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Q8NBP5

- MFSD9_HUMAN

UniProt

Q8NBP5 - MFSD9_HUMAN

Protein

Major facilitator superfamily domain-containing protein 9

Gene

MFSD9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 2 (02 Oct 2007)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. transporter activity Source: InterPro

    GO - Biological processi

    1. transmembrane transport Source: InterPro

    Keywords - Biological processi

    Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Major facilitator superfamily domain-containing protein 9
    Gene namesi
    Name:MFSD9
    ORF Names:PSEC0066
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:28158. MFSD9.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: InterPro

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162395873.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 474474Major facilitator superfamily domain-containing protein 9PRO_0000305025Add
    BLAST

    Proteomic databases

    MaxQBiQ8NBP5.
    PaxDbiQ8NBP5.
    PRIDEiQ8NBP5.

    PTM databases

    PhosphoSiteiQ8NBP5.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8NBP5.
    BgeeiQ8NBP5.
    CleanExiHS_MFSD9.
    GenevestigatoriQ8NBP5.

    Organism-specific databases

    HPAiHPA055293.

    Interactioni

    Protein-protein interaction databases

    BioGridi124268. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NBP5.
    SMRiQ8NBP5. Positions 41-232.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei45 – 6521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei80 – 10021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei116 – 13621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei167 – 18721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei197 – 21721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei288 – 30821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei323 – 34321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei359 – 37921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei436 – 45621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the major facilitator superfamily.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0477.
    HOGENOMiHOG000113574.
    HOVERGENiHBG102759.
    InParanoidiQ8NBP5.
    OMAiFFPWREA.
    OrthoDBiEOG7N63P6.
    PhylomeDBiQ8NBP5.
    TreeFamiTF314512.

    Family and domain databases

    InterProiIPR011701. MFS.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR005829. Sugar_transporter_CS.
    IPR001958. Tet-R_TetA/multi-R_MdtG.
    [Graphical view]
    PfamiPF07690. MFS_1. 1 hit.
    [Graphical view]
    PRINTSiPR01035. TCRTETA.
    SUPFAMiSSF103473. SSF103473. 2 hits.
    PROSITEiPS50850. MFS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NBP5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MELGGHWDMN SAPRLVSETA ERKQEQKTGT EAEAADSGAV GARRFLLCLY    50
    LVGFLDLFGV SMVVPLLSLH VKSLGASPTV AGIVGSSYGI LQLFSSTLVG 100
    CWSDVVGRRS SLLACILLSA LGYLLLGAAT NVFLFVLARV PAGIFKHTLS 150
    ISRALLSDVV PEKERPLVIG HFNTASGVGF ILGPVVGGYL TELEDGFYLT 200
    AFICFLVFIL NAGLVWFFPW REAKPGSTEK GLPLRKTHVL LGRSHDTVQE 250
    AATSRRARAS KKTAQPWVEV VLALRNMKNL LFSEMWDIFL VRLLMAMAVM 300
    LYYSNFVLAL EERFGVRPKV TGYLISYSSM LGAVAGLALG PILRLYKHNS 350
    QALLLHSSIL TCTLLLLYSL APTMGAVVLS STLLSFSTAI GRTCITDLQL 400
    TVGGAQASGT LIGVGQSVTA VGRIIAPLLS GVAQEVSPCG PPSLGAVLAL 450
    VAIFIMSLNK RHSSGDGNSK LKSE 474
    Length:474
    Mass (Da):50,619
    Last modified:October 2, 2007 - v2
    Checksum:iD2D7CA146876384B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti190 – 1901L → P in BAC11577. (PubMed:16303743)Curated
    Sequence conflicti278 – 2781K → R in BAC11577. (PubMed:16303743)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti59 – 591G → A in a breast cancer sample; somatic mutation. 1 Publication
    VAR_035966
    Natural varianti84 – 841V → A in a breast cancer sample; somatic mutation. 1 Publication
    VAR_035967
    Natural varianti129 – 1291A → S.
    Corresponds to variant rs7601509 [ dbSNP | Ensembl ].
    VAR_035152
    Natural varianti288 – 2881I → T.
    Corresponds to variant rs33993717 [ dbSNP | Ensembl ].
    VAR_035153
    Natural varianti376 – 3761A → T.
    Corresponds to variant rs34096572 [ dbSNP | Ensembl ].
    VAR_061383

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK075376 mRNA. Translation: BAC11577.1.
    AC007239 Genomic DNA. Translation: AAX88847.1.
    AC007251 Genomic DNA. Translation: AAY14910.1.
    CH471127 Genomic DNA. Translation: EAX01787.1.
    BC006242 mRNA. Translation: AAH06242.1.
    BC009310 mRNA. Translation: AAH09310.2.
    CCDSiCCDS2063.1.
    RefSeqiNP_116107.3. NM_032718.3.
    UniGeneiHs.590898.
    Hs.720914.

    Genome annotation databases

    EnsembliENST00000258436; ENSP00000258436; ENSG00000135953.
    GeneIDi84804.
    KEGGihsa:84804.
    UCSCiuc002tcb.2. human.

    Polymorphism databases

    DMDMi158706133.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK075376 mRNA. Translation: BAC11577.1 .
    AC007239 Genomic DNA. Translation: AAX88847.1 .
    AC007251 Genomic DNA. Translation: AAY14910.1 .
    CH471127 Genomic DNA. Translation: EAX01787.1 .
    BC006242 mRNA. Translation: AAH06242.1 .
    BC009310 mRNA. Translation: AAH09310.2 .
    CCDSi CCDS2063.1.
    RefSeqi NP_116107.3. NM_032718.3.
    UniGenei Hs.590898.
    Hs.720914.

    3D structure databases

    ProteinModelPortali Q8NBP5.
    SMRi Q8NBP5. Positions 41-232.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124268. 1 interaction.

    PTM databases

    PhosphoSitei Q8NBP5.

    Polymorphism databases

    DMDMi 158706133.

    Proteomic databases

    MaxQBi Q8NBP5.
    PaxDbi Q8NBP5.
    PRIDEi Q8NBP5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000258436 ; ENSP00000258436 ; ENSG00000135953 .
    GeneIDi 84804.
    KEGGi hsa:84804.
    UCSCi uc002tcb.2. human.

    Organism-specific databases

    CTDi 84804.
    GeneCardsi GC02M103332.
    H-InvDB HIX0002333.
    HGNCi HGNC:28158. MFSD9.
    HPAi HPA055293.
    neXtProti NX_Q8NBP5.
    PharmGKBi PA162395873.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0477.
    HOGENOMi HOG000113574.
    HOVERGENi HBG102759.
    InParanoidi Q8NBP5.
    OMAi FFPWREA.
    OrthoDBi EOG7N63P6.
    PhylomeDBi Q8NBP5.
    TreeFami TF314512.

    Miscellaneous databases

    ChiTaRSi MFSD9. human.
    GenomeRNAii 84804.
    NextBioi 74974.
    PROi Q8NBP5.

    Gene expression databases

    ArrayExpressi Q8NBP5.
    Bgeei Q8NBP5.
    CleanExi HS_MFSD9.
    Genevestigatori Q8NBP5.

    Family and domain databases

    InterProi IPR011701. MFS.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR005829. Sugar_transporter_CS.
    IPR001958. Tet-R_TetA/multi-R_MdtG.
    [Graphical view ]
    Pfami PF07690. MFS_1. 1 hit.
    [Graphical view ]
    PRINTSi PR01035. TCRTETA.
    SUPFAMi SSF103473. SSF103473. 2 hits.
    PROSITEi PS50850. MFS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
      Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
      , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
      DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain and Ovary.
    5. Cited for: VARIANTS [LARGE SCALE ANALYSIS] ALA-59 AND ALA-84.

    Entry informationi

    Entry nameiMFSD9_HUMAN
    AccessioniPrimary (citable) accession number: Q8NBP5
    Secondary accession number(s): Q4ZG89
    , Q53TU0, Q96GQ4, Q9BRI8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 2, 2007
    Last sequence update: October 2, 2007
    Last modified: October 1, 2014
    This is version 94 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3