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Protein

Estradiol 17-beta-dehydrogenase 11

Gene

HSD17B11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor-associated antigen in cutaneous T-cell lymphoma.

Catalytic activityi

17-beta-estradiol + NAD(P)+ = estrone + NAD(P)H.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei172SubstrateBy similarity1
Active sitei185Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi40 – 64NADPBy similarityAdd BLAST25

GO - Molecular functioni

  • estradiol 17-beta-dehydrogenase activity Source: Reactome
  • steroid dehydrogenase activity Source: HGNC

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciZFISH:HS11363-MONOMER.
ReactomeiR-HSA-193144. Estrogen biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Estradiol 17-beta-dehydrogenase 11 (EC:1.1.1.62)
Alternative name(s):
17-beta-hydroxysteroid dehydrogenase 11
Short name:
17-beta-HSD 11
Short name:
17bHSD11
Short name:
17betaHSD11
17-beta-hydroxysteroid dehydrogenase XI
Short name:
17-beta-HSD XI
Short name:
17betaHSDXI
Cutaneous T-cell lymphoma-associated antigen HD-CL-03
Short name:
CTCL-associated antigen HD-CL-03
Dehydrogenase/reductase SDR family member 8
Retinal short-chain dehydrogenase/reductase 2
Short name:
retSDR2
Short chain dehydrogenase/reductase family 16C member 2
Gene namesi
Name:HSD17B11
Synonyms:DHRS8, PAN1B, SDR16C2
ORF Names:PSEC0029, UNQ207/PRO233
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:22960. HSD17B11.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HGNC
  • cytosol Source: Reactome
  • extracellular region Source: UniProtKB-SubCell
  • intracellular membrane-bounded organelle Source: HPA
  • lipid particle Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi51170.
PharmGKBiPA162391655.

Polymorphism and mutation databases

BioMutaiHSD17B11.
DMDMi296439374.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000003197020 – 300Estradiol 17-beta-dehydrogenase 11Add BLAST281

Proteomic databases

EPDiQ8NBQ5.
MaxQBiQ8NBQ5.
PaxDbiQ8NBQ5.
PeptideAtlasiQ8NBQ5.
PRIDEiQ8NBQ5.

PTM databases

iPTMnetiQ8NBQ5.
PhosphoSitePlusiQ8NBQ5.

Expressioni

Tissue specificityi

Present at high level in steroidogenic cells such as syncytiotrophoblasts, sebaceous gland, Leydig cells, and granulosa cells of the dominant follicle and corpus luteum. In lung, it is detected in the ciliated epithelium and in acini of adult trachea, in bronchioles, but not in alveoli. In the eye, it is detected in the nonpigmented epithelium of the ciliary body and, at lower level, in the inner nuclear layer of the retina (at protein level). Widely expressed. Highly expressed in retina, pancreas, kidney, liver, lung, adrenal, small intestine, ovary and heart.4 Publications

Gene expression databases

BgeeiENSG00000198189.
CleanExiHS_HSD17B11.
ExpressionAtlasiQ8NBQ5. baseline and differential.
GenevisibleiQ8NBQ5. HS.

Organism-specific databases

HPAiHPA021608.

Interactioni

Protein-protein interaction databases

BioGridi119349. 5 interactors.
IntActiQ8NBQ5. 1 interactor.
STRINGi9606.ENSP00000351035.

Structurei

Secondary structure

1300
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi38 – 42Combined sources5
Turni43 – 45Combined sources3
Helixi47 – 58Combined sources12
Beta strandi62 – 68Combined sources7
Helixi70 – 82Combined sources13
Beta strandi87 – 91Combined sources5
Helixi97 – 110Combined sources14
Beta strandi115 – 119Combined sources5
Helixi130 – 132Combined sources3
Helixi133 – 144Combined sources12
Helixi146 – 161Combined sources16
Beta strandi165 – 170Combined sources6
Helixi179 – 205Combined sources27
Beta strandi211 – 218Combined sources8
Helixi220 – 223Combined sources4
Helixi230 – 233Combined sources4
Helixi239 – 251Combined sources13
Beta strandi255 – 259Combined sources5
Helixi265 – 270Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YB1X-ray1.95A/B28-275[»]
ProteinModelPortaliQ8NBQ5.
SMRiQ8NBQ5.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8NBQ5.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1201. Eukaryota.
COG1028. LUCA.
HOVERGENiHBG051352.
InParanoidiQ8NBQ5.
OrthoDBiEOG091G0825.
PhylomeDBiQ8NBQ5.
TreeFamiTF312837.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8NBQ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFLLDILLL LPLLIVCSLE SFVKLFIPKR RKSVTGEIVL ITGAGHGIGR
60 70 80 90 100
LTAYEFAKLK SKLVLWDINK HGLEETAAKC KGLGAKVHTF VVDCSNREDI
110 120 130 140 150
YSSAKKVKAE IGDVSILVNN AGVVYTSDLF ATQDPQIEKT FEVNVLAHFW
160 170 180 190 200
TTKAFLPAMT KNNHGHIVTV ASAAGHVSVP FLLAYCSSKF AAVGFHKTLT
210 220 230 240 250
DELAALQITG VKTTCLCPNF VNTGFIKNPS TSLGPTLEPE EVVNRLMHGI
260 270 280 290 300
LTEQKMIFIP SSIAFLTTLE RILPERFLAV LKQKISVKFD AVIGYKMKAQ
Length:300
Mass (Da):32,936
Last modified:May 18, 2010 - v3
Checksum:i51DE633A205EBE86
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23V → E in AAH08650 (PubMed:15489334).Curated1
Sequence conflicti38I → T in BAC11560 (PubMed:16303743).Curated1
Sequence conflicti106K → N in AAH08650 (PubMed:15489334).Curated1
Sequence conflicti107V → C in AAH08650 (PubMed:15489334).Curated1
Sequence conflicti228N → K in AAH08650 (PubMed:15489334).Curated1
Sequence conflicti229P → M in AAH08650 (PubMed:15489334).Curated1
Sequence conflicti263I → N in AAH08650 (PubMed:15489334).Curated1
Sequence conflicti264A → C in AAH08650 (PubMed:15489334).Curated1
Sequence conflicti265F → I in AAH08650 (PubMed:15489334).Curated1
Sequence conflicti283Q → R in AAF06939 (PubMed:10800688).Curated1
Sequence conflicti283Q → R in AAM44459 (PubMed:14996095).Curated1
Sequence conflicti283Q → R in AAQ88917 (PubMed:12975309).Curated1
Sequence conflicti283Q → R in BAC11560 (PubMed:16303743).Curated1
Sequence conflicti283Q → R in AAH08650 (PubMed:15489334).Curated1
Sequence conflicti283Q → R in AAH14327 (PubMed:15489334).Curated1
Sequence conflicti283Q → R in AAH16367 (PubMed:15489334).Curated1
Sequence conflicti283Q → R in AAH21673 (PubMed:15489334).Curated1
Sequence conflicti283Q → R in AAH36001 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF126780 mRNA. Translation: AAF06939.1.
AF273056 mRNA. Translation: AAM44459.1.
AY358553 mRNA. Translation: AAQ88917.1.
AK075348 mRNA. Translation: BAC11560.1.
AC108516 Genomic DNA. No translation available.
BC008650 mRNA. Translation: AAH08650.1.
BC014327 mRNA. Translation: AAH14327.1.
BC016367 mRNA. Translation: AAH16367.1.
BC021673 mRNA. Translation: AAH21673.1.
BC036001 mRNA. Translation: AAH36001.1.
CCDSiCCDS3619.1.
RefSeqiNP_057329.3. NM_016245.4.
UniGeneiHs.594923.

Genome annotation databases

EnsembliENST00000358290; ENSP00000351035; ENSG00000198189.
GeneIDi51170.
KEGGihsa:51170.
UCSCiuc003hqp.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF126780 mRNA. Translation: AAF06939.1.
AF273056 mRNA. Translation: AAM44459.1.
AY358553 mRNA. Translation: AAQ88917.1.
AK075348 mRNA. Translation: BAC11560.1.
AC108516 Genomic DNA. No translation available.
BC008650 mRNA. Translation: AAH08650.1.
BC014327 mRNA. Translation: AAH14327.1.
BC016367 mRNA. Translation: AAH16367.1.
BC021673 mRNA. Translation: AAH21673.1.
BC036001 mRNA. Translation: AAH36001.1.
CCDSiCCDS3619.1.
RefSeqiNP_057329.3. NM_016245.4.
UniGeneiHs.594923.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YB1X-ray1.95A/B28-275[»]
ProteinModelPortaliQ8NBQ5.
SMRiQ8NBQ5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119349. 5 interactors.
IntActiQ8NBQ5. 1 interactor.
STRINGi9606.ENSP00000351035.

PTM databases

iPTMnetiQ8NBQ5.
PhosphoSitePlusiQ8NBQ5.

Polymorphism and mutation databases

BioMutaiHSD17B11.
DMDMi296439374.

Proteomic databases

EPDiQ8NBQ5.
MaxQBiQ8NBQ5.
PaxDbiQ8NBQ5.
PeptideAtlasiQ8NBQ5.
PRIDEiQ8NBQ5.

Protocols and materials databases

DNASUi51170.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358290; ENSP00000351035; ENSG00000198189.
GeneIDi51170.
KEGGihsa:51170.
UCSCiuc003hqp.3. human.

Organism-specific databases

CTDi51170.
DisGeNETi51170.
GeneCardsiHSD17B11.
H-InvDBHIX0004358.
HGNCiHGNC:22960. HSD17B11.
HPAiHPA021608.
MIMi612831. gene.
neXtProtiNX_Q8NBQ5.
PharmGKBiPA162391655.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1201. Eukaryota.
COG1028. LUCA.
HOVERGENiHBG051352.
InParanoidiQ8NBQ5.
OrthoDBiEOG091G0825.
PhylomeDBiQ8NBQ5.
TreeFamiTF312837.

Enzyme and pathway databases

BioCyciZFISH:HS11363-MONOMER.
ReactomeiR-HSA-193144. Estrogen biosynthesis.

Miscellaneous databases

ChiTaRSiHSD17B11. human.
EvolutionaryTraceiQ8NBQ5.
GeneWikiiHSD17B11.
GenomeRNAii51170.
PROiQ8NBQ5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198189.
CleanExiHS_HSD17B11.
ExpressionAtlasiQ8NBQ5. baseline and differential.
GenevisibleiQ8NBQ5. HS.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDHB11_HUMAN
AccessioniPrimary (citable) accession number: Q8NBQ5
Secondary accession number(s): Q96HF6, Q9UKU4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: May 18, 2010
Last modified: November 2, 2016
This is version 132 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.