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Q8NBL3

- T178A_HUMAN

UniProt

Q8NBL3 - T178A_HUMAN

Protein

Transmembrane protein 178A

Gene

TMEM178A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Protein family/group databases

    TCDBi8.A.16.2.8. the ca(+) channel auxiliary subunit 1-8 (cca) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transmembrane protein 178A
    Gene namesi
    Name:TMEM178A
    Synonyms:TMEM178
    ORF Names:PSEC0131, UNQ5926/PRO19820
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:28517. TMEM178A.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162405994.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 297272Transmembrane protein 178APRO_0000287280Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi158 – 1581N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ8NBL3.
    PRIDEiQ8NBL3.

    Expressioni

    Gene expression databases

    BgeeiQ8NBL3.
    CleanExiHS_TMEM178.
    GenevestigatoriQ8NBL3.

    Organism-specific databases

    HPAiHPA052128.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000281961.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NBL3.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini26 – 179154ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini201 – 2088CytoplasmicSequence Analysis
    Topological domaini230 – 25728ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini279 – 29719CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei180 – 20021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei209 – 22921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei258 – 27821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TMEM178 family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG42792.
    HOGENOMiHOG000063712.
    HOVERGENiHBG070972.
    InParanoidiQ8NBL3.
    OMAiWYETDTR.
    OrthoDBiEOG79PJPS.
    PhylomeDBiQ8NBL3.
    TreeFamiTF331307.

    Family and domain databases

    InterProiIPR004031. PMP22/EMP/MP20/Claudin.
    [Graphical view]
    PfamiPF13903. Claudin_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8NBL3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEPRALVTAL SLGLSLCSLG LLVTAIFTDH WYETDPRRHK ESCERSRAGA    50
    DPPDQKNRLM PLSHLPLRDS PPLGRRLLPG GPGRADPESW RSLLGLGGLD 100
    AECGRPLFAT YSGLWRKCYF LGIDRDIDTL ILKGIAQRCT AIKYHFSQPI 150
    RLRNIPFNLT KTIQQDEWHL LHLRRITAGF LGMAVAVLLC GCIVATVSFF 200
    WEESLTQHVA GLLFLMTGIF CTISLCTYAA SISYDLNRLP KLIYSLPADV 250
    EHGYSWSIFC AWCSLGFIVA AGGLCIAYPF ISRTKIAQLK SGRDSTV 297
    Length:297
    Mass (Da):33,019
    Last modified:October 1, 2002 - v1
    Checksum:i757C5C9F7F2CFA53
    GO
    Isoform 2 (identifier: Q8NBL3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         66-111: PLRDSPPLGR...ECGRPLFATY → LGPLEEVLLP...SAHPLAKHSF
         112-297: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:111
    Mass (Da):12,447
    Checksum:iCB052D882F0416D9
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti107 – 1071L → V.1 Publication
    Corresponds to variant rs17852679 [ dbSNP | Ensembl ].
    VAR_032296

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei66 – 11146PLRDS…LFATY → LGPLEEVLLPGHRPGHRHPH PERYCAAMHGHQVPLFSAHP LAKHSF in isoform 2. 1 PublicationVSP_025428Add
    BLAST
    Alternative sequencei112 – 297186Missing in isoform 2. 1 PublicationVSP_025429Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY358773 mRNA. Translation: AAQ89133.1.
    AK075440 mRNA. Translation: BAC11622.1.
    AC007246 Genomic DNA. Translation: AAX93064.1.
    BC029530 mRNA. Translation: AAH29530.1.
    CCDSiCCDS1804.1. [Q8NBL3-1]
    RefSeqiNP_001161431.1. NM_001167959.1.
    NP_689603.2. NM_152390.2. [Q8NBL3-1]
    UniGeneiHs.40808.

    Genome annotation databases

    EnsembliENST00000281961; ENSP00000281961; ENSG00000152154. [Q8NBL3-1]
    GeneIDi130733.
    KEGGihsa:130733.
    UCSCiuc002rrt.3. human. [Q8NBL3-1]

    Polymorphism databases

    DMDMi74723755.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY358773 mRNA. Translation: AAQ89133.1 .
    AK075440 mRNA. Translation: BAC11622.1 .
    AC007246 Genomic DNA. Translation: AAX93064.1 .
    BC029530 mRNA. Translation: AAH29530.1 .
    CCDSi CCDS1804.1. [Q8NBL3-1 ]
    RefSeqi NP_001161431.1. NM_001167959.1.
    NP_689603.2. NM_152390.2. [Q8NBL3-1 ]
    UniGenei Hs.40808.

    3D structure databases

    ProteinModelPortali Q8NBL3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000281961.

    Protein family/group databases

    TCDBi 8.A.16.2.8. the ca(+) channel auxiliary subunit 1-8 (cca) family.

    Polymorphism databases

    DMDMi 74723755.

    Proteomic databases

    PaxDbi Q8NBL3.
    PRIDEi Q8NBL3.

    Protocols and materials databases

    DNASUi 130733.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000281961 ; ENSP00000281961 ; ENSG00000152154 . [Q8NBL3-1 ]
    GeneIDi 130733.
    KEGGi hsa:130733.
    UCSCi uc002rrt.3. human. [Q8NBL3-1 ]

    Organism-specific databases

    CTDi 130733.
    GeneCardsi GC02P039893.
    HGNCi HGNC:28517. TMEM178A.
    HPAi HPA052128.
    neXtProti NX_Q8NBL3.
    PharmGKBi PA162405994.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG42792.
    HOGENOMi HOG000063712.
    HOVERGENi HBG070972.
    InParanoidi Q8NBL3.
    OMAi WYETDTR.
    OrthoDBi EOG79PJPS.
    PhylomeDBi Q8NBL3.
    TreeFami TF331307.

    Miscellaneous databases

    GenomeRNAii 130733.
    NextBioi 82802.
    PROi Q8NBL3.

    Gene expression databases

    Bgeei Q8NBL3.
    CleanExi HS_TMEM178.
    Genevestigatori Q8NBL3.

    Family and domain databases

    InterProi IPR004031. PMP22/EMP/MP20/Claudin.
    [Graphical view ]
    Pfami PF13903. Claudin_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    2. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
      Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
      , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
      DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Placenta.
    3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT VAL-107.
      Tissue: Brain.

    Entry informationi

    Entry nameiT178A_HUMAN
    AccessioniPrimary (citable) accession number: Q8NBL3
    Secondary accession number(s): Q6UWI6, Q8N6N4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 15, 2007
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3