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Protein

Aquaporin-11

Gene

AQP11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiREACT_23826. Passive transport by Aquaporins.

Protein family/group databases

TCDBi1.A.8.17.1. the major intrinsic protein (mip) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Aquaporin-11
Short name:
AQP-11
Gene namesi
Name:AQP11
Synonyms:AQPX1
ORF Names:PSEC0027
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:19940. AQP11.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei15 – 3521Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei42 – 6221Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei75 – 9521Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei164 – 18421Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei195 – 21521Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei235 – 25521Helical; Name=6Sequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134949682.

Polymorphism and mutation databases

BioMutaiAQP11.
DMDMi47115841.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 271271Aquaporin-11PRO_0000063968Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi264 – 2641N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8NBQ7.
PaxDbiQ8NBQ7.
PRIDEiQ8NBQ7.

Expressioni

Gene expression databases

BgeeiQ8NBQ7.
CleanExiHS_AQP11.
GenevisibleiQ8NBQ7. HS.

Organism-specific databases

HPAiHPA042879.

Interactioni

Protein-protein interaction databases

BioGridi129399. 1 interaction.
IntActiQ8NBQ7. 1 interaction.
STRINGi9606.ENSP00000318770.

Structurei

3D structure databases

ProteinModelPortaliQ8NBQ7.
SMRiQ8NBQ7. Positions 160-262.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi99 – 1013NPA 1
Motifi216 – 2183NPA 2

Domaini

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG41656.
GeneTreeiENSGT00530000063816.
HOGENOMiHOG000034024.
HOVERGENiHBG050556.
InParanoidiQ8NBQ7.
KOiK09870.
OMAiCCTHELQ.
OrthoDBiEOG7327QH.
PhylomeDBiQ8NBQ7.
TreeFamiTF320251.

Family and domain databases

Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR023266. Aquaporin_11.
IPR016697. Aquaporin_11/12.
IPR000425. MIP.
[Graphical view]
PANTHERiPTHR21191:SF7. PTHR21191:SF7. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PIRSFiPIRSF017529. Aquaporin_11/12. 1 hit.
PRINTSiPR02024. AQUAPORIN11.
PR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8NBQ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPLLGLRSE LQDTCTSLGL MLSVVLLMGL ARVVARQQLH RPVAHAFVLE
60 70 80 90 100
FLATFQLCCC THELQLLSEQ HPAHPTWTLT LVYFFSLVHG LTLVGTSSNP
110 120 130 140 150
CGVMMQMMLG GMSPETGAVR LLAQLVSALC SRYCTSALWS LGLTQYHVSE
160 170 180 190 200
RSFACKNPIR VDLLKAVITE AVCSFLFHSA LLHFQEVRTK LRIHLLAALI
210 220 230 240 250
TFLVYAGGSL TGAVFNPALA LSLHFMCFDE AFPQFFIVYW LAPSLGILLM
260 270
ILMFSFFLPW LHNNHTINKK E
Length:271
Mass (Da):30,203
Last modified:October 1, 2002 - v1
Checksum:iC4CB292B544C5A40
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti102 – 1021G → S.
Corresponds to variant rs2276415 [ dbSNP | Ensembl ].
VAR_020446

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028147 mRNA. Translation: BAC45004.1.
AK075346 mRNA. Translation: BAC11558.1.
BC040443 mRNA. Translation: AAH40443.1.
CCDSiCCDS8251.1.
RefSeqiNP_766627.1. NM_173039.2.
UniGeneiHs.503345.

Genome annotation databases

EnsembliENST00000313578; ENSP00000318770; ENSG00000178301.
GeneIDi282679.
KEGGihsa:282679.
UCSCiuc001oyj.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028147 mRNA. Translation: BAC45004.1.
AK075346 mRNA. Translation: BAC11558.1.
BC040443 mRNA. Translation: AAH40443.1.
CCDSiCCDS8251.1.
RefSeqiNP_766627.1. NM_173039.2.
UniGeneiHs.503345.

3D structure databases

ProteinModelPortaliQ8NBQ7.
SMRiQ8NBQ7. Positions 160-262.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129399. 1 interaction.
IntActiQ8NBQ7. 1 interaction.
STRINGi9606.ENSP00000318770.

Protein family/group databases

TCDBi1.A.8.17.1. the major intrinsic protein (mip) family.

Polymorphism and mutation databases

BioMutaiAQP11.
DMDMi47115841.

Proteomic databases

MaxQBiQ8NBQ7.
PaxDbiQ8NBQ7.
PRIDEiQ8NBQ7.

Protocols and materials databases

DNASUi282679.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000313578; ENSP00000318770; ENSG00000178301.
GeneIDi282679.
KEGGihsa:282679.
UCSCiuc001oyj.3. human.

Organism-specific databases

CTDi282679.
GeneCardsiGC11P077300.
HGNCiHGNC:19940. AQP11.
HPAiHPA042879.
MIMi609914. gene.
neXtProtiNX_Q8NBQ7.
PharmGKBiPA134949682.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG41656.
GeneTreeiENSGT00530000063816.
HOGENOMiHOG000034024.
HOVERGENiHBG050556.
InParanoidiQ8NBQ7.
KOiK09870.
OMAiCCTHELQ.
OrthoDBiEOG7327QH.
PhylomeDBiQ8NBQ7.
TreeFamiTF320251.

Enzyme and pathway databases

ReactomeiREACT_23826. Passive transport by Aquaporins.

Miscellaneous databases

GenomeRNAii282679.
NextBioi93479.
PROiQ8NBQ7.
SOURCEiSearch...

Gene expression databases

BgeeiQ8NBQ7.
CleanExiHS_AQP11.
GenevisibleiQ8NBQ7. HS.

Family and domain databases

Gene3Di1.20.1080.10. 1 hit.
InterProiIPR023271. Aquaporin-like.
IPR023266. Aquaporin_11.
IPR016697. Aquaporin_11/12.
IPR000425. MIP.
[Graphical view]
PANTHERiPTHR21191:SF7. PTHR21191:SF7. 1 hit.
PfamiPF00230. MIP. 1 hit.
[Graphical view]
PIRSFiPIRSF017529. Aquaporin_11/12. 1 hit.
PRINTSiPR02024. AQUAPORIN11.
PR00783. MINTRINSICP.
SUPFAMiSSF81338. SSF81338. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a new superfamily of aquaporin."
    Ishibashi K.
    Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
    Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
    , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
    DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Teratocarcinoma.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiAQP11_HUMAN
AccessioniPrimary (citable) accession number: Q8NBQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: October 1, 2002
Last modified: June 24, 2015
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.