Reviewed,
UniProtKB/Swiss-Prot Q8NBQ5 (DHB11_HUMAN)
Last modified
January 19, 2010.
Version 70.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Estradiol 17-beta-dehydrogenase 11 EC=1.1.1.62 Alternative name(s): 17-beta-hydroxysteroid dehydrogenase 11 Short name=17-beta-HSD 11 Short name=17betaHSD11 Short name=17bHSD11 17-beta-HSD XI Short name=17betaHSDXI Dehydrogenase/reductase SDR family member 8 Retinal short-chain dehydrogenase/reductase 2 Short name=retSDR2 Cutaneous T-cell lymphoma-associated antigen HD-CL-03 CTCL tumor antigen HD-CL-03 | ||||||
| Gene names |
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| Organism | Homo sapiens (Human) [Complete proteome] | ||||||
| Taxonomic identifier | 9606 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 300 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor-associated antigen in cutaneous T-cell lymphoma. |
| Catalytic activity | Estradiol-17-beta + NAD(P)+ = estrone + NAD(P)H. Ref.8 |
| Subcellular location | Secreted Potential. |
| Tissue specificity | Present at high level in steroidogenic cells such as syncytiotrophoblasts, sebaceous gland, Leydig cells, and granulosa cells of the dominant follicle and corpus luteum. In lung, it is detected in the ciliated epithelium and in acini of adult trachea, in bronchioles, but not in alveoli. In the eye, it is detected in the nonpigmented epithelium of the ciliary body and, at lower level, in the inner nuclear layer of the retina (at protein level). Widely expressed. Highly expressed in retina, pancreas, kidney, liver, lung, adrenal, small intestine, ovary and heart. Ref.8 Ref.1 Ref.6 Ref.7 |
| Sequence similarities | Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Lipid synthesis Steroid biosynthesis |
| Cellular component | Secreted |
| Domain | Signal |
| Ligand | NADP |
| Molecular function | Oxidoreductase |
| Technical term | 3D-structure Complete proteome |
| Gene Ontology (GO) | |
| Biological process | androgen catabolic process Ref.8 Inferred from direct assay. Source: HGNC oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW steroid biosynthetic processInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Ref.8 Inferred from direct assay. Source: HGNC extracellular regionInferred from electronic annotation. Source: UniProtKB-SubCell nucleusInferred from direct assay. Source: HPA |
| Molecular function | binding Inferred from electronic annotation. Source: InterPro estradiol 17-beta-dehydrogenase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||||||||||||||||||||||||||||||||||||
Molecule processing | |||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 19 | 19 | Potential | ||||||||||||||||||||||||||||||||||||||||||
| Chain | 20 – 300 | 281 | Estradiol 17-beta-dehydrogenase 11 | PRO_0000031970 | |||||||||||||||||||||||||||||||||||||||||
Regions | |||||||||||||||||||||||||||||||||||||||||||||
| Nucleotide binding | 40 – 64 | 25 | NADP By similarity | ||||||||||||||||||||||||||||||||||||||||||
Sites | |||||||||||||||||||||||||||||||||||||||||||||
| Active site | 185 | 1 | Proton acceptor By similarity | ||||||||||||||||||||||||||||||||||||||||||
| Binding site | 172 | 1 | Substrate By similarity | ||||||||||||||||||||||||||||||||||||||||||
Experimental info | |||||||||||||||||||||||||||||||||||||||||||||
| Sequence conflict | 23 | 1 | V → E in AAH08650. Ref.5 | ||||||||||||||||||||||||||||||||||||||||||
| Sequence conflict | 38 | 1 | I → T in BAC11560. Ref.4 | ||||||||||||||||||||||||||||||||||||||||||
| Sequence conflict | 106 | 1 | K → N in AAH08650. Ref.5 | ||||||||||||||||||||||||||||||||||||||||||
| Sequence conflict | 107 | 1 | V → C in AAH08650. Ref.5 | ||||||||||||||||||||||||||||||||||||||||||
| Sequence conflict | 228 | 1 | N → K in AAH08650. Ref.5 | ||||||||||||||||||||||||||||||||||||||||||
| Sequence conflict | 229 | 1 | P → M in AAH08650. Ref.5 | ||||||||||||||||||||||||||||||||||||||||||
| Sequence conflict | 263 | 1 | I → N in AAH08650. Ref.5 | ||||||||||||||||||||||||||||||||||||||||||
| Sequence conflict | 264 | 1 | A → C in AAH08650. Ref.5 | ||||||||||||||||||||||||||||||||||||||||||
| Sequence conflict | 265 | 1 | F → I in AAH08650. Ref.5 | ||||||||||||||||||||||||||||||||||||||||||
Secondary structure | |||||||||||||||||||||||||||||||||||||||||||||
Helix Strand Turn | |||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 38 – 42 | 5 | |||||||||||||||||||||||||||||||||||||||||||
| Turn | 43 – 45 | 3 | |||||||||||||||||||||||||||||||||||||||||||
| Helix | 47 – 58 | 12 | |||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 62 – 68 | 7 | |||||||||||||||||||||||||||||||||||||||||||
| Helix | 70 – 82 | 13 | |||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 87 – 91 | 5 | |||||||||||||||||||||||||||||||||||||||||||
| Helix | 97 – 110 | 14 | |||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 115 – 119 | 5 | |||||||||||||||||||||||||||||||||||||||||||
| Helix | 130 – 132 | 3 | |||||||||||||||||||||||||||||||||||||||||||
| Helix | 133 – 144 | 12 | |||||||||||||||||||||||||||||||||||||||||||
| Helix | 146 – 161 | 16 | |||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 165 – 170 | 6 | |||||||||||||||||||||||||||||||||||||||||||
| Helix | 179 – 205 | 27 | |||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 211 – 218 | 8 | |||||||||||||||||||||||||||||||||||||||||||
| Helix | 220 – 223 | 4 | |||||||||||||||||||||||||||||||||||||||||||
| Helix | 230 – 233 | 4 | |||||||||||||||||||||||||||||||||||||||||||
| Helix | 239 – 251 | 13 | |||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 255 – 259 | 5 | |||||||||||||||||||||||||||||||||||||||||||
| Helix | 265 – 270 | 6 | |||||||||||||||||||||||||||||||||||||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Short-chain dehydrogenases/reductases in retina." Haeseleer F., Palczewski K. Methods Enzymol. 316:372-383(2000) [PubMed: 10800688] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Retina. |
| [2] | "SEREX identification of new tumour-associated antigens in cutaneous T-cell lymphoma." Hartmann T.B., Thiel D., Dummer R., Schadendorf D., Eichmueller S. Br. J. Dermatol. 150:252-258(2004) [PubMed: 14996095] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Lymphoma. |
| [3] | "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. Gray A.M.Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [4] | "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries." Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y. Isogai T.DNA Res. 12:117-126(2005) [PubMed: 16303743] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Teratocarcinoma. |
| [5] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Bone marrow, Colon, Kidney, Liver and Urinary bladder. |
| [6] | "Cloning and expression of a novel tissue specific 17beta-hydroxysteroid dehydrogenase." Li K.X.Z., Smith R.E., Krozowski Z.S. Endocr. Res. 24:663-667(1998) [PubMed: 9888557] [Abstract] Cited for: TISSUE SPECIFICITY. |
| [7] | "Pan1b (17betaHSD11)-enzymatic activity and distribution in the lung." Brereton P., Suzuki T., Sasano H., Li K., Duarte C., Obeyesekere V., Haeseleer F., Palczewski K., Smith I., Komesaroff P., Krozowski Z. Mol. Cell. Endocrinol. 171:111-117(2001) [PubMed: 11165019] [Abstract] Cited for: TISSUE SPECIFICITY. |
| [8] | "17 beta-hydroxysteroid dehydrogenase type XI localizes to human steroidogenic cells." Chai Z., Brereton P., Suzuki T., Sasano H., Obeyesekere V., Escher G., Saffery R., Fuller P., Enriquez C., Krozowski Z. Endocrinology 144:2084-2091(2003) [PubMed: 12697717] [Abstract] Cited for: ENZYME ACTIVITY IN VITRO, TISSUE SPECIFICITY. |
| [9] | Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. |
| [10] | "Crystal structure of human 17-beta-hydroxysteroid dehydrogenase type XI." Lukacik P., Bunkoczi G., Kavanagh K., Ng S., Von delft F., Bray J., Edwards A., Arrowsmith C., Sundstrom M., Oppermann U. Submitted (DEC-2004) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 28-275. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EMBL GenBank DDBJ | AF126780 mRNA. Translation: AAF06939.1. AF273056 mRNA. Translation: AAM44459.1. AY358553 mRNA. Translation: AAQ88917.1. AK075348 mRNA. Translation: BAC11560.1. BC008650 mRNA. Translation: AAH08650.1. BC014327 mRNA. Translation: AAH14327.1. BC016367 mRNA. Translation: AAH16367.1. BC021673 mRNA. Translation: AAH21673.1. BC036001 mRNA. Translation: AAH36001.1. | ||||||||||||
| IPI | IPI00329598. | ||||||||||||
| RefSeq | NP_057329.2. | ||||||||||||
| UniGene | Hs.594923 | ||||||||||||
3D structure databases | |||||||||||||
| PDBe RCSB PDB PDBj |
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| ModBase | Search... | ||||||||||||
Protein-protein interaction databases | |||||||||||||
| IntAct | Q8NBQ5. 3 interactions. | ||||||||||||
| STRING | Q8NBQ5. | ||||||||||||
Proteomic databases | |||||||||||||
| PRIDE | Q8NBQ5. | ||||||||||||
Genome annotation databases | |||||||||||||
| Ensembl | ENST00000358290; ENSP00000351035; ENSG00000198189; Homo sapiens. [Genome view] | ||||||||||||
| GeneID | 51170. | ||||||||||||
| KEGG | hsa:51170. | ||||||||||||
| UCSC | uc003hqp.2. human. | ||||||||||||
Organism-specific databases | |||||||||||||
| CTD | 51170. | ||||||||||||
| GeneCards | GC04M088477. | ||||||||||||
| H-InvDB | HIX0004358. | ||||||||||||
| HGNC | HGNC:22960. HSD17B11. | ||||||||||||
| HPA | HPA021608. | ||||||||||||
| PharmGKB | PA134981822. | ||||||||||||
| GenAtlas | Search... | ||||||||||||
Phylogenomic databases | |||||||||||||
| eggNOG | prNOG11153. | ||||||||||||
| HOGENOM | HBG750976. | ||||||||||||
| HOVERGEN | Q8NBQ5. | ||||||||||||
| InParanoid | Q8NBQ5. | ||||||||||||
| PhylomeDB | Q8NBQ5. | ||||||||||||
Enzyme and pathway databases | |||||||||||||
| BRENDA | 1.1.1.62. 247. | ||||||||||||
Gene expression databases | |||||||||||||
| ArrayExpress | Q8NBQ5. | ||||||||||||
| Bgee | Q8NBQ5. | ||||||||||||
| CleanEx | HS_HSD17B11. | ||||||||||||
| Genevestigator | Q8NBQ5. | ||||||||||||
| GermOnline | ENSG00000198189. Homo sapiens. | ||||||||||||
Family and domain databases | |||||||||||||
| InterPro | IPR002198. DH_sc/Rdtase_SDR. IPR002347. Glc/ribitol_DH. IPR016040. NAD(P)-bd_dom. [Graphical view] | ||||||||||||
| Gene3D | G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. | ||||||||||||
| PANTHER | PTHR19410. ADH_short_C2. 1 hit. | ||||||||||||
| Pfam | PF00106. adh_short. 1 hit. [Graphical view] | ||||||||||||
| PRINTS | PR00081. GDHRDH. PR00080. SDRFAMILY. | ||||||||||||
| PROSITE | PS00061. ADH_SHORT. False negative. [Graphical view] | ||||||||||||
| ProtoNet | Search... | ||||||||||||
Other Resources | |||||||||||||
| NextBio | 54111. | ||||||||||||
Entry information
| Entry name | DHB11_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q8NBQ5 Secondary accession number(s): Q96HF6, Q9UKU4 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 4 Human chromosome 4: entries, gene names and cross-references to MIM |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with


