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Protein

Estradiol 17-beta-dehydrogenase 11

Gene

HSD17B11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor-associated antigen in cutaneous T-cell lymphoma.

Catalytic activityi

17-beta-estradiol + NAD(P)+ = estrone + NAD(P)H.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei172SubstrateBy similarity1
Active sitei185Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi40 – 64NADPBy similarityAdd BLAST25

GO - Molecular functioni

  • estradiol 17-beta-dehydrogenase activity Source: Reactome
  • steroid dehydrogenase activity Source: HGNC

GO - Biological processi

  • androgen catabolic process Source: HGNC
  • estrogen biosynthetic process Source: Reactome

Keywordsi

Molecular functionOxidoreductase
Biological processLipid biosynthesis, Lipid metabolism, Steroid biosynthesis
LigandNADP

Enzyme and pathway databases

ReactomeiR-HSA-193144 Estrogen biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Estradiol 17-beta-dehydrogenase 11 (EC:1.1.1.62)
Alternative name(s):
17-beta-hydroxysteroid dehydrogenase 11
Short name:
17-beta-HSD 11
Short name:
17bHSD11
Short name:
17betaHSD11
17-beta-hydroxysteroid dehydrogenase XI
Short name:
17-beta-HSD XI
Short name:
17betaHSDXI
Cutaneous T-cell lymphoma-associated antigen HD-CL-03
Short name:
CTCL-associated antigen HD-CL-03
Dehydrogenase/reductase SDR family member 8
Retinal short-chain dehydrogenase/reductase 2
Short name:
retSDR2
Short chain dehydrogenase/reductase family 16C member 2
Gene namesi
Name:HSD17B11
Synonyms:DHRS8, PAN1B, SDR16C2
ORF Names:PSEC0029, UNQ207/PRO233
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000198189.10
HGNCiHGNC:22960 HSD17B11
MIMi612831 gene
neXtProtiNX_Q8NBQ5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi51170
PharmGKBiPA162391655

Chemistry databases

DrugBankiDB02854 Aetiocholanolone

Polymorphism and mutation databases

BioMutaiHSD17B11
DMDMi296439374

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000003197020 – 300Estradiol 17-beta-dehydrogenase 11Add BLAST281

Proteomic databases

EPDiQ8NBQ5
MaxQBiQ8NBQ5
PaxDbiQ8NBQ5
PeptideAtlasiQ8NBQ5
PRIDEiQ8NBQ5

PTM databases

iPTMnetiQ8NBQ5
PhosphoSitePlusiQ8NBQ5

Expressioni

Tissue specificityi

Present at high level in steroidogenic cells such as syncytiotrophoblasts, sebaceous gland, Leydig cells, and granulosa cells of the dominant follicle and corpus luteum. In lung, it is detected in the ciliated epithelium and in acini of adult trachea, in bronchioles, but not in alveoli. In the eye, it is detected in the nonpigmented epithelium of the ciliary body and, at lower level, in the inner nuclear layer of the retina (at protein level). Widely expressed. Highly expressed in retina, pancreas, kidney, liver, lung, adrenal, small intestine, ovary and heart.4 Publications

Gene expression databases

BgeeiENSG00000198189
CleanExiHS_HSD17B11
ExpressionAtlasiQ8NBQ5 baseline and differential
GenevisibleiQ8NBQ5 HS

Organism-specific databases

HPAiHPA021608

Interactioni

Protein-protein interaction databases

BioGridi119349, 6 interactors
IntActiQ8NBQ5, 5 interactors
MINTiQ8NBQ5
STRINGi9606.ENSP00000351035

Structurei

Secondary structure

1300
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi38 – 42Combined sources5
Turni43 – 45Combined sources3
Helixi47 – 58Combined sources12
Beta strandi62 – 68Combined sources7
Helixi70 – 82Combined sources13
Beta strandi87 – 91Combined sources5
Helixi97 – 110Combined sources14
Beta strandi115 – 119Combined sources5
Helixi130 – 132Combined sources3
Helixi133 – 144Combined sources12
Helixi146 – 161Combined sources16
Beta strandi165 – 170Combined sources6
Helixi179 – 205Combined sources27
Beta strandi211 – 218Combined sources8
Helixi220 – 223Combined sources4
Helixi230 – 233Combined sources4
Helixi239 – 251Combined sources13
Beta strandi255 – 259Combined sources5
Helixi265 – 270Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YB1X-ray1.95A/B28-275[»]
ProteinModelPortaliQ8NBQ5
SMRiQ8NBQ5
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8NBQ5

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1201 Eukaryota
COG1028 LUCA
HOVERGENiHBG051352
InParanoidiQ8NBQ5
OrthoDBiEOG091G0825
PhylomeDBiQ8NBQ5
TreeFamiTF312837

Family and domain databases

InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR002347 SDR_fam
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PRINTSiPR00081 GDHRDH
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8NBQ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFLLDILLL LPLLIVCSLE SFVKLFIPKR RKSVTGEIVL ITGAGHGIGR
60 70 80 90 100
LTAYEFAKLK SKLVLWDINK HGLEETAAKC KGLGAKVHTF VVDCSNREDI
110 120 130 140 150
YSSAKKVKAE IGDVSILVNN AGVVYTSDLF ATQDPQIEKT FEVNVLAHFW
160 170 180 190 200
TTKAFLPAMT KNNHGHIVTV ASAAGHVSVP FLLAYCSSKF AAVGFHKTLT
210 220 230 240 250
DELAALQITG VKTTCLCPNF VNTGFIKNPS TSLGPTLEPE EVVNRLMHGI
260 270 280 290 300
LTEQKMIFIP SSIAFLTTLE RILPERFLAV LKQKISVKFD AVIGYKMKAQ
Length:300
Mass (Da):32,936
Last modified:May 18, 2010 - v3
Checksum:i51DE633A205EBE86
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23V → E in AAH08650 (PubMed:15489334).Curated1
Sequence conflicti38I → T in BAC11560 (PubMed:16303743).Curated1
Sequence conflicti106K → N in AAH08650 (PubMed:15489334).Curated1
Sequence conflicti107V → C in AAH08650 (PubMed:15489334).Curated1
Sequence conflicti228N → K in AAH08650 (PubMed:15489334).Curated1
Sequence conflicti229P → M in AAH08650 (PubMed:15489334).Curated1
Sequence conflicti263I → N in AAH08650 (PubMed:15489334).Curated1
Sequence conflicti264A → C in AAH08650 (PubMed:15489334).Curated1
Sequence conflicti265F → I in AAH08650 (PubMed:15489334).Curated1
Sequence conflicti283Q → R in AAF06939 (PubMed:10800688).Curated1
Sequence conflicti283Q → R in AAM44459 (PubMed:14996095).Curated1
Sequence conflicti283Q → R in AAQ88917 (PubMed:12975309).Curated1
Sequence conflicti283Q → R in BAC11560 (PubMed:16303743).Curated1
Sequence conflicti283Q → R in AAH08650 (PubMed:15489334).Curated1
Sequence conflicti283Q → R in AAH14327 (PubMed:15489334).Curated1
Sequence conflicti283Q → R in AAH16367 (PubMed:15489334).Curated1
Sequence conflicti283Q → R in AAH21673 (PubMed:15489334).Curated1
Sequence conflicti283Q → R in AAH36001 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF126780 mRNA Translation: AAF06939.1
AF273056 mRNA Translation: AAM44459.1
AY358553 mRNA Translation: AAQ88917.1
AK075348 mRNA Translation: BAC11560.1
AC108516 Genomic DNA No translation available.
BC008650 mRNA Translation: AAH08650.1
BC014327 mRNA Translation: AAH14327.1
BC016367 mRNA Translation: AAH16367.1
BC021673 mRNA Translation: AAH21673.1
BC036001 mRNA Translation: AAH36001.1
CCDSiCCDS3619.1
RefSeqiNP_057329.3, NM_016245.4
UniGeneiHs.594923

Genome annotation databases

EnsembliENST00000358290; ENSP00000351035; ENSG00000198189
GeneIDi51170
KEGGihsa:51170
UCSCiuc003hqp.3 human

Similar proteinsi

Entry informationi

Entry nameiDHB11_HUMAN
AccessioniPrimary (citable) accession number: Q8NBQ5
Secondary accession number(s): Q96HF6, Q9UKU4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: May 18, 2010
Last modified: March 28, 2018
This is version 141 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health