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Reviewed, UniProtKB/Swiss-Prot Q8NBL1 (KTEL1_HUMAN)

Last modified June 16, 2009. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    KTEL motif-containing protein 1
Alternative name(s):
    CAP10-like 46 kDa protein
    Myelodysplastic syndromes relative protein
Gene names
Name: KTELC1
Synonyms: C3orf9, CLP46, MDSRP
ORF Names: MDS010, UNQ490/PRO1006
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length392 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

May be involved in important physiological functions in the liver.

Subcellular location

Endoplasmic reticulum lumen.

Tissue specificity

Expressed in most adult tissues at different intensities. Abundantly expressed in liver. Expressed also in brain, heart, skeletal muscle, spleen, kidney, placenta, lung and peripheral blood leukocyte. Not detectable in colon, thymus and small intestine.

Miscellaneous

Possess the ability of promoting cell proliferation.

Sequence similarities

Belongs to the CAP10 family.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
   Coding sequence diversityPolymorphism
   DomainSignal
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Cellular componentendoplasmic reticulum

Inferred from electronic annotation. Source: UniProtKB-KW

endoplasmic reticulum lumen

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Ref.6
Chain24 – 392369KTEL motif-containing protein 1
PRO_0000246685

Regions

Motif389 – 3924Prevents secretion from ER Potential

Natural variations

Natural variant751K → R: dbSNP rs11556605. Ref.5
VAR_027041
Natural variant2291P → T: dbSNP rs17852785. Ref.5
VAR_027042

Experimental info

Sequence conflict2871G → D in BAD96657. Ref.4
Sequence conflict3711S → P in BAD96657. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q8NBL1-1 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 25B0370757A6B224

FASTA39246,189
        10         20         30         40         50         60 
MEWWASSPLR LWLLLFLLPS AQGRQKESGS KWKVFIDQIN RSLENYEPCS SQNCSCYHGV 

        70         80         90        100        110        120 
IEEDLTPFRG GISRKMMAEV VRRKLGTHYQ ITKNRLYREN DCMFPSRCSG VEHFILEVIG 

       130        140        150        160        170        180 
RLPDMEMVIN VRDYPQVPKW MEPAIPVFSF SKTSEYHDIM YPAWTFWEGG PAVWPIYPTG 

       190        200        210        220        230        240 
LGRWDLFRED LVRSAAQWPW KKKNSTAYFR GSRTSPERDP LILLSRKNPK LVDAEYTKNQ 

       250        260        270        280        290        300 
AWKSMKDTLG KPAAKDVHLV DHCKYKYLFN FRGVAASFRF KHLFLCGSLV FHVGDEWLEF 

       310        320        330        340        350        360 
FYPQLKPWVH YIPVKTDLSN VQELLQFVKA NDDVAQEIAE RGSQFIRNHL QMDDITCYWE 

       370        380        390 
NLLSEYSKFL SYNVTRRKGY DQIIPKMLKT EL 

« Hide

References

« Hide 'large scale' references
[1]"Cloning, expression and characterization of a novel human CAP10-like gene hCLP46 from CD34+ stem/progenitor cells."
Teng Y., Liu Q., Ma J., Liu F., Han Z., Wang Y., Wang W.
Gene 371:7-15(2006) [PubMed: 16524674] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Hematopoietic stem cell.
[2]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y. expand/collapse author list , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
DNA Res. 12:117-126(2005) [PubMed: 16303743] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.
[4]Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ARG-75 AND THR-229.
Tissue: Fetal brain and Hypothalamus.
[6]"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z., Henzel W.J.
Protein Sci. 13:2819-2824(2004) [PubMed: 15340161] [Abstract]
Cited for: PROTEIN SEQUENCE OF 24-38.

Cross-references

Sequence databases

AY298903 mRNA. Translation: AAP56253.1.
AY358581 mRNA. Translation: AAQ88944.1.
AK075444 mRNA. Translation: BAC11625.1.
AK222937 mRNA. Translation: BAD96657.1.
BC030614 mRNA. Translation: AAH30614.1.
BC048810 mRNA. Translation: AAH48810.1.
IPIIPI00301163.
RefSeqNP_689518.1.
UniGeneHs.231750

3D structure databases

ModBaseSearch...

Protein family/group databases

CAZyGT90. Glycosyltransferase Family 90.

Proteomic databases

PRIDEQ8NBL1.

Genome annotation databases

EnsemblENSG00000163389. Homo sapiens. [Contig view]
GeneID56983.
KEGGhsa:56983.

Organism-specific databases

GeneCardsGC03P120672.
HGNCHGNC:22954. KTELC1.
GenAtlasSearch...

Phylogenomic databases

HOVERGENQ8NBL1.
OMAQ8NBL1. DEWQEFF.

Gene expression databases

ArrayExpressQ8NBL1.
BgeeQ8NBL1.
CleanExHS_KTELC1.
GermOnlineENSG00000163389. Homo sapiens.

Family and domain databases

InterProIPR006598. CAP10.
IPR008539. DUF821_CAP10-like.
IPR000886. ER_targeting_sequence.
[Graphical view]
PfamPF05686. DUF821. 1 hit.
[Graphical view]
SMARTSM00672. CAP10. 1 hit.
[Graphical view]
PROSITEPS00014. ER_TARGET. False negative.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio62657.

Entry information

Entry nameKTEL1_HUMAN
AccessionPrimary (citable) accession number: Q8NBL1
Secondary accession number(s): Q53GJ4, Q8N2T1
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: October 1, 2002
Last modified: June 16, 2009
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents