Q8NBM4 (UBAC2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ubiquitin-associated domain-containing protein 2
Short name=UBA domain-containing protein 2

Alternative name(s):
Phosphoglycerate dehydrogenase-like protein 1

Gene names

Name:	UBAC2
Synonyms:	PHGDHL1
ORF Names:	PSEC0110

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	344 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Contains 1 UBA domain.
Sequence caution	The sequence AAH72674.1 differs from that shown. Reason: Erroneous initiation. The sequence AAI21139.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Signal Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8NBM4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8NBM4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-35: Missing.
     36-130: HCQKLFVYDL...TAASNLPSGF → MCFFFSLQEE...TFTQSRTTSS

Isoform 3 (identifier: Q8NBM4-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-113: Missing.

Isoform 4 (identifier: Q8NBM4-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-187: Missing.

Isoform 5 (identifier: Q8NBM4-5)

The sequence of this isoform differs from the canonical sequence as follows:
     54-141: IWRLICGRII...APVFALFVPF → PGTCVCSVCT...LDGKILFLDT
     142-344: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 35	35	Potential
	Chain	36 – 344	309	Ubiquitin-associated domain-containing protein 2		PRO_0000280754
Regions
	Topological domain	36 – 91	56	Extracellular Potential
	Transmembrane	92 – 112	21	Helical; Potential
	Topological domain	113 – 125	13	Cytoplasmic Potential
	Transmembrane	126 – 146	21	Helical; Potential
	Topological domain	147 – 163	17	Extracellular Potential
	Transmembrane	164 – 184	21	Helical; Potential
	Topological domain	185 – 344	160	Cytoplasmic Potential
	Domain	304 – 344	41	UBA
Amino acid modifications
	Glycosylation	161	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	1 – 187	187	Missing in isoform 4.		VSP_023909
	Alternative sequence	1 – 113	113	Missing in isoform 3.		VSP_023910
	Alternative sequence	1 – 35	35	Missing in isoform 2.		VSP_023911
	Alternative sequence	36 – 130	95	HCQKL…LPSGF → MCFFFSLQEEFLDKHTLMRV LSSGGKLGSRGEGAQLCCWM LLFSWRVSGGQQTRRLCRRA FCWSPVPSPSCSPSSCLTAR SSLCMTFTQSRTTSS in isoform 2.		VSP_023912
	Alternative sequence	54 – 141	88	IWRLI…LFVPF → PGTCVCSVCTILLLHTKSPS GTNSGSVVHHKQDIDLYIGT AAFHLWFLHLDCSHKWTYVR SVLRQQNVPGASGALHPQLD GKILFLDT in isoform 5.		VSP_023913
	Alternative sequence	142 – 344	203	Missing in isoform 5.		VSP_023914

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: A8C5D4D68B64CEB3	FASTA	344	38,964
	10 20 30 40 50 60 MFTSTGSSGL YKAPLSKSLL LVPSALSLLL ALLLPHCQKL FVYDLHAVKN DFQIWRLICG 70 80 90 100 110 120 RIICLDLKDT FCSSLLIYNF RIFERRYGSR KFASFLLGSW VLSALFDFLL IEAMQYFFGI 130 140 150 160 170 180 TAASNLPSGF LAPVFALFVP FYCSIPRVQV AQILGPLSIT NKTLIYILGL QLFTSGSYIW 190 200 210 220 230 240 IVAISGLMSG LCYDSKMFQV HQVLCIPSWM AKFFSWTLEP IFSSSEPTSE ARIGMGATLD 250 260 270 280 290 300 IQRQQRMELL DRQLMFSQFA QGRRQRQQQG GMINWNRLFP PLRQRQNVNY QGGRQSEPAA 310 320 330 340 PPLEVSEEQV ARLMEMGFSR GDALEALRAS NNDLNVATNF LLQH
	Isoform 2 [UniParc]. Checksum: 8DBCCCADAB551956	FASTA	309	34,876
	10 20 30 40 50 60 MCFFFSLQEE FLDKHTLMRV LSSGGKLGSR GEGAQLCCWM LLFSWRVSGG QQTRRLCRRA 70 80 90 100 110 120 FCWSPVPSPS CSPSSCLTAR SSLCMTFTQS RTTSSLAPVF ALFVPFYCSI PRVQVAQILG 130 140 150 160 170 180 PLSITNKTLI YILGLQLFTS GSYIWIVAIS GLMSGLCYDS KMFQVHQVLC IPSWMAKFFS 190 200 210 220 230 240 WTLEPIFSSS EPTSEARIGM GATLDIQRQQ RMELLDRQLM FSQFAQGRRQ RQQQGGMINW 250 260 270 280 290 300 NRLFPPLRQR QNVNYQGGRQ SEPAAPPLEV SEEQVARLME MGFSRGDALE ALRASNNDLN VATNFLLQH
	Isoform 3 [UniParc]. Checksum: 0BFAA7849E602840	FASTA	231	26,097
	10 20 30 40 50 60 MQYFFGITAA SNLPSGFLAP VFALFVPFYC SIPRVQVAQI LGPLSITNKT LIYILGLQLF 70 80 90 100 110 120 TSGSYIWIVA ISGLMSGLCY DSKMFQVHQV LCIPSWMAKF FSWTLEPIFS SSEPTSEARI 130 140 150 160 170 180 GMGATLDIQR QQRMELLDRQ LMFSQFAQGR RQRQQQGGMI NWNRLFPPLR QRQNVNYQGG 190 200 210 220 230 RQSEPAAPPL EVSEEQVARL MEMGFSRGDA LEALRASNND LNVATNFLLQ H
	Isoform 4 [UniParc]. Checksum: F87E4C44784F0876	FASTA	157	18,055
	10 20 30 40 50 60 MSGLCYDSKM FQVHQVLCIP SWMAKFFSWT LEPIFSSSEP TSEARIGMGA TLDIQRQQRM 70 80 90 100 110 120 ELLDRQLMFS QFAQGRRQRQ QQGGMINWNR LFPPLRQRQN VNYQGGRQSE PAAPPLEVSE 130 140 150 EQVARLMEMG FSRGDALEAL RASNNDLNVA TNFLLQH
	Isoform 5 [UniParc]. Checksum: 93054CCD541AEDFE	FASTA	141	15,426
	10 20 30 40 50 60 MFTSTGSSGL YKAPLSKSLL LVPSALSLLL ALLLPHCQKL FVYDLHAVKN DFQPGTCVCS 70 80 90 100 110 120 VCTILLLHTK SPSGTNSGSV VHHKQDIDLY IGTAAFHLWF LHLDCSHKWT YVRSVLRQQN 130 140 VPGASGALHP QLDGKILFLD T

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4). Tissue: Brain.
[2]	"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries." Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y. , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T. DNA Res. 12:117-126(2005) [PubMed: 16303743] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Embryo and Placenta.
[3]	"The DNA sequence and analysis of human chromosome 13." Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T. Nature 428:522-528(2004) [PubMed: 15057823] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 54-344 (ISOFORM 1). Tissue: Blood and Placenta.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK054563 mRNA. Translation: BAB70757.1. AK055110 mRNA. Translation: BAG51469.1. AK075419 mRNA. Translation: BAC11609.1. AK075516 mRNA. Translation: BAC11665.1. AL136961, AL159981, AL160155 Genomic DNA. Translation: CAH70935.1. Different termination. AL136961, AL159981, AL160155 Genomic DNA. Translation: CAH70936.1. AL136961, AL159981, AL160155 Genomic DNA. Translation: CAH70937.1. AL159981, AL136961, AL160155 Genomic DNA. Translation: CAI16940.1. AL159981, AL136961, AL160155 Genomic DNA. Translation: CAI16941.1. AL159981, AL136961, AL160155 Genomic DNA. Translation: CAI16943.1. AL160155, AL136961, AL159981 Genomic DNA. Translation: CAI14300.1. AL160155, AL136961, AL159981 Genomic DNA. Translation: CAI14301.1. AL160155, AL136961, AL159981 Genomic DNA. Translation: CAI14303.1. BC063559 mRNA. Translation: AAH63559.1. BC072674 mRNA. Translation: AAH72674.1. Different initiation. BC121138 mRNA. Translation: AAI21139.1. Different initiation. BC121139 mRNA. Translation: AAI21140.1.
IPI	IPI00007034. IPI00168284. IPI00829931. IPI00829996. IPI00941744.
RefSeq	NP_001137544.1. NM_001144072.1. NP_808882.1. NM_177967.3.
UniGene	Hs.508545.
3D structure databases
HSSP	HSSP built from PDB template 1Z96 based on UniProtKB Q10256.
ProteinModelPortal	Q8NBM4.
SMR	Q8NBM4. Positions 308-342.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8NBM4. 3 interactions.
MINT	MINT-1428002.
PTM databases
PhosphoSite	Q8NBM4.
Polymorphism databases
DMDM	74751173.
Proteomic databases
PRIDE	Q8NBM4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000403766; ENSP00000383911; ENSG00000134882.
GeneID	337867.
KEGG	hsa:337867.
UCSC	uc001vnz.2. human. uc001vob.2. human.
Organism-specific databases
CTD	337867.
GeneCards	GC13P099852.
H-InvDB	HIX0011423.
HGNC	HGNC:20486. UBAC2.
HPA	HPA013448.
neXtProt	NX_Q8NBM4.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG09356.
GeneTree	ENSGT00390000000865.
HOVERGEN	HBG106192.
InParanoid	Q8NBM4.
OMA	LVEAMQY.
OrthoDB	EOG4W9J4B.
PhylomeDB	Q8NBM4.
Gene expression databases
ArrayExpress	Q8NBM4.
Bgee	Q8NBM4.
CleanEx	HS_UBAC2.
Genevestigator	Q8NBM4.
Family and domain databases
InterPro	IPR009060. UBA-like. IPR000449. UBA/transl_elong_EF1B_N. IPR015940. UBA/transl_elong_EF1B_N_euk. [Graphical view]
Pfam	PF00627. UBA. 1 hit. [Graphical view]
SMART	SM00165. UBA. 1 hit. [Graphical view]
SUPFAM	SSF46934. UBA_like. 1 hit.
PROSITE	PS50030. UBA. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	96748.

Entry information

Entry name

UBAC2_HUMAN

Accession

Primary (citable) accession number: Q8NBM4
Secondary accession number(s): B3KNV7 , Q0VAB5, Q5W0W6, Q5W0W9, Q6GQR2, Q6P4B0, Q8N2E8, Q96NW2

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
Last sequence update:	October 1, 2002
Last modified:	January 25, 2012
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.