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Protein

Transmembrane protein 178A

Gene

TMEM178A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Protein family/group databases

TCDBi8.A.16.2.8. the ca(+) channel auxiliary subunit 1-8 (cca) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 178A
Gene namesi
Name:TMEM178A
Synonyms:TMEM178
ORF Names:PSEC0131, UNQ5926/PRO19820
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:28517. TMEM178A.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 179154ExtracellularSequence AnalysisAdd
BLAST
Transmembranei180 – 20021HelicalSequence AnalysisAdd
BLAST
Topological domaini201 – 2088CytoplasmicSequence Analysis
Transmembranei209 – 22921HelicalSequence AnalysisAdd
BLAST
Topological domaini230 – 25728ExtracellularSequence AnalysisAdd
BLAST
Transmembranei258 – 27821HelicalSequence AnalysisAdd
BLAST
Topological domaini279 – 29719CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162405994.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Chaini26 – 297272Transmembrane protein 178APRO_0000287280Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi158 – 1581N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8NBL3.
PRIDEiQ8NBL3.

Expressioni

Gene expression databases

BgeeiQ8NBL3.
CleanExiHS_TMEM178.
GenevestigatoriQ8NBL3.

Organism-specific databases

HPAiHPA052128.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000281961.

Structurei

3D structure databases

ProteinModelPortaliQ8NBL3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM178 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG42792.
GeneTreeiENSGT00390000015299.
HOGENOMiHOG000063712.
HOVERGENiHBG070972.
InParanoidiQ8NBL3.
OMAiWYETDTR.
OrthoDBiEOG79PJPS.
PhylomeDBiQ8NBL3.
TreeFamiTF331307.

Family and domain databases

InterProiIPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PfamiPF13903. Claudin_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NBL3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPRALVTAL SLGLSLCSLG LLVTAIFTDH WYETDPRRHK ESCERSRAGA
60 70 80 90 100
DPPDQKNRLM PLSHLPLRDS PPLGRRLLPG GPGRADPESW RSLLGLGGLD
110 120 130 140 150
AECGRPLFAT YSGLWRKCYF LGIDRDIDTL ILKGIAQRCT AIKYHFSQPI
160 170 180 190 200
RLRNIPFNLT KTIQQDEWHL LHLRRITAGF LGMAVAVLLC GCIVATVSFF
210 220 230 240 250
WEESLTQHVA GLLFLMTGIF CTISLCTYAA SISYDLNRLP KLIYSLPADV
260 270 280 290
EHGYSWSIFC AWCSLGFIVA AGGLCIAYPF ISRTKIAQLK SGRDSTV
Length:297
Mass (Da):33,019
Last modified:October 1, 2002 - v1
Checksum:i757C5C9F7F2CFA53
GO
Isoform 2 (identifier: Q8NBL3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     66-111: PLRDSPPLGR...ECGRPLFATY → LGPLEEVLLP...SAHPLAKHSF
     112-297: Missing.

Note: No experimental confirmation available.

Show »
Length:111
Mass (Da):12,447
Checksum:iCB052D882F0416D9
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti107 – 1071L → V.1 Publication
Corresponds to variant rs17852679 [ dbSNP | Ensembl ].
VAR_032296

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei66 – 11146PLRDS…LFATY → LGPLEEVLLPGHRPGHRHPH PERYCAAMHGHQVPLFSAHP LAKHSF in isoform 2. 1 PublicationVSP_025428Add
BLAST
Alternative sequencei112 – 297186Missing in isoform 2. 1 PublicationVSP_025429Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358773 mRNA. Translation: AAQ89133.1.
AK075440 mRNA. Translation: BAC11622.1.
AC007246 Genomic DNA. Translation: AAX93064.1.
BC029530 mRNA. Translation: AAH29530.1.
CCDSiCCDS1804.1. [Q8NBL3-1]
RefSeqiNP_001161431.1. NM_001167959.1.
NP_689603.2. NM_152390.2. [Q8NBL3-1]
UniGeneiHs.40808.

Genome annotation databases

EnsembliENST00000281961; ENSP00000281961; ENSG00000152154. [Q8NBL3-1]
ENST00000618232; ENSP00000477622; ENSG00000152154. [Q8NBL3-2]
GeneIDi130733.
KEGGihsa:130733.
UCSCiuc002rrt.3. human. [Q8NBL3-1]

Polymorphism databases

DMDMi74723755.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358773 mRNA. Translation: AAQ89133.1.
AK075440 mRNA. Translation: BAC11622.1.
AC007246 Genomic DNA. Translation: AAX93064.1.
BC029530 mRNA. Translation: AAH29530.1.
CCDSiCCDS1804.1. [Q8NBL3-1]
RefSeqiNP_001161431.1. NM_001167959.1.
NP_689603.2. NM_152390.2. [Q8NBL3-1]
UniGeneiHs.40808.

3D structure databases

ProteinModelPortaliQ8NBL3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000281961.

Protein family/group databases

TCDBi8.A.16.2.8. the ca(+) channel auxiliary subunit 1-8 (cca) family.

Polymorphism databases

DMDMi74723755.

Proteomic databases

PaxDbiQ8NBL3.
PRIDEiQ8NBL3.

Protocols and materials databases

DNASUi130733.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000281961; ENSP00000281961; ENSG00000152154. [Q8NBL3-1]
ENST00000618232; ENSP00000477622; ENSG00000152154. [Q8NBL3-2]
GeneIDi130733.
KEGGihsa:130733.
UCSCiuc002rrt.3. human. [Q8NBL3-1]

Organism-specific databases

CTDi130733.
GeneCardsiGC02P039893.
HGNCiHGNC:28517. TMEM178A.
HPAiHPA052128.
neXtProtiNX_Q8NBL3.
PharmGKBiPA162405994.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG42792.
GeneTreeiENSGT00390000015299.
HOGENOMiHOG000063712.
HOVERGENiHBG070972.
InParanoidiQ8NBL3.
OMAiWYETDTR.
OrthoDBiEOG79PJPS.
PhylomeDBiQ8NBL3.
TreeFamiTF331307.

Miscellaneous databases

GenomeRNAii130733.
NextBioi82802.
PROiQ8NBL3.

Gene expression databases

BgeeiQ8NBL3.
CleanExiHS_TMEM178.
GenevestigatoriQ8NBL3.

Family and domain databases

InterProiIPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PfamiPF13903. Claudin_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  2. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
    Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
    , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
    DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Placenta.
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT VAL-107.
    Tissue: Brain.

Entry informationi

Entry nameiT178A_HUMAN
AccessioniPrimary (citable) accession number: Q8NBL3
Secondary accession number(s): Q6UWI6, Q8N6N4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: October 1, 2002
Last modified: January 7, 2015
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.