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Protein

Transmembrane protein 87A

Gene

TMEM87A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 87A
Gene namesi
Name:TMEM87A
ORF Names:PSEC0094
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:24522. TMEM87A.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei226 – 246HelicalSequence analysisAdd BLAST21
Transmembranei258 – 278HelicalSequence analysisAdd BLAST21
Transmembranei326 – 346HelicalSequence analysisAdd BLAST21
Transmembranei362 – 382HelicalSequence analysisAdd BLAST21
Transmembranei404 – 424HelicalSequence analysisAdd BLAST21
Transmembranei438 – 458HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000103978.
PharmGKBiPA142670739.

Polymorphism and mutation databases

DMDMi126302609.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000027075122 – 555Transmembrane protein 87AAdd BLAST534

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi79N-linked (GlcNAc...)Sequence analysis1
Glycosylationi127N-linked (GlcNAc...)Sequence analysis1
Glycosylationi157N-linked (GlcNAc...)1 Publication1
Glycosylationi160N-linked (GlcNAc...)1 Publication1
Modified residuei540PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ8NBN3.
MaxQBiQ8NBN3.
PaxDbiQ8NBN3.
PeptideAtlasiQ8NBN3.
PRIDEiQ8NBN3.

PTM databases

iPTMnetiQ8NBN3.
PhosphoSitePlusiQ8NBN3.
SwissPalmiQ8NBN3.

Expressioni

Gene expression databases

BgeeiENSG00000103978.
CleanExiHS_TMEM87A.
ExpressionAtlasiQ8NBN3. baseline and differential.
GenevisibleiQ8NBN3. HS.

Organism-specific databases

HPAiHPA018104.
HPA018189.

Interactioni

Protein-protein interaction databases

BioGridi117453. 19 interactors.
IntActiQ8NBN3. 5 interactors.
STRINGi9606.ENSP00000374484.

Structurei

3D structure databases

ProteinModelPortaliQ8NBN3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi476 – 482Poly-Glu7

Sequence similaritiesi

Belongs to the LU7TM family. TMEM87 subfamily.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2568. Eukaryota.
ENOG410XS1Q. LUCA.
GeneTreeiENSGT00390000015417.
HOGENOMiHOG000231789.
HOVERGENiHBG068138.
InParanoidiQ8NBN3.
OMAiRSKWHIP.
OrthoDBiEOG091G042P.
PhylomeDBiQ8NBN3.
TreeFamiTF314452.

Family and domain databases

InterProiIPR009637. GPR107-like.
[Graphical view]
PANTHERiPTHR21229. PTHR21229. 1 hit.
PfamiPF06814. Lung_7-TM_R. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NBN3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAAWLQVL PVILLLLGAH PSPLSFFSAG PATVAAADRS KWHIPIPSGK
60 70 80 90 100
NYFSFGKILF RNTTIFLKFD GEPCDLSLNI TWYLKSADCY NEIYNFKAEE
110 120 130 140 150
VELYLEKLKE KRGLSGKYQT SSKLFQNCSE LFKTQTFSGD FMHRLPLLGE
160 170 180 190 200
KQEAKENGTN LTFIGDKTAM HEPLQTWQDA PYIFIVHIGI SSSKESSKEN
210 220 230 240 250
SLSNLFTMTV EVKGPYEYLT LEDYPLMIFF MVMCIVYVLF GVLWLAWSAC
260 270 280 290 300
YWRDLLRIQF WIGAVIFLGM LEKAVFYAEF QNIRYKGESV QGALILAELL
310 320 330 340 350
SAVKRSLART LVIIVSLGYG IVKPRLGVTL HKVVVAGALY LLFSGMEGVL
360 370 380 390 400
RVTGAQTDLA SLAFIPLAFL DTALCWWIFI SLTQTMKLLK LRRNIVKLSL
410 420 430 440 450
YRHFTNTLIL AVAASIVFII WTTMKFRIVT CQSDWRELWV DDAIWRLLFS
460 470 480 490 500
MILFVIMVLW RPSANNQRFA FSPLSEEEEE DEQKEPMLKE SFEGMKMRST
510 520 530 540 550
KQEPNGNSKV NKAQEDDLKW VEENVPSSVT DVALPALLDS DEERMITHFE

RSKME
Length:555
Mass (Da):63,430
Last modified:February 20, 2007 - v3
Checksum:i1ED560B42FA01076
GO
Isoform 2 (identifier: Q8NBN3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     169-181: AMHEPLQTWQDAP → IQMPFLKKHFLDC
     182-555: Missing.

Show »
Length:181
Mass (Da):20,529
Checksum:iE484518255201436
GO
Isoform 3 (identifier: Q8NBN3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-69: MAAAAWLQVL...FRNTTIFLKF → MAHSDTVV

Show »
Length:494
Mass (Da):56,774
Checksum:iA4DA96F31ABD0AA2
GO

Sequence cautioni

The sequence BAC11598 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti117 – 118KY → NI in AAF66444 (Ref. 1) Curated2
Sequence conflicti313I → S in AAF66444 (Ref. 1) Curated1
Sequence conflicti424 – 425MK → KG in CAB43218 (PubMed:17974005).Curated2
Sequence conflicti485E → V in CAB43218 (PubMed:17974005).Curated1
Sequence conflicti518L → S in BAC11598 (PubMed:16303743).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0222071 – 69MAAAA…IFLKF → MAHSDTVV in isoform 3. 1 PublicationAdd BLAST69
Alternative sequenceiVSP_022208169 – 181AMHEP…WQDAP → IQMPFLKKHFLDC in isoform 2. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_022209182 – 555Missing in isoform 2. 1 PublicationAdd BLAST374

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132733 mRNA. Translation: AAF66444.1.
AK074870 mRNA. Translation: BAC11256.1.
AK075403 mRNA. Translation: BAC11598.1. Different initiation.
BC005335 mRNA. Translation: AAH05335.1.
BC069240 mRNA. Translation: AAH69240.1.
AL049944 mRNA. Translation: CAB43218.1.
CCDSiCCDS32205.1. [Q8NBN3-1]
CCDS45243.1. [Q8NBN3-2]
CCDS66742.1. [Q8NBN3-3]
PIRiT08676.
RefSeqiNP_001103973.1. NM_001110503.2. [Q8NBN3-2]
NP_001273416.1. NM_001286487.1. [Q8NBN3-3]
NP_056312.2. NM_015497.4. [Q8NBN3-1]
UniGeneiHs.511138.
Hs.720520.
Hs.744941.

Genome annotation databases

EnsembliENST00000307216; ENSP00000305894; ENSG00000103978. [Q8NBN3-2]
ENST00000389834; ENSP00000374484; ENSG00000103978. [Q8NBN3-1]
ENST00000448392; ENSP00000405379; ENSG00000103978. [Q8NBN3-3]
GeneIDi25963.
KEGGihsa:25963.
UCSCiuc001zpg.4. human. [Q8NBN3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132733 mRNA. Translation: AAF66444.1.
AK074870 mRNA. Translation: BAC11256.1.
AK075403 mRNA. Translation: BAC11598.1. Different initiation.
BC005335 mRNA. Translation: AAH05335.1.
BC069240 mRNA. Translation: AAH69240.1.
AL049944 mRNA. Translation: CAB43218.1.
CCDSiCCDS32205.1. [Q8NBN3-1]
CCDS45243.1. [Q8NBN3-2]
CCDS66742.1. [Q8NBN3-3]
PIRiT08676.
RefSeqiNP_001103973.1. NM_001110503.2. [Q8NBN3-2]
NP_001273416.1. NM_001286487.1. [Q8NBN3-3]
NP_056312.2. NM_015497.4. [Q8NBN3-1]
UniGeneiHs.511138.
Hs.720520.
Hs.744941.

3D structure databases

ProteinModelPortaliQ8NBN3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117453. 19 interactors.
IntActiQ8NBN3. 5 interactors.
STRINGi9606.ENSP00000374484.

PTM databases

iPTMnetiQ8NBN3.
PhosphoSitePlusiQ8NBN3.
SwissPalmiQ8NBN3.

Polymorphism and mutation databases

DMDMi126302609.

Proteomic databases

EPDiQ8NBN3.
MaxQBiQ8NBN3.
PaxDbiQ8NBN3.
PeptideAtlasiQ8NBN3.
PRIDEiQ8NBN3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307216; ENSP00000305894; ENSG00000103978. [Q8NBN3-2]
ENST00000389834; ENSP00000374484; ENSG00000103978. [Q8NBN3-1]
ENST00000448392; ENSP00000405379; ENSG00000103978. [Q8NBN3-3]
GeneIDi25963.
KEGGihsa:25963.
UCSCiuc001zpg.4. human. [Q8NBN3-1]

Organism-specific databases

CTDi25963.
GeneCardsiTMEM87A.
HGNCiHGNC:24522. TMEM87A.
HPAiHPA018104.
HPA018189.
neXtProtiNX_Q8NBN3.
OpenTargetsiENSG00000103978.
PharmGKBiPA142670739.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2568. Eukaryota.
ENOG410XS1Q. LUCA.
GeneTreeiENSGT00390000015417.
HOGENOMiHOG000231789.
HOVERGENiHBG068138.
InParanoidiQ8NBN3.
OMAiRSKWHIP.
OrthoDBiEOG091G042P.
PhylomeDBiQ8NBN3.
TreeFamiTF314452.

Miscellaneous databases

ChiTaRSiTMEM87A. human.
GenomeRNAii25963.
PROiQ8NBN3.

Gene expression databases

BgeeiENSG00000103978.
CleanExiHS_TMEM87A.
ExpressionAtlasiQ8NBN3. baseline and differential.
GenevisibleiQ8NBN3. HS.

Family and domain databases

InterProiIPR009637. GPR107-like.
[Graphical view]
PANTHERiPTHR21229. PTHR21229. 1 hit.
PfamiPF06814. Lung_7-TM_R. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTM87A_HUMAN
AccessioniPrimary (citable) accession number: Q8NBN3
Secondary accession number(s): Q6NT77
, Q8NCA4, Q9BS46, Q9P103, Q9Y3Y7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: February 20, 2007
Last modified: November 2, 2016
This is version 106 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.