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Q8NBL3 (T178A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transmembrane protein 178A
Gene names
Name:TMEM178A
Synonyms:TMEM178
ORF Names:PSEC0131, UNQ5926/PRO19820
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length297 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the TMEM178 family.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainSignal
Transmembrane
Transmembrane helix
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8NBL3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8NBL3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     66-111: PLRDSPPLGR...ECGRPLFATY → LGPLEEVLLP...SAHPLAKHSF
     112-297: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Chain26 – 297272Transmembrane protein 178A
PRO_0000287280

Regions

Topological domain26 – 179154Extracellular Potential
Transmembrane180 – 20021Helical; Potential
Topological domain201 – 2088Cytoplasmic Potential
Transmembrane209 – 22921Helical; Potential
Topological domain230 – 25728Extracellular Potential
Transmembrane258 – 27821Helical; Potential
Topological domain279 – 29719Cytoplasmic Potential

Amino acid modifications

Glycosylation1581N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence66 – 11146PLRDS…LFATY → LGPLEEVLLPGHRPGHRHPH PERYCAAMHGHQVPLFSAHP LAKHSF in isoform 2.
VSP_025428
Alternative sequence112 – 297186Missing in isoform 2.
VSP_025429
Natural variant1071L → V. Ref.4
Corresponds to variant rs17852679 [ dbSNP | Ensembl ].
VAR_032296

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 757C5C9F7F2CFA53

FASTA29733,019
        10         20         30         40         50         60 
MEPRALVTAL SLGLSLCSLG LLVTAIFTDH WYETDPRRHK ESCERSRAGA DPPDQKNRLM 

        70         80         90        100        110        120 
PLSHLPLRDS PPLGRRLLPG GPGRADPESW RSLLGLGGLD AECGRPLFAT YSGLWRKCYF 

       130        140        150        160        170        180 
LGIDRDIDTL ILKGIAQRCT AIKYHFSQPI RLRNIPFNLT KTIQQDEWHL LHLRRITAGF 

       190        200        210        220        230        240 
LGMAVAVLLC GCIVATVSFF WEESLTQHVA GLLFLMTGIF CTISLCTYAA SISYDLNRLP 

       250        260        270        280        290 
KLIYSLPADV EHGYSWSIFC AWCSLGFIVA AGGLCIAYPF ISRTKIAQLK SGRDSTV 

« Hide

Isoform 2 [UniParc].

Checksum: CB052D882F0416D9
Show »

FASTA11112,447

References

[1]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[2]"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y. expand/collapse author list , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Placenta.
[3]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT VAL-107.
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY358773 mRNA. Translation: AAQ89133.1.
AK075440 mRNA. Translation: BAC11622.1.
AC007246 Genomic DNA. Translation: AAX93064.1.
BC029530 mRNA. Translation: AAH29530.1.
CCDSCCDS1804.1. [Q8NBL3-1]
RefSeqNP_001161431.1. NM_001167959.1.
NP_689603.2. NM_152390.2. [Q8NBL3-1]
UniGeneHs.40808.

3D structure databases

ProteinModelPortalQ8NBL3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000281961.

Protein family/group databases

TCDB8.A.16.2.8. the ca(+) channel auxiliary subunit 1-8 (cca) family.

Polymorphism databases

DMDM74723755.

Proteomic databases

PaxDbQ8NBL3.
PRIDEQ8NBL3.

Protocols and materials databases

DNASU130733.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000281961; ENSP00000281961; ENSG00000152154. [Q8NBL3-1]
GeneID130733.
KEGGhsa:130733.
UCSCuc002rrt.3. human. [Q8NBL3-1]

Organism-specific databases

CTD130733.
GeneCardsGC02P039893.
HGNCHGNC:28517. TMEM178A.
HPAHPA052128.
neXtProtNX_Q8NBL3.
PharmGKBPA162405994.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG42792.
HOGENOMHOG000063712.
HOVERGENHBG070972.
InParanoidQ8NBL3.
OMAWYETDTR.
OrthoDBEOG79PJPS.
PhylomeDBQ8NBL3.
TreeFamTF331307.

Gene expression databases

BgeeQ8NBL3.
CleanExHS_TMEM178.
GenevestigatorQ8NBL3.

Family and domain databases

InterProIPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PfamPF13903. Claudin_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi130733.
NextBio82802.
PROQ8NBL3.

Entry information

Entry nameT178A_HUMAN
AccessionPrimary (citable) accession number: Q8NBL3
Secondary accession number(s): Q6UWI6, Q8N6N4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM