSLGL MLSVVLLMGL ARVVARQQLH RPVAHAFVLE    50
FLATFQLCCC THELQLLSEQ HPAHPTWTLT LVYFFSLVHG LTLVGTSSNP 100
CGVMMQMMLG GMSPETGAVR LLAQLVSALC SRYCTSALWS LGLTQYHVSE 150
RSFACKNPIR VDLLKAVITE AVCSFLFHSA LLHFQEVRTK LRIHLLAALI 200
TFLVYAGGSL TGAVFNPALA LSLHFMCFDE AFPQFFIVYW LAPSLGILLM 250
ILMFSFFLPW LHNNHTINKK E 271
Length:271
Mass (Da):30,203
Last modified:October 1, 2002 - v1
Checksum:iC4CB292B544C5A40
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti102 – 1021G → S.
Corresponds to variant rs2276415 [ dbSNP | Ensembl ].
VAR_020446

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB028147 mRNA. Translation: BAC45004.1.
AK075346 mRNA. Translation: BAC11558.1.
BC040443 mRNA. Translation: AAH40443.1.
CCDSiCCDS8251.1.
RefSeqiNP_766627.1. NM_173039.2.
UniGeneiHs.503345.

Genome annotation databases

EnsembliENST00000313578; ENSP00000318770; ENSG00000178301.
GeneIDi282679.
KEGGihsa:282679.
UCSCiuc001oyj.3. human.

Polymorphism databases

DMDMi47115841.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB028147 mRNA. Translation: BAC45004.1 .
AK075346 mRNA. Translation: BAC11558.1 .
BC040443 mRNA. Translation: AAH40443.1 .
CCDSi CCDS8251.1.
RefSeqi NP_766627.1. NM_173039.2.
UniGenei Hs.503345.

3D structure databases

ProteinModelPortali Q8NBQ7.
SMRi Q8NBQ7. Positions 42-139, 161-263.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 129399. 2 interactions.
IntActi Q8NBQ7. 1 interaction.
STRINGi 9606.ENSP00000318770.

Protein family/group databases

TCDBi 1.A.8.17.1. the major intrinsic protein (mip) family.

Polymorphism databases

DMDMi 47115841.

Proteomic databases

MaxQBi Q8NBQ7.
PaxDbi Q8NBQ7.
PRIDEi Q8NBQ7.

Protocols and materials databases

DNASUi 282679.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000313578 ; ENSP00000318770 ; ENSG00000178301 .
GeneIDi 282679.
KEGGi hsa:282679.
UCSCi uc001oyj.3. human.

Organism-specific databases

CTDi 282679.
GeneCardsi GC11P077300.
HGNCi HGNC:19940. AQP11.
HPAi HPA042879.
MIMi 609914. gene.
neXtProti NX_Q8NBQ7.
PharmGKBi PA134949682.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG41656.
HOGENOMi HOG000034024.
HOVERGENi HBG050556.
InParanoidi Q8NBQ7.
KOi K09870.
OMAi CCTHELQ.
OrthoDBi EOG7327QH.
PhylomeDBi Q8NBQ7.
TreeFami TF320251.

Enzyme and pathway databases

Reactomei REACT_23826. Passive transport by Aquaporins.

Miscellaneous databases

GenomeRNAii 282679.
NextBioi 93479.
PROi Q8NBQ7.
SOURCEi Search...

Gene expression databases

Bgeei Q8NBQ7.
CleanExi HS_AQP11.
Genevestigatori Q8NBQ7.

Family and domain databases

Gene3Di 1.20.1080.10. 1 hit.
InterProi IPR023271. Aquaporin-like.
IPR023266. Aquaporin_11.
IPR016697. Aquaporin_11/12.
IPR000425. MIP.
[Graphical view ]
PANTHERi PTHR21191:SF7. PTHR21191:SF7. 1 hit.
Pfami PF00230. MIP. 1 hit.
[Graphical view ]
PIRSFi PIRSF017529. Aquaporin_11/12. 1 hit.
PRINTSi PR02024. AQUAPORIN11.
PR00783. MINTRINSICP.
SUPFAMi SSF81338. SSF81338. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a new superfamily of aquaporin."
    Ishibashi K.
    Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
    Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
    , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
    DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Teratocarcinoma.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiAQP11_HUMAN
AccessioniPrimary (citable) accession number: Q8NBQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: October 1, 2002
Last modified: September 3, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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