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Q8NBP5

- MFSD9_HUMAN

UniProt

Q8NBP5 - MFSD9_HUMAN

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Protein

Major facilitator superfamily domain-containing protein 9

Gene

MFSD9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. transporter activity Source: InterPro

GO - Biological processi

  1. transmembrane transport Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Major facilitator superfamily domain-containing protein 9
Gene namesi
Name:MFSD9
ORF Names:PSEC0066
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:28158. MFSD9.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei45 – 6521HelicalSequence AnalysisAdd
BLAST
Transmembranei80 – 10021HelicalSequence AnalysisAdd
BLAST
Transmembranei116 – 13621HelicalSequence AnalysisAdd
BLAST
Transmembranei167 – 18721HelicalSequence AnalysisAdd
BLAST
Transmembranei197 – 21721HelicalSequence AnalysisAdd
BLAST
Transmembranei288 – 30821HelicalSequence AnalysisAdd
BLAST
Transmembranei323 – 34321HelicalSequence AnalysisAdd
BLAST
Transmembranei359 – 37921HelicalSequence AnalysisAdd
BLAST
Transmembranei436 – 45621HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162395873.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 474474Major facilitator superfamily domain-containing protein 9PRO_0000305025Add
BLAST

Proteomic databases

MaxQBiQ8NBP5.
PaxDbiQ8NBP5.
PRIDEiQ8NBP5.

PTM databases

PhosphoSiteiQ8NBP5.

Expressioni

Gene expression databases

BgeeiQ8NBP5.
CleanExiHS_MFSD9.
ExpressionAtlasiQ8NBP5. baseline and differential.
GenevestigatoriQ8NBP5.

Organism-specific databases

HPAiHPA055293.

Interactioni

Protein-protein interaction databases

BioGridi124268. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ8NBP5.
SMRiQ8NBP5. Positions 41-232.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the major facilitator superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00770000120604.
HOGENOMiHOG000113574.
HOVERGENiHBG102759.
InParanoidiQ8NBP5.
OMAiFFPWREA.
OrthoDBiEOG7N63P6.
PhylomeDBiQ8NBP5.
TreeFamiTF314512.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005829. Sugar_transporter_CS.
IPR001958. Tet-R_TetA/multi-R_MdtG.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
PRINTSiPR01035. TCRTETA.
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NBP5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MELGGHWDMN SAPRLVSETA ERKQEQKTGT EAEAADSGAV GARRFLLCLY
60 70 80 90 100
LVGFLDLFGV SMVVPLLSLH VKSLGASPTV AGIVGSSYGI LQLFSSTLVG
110 120 130 140 150
CWSDVVGRRS SLLACILLSA LGYLLLGAAT NVFLFVLARV PAGIFKHTLS
160 170 180 190 200
ISRALLSDVV PEKERPLVIG HFNTASGVGF ILGPVVGGYL TELEDGFYLT
210 220 230 240 250
AFICFLVFIL NAGLVWFFPW REAKPGSTEK GLPLRKTHVL LGRSHDTVQE
260 270 280 290 300
AATSRRARAS KKTAQPWVEV VLALRNMKNL LFSEMWDIFL VRLLMAMAVM
310 320 330 340 350
LYYSNFVLAL EERFGVRPKV TGYLISYSSM LGAVAGLALG PILRLYKHNS
360 370 380 390 400
QALLLHSSIL TCTLLLLYSL APTMGAVVLS STLLSFSTAI GRTCITDLQL
410 420 430 440 450
TVGGAQASGT LIGVGQSVTA VGRIIAPLLS GVAQEVSPCG PPSLGAVLAL
460 470
VAIFIMSLNK RHSSGDGNSK LKSE
Length:474
Mass (Da):50,619
Last modified:October 2, 2007 - v2
Checksum:iD2D7CA146876384B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti190 – 1901L → P in BAC11577. (PubMed:16303743)Curated
Sequence conflicti278 – 2781K → R in BAC11577. (PubMed:16303743)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti59 – 591G → A in a breast cancer sample; somatic mutation. 1 Publication
VAR_035966
Natural varianti84 – 841V → A in a breast cancer sample; somatic mutation. 1 Publication
VAR_035967
Natural varianti129 – 1291A → S.
Corresponds to variant rs7601509 [ dbSNP | Ensembl ].
VAR_035152
Natural varianti288 – 2881I → T.
Corresponds to variant rs33993717 [ dbSNP | Ensembl ].
VAR_035153
Natural varianti376 – 3761A → T.
Corresponds to variant rs34096572 [ dbSNP | Ensembl ].
VAR_061383

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK075376 mRNA. Translation: BAC11577.1.
AC007239 Genomic DNA. Translation: AAX88847.1.
AC007251 Genomic DNA. Translation: AAY14910.1.
CH471127 Genomic DNA. Translation: EAX01787.1.
BC006242 mRNA. Translation: AAH06242.1.
BC009310 mRNA. Translation: AAH09310.2.
CCDSiCCDS2063.1.
RefSeqiNP_116107.3. NM_032718.3.
UniGeneiHs.590898.
Hs.720914.

Genome annotation databases

EnsembliENST00000258436; ENSP00000258436; ENSG00000135953.
GeneIDi84804.
KEGGihsa:84804.
UCSCiuc002tcb.2. human.

Polymorphism databases

DMDMi158706133.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK075376 mRNA. Translation: BAC11577.1 .
AC007239 Genomic DNA. Translation: AAX88847.1 .
AC007251 Genomic DNA. Translation: AAY14910.1 .
CH471127 Genomic DNA. Translation: EAX01787.1 .
BC006242 mRNA. Translation: AAH06242.1 .
BC009310 mRNA. Translation: AAH09310.2 .
CCDSi CCDS2063.1.
RefSeqi NP_116107.3. NM_032718.3.
UniGenei Hs.590898.
Hs.720914.

3D structure databases

ProteinModelPortali Q8NBP5.
SMRi Q8NBP5. Positions 41-232.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124268. 1 interaction.

PTM databases

PhosphoSitei Q8NBP5.

Polymorphism databases

DMDMi 158706133.

Proteomic databases

MaxQBi Q8NBP5.
PaxDbi Q8NBP5.
PRIDEi Q8NBP5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000258436 ; ENSP00000258436 ; ENSG00000135953 .
GeneIDi 84804.
KEGGi hsa:84804.
UCSCi uc002tcb.2. human.

Organism-specific databases

CTDi 84804.
GeneCardsi GC02M103332.
H-InvDB HIX0002333.
HGNCi HGNC:28158. MFSD9.
HPAi HPA055293.
neXtProti NX_Q8NBP5.
PharmGKBi PA162395873.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0477.
GeneTreei ENSGT00770000120604.
HOGENOMi HOG000113574.
HOVERGENi HBG102759.
InParanoidi Q8NBP5.
OMAi FFPWREA.
OrthoDBi EOG7N63P6.
PhylomeDBi Q8NBP5.
TreeFami TF314512.

Miscellaneous databases

ChiTaRSi MFSD9. human.
GenomeRNAii 84804.
NextBioi 74974.
PROi Q8NBP5.

Gene expression databases

Bgeei Q8NBP5.
CleanExi HS_MFSD9.
ExpressionAtlasi Q8NBP5. baseline and differential.
Genevestigatori Q8NBP5.

Family and domain databases

InterProi IPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005829. Sugar_transporter_CS.
IPR001958. Tet-R_TetA/multi-R_MdtG.
[Graphical view ]
Pfami PF07690. MFS_1. 1 hit.
[Graphical view ]
PRINTSi PR01035. TCRTETA.
SUPFAMi SSF103473. SSF103473. 2 hits.
PROSITEi PS50850. MFS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
    Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
    , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
    DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Ovary.
  5. Cited for: VARIANTS [LARGE SCALE ANALYSIS] ALA-59 AND ALA-84.

Entry informationi

Entry nameiMFSD9_HUMAN
AccessioniPrimary (citable) accession number: Q8NBP5
Secondary accession number(s): Q4ZG89
, Q53TU0, Q96GQ4, Q9BRI8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: November 26, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3