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Protein

Tetratricopeptide repeat protein 13

Gene

TTC13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Tetratricopeptide repeat protein 13
Short name:
TPR repeat protein 13
Gene namesi
Name:TTC13
ORF Names:PSEC0076
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:26204. TTC13.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134931681.

Polymorphism and mutation databases

BioMutaiTTC13.
DMDMi212276494.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 860860Tetratricopeptide repeat protein 13PRO_0000106398Add
BLAST

Proteomic databases

EPDiQ8NBP0.
MaxQBiQ8NBP0.
PaxDbiQ8NBP0.
PRIDEiQ8NBP0.

PTM databases

iPTMnetiQ8NBP0.
PhosphoSiteiQ8NBP0.

Expressioni

Gene expression databases

BgeeiQ8NBP0.
CleanExiHS_TTC13.
ExpressionAtlasiQ8NBP0. baseline and differential.
GenevisibleiQ8NBP0. HS.

Organism-specific databases

HPAiHPA018022.
HPA051558.

Interactioni

Protein-protein interaction databases

BioGridi122720. 2 interactions.
IntActiQ8NBP0. 1 interaction.
STRINGi9606.ENSP00000355621.

Structurei

3D structure databases

ProteinModelPortaliQ8NBP0.
SMRiQ8NBP0. Positions 157-416.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati143 – 17634TPR 1Add
BLAST
Repeati216 – 24833TPR 2Add
BLAST
Repeati249 – 28234TPR 3Add
BLAST
Repeati284 – 31633TPR 4Add
BLAST
Repeati317 – 35034TPR 5Add
BLAST
Repeati352 – 38433TPR 6Add
BLAST
Repeati386 – 41833TPR 7Add
BLAST

Sequence similaritiesi

Contains 7 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG4626. Eukaryota.
COG0457. LUCA.
GeneTreeiENSGT00730000110941.
HOGENOMiHOG000007934.
HOVERGENiHBG057893.
InParanoidiQ8NBP0.
OMAiHQNFESY.
OrthoDBiEOG7JX33J.
PhylomeDBiQ8NBP0.
TreeFamiTF332283.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF00515. TPR_1. 1 hit.
PF13181. TPR_8. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 6 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 2 hits.
PROSITEiPS50005. TPR. 6 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NBP0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPAGCCCCC CFWGGAVAAA GAARRVLLLL LLGVLSAGLR PGALATEHYS
60 70 80 90 100
PLSLLKQELQ HRQQQEAPAG GGGCSPQSGD WGDQYSAECG ESSFLNFHDS
110 120 130 140 150
DCEPKGSSPC DSLLSLNTEK ILSQAKSIAE QKRFPFATDN DSTNEELAIA
160 170 180 190 200
YVLIGSGLYD EAIRHFSTML QEEPDLVSAI YGRGIAYGKK GLHDIKNAEL
210 220 230 240 250
ALFELSRVIT LEPDRPEVFE QRAEILSPLG RINEAVNDLT KAIQLQPSAR
260 270 280 290 300
LYRHRGTLYF ISEDYATAHE DFQQSLELNK NQPIAMLYKG LTFFHRGLLK
310 320 330 340 350
EAIESFKEAL KQKVDFIDAY KSLGQAYREL GNFEAATESF QKALLLNQNH
360 370 380 390 400
VQTLQLRGMM LYHHGSLQEA LKNFKRCLQL EPYNEVCQYM KGLSHVAMGQ
410 420 430 440 450
FYEGIKAQTK VMLNDPLPGQ KASPEYLKVK YLREYSRYLH AHLDTPLTEY
460 470 480 490 500
NIDVDLPGSF KDHWAKNLPF LIEDYEEQPG LQPHIKDVLH QNFESYKPEV
510 520 530 540 550
QELICVADRL GSLMQYETPG FLPNKRIHRA MGLAALEVMQ AVQRTWTNSK
560 570 580 590 600
VRMNGKTRLM QWRDMFDIAV KWRRIADPDQ PVLWLDQMPA RSLSRGFNNH
610 620 630 640 650
INLIRGQVIN MRYLEYFEKI LHFIKDRILV YHGANNPKGL LEVREALEKV
660 670 680 690 700
HKVEDLLPIM KQFNTKTKDG FTVNTKVPSL KDQGKEYDGF TITITGDKVG
710 720 730 740 750
NILFSVETQT TEERTQLYHA EIDALYKDLT AKGKVLILSS EFGEADAVCN
760 770 780 790 800
LILSLVYYFY NLMPLSRGSS VIAYSVIVGA LMASGKEVAG KIPKGKLVDF
810 820 830 840 850
EAMTAPGSEA FSKVAKSWMN LKSISPSYKT LPSVSETFPT LRSMIEVLNT
860
DSSPRCLKKL
Length:860
Mass (Da):96,813
Last modified:November 4, 2008 - v3
Checksum:i75747278086D7160
GO
Isoform 2 (identifier: Q8NBP0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     172-224: Missing.
     662-662: Missing.

Show »
Length:806
Mass (Da):90,718
Checksum:i158BE03F91CBB8B0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti38 – 381G → R in BAC11700 (PubMed:16303743).Curated
Sequence conflicti438 – 4381Y → H in BAC11586 (PubMed:16303743).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei172 – 22453Missing in isoform 2. 3 PublicationsVSP_011644Add
BLAST
Alternative sequencei662 – 6621Missing in isoform 2. 3 PublicationsVSP_035660

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK075386 mRNA. Translation: BAC11586.1.
AK075561 mRNA. Translation: BAC11700.1.
AL834453 mRNA. Translation: CAD39113.1.
AL844165 Genomic DNA. No translation available.
FO393421 Genomic DNA. No translation available.
BC042683 mRNA. Translation: AAH42683.1.
CCDSiCCDS1588.1. [Q8NBP0-1]
CCDS44332.2. [Q8NBP0-2]
RefSeqiNP_001116307.2. NM_001122835.2. [Q8NBP0-2]
NP_078801.3. NM_024525.4. [Q8NBP0-1]
UniGeneiHs.424788.

Genome annotation databases

EnsembliENST00000366661; ENSP00000355621; ENSG00000143643. [Q8NBP0-1]
ENST00000366662; ENSP00000355622; ENSG00000143643. [Q8NBP0-2]
GeneIDi79573.
KEGGihsa:79573.
UCSCiuc001huf.5. human. [Q8NBP0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK075386 mRNA. Translation: BAC11586.1.
AK075561 mRNA. Translation: BAC11700.1.
AL834453 mRNA. Translation: CAD39113.1.
AL844165 Genomic DNA. No translation available.
FO393421 Genomic DNA. No translation available.
BC042683 mRNA. Translation: AAH42683.1.
CCDSiCCDS1588.1. [Q8NBP0-1]
CCDS44332.2. [Q8NBP0-2]
RefSeqiNP_001116307.2. NM_001122835.2. [Q8NBP0-2]
NP_078801.3. NM_024525.4. [Q8NBP0-1]
UniGeneiHs.424788.

3D structure databases

ProteinModelPortaliQ8NBP0.
SMRiQ8NBP0. Positions 157-416.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122720. 2 interactions.
IntActiQ8NBP0. 1 interaction.
STRINGi9606.ENSP00000355621.

PTM databases

iPTMnetiQ8NBP0.
PhosphoSiteiQ8NBP0.

Polymorphism and mutation databases

BioMutaiTTC13.
DMDMi212276494.

Proteomic databases

EPDiQ8NBP0.
MaxQBiQ8NBP0.
PaxDbiQ8NBP0.
PRIDEiQ8NBP0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000366661; ENSP00000355621; ENSG00000143643. [Q8NBP0-1]
ENST00000366662; ENSP00000355622; ENSG00000143643. [Q8NBP0-2]
GeneIDi79573.
KEGGihsa:79573.
UCSCiuc001huf.5. human. [Q8NBP0-1]

Organism-specific databases

CTDi79573.
GeneCardsiTTC13.
H-InvDBHIX0001688.
HGNCiHGNC:26204. TTC13.
HPAiHPA018022.
HPA051558.
neXtProtiNX_Q8NBP0.
PharmGKBiPA134931681.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4626. Eukaryota.
COG0457. LUCA.
GeneTreeiENSGT00730000110941.
HOGENOMiHOG000007934.
HOVERGENiHBG057893.
InParanoidiQ8NBP0.
OMAiHQNFESY.
OrthoDBiEOG7JX33J.
PhylomeDBiQ8NBP0.
TreeFamiTF332283.

Miscellaneous databases

ChiTaRSiTTC13. human.
GenomeRNAii79573.
NextBioi68540.
PROiQ8NBP0.

Gene expression databases

BgeeiQ8NBP0.
CleanExiHS_TTC13.
ExpressionAtlasiQ8NBP0. baseline and differential.
GenevisibleiQ8NBP0. HS.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF00515. TPR_1. 1 hit.
PF13181. TPR_8. 1 hit.
[Graphical view]
SMARTiSM00028. TPR. 6 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 2 hits.
PROSITEiPS50005. TPR. 6 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
    Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
    , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
    DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Teratocarcinoma.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 331-860 (ISOFORM 2).
    Tissue: Brain.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 358-860 (ISOFORM 2).
    Tissue: Skin.

Entry informationi

Entry nameiTTC13_HUMAN
AccessioniPrimary (citable) accession number: Q8NBP0
Secondary accession number(s): B1AQI1
, B1AQI2, Q8IVP8, Q8NBI0, Q8ND20
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: November 4, 2008
Last modified: May 11, 2016
This is version 116 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.