##gff-version 3 Q8NBP7 UniProtKB Signal peptide 1 30 . . . Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12552133;Dbxref=PMID:12552133 Q8NBP7 UniProtKB Propeptide 31 152 . . . ID=PRO_0000027120;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12552133;Dbxref=PMID:12552133 Q8NBP7 UniProtKB Chain 153 692 . . . ID=PRO_0000027121;Note=Proprotein convertase subtilisin/kexin type 9 Q8NBP7 UniProtKB Domain 77 149 . . . Note=Inhibitor I9;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q8NBP7 UniProtKB Domain 155 461 . . . Note=Peptidase S8;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01240 Q8NBP7 UniProtKB Region 450 692 . . . Note=C-terminal domain Q8NBP7 UniProtKB Active site 186 186 . . . Note=Charge relay system;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01240 Q8NBP7 UniProtKB Active site 226 226 . . . Note=Charge relay system;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01240 Q8NBP7 UniProtKB Active site 386 386 . . . Note=Charge relay system;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01240 Q8NBP7 UniProtKB Site 152 153 . . . Note=Cleavage%3B by autolysis;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14622975;Dbxref=PMID:14622975 Q8NBP7 UniProtKB Site 218 219 . . . Note=Cleavage%3B by furin and PCSK5;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16912035;Dbxref=PMID:16912035 Q8NBP7 UniProtKB Modified residue 38 38 . . . Note=Sulfotyrosine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16912035;Dbxref=PMID:16912035 Q8NBP7 UniProtKB Modified residue 47 47 . . . Note=Phosphoserine%3B by FAM20C;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18498363,ECO:0000269|PubMed:26091039;Dbxref=PMID:18498363,PMID:26091039 Q8NBP7 UniProtKB Modified residue 688 688 . . . Note=Phosphoserine%3B by FAM20C;Ontology_term=ECO:0000269,ECO:0000269,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:18498363,ECO:0000269|PubMed:26091039,ECO:0007744|PubMed:17081983,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:17081983,PMID:18498363,PMID:20068231,PMID:21406692,PMID:23186163,PMID:26091039 Q8NBP7 UniProtKB Glycosylation 533 533 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16912035;Dbxref=PMID:16912035 Q8NBP7 UniProtKB Disulfide bond 223 255 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 Q8NBP7 UniProtKB Disulfide bond 323 358 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 Q8NBP7 UniProtKB Disulfide bond 457 527 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 Q8NBP7 UniProtKB Disulfide bond 477 526 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 Q8NBP7 UniProtKB Disulfide bond 486 509 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 Q8NBP7 UniProtKB Disulfide bond 534 601 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 Q8NBP7 UniProtKB Disulfide bond 552 600 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 Q8NBP7 UniProtKB Disulfide bond 562 588 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 Q8NBP7 UniProtKB Disulfide bond 608 679 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 Q8NBP7 UniProtKB Disulfide bond 626 678 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 Q8NBP7 UniProtKB Disulfide bond 635 654 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 Q8NBP7 UniProtKB Alternative sequence 1 174 . . . ID=VSP_008844;Note=In isoform 2. MGTVSSRRSWWPLPLLLLLLLLLGPAGARAQEDEDGDYEELVLALRSEEDGLAEAPEHGTTATFHRCAKDPWRLPGTYVVVLKEETHLSQSERTARRLQAQAARRGYLTKILHVFHGLLPGFLVKMSGDLLELALKLPHVDYIEEDSSVFAQSIPWNLERITPPRYRADEYQPP->MSPWK;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 Q8NBP7 UniProtKB Alternative sequence 333 365 . . . ID=VSP_008845;Note=In isoform 2. VITVGATNAQDQPVTLGTLGTNFGRCVDLFAPG->GRTSLVPPATAAPALCHRVGHHRLLPTWLALQP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 Q8NBP7 UniProtKB Alternative sequence 366 692 . . . ID=VSP_008846;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 Q8NBP7 UniProtKB Natural variant 23 23 . . . ID=VAR_021336;Note=This variant seems to have a modifier effect on LDLR mutation and familial hypercholesterolemia. L->LL;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:19319977,ECO:0000269|PubMed:22095935,ECO:0000269|Ref.4,ECO:0000269|Ref.5;Dbxref=PMID:19319977,PMID:22095935 Q8NBP7 UniProtKB Natural variant 46 46 . . . ID=VAR_017197;Note=Correlated with lower plasma levels of low-density lipoprotein cholesterol%3B reduced phosphorylation at Ser-47. R->L;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12730697,ECO:0000269|PubMed:16465619,ECO:0000269|PubMed:22095935,ECO:0000269|Ref.4;Dbxref=dbSNP:rs11591147,PMID:12730697,PMID:16465619,PMID:22095935 Q8NBP7 UniProtKB Natural variant 53 53 . . . ID=VAR_017198;Note=Reduced phosphorylation at Ser-47. A->V;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12730697,ECO:0000269|PubMed:16465619,ECO:0000269|PubMed:22095935,ECO:0000269|Ref.4;Dbxref=dbSNP:rs11583680,PMID:12730697,PMID:16465619,PMID:22095935 Q8NBP7 UniProtKB Natural variant 57 57 . . . ID=VAR_025451;Note=E->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16465619;Dbxref=dbSNP:rs145886902,PMID:16465619 Q8NBP7 UniProtKB Natural variant 77 77 . . . ID=VAR_058520;Note=T->I;Dbxref=dbSNP:rs756060557 Q8NBP7 UniProtKB Natural variant 93 93 . . . ID=VAR_058521;Note=R->C;Dbxref=dbSNP:rs151193009 Q8NBP7 UniProtKB Natural variant 106 106 . . . ID=VAR_058522;Note=G->R Q8NBP7 UniProtKB Natural variant 114 114 . . . ID=VAR_058523;Note=V->A;Dbxref=dbSNP:rs775988212 Q8NBP7 UniProtKB Natural variant 127 127 . . . ID=VAR_017199;Note=In FHCL3. S->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12730697;Dbxref=dbSNP:rs28942111,PMID:12730697 Q8NBP7 UniProtKB Natural variant 129 129 . . . ID=VAR_058524;Note=In FHCL3. D->G;Dbxref=dbSNP:rs1553135971 Q8NBP7 UniProtKB Natural variant 157 157 . . . ID=VAR_058525;Note=N->K;Dbxref=dbSNP:rs143117125 Q8NBP7 UniProtKB Natural variant 174 174 . . . ID=VAR_067351;Note=Found in patients with familial hypercholesterolemia carrying a homozygous LDLR mutation%3B acts as a disease modifier resulting in a mild phenotype. P->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22417841;Dbxref=dbSNP:rs533273863,PMID:22417841 Q8NBP7 UniProtKB Natural variant 215 215 . . . ID=VAR_058526;Note=In FHCL3. R->H;Dbxref=dbSNP:rs794728683 Q8NBP7 UniProtKB Natural variant 216 216 . . . ID=VAR_017200;Note=In FHCL3%3B partial loss of cleavage by furin and PCSK5. F->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12730697;Dbxref=dbSNP:rs28942112,PMID:12730697 Q8NBP7 UniProtKB Natural variant 218 218 . . . ID=VAR_058527;Note=In FHCL3%3B complete loss of cleavage by furin and PCSK5%3B reduces glycosylation levels%3B no effect on protein sulfation and phosphorylation%3B no effect on protein sulfation but inhibits phosphorylation when associated with Y-374%3B highly reduces LDL uptake when associated with Y-374. R->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18799458,ECO:0000269|PubMed:24808179;Dbxref=dbSNP:rs970575319,PMID:18799458,PMID:24808179 Q8NBP7 UniProtKB Natural variant 219 219 . . . ID=VAR_058528;Note=Q->E;Dbxref=dbSNP:rs778617372 Q8NBP7 UniProtKB Natural variant 237 237 . . . ID=VAR_025452;Note=R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16465619;Dbxref=dbSNP:rs148195424,PMID:16465619 Q8NBP7 UniProtKB Natural variant 239 239 . . . ID=VAR_058529;Note=A->D Q8NBP7 UniProtKB Natural variant 253 253 . . . ID=VAR_025453;Note=Correlated with lower plasma levels of low-density lipoprotein cholesterol. L->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16465619;Dbxref=dbSNP:rs72646508,PMID:16465619 Q8NBP7 UniProtKB Natural variant 357 357 . . . ID=VAR_058530;Note=In FHCL3. R->H;Dbxref=dbSNP:rs370507566 Q8NBP7 UniProtKB Natural variant 374 374 . . . ID=VAR_058531;Note=In FHCL3. D->H;Dbxref=dbSNP:rs137852912 Q8NBP7 UniProtKB Natural variant 374 374 . . . ID=VAR_058532;Note=In FHCL3%3B partial loss of cleavage by furin and PCSK5%3B no effect on protein sulfation but inhibits phosphorylation when associated with S-218%3B highly increases LDL uptake when associated with S-218. D->Y;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18799458,ECO:0000269|PubMed:24808179;Dbxref=dbSNP:rs137852912,PMID:18799458,PMID:24808179 Q8NBP7 UniProtKB Natural variant 391 391 . . . ID=VAR_025454;Note=H->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16465619;Dbxref=dbSNP:rs146471967,PMID:16465619 Q8NBP7 UniProtKB Natural variant 394 394 . . . ID=VAR_067282;Note=In FHCL3%3B uncertain significance. G->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22095935;Dbxref=dbSNP:rs368257906,PMID:22095935 Q8NBP7 UniProtKB Natural variant 417 417 . . . ID=VAR_025455;Note=H->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16465619;Dbxref=dbSNP:rs143275858,PMID:16465619 Q8NBP7 UniProtKB Natural variant 425 425 . . . ID=VAR_021337;Note=N->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16465619,ECO:0000269|Ref.4;Dbxref=dbSNP:rs28362261,PMID:16465619 Q8NBP7 UniProtKB Natural variant 443 443 . . . ID=VAR_021338;Note=Correlated with lower plasma levels of low-density lipoprotein cholesterol%3B more extensive cleavage by furin and PCSK5. A->T;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16465619,ECO:0000269|Ref.4;Dbxref=dbSNP:rs28362263,PMID:16465619 Q8NBP7 UniProtKB Natural variant 452 452 . . . ID=VAR_058533;Note=G->D Q8NBP7 UniProtKB Natural variant 469 469 . . . ID=VAR_025456;Note=R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16465619;Dbxref=dbSNP:rs141502002,PMID:16465619 Q8NBP7 UniProtKB Natural variant 474 474 . . . ID=VAR_021339;Note=V->I;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:16465619,ECO:0000269|PubMed:17971861,ECO:0000269|PubMed:22095935,ECO:0000269|Ref.1,ECO:0000269|Ref.4,ECO:0000269|Ref.5,ECO:0000269|Ref.7;Dbxref=dbSNP:rs562556,PMID:14702039,PMID:16465619,PMID:17971861,PMID:22095935 Q8NBP7 UniProtKB Natural variant 482 482 . . . ID=VAR_025457;Note=E->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16465619;Dbxref=dbSNP:rs141995194,PMID:16465619 Q8NBP7 UniProtKB Natural variant 482 482 . . . ID=VAR_073657;Note=No effect on interaction with ANXA2. E->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24808179;Dbxref=PMID:24808179 Q8NBP7 UniProtKB Natural variant 496 496 . . . ID=VAR_058534;Note=In FHCL3. R->W;Dbxref=dbSNP:rs374603772 Q8NBP7 UniProtKB Natural variant 515 515 . . . ID=VAR_025458;Note=F->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16465619;Dbxref=dbSNP:rs1356131564,PMID:16465619 Q8NBP7 UniProtKB Natural variant 522 522 . . . ID=VAR_058535;Note=A->T;Dbxref=dbSNP:rs777300852 Q8NBP7 UniProtKB Natural variant 553 553 . . . ID=VAR_021340;Note=H->R;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16465619,ECO:0000269|Ref.4;Dbxref=dbSNP:rs28362270,PMID:16465619 Q8NBP7 UniProtKB Natural variant 554 554 . . . ID=VAR_025459;Note=Increases interaction with ANXA2. Q->E;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16465619,ECO:0000269|PubMed:18799458;Dbxref=dbSNP:rs149311926,PMID:16465619,PMID:18799458 Q8NBP7 UniProtKB Natural variant 616 616 . . . ID=VAR_058536;Note=P->L;Dbxref=dbSNP:rs755750316 Q8NBP7 UniProtKB Natural variant 619 619 . . . ID=VAR_021341;Note=Q->P;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16465619,ECO:0000269|Ref.4;Dbxref=dbSNP:rs28362277,PMID:16465619 Q8NBP7 UniProtKB Natural variant 668 668 . . . ID=VAR_058537;Note=S->R;Dbxref=dbSNP:rs762298323 Q8NBP7 UniProtKB Natural variant 670 670 . . . ID=VAR_017201;Note=G->E;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12730697,ECO:0000269|PubMed:16465619,ECO:0000269|PubMed:17971861,ECO:0000269|PubMed:22095935,ECO:0000269|Ref.1,ECO:0000269|Ref.4,ECO:0000269|Ref.5,ECO:0000269|Ref.7;Dbxref=dbSNP:rs505151,PMID:12730697,PMID:16465619,PMID:17971861,PMID:22095935 Q8NBP7 UniProtKB Mutagenesis 67 67 . . . Note=Does not affect multimerization or zymogen processing. C->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12552133;Dbxref=PMID:12552133 Q8NBP7 UniProtKB Mutagenesis 226 226 . . . Note=Remains in the endoplasmic reticulum and is not secreted. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12552133;Dbxref=PMID:12552133 Q8NBP7 UniProtKB Mutagenesis 533 533 . . . Note=1.5 kDa decrease of the apparent molecular mass of pro-PCSK9 and PCSK9 and no effect on processing and secretion. N->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12552133;Dbxref=PMID:12552133 Q8NBP7 UniProtKB Sequence conflict 423 423 . . . Note=V->A;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q8NBP7 UniProtKB Beta strand 34 36 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6MV5 Q8NBP7 UniProtKB Helix 37 45 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6MV5 Q8NBP7 UniProtKB Beta strand 63 65 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6U26 Q8NBP7 UniProtKB Helix 70 72 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6U26 Q8NBP7 UniProtKB Beta strand 73 82 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6U26 Q8NBP7 UniProtKB Beta strand 84 86 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4OV6 Q8NBP7 UniProtKB Helix 88 104 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6U26 Q8NBP7 UniProtKB Beta strand 110 115 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6U26 Q8NBP7 UniProtKB Beta strand 117 119 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6U26 Q8NBP7 UniProtKB Beta strand 121 125 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6U26 Q8NBP7 UniProtKB Helix 128 130 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6U26 Q8NBP7 UniProtKB Helix 131 135 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6U26 Q8NBP7 UniProtKB Beta strand 140 151 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6U26 Q8NBP7 UniProtKB Helix 156 160 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6U26 Q8NBP7 UniProtKB Helix 168 170 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3BPS Q8NBP7 UniProtKB Beta strand 180 187 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6U26 Q8NBP7 UniProtKB Turn 194 199 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6U26 Q8NBP7 UniProtKB Beta strand 200 206 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6U26 Q8NBP7 UniProtKB Beta strand 212 214 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4NMX Q8NBP7 UniProtKB Turn 218 220 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3H42 Q8NBP7 UniProtKB Turn 221 224 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6U26 Q8NBP7 UniProtKB Helix 225 235 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6U26 Q8NBP7 UniProtKB Turn 237 239 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6U26 Q8NBP7 UniProtKB Beta strand 241 244 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2P4E Q8NBP7 UniProtKB Beta strand 246 251 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6U26 Q8NBP7 UniProtKB Beta strand 257 260 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6U26 Q8NBP7 UniProtKB Helix 261 277 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6U26 Q8NBP7 UniProtKB Beta strand 283 287 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6U26 Q8NBP7 UniProtKB Beta strand 289 292 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6U26 Q8NBP7 UniProtKB Helix 295 306 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6U26 Q8NBP7 UniProtKB Beta strand 310 314 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6U26 Q8NBP7 UniProtKB Beta strand 317 321 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6U26 Q8NBP7 UniProtKB Helix 322 324 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6U26 Q8NBP7 UniProtKB Turn 327 329 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6U26 Q8NBP7 UniProtKB Beta strand 333 339 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6U26 Q8NBP7 UniProtKB Beta strand 343 345 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2PMW Q8NBP7 UniProtKB Beta strand 349 352 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2W2Q Q8NBP7 UniProtKB Beta strand 355 358 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3P5B Q8NBP7 UniProtKB Beta strand 361 364 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6U26 Q8NBP7 UniProtKB Beta strand 366 371 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6U26 Q8NBP7 UniProtKB Beta strand 373 375 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5VLL Q8NBP7 UniProtKB Beta strand 379 382 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6U26 Q8NBP7 UniProtKB Helix 385 402 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6U26 Q8NBP7 UniProtKB Helix 408 418 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6U26 Q8NBP7 UniProtKB Beta strand 419 422 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6U26 Q8NBP7 UniProtKB Helix 426 428 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6U26 Q8NBP7 UniProtKB Helix 431 433 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6U26 Q8NBP7 UniProtKB Turn 434 436 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6U26 Q8NBP7 UniProtKB Beta strand 440 442 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3P5B Q8NBP7 UniProtKB Beta strand 457 461 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6U26 Q8NBP7 UniProtKB Beta strand 469 471 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6U3X Q8NBP7 UniProtKB Beta strand 472 475 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6U26 Q8NBP7 UniProtKB Beta strand 482 489 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6U26 Q8NBP7 UniProtKB Beta strand 491 493 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3GCX Q8NBP7 UniProtKB Beta strand 495 501 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6U26 Q8NBP7 UniProtKB Beta strand 508 513 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6U26 Q8NBP7 UniProtKB Beta strand 515 517 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5OCA Q8NBP7 UniProtKB Beta strand 521 527 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6U26 Q8NBP7 UniProtKB Beta strand 535 539 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6U26 Q8NBP7 UniProtKB Beta strand 544 546 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2QTW Q8NBP7 UniProtKB Beta strand 549 551 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6U26 Q8NBP7 UniProtKB Beta strand 554 556 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5VL7 Q8NBP7 UniProtKB Beta strand 557 565 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6U26 Q8NBP7 UniProtKB Beta strand 568 570 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2P4E Q8NBP7 UniProtKB Beta strand 587 589 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6U26 Q8NBP7 UniProtKB Beta strand 594 602 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6U26 Q8NBP7 UniProtKB Beta strand 606 615 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6U26 Q8NBP7 UniProtKB Beta strand 621 625 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6U26 Q8NBP7 UniProtKB Beta strand 631 637 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6U26 Q8NBP7 UniProtKB Turn 641 643 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6U3I Q8NBP7 UniProtKB Beta strand 644 650 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6U26 Q8NBP7 UniProtKB Beta strand 653 658 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6U26 Q8NBP7 UniProtKB Beta strand 672 681 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6U26