Q8NBN7 (RDH13_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Retinol dehydrogenase 13
EC=1.1.1.-

Gene names

Name:	RDH13
ORF Names:	PSEC0082, UNQ736/PRO1430

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	331 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Does not exhibit retinol dehydrogenase (RDH) activity in vitro.
Tissue specificity	Expressed mostly in eye, pancreas, placenta and lung. In the retina, detected in the inner segment of the photoreceptor cells. Weak signals were observed in a small population of inner nuclear neurons and the inner plexiform layer. Ref.5
Sequence similarities	Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	nucleotide binding Inferred from electronic annotation. Source: InterPro oxidoreductase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8NBN7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8NBN7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-71: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 331	331	Retinol dehydrogenase 13		PRO_0000054768
Regions
	Nucleotide binding	45 – 51	7	NAD or NADP By similarity
Sites
	Active site	200	1	Proton acceptor By similarity
	Binding site	174	1	Substrate By similarity
Natural variations
	Alternative sequence	1 – 71	71	Missing in isoform 2.		VSP_040383
Experimental info
	Sequence conflict	106	1	E → V in BAC11591. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 29, 2005. Version 2. Checksum: DC5C1A6E54F1E6CC	FASTA	331	35,932
	10 20 30 40 50 60 MSRYLLPLSA LGTVAGAAVL LKDYVTGGAC PSKATIPGKT VIVTGANTGI GKQTALELAR 70 80 90 100 110 120 RGGNIILACR DMEKCEAAAK DIRGETLNHH VNARHLDLAS LKSIREFAAK IIEEEERVDI 130 140 150 160 170 180 LINNAGVMRC PHWTTEDGFE MQFGVNHLGH FLLTNLLLDK LKASAPSRII NLSSLAHVAG 190 200 210 220 230 240 HIDFDDLNWQ TRKYNTKAAY CQSKLAIVLF TKELSRRLQG SGVTVNALHP GVARTELGRH 250 260 270 280 290 300 TGIHGSTFSS TTLGPIFWLL VKSPELAAQP STYLAVAEEL ADVSGKYFDG LKQKAPAPEA 310 320 330 EDEEVARRLW AESARLVGLE APSVREQPLP R
	Isoform 2 [UniParc]. Checksum: 12C82526B01A3174	FASTA	260	28,794
	10 20 30 40 50 60 MEKCEAAAKD IRGETLNHHV NARHLDLASL KSIREFAAKI IEEEERVDIL INNAGVMRCP 70 80 90 100 110 120 HWTTEDGFEM QFGVNHLGHF LLTNLLLDKL KASAPSRIIN LSSLAHVAGH IDFDDLNWQT 130 140 150 160 170 180 RKYNTKAAYC QSKLAIVLFT KELSRRLQGS GVTVNALHPG VARTELGRHT GIHGSTFSST 190 200 210 220 230 240 TLGPIFWLLV KSPELAAQPS TYLAVAEELA DVSGKYFDGL KQKAPAPEAE DEEVARRLWA 250 260 ESARLVGLEA PSVREQPLPR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[2]	"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries." Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y. , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T. DNA Res. 12:117-126(2005) [PubMed: 16303743] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Teratocarcinoma.
[3]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed: 15057824] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Placenta.
[5]	"Dual-substrate specificity short chain retinol dehydrogenases from the vertebrate retina." Haeseleer F., Jang G.-F., Imanishi Y., Driessen C.A.G.G., Matsumura M., Nelson P.S., Palczewski K. J. Biol. Chem. 277:45537-45546(2002) [PubMed: 12226107] [Abstract] Cited for: TISSUE SPECIFICITY, ENZYME ACTIVITY.
[6]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY358473 mRNA. Translation: AAQ88837.1. AK075392 mRNA. Translation: BAC11591.1. AC011476 Genomic DNA. No translation available. BC009881 mRNA. Translation: AAH09881.1.
IPI	IPI00301204. IPI00794338.
RefSeq	NP_001139443.1. NM_001145971.1. NP_612421.1. NM_138412.3.
UniGene	Hs.327631.
3D structure databases
ProteinModelPortal	Q8NBN7.
SMR	Q8NBN7. Positions 34-322.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8NBN7. 2 interactions.
STRING	Q8NBN7.
PTM databases
PhosphoSite	Q8NBN7.
Polymorphism databases
DMDM	62298570.
Proteomic databases
PRIDE	Q8NBN7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000415061; ENSP00000391121; ENSG00000160439.
GeneID	112724.
KEGG	hsa:112724.
UCSC	uc002qio.2. human.
Organism-specific databases
CTD	112724.
GeneCards	GC19M055556.
H-InvDB	HIX0015451.
HGNC	HGNC:19978. RDH13.
HPA	HPA042006.
neXtProt	NX_Q8NBN7.
GenAtlas	Search...
Phylogenomic databases
eggNOG	maNOG11893.
GeneTree	ENSGT00570000078988.
HOGENOM	HBG750976.
HOVERGEN	HBG078800.
InParanoid	Q8NBN7.
OMA	GPIFWLL.
OrthoDB	EOG43R3N9.
PhylomeDB	Q8NBN7.
Gene expression databases
ArrayExpress	Q8NBN7.
Bgee	Q8NBN7.
CleanEx	HS_RDH13.
Genevestigator	Q8NBN7.
GermOnline	ENSG00000160439. Homo sapiens.
Family and domain databases
InterPro	IPR002198. DH_sc/Rdtase_SDR. IPR002347. Glc/ribitol_DH. IPR016040. NAD(P)-bd_dom. IPR020904. Sc_DH/Rdtase_CS. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K11161.
Pfam	PF00106. adh_short. 1 hit. [Graphical view]
PRINTS	PR00081. GDHRDH. PR00080. SDRFAMILY.
PROSITE	PS00061. ADH_SHORT. 1 hit. [Graphical view]
ProtoNet	Search...
Other
DrugBank	DB00162. Vitamin A.
NextBio	78643.

Entry information

Entry name

RDH13_HUMAN

Accession

Primary (citable) accession number: Q8NBN7
Secondary accession number(s): Q6UX79, Q96G88

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 29, 2003
Last sequence update:	March 29, 2005
Last modified:	January 25, 2012
This is version 83 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.