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Protein

Transmembrane protein 178A

Gene

TMEM178A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a negative regulator of osteoclast differentiation in basal and inflammatory conditions by regulating TNFSF11-induced Ca (2+) fluxes, thereby controlling the induction of NFATC1.By similarity

GO - Biological processi

Complete GO annotation...

Protein family/group databases

TCDBi8.A.16.2.8. the ca(+) channel auxiliary subunit Gama1-Gama8 (ccaGama) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 178A
Gene namesi
Name:TMEM178A
Synonyms:TMEM178
ORF Names:PSEC0131, UNQ5926/PRO19820
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:28517. TMEM178A.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 179ExtracellularSequence analysisAdd BLAST154
Transmembranei180 – 200HelicalSequence analysisAdd BLAST21
Topological domaini201 – 208CytoplasmicSequence analysis8
Transmembranei209 – 229HelicalSequence analysisAdd BLAST21
Topological domaini230 – 257ExtracellularSequence analysisAdd BLAST28
Transmembranei258 – 278HelicalSequence analysisAdd BLAST21
Topological domaini279 – 297CytoplasmicSequence analysisAdd BLAST19

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi130733.
OpenTargetsiENSG00000152154.
PharmGKBiPA162405994.

Polymorphism and mutation databases

BioMutaiTMEM178A.
DMDMi74723755.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000028728026 – 297Transmembrane protein 178AAdd BLAST272

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi158N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ8NBL3.
PaxDbiQ8NBL3.
PRIDEiQ8NBL3.
TopDownProteomicsiQ8NBL3-1. [Q8NBL3-1]

Expressioni

Gene expression databases

BgeeiENSG00000152154.
CleanExiHS_TMEM178.
GenevisibleiQ8NBL3. HS.

Organism-specific databases

HPAiHPA052128.

Interactioni

Subunit structurei

Interacts with STIM1.By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000281961.

Structurei

3D structure databases

ProteinModelPortaliQ8NBL3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM178 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEXN. Eukaryota.
ENOG410YC3G. LUCA.
GeneTreeiENSGT00390000015299.
HOGENOMiHOG000063712.
HOVERGENiHBG070972.
InParanoidiQ8NBL3.
OMAiWYETDTR.
OrthoDBiEOG091G0DO4.
PhylomeDBiQ8NBL3.
TreeFamiTF331307.

Family and domain databases

InterProiIPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PfamiPF13903. Claudin_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NBL3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPRALVTAL SLGLSLCSLG LLVTAIFTDH WYETDPRRHK ESCERSRAGA
60 70 80 90 100
DPPDQKNRLM PLSHLPLRDS PPLGRRLLPG GPGRADPESW RSLLGLGGLD
110 120 130 140 150
AECGRPLFAT YSGLWRKCYF LGIDRDIDTL ILKGIAQRCT AIKYHFSQPI
160 170 180 190 200
RLRNIPFNLT KTIQQDEWHL LHLRRITAGF LGMAVAVLLC GCIVATVSFF
210 220 230 240 250
WEESLTQHVA GLLFLMTGIF CTISLCTYAA SISYDLNRLP KLIYSLPADV
260 270 280 290
EHGYSWSIFC AWCSLGFIVA AGGLCIAYPF ISRTKIAQLK SGRDSTV
Length:297
Mass (Da):33,019
Last modified:October 1, 2002 - v1
Checksum:i757C5C9F7F2CFA53
GO
Isoform 2 (identifier: Q8NBL3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     66-111: PLRDSPPLGR...ECGRPLFATY → LGPLEEVLLP...SAHPLAKHSF
     112-297: Missing.

Note: No experimental confirmation available.
Show »
Length:111
Mass (Da):12,447
Checksum:iCB052D882F0416D9
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032296107L → V.1 PublicationCorresponds to variant rs17852679dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02542866 – 111PLRDS…LFATY → LGPLEEVLLPGHRPGHRHPH PERYCAAMHGHQVPLFSAHP LAKHSF in isoform 2. 1 PublicationAdd BLAST46
Alternative sequenceiVSP_025429112 – 297Missing in isoform 2. 1 PublicationAdd BLAST186

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358773 mRNA. Translation: AAQ89133.1.
AK075440 mRNA. Translation: BAC11622.1.
AC007246 Genomic DNA. Translation: AAX93064.1.
BC029530 mRNA. Translation: AAH29530.1.
CCDSiCCDS1804.1. [Q8NBL3-1]
RefSeqiNP_001161431.1. NM_001167959.1.
NP_689603.2. NM_152390.2. [Q8NBL3-1]
UniGeneiHs.40808.

Genome annotation databases

EnsembliENST00000281961; ENSP00000281961; ENSG00000152154. [Q8NBL3-1]
ENST00000618232; ENSP00000477622; ENSG00000152154. [Q8NBL3-2]
GeneIDi130733.
KEGGihsa:130733.
UCSCiuc002rrt.5. human. [Q8NBL3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358773 mRNA. Translation: AAQ89133.1.
AK075440 mRNA. Translation: BAC11622.1.
AC007246 Genomic DNA. Translation: AAX93064.1.
BC029530 mRNA. Translation: AAH29530.1.
CCDSiCCDS1804.1. [Q8NBL3-1]
RefSeqiNP_001161431.1. NM_001167959.1.
NP_689603.2. NM_152390.2. [Q8NBL3-1]
UniGeneiHs.40808.

3D structure databases

ProteinModelPortaliQ8NBL3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000281961.

Protein family/group databases

TCDBi8.A.16.2.8. the ca(+) channel auxiliary subunit Gama1-Gama8 (ccaGama) family.

Polymorphism and mutation databases

BioMutaiTMEM178A.
DMDMi74723755.

Proteomic databases

EPDiQ8NBL3.
PaxDbiQ8NBL3.
PRIDEiQ8NBL3.
TopDownProteomicsiQ8NBL3-1. [Q8NBL3-1]

Protocols and materials databases

DNASUi130733.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000281961; ENSP00000281961; ENSG00000152154. [Q8NBL3-1]
ENST00000618232; ENSP00000477622; ENSG00000152154. [Q8NBL3-2]
GeneIDi130733.
KEGGihsa:130733.
UCSCiuc002rrt.5. human. [Q8NBL3-1]

Organism-specific databases

CTDi130733.
DisGeNETi130733.
GeneCardsiTMEM178A.
HGNCiHGNC:28517. TMEM178A.
HPAiHPA052128.
neXtProtiNX_Q8NBL3.
OpenTargetsiENSG00000152154.
PharmGKBiPA162405994.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEXN. Eukaryota.
ENOG410YC3G. LUCA.
GeneTreeiENSGT00390000015299.
HOGENOMiHOG000063712.
HOVERGENiHBG070972.
InParanoidiQ8NBL3.
OMAiWYETDTR.
OrthoDBiEOG091G0DO4.
PhylomeDBiQ8NBL3.
TreeFamiTF331307.

Miscellaneous databases

GenomeRNAii130733.
PROiQ8NBL3.

Gene expression databases

BgeeiENSG00000152154.
CleanExiHS_TMEM178.
GenevisibleiQ8NBL3. HS.

Family and domain databases

InterProiIPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PfamiPF13903. Claudin_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiT178A_HUMAN
AccessioniPrimary (citable) accession number: Q8NBL3
Secondary accession number(s): Q6UWI6, Q8N6N4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.