Q8NBP5 (MFSD9_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Major facilitator superfamily domain-containing protein 9

Gene names

Name:	MFSD9
ORF Names:	PSEC0066

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	474 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the major facilitator superfamily.

Ontologies

Keywords
Biological process	Transport
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	transmembrane transport Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: InterPro
Molecular_function	transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 474	474	Major facilitator superfamily domain-containing protein 9		PRO_0000305025
Regions
	Transmembrane	45 – 65	21	Helical; Potential
	Transmembrane	80 – 100	21	Helical; Potential
	Transmembrane	116 – 136	21	Helical; Potential
	Transmembrane	167 – 187	21	Helical; Potential
	Transmembrane	197 – 217	21	Helical; Potential
	Transmembrane	288 – 308	21	Helical; Potential
	Transmembrane	323 – 343	21	Helical; Potential
	Transmembrane	359 – 379	21	Helical; Potential
	Transmembrane	436 – 456	21	Helical; Potential
Natural variations
	Natural variant	59	1	G → A in a breast cancer sample; somatic mutation. Ref.5		VAR_035966
	Natural variant	84	1	V → A in a breast cancer sample; somatic mutation. Ref.5		VAR_035967
	Natural variant	129	1	A → S. Corresponds to variant rs7601509 [ dbSNP | Ensembl ].		VAR_035152
	Natural variant	288	1	I → T. Corresponds to variant rs33993717 [ dbSNP | Ensembl ].		VAR_035153
	Natural variant	376	1	A → T. Corresponds to variant rs34096572 [ dbSNP | Ensembl ].		VAR_061383
Experimental info
	Sequence conflict	190	1	L → P in BAC11577. Ref.1
	Sequence conflict	278	1	K → R in BAC11577. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q8NBP5 [UniParc]. Last modified October 2, 2007. Version 2. Checksum: D2D7CA146876384B	FASTA	474	50,619
	10 20 30 40 50 60 MELGGHWDMN SAPRLVSETA ERKQEQKTGT EAEAADSGAV GARRFLLCLY LVGFLDLFGV 70 80 90 100 110 120 SMVVPLLSLH VKSLGASPTV AGIVGSSYGI LQLFSSTLVG CWSDVVGRRS SLLACILLSA 130 140 150 160 170 180 LGYLLLGAAT NVFLFVLARV PAGIFKHTLS ISRALLSDVV PEKERPLVIG HFNTASGVGF 190 200 210 220 230 240 ILGPVVGGYL TELEDGFYLT AFICFLVFIL NAGLVWFFPW REAKPGSTEK GLPLRKTHVL 250 260 270 280 290 300 LGRSHDTVQE AATSRRARAS KKTAQPWVEV VLALRNMKNL LFSEMWDIFL VRLLMAMAVM 310 320 330 340 350 360 LYYSNFVLAL EERFGVRPKV TGYLISYSSM LGAVAGLALG PILRLYKHNS QALLLHSSIL 370 380 390 400 410 420 TCTLLLLYSL APTMGAVVLS STLLSFSTAI GRTCITDLQL TVGGAQASGT LIGVGQSVTA 430 440 450 460 470 VGRIIAPLLS GVAQEVSPCG PPSLGAVLAL VAIFIMSLNK RHSSGDGNSK LKSE

References

[1]	"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries." Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y. , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T. DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain and Ovary.
[5]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] ALA-59 AND ALA-84.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK075376 mRNA. Translation: BAC11577.1. AC007239 Genomic DNA. Translation: AAX88847.1. AC007251 Genomic DNA. Translation: AAY14910.1. CH471127 Genomic DNA. Translation: EAX01787.1. BC006242 mRNA. Translation: AAH06242.1. BC009310 mRNA. Translation: AAH09310.2.
IPI	IPI00301231.
RefSeq	NP_116107.3. NM_032718.3.
UniGene	Hs.720914.
3D structure databases
ProteinModelPortal	Q8NBP5.
ModBase	Search...
PTM databases
PhosphoSite	Q8NBP5.
Polymorphism databases
DMDM	158706133.
Proteomic databases
PaxDb	Q8NBP5.
PRIDE	Q8NBP5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000258436; ENSP00000258436; ENSG00000135953.
GeneID	84804.
KEGG	hsa:84804.
UCSC	uc002tcb.2. human.
Organism-specific databases
CTD	84804.
GeneCards	GC02M103332.
H-InvDB	HIX0002333.
HGNC	HGNC:28158. MFSD9.
HPA	HPA055293.
neXtProt	NX_Q8NBP5.
PharmGKB	PA162395873.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0477.
HOGENOM	HOG000113574.
HOVERGEN	HBG102759.
InParanoid	Q8NBP5.
OMA	FFPWREA.
OrthoDB	EOG48PMKC.
PhylomeDB	Q8NBP5.
Gene expression databases
ArrayExpress	Q8NBP5.
Bgee	Q8NBP5.
CleanEx	HS_MFSD9.
Genevestigator	Q8NBP5.
Family and domain databases
InterPro	IPR011701. MFS. IPR020846. MFS_dom. IPR016196. MFS_dom_general_subst_transpt. IPR005829. Sugar_transporter_CS. IPR001958. Tet-R_TetA/multi-R_MdtG. [Graphical view]
Pfam	PF07690. MFS_1. 1 hit. [Graphical view]
PRINTS	PR01035. TCRTETA.
SUPFAM	SSF103473. MFS_gen_substrate_transporter. 1 hit.
PROSITE	PS50850. MFS. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	MFSD9. human.
GenomeRNAi	84804.
NextBio	74974.

Entry information

Entry name

MFSD9_HUMAN

Accession

Primary (citable) accession number: Q8NBP5
Secondary accession number(s): Q4ZG89 , Q53TU0, Q96GQ4, Q9BRI8

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
Last sequence update:	October 2, 2007
Last modified:	May 1, 2013
This is version 85 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.