Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q8NBP5 (MFSD9_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Major facilitator superfamily domain-containing protein 9
Gene names
Name:MFSD9
ORF Names:PSEC0066
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length474 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the major facilitator superfamily.

Ontologies

Keywords
   Biological processTransport
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtransmembrane transport

Inferred from electronic annotation. Source: InterPro

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: InterPro

   Molecular_functiontransporter activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 474474Major facilitator superfamily domain-containing protein 9
PRO_0000305025

Regions

Transmembrane45 – 6521Helical; Potential
Transmembrane80 – 10021Helical; Potential
Transmembrane116 – 13621Helical; Potential
Transmembrane167 – 18721Helical; Potential
Transmembrane197 – 21721Helical; Potential
Transmembrane288 – 30821Helical; Potential
Transmembrane323 – 34321Helical; Potential
Transmembrane359 – 37921Helical; Potential
Transmembrane436 – 45621Helical; Potential

Natural variations

Natural variant591G → A in a breast cancer sample; somatic mutation. Ref.5
VAR_035966
Natural variant841V → A in a breast cancer sample; somatic mutation. Ref.5
VAR_035967
Natural variant1291A → S.
Corresponds to variant rs7601509 [ dbSNP | Ensembl ].
VAR_035152
Natural variant2881I → T.
Corresponds to variant rs33993717 [ dbSNP | Ensembl ].
VAR_035153
Natural variant3761A → T.
Corresponds to variant rs34096572 [ dbSNP | Ensembl ].
VAR_061383

Experimental info

Sequence conflict1901L → P in BAC11577. Ref.1
Sequence conflict2781K → R in BAC11577. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q8NBP5 [UniParc].

Last modified October 2, 2007. Version 2.
Checksum: D2D7CA146876384B

FASTA47450,619
        10         20         30         40         50         60 
MELGGHWDMN SAPRLVSETA ERKQEQKTGT EAEAADSGAV GARRFLLCLY LVGFLDLFGV 

        70         80         90        100        110        120 
SMVVPLLSLH VKSLGASPTV AGIVGSSYGI LQLFSSTLVG CWSDVVGRRS SLLACILLSA 

       130        140        150        160        170        180 
LGYLLLGAAT NVFLFVLARV PAGIFKHTLS ISRALLSDVV PEKERPLVIG HFNTASGVGF 

       190        200        210        220        230        240 
ILGPVVGGYL TELEDGFYLT AFICFLVFIL NAGLVWFFPW REAKPGSTEK GLPLRKTHVL 

       250        260        270        280        290        300 
LGRSHDTVQE AATSRRARAS KKTAQPWVEV VLALRNMKNL LFSEMWDIFL VRLLMAMAVM 

       310        320        330        340        350        360 
LYYSNFVLAL EERFGVRPKV TGYLISYSSM LGAVAGLALG PILRLYKHNS QALLLHSSIL 

       370        380        390        400        410        420 
TCTLLLLYSL APTMGAVVLS STLLSFSTAI GRTCITDLQL TVGGAQASGT LIGVGQSVTA 

       430        440        450        460        470 
VGRIIAPLLS GVAQEVSPCG PPSLGAVLAL VAIFIMSLNK RHSSGDGNSK LKSE 

« Hide

References

[1]"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y. expand/collapse author list , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain and Ovary.
[5]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS [LARGE SCALE ANALYSIS] ALA-59 AND ALA-84.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK075376 mRNA. Translation: BAC11577.1.
AC007239 Genomic DNA. Translation: AAX88847.1.
AC007251 Genomic DNA. Translation: AAY14910.1.
CH471127 Genomic DNA. Translation: EAX01787.1.
BC006242 mRNA. Translation: AAH06242.1.
BC009310 mRNA. Translation: AAH09310.2.
CCDSCCDS2063.1.
RefSeqNP_116107.3. NM_032718.3.
UniGeneHs.590898.
Hs.720914.

3D structure databases

ProteinModelPortalQ8NBP5.
SMRQ8NBP5. Positions 41-232.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid124268. 1 interaction.

PTM databases

PhosphoSiteQ8NBP5.

Polymorphism databases

DMDM158706133.

Proteomic databases

MaxQBQ8NBP5.
PaxDbQ8NBP5.
PRIDEQ8NBP5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000258436; ENSP00000258436; ENSG00000135953.
GeneID84804.
KEGGhsa:84804.
UCSCuc002tcb.2. human.

Organism-specific databases

CTD84804.
GeneCardsGC02M103332.
H-InvDBHIX0002333.
HGNCHGNC:28158. MFSD9.
HPAHPA055293.
neXtProtNX_Q8NBP5.
PharmGKBPA162395873.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0477.
HOGENOMHOG000113574.
HOVERGENHBG102759.
InParanoidQ8NBP5.
OMAFFPWREA.
OrthoDBEOG7N63P6.
PhylomeDBQ8NBP5.
TreeFamTF314512.

Gene expression databases

ArrayExpressQ8NBP5.
BgeeQ8NBP5.
CleanExHS_MFSD9.
GenevestigatorQ8NBP5.

Family and domain databases

InterProIPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005829. Sugar_transporter_CS.
IPR001958. Tet-R_TetA/multi-R_MdtG.
[Graphical view]
PfamPF07690. MFS_1. 1 hit.
[Graphical view]
PRINTSPR01035. TCRTETA.
SUPFAMSSF103473. SSF103473. 2 hits.
PROSITEPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSMFSD9. human.
GenomeRNAi84804.
NextBio74974.
PROQ8NBP5.

Entry information

Entry nameMFSD9_HUMAN
AccessionPrimary (citable) accession number: Q8NBP5
Secondary accession number(s): Q4ZG89 expand/collapse secondary AC list , Q53TU0, Q96GQ4, Q9BRI8
Entry history
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: July 9, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM