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Protein

SID1 transmembrane family member 2

Gene

SIDT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Protein family/group databases

TCDBi1.A.79.1.3. the cholesterol uptake protein (chup) or double stranded rna uptake family.

Names & Taxonomyi

Protein namesi
Recommended name:
SID1 transmembrane family member 2
Gene namesi
Name:SIDT2
ORF Names:CGI-40, PSEC0072, UNQ685/PRO1325
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:24272. SIDT2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 296ExtracellularSequence analysisAdd BLAST278
Transmembranei297 – 317HelicalSequence analysisAdd BLAST21
Topological domaini318 – 447CytoplasmicSequence analysisAdd BLAST130
Transmembranei448 – 468HelicalSequence analysisAdd BLAST21
Topological domaini469 – 499ExtracellularSequence analysisAdd BLAST31
Transmembranei500 – 520HelicalSequence analysisAdd BLAST21
Topological domaini521 – 546CytoplasmicSequence analysisAdd BLAST26
Transmembranei547 – 567HelicalSequence analysisAdd BLAST21
Topological domaini568 – 605ExtracellularSequence analysisAdd BLAST38
Transmembranei606 – 626HelicalSequence analysisAdd BLAST21
Topological domaini627 – 631CytoplasmicSequence analysis5
Transmembranei632 – 652HelicalSequence analysisAdd BLAST21
Topological domaini653 – 688ExtracellularSequence analysisAdd BLAST36
Transmembranei689 – 709HelicalSequence analysisAdd BLAST21
Topological domaini710 – 715CytoplasmicSequence analysis6
Transmembranei716 – 736HelicalSequence analysisAdd BLAST21
Topological domaini737 – 746ExtracellularSequence analysis10
Transmembranei747 – 767HelicalSequence analysisAdd BLAST21
Topological domaini768 – 796CytoplasmicSequence analysisAdd BLAST29
Transmembranei797 – 817HelicalSequence analysisAdd BLAST21
Topological domaini818 – 832ExtracellularSequence analysisAdd BLAST15

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • lysosomal membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Lysosome, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi51092.
OpenTargetsiENSG00000149577.
PharmGKBiPA134910333.

Polymorphism and mutation databases

BioMutaiSIDT2.
DMDMi62901098.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 181 PublicationAdd BLAST18
ChainiPRO_000003257819 – 832SID1 transmembrane family member 2Add BLAST814

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi27N-linked (GlcNAc...)Sequence analysis1
Glycosylationi54N-linked (GlcNAc...)Sequence analysis1
Glycosylationi60N-linked (GlcNAc...)Sequence analysis1
Glycosylationi123N-linked (GlcNAc...)Sequence analysis1
Glycosylationi141N-linked (GlcNAc...)Sequence analysis1
Glycosylationi165N-linked (GlcNAc...)Sequence analysis1
Modified residuei401PhosphoserineCombined sources1
Modified residuei403PhosphoserineCombined sources1
Modified residuei404PhosphoserineCombined sources1
Glycosylationi476N-linked (GlcNAc...)Sequence analysis1
Glycosylationi496N-linked (GlcNAc...)Sequence analysis1
Glycosylationi572N-linked (GlcNAc...)Sequence analysis1
Glycosylationi603N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Glycosylated.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ8NBJ9.
MaxQBiQ8NBJ9.
PaxDbiQ8NBJ9.
PeptideAtlasiQ8NBJ9.
PRIDEiQ8NBJ9.

PTM databases

iPTMnetiQ8NBJ9.
PhosphoSitePlusiQ8NBJ9.
SwissPalmiQ8NBJ9.

Expressioni

Gene expression databases

BgeeiENSG00000149577.
CleanExiHS_SIDT2.
ExpressionAtlasiQ8NBJ9. baseline and differential.
GenevisibleiQ8NBJ9. HS.

Organism-specific databases

HPAiHPA052352.

Interactioni

Protein-protein interaction databases

BioGridi119281. 16 interactors.
IntActiQ8NBJ9. 2 interactors.
STRINGi9606.ENSP00000314023.

Structurei

3D structure databases

ProteinModelPortaliQ8NBJ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi764 – 767Poly-Phe4

Sequence similaritiesi

Belongs to the SID1 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF6Z. Eukaryota.
ENOG410XPBN. LUCA.
GeneTreeiENSGT00390000010091.
HOGENOMiHOG000020635.
HOVERGENiHBG079188.
InParanoidiQ8NBJ9.
PhylomeDBiQ8NBJ9.
TreeFamiTF313076.

Family and domain databases

InterProiIPR025958. SID1_TM_fam.
[Graphical view]
PfamiPF13965. SID-1_RNA_chan. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NBJ9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFALGLPFLV LLVASVESHL GVLGPKNVSQ KDAEFERTYV DEVNSELVNI
60 70 80 90 100
YTFNHTVTRN RTEGVRVSVN VLNKQKGAPL LFVVRQKEAV VSFQVPLILR
110 120 130 140 150
GMFQRKYLYQ KVERTLCQPP TKNESEIQFF YVDVSTLSPV NTTYQLRVSR
160 170 180 190 200
MDDFVLRTGE QFSFNTTAAQ PQYFKYEFPE GVDSVIVKVT SNKAFPCSVI
210 220 230 240 250
SIQDVLCPVY DLDNNVAFIG MYQTMTKKAA ITVQRKDFPS NSFYVVVVVK
260 270 280 290 300
TEDQACGGSL PFYPFAEDEP VDQGHRQKTL SVLVSQAVTS EAYVSGMLFC
310 320 330 340 350
LGIFLSFYLL TVLLACWENW RQKKKTLLVA IDRACPESGH PRVLADSFPG
360 370 380 390 400
SSPYEGYNYG SFENVSGSTD GLVDSAGTGD LSYGYQGRSF EPVGTRPRVD
410 420 430 440 450
SMSSVEEDDY DTLTDIDSDK NVIRTKQYLY VADLARKDKR VLRKKYQIYF
460 470 480 490 500
WNIATIAVFY ALPVVQLVIT YQTVVNVTGN QDICYYNFLC AHPLGNLSAF
510 520 530 540 550
NNILSNLGYI LLGLLFLLII LQREINHNRA LLRNDLCALE CGIPKHFGLF
560 570 580 590 600
YAMGTALMME GLLSACYHVC PNYTNFQFDT SFMYMIAGLC MLKLYQKRHP
610 620 630 640 650
DINASAYSAY ACLAIVIFFS VLGVVFGKGN TAFWIVFSII HIIATLLLST
660 670 680 690 700
QLYYMGRWKL DSGIFRRILH VLYTDCIRQC SGPLYVDRMV LLVMGNVINW
710 720 730 740 750
SLAAYGLIMR PNDFASYLLA IGICNLLLYF AFYIIMKLRS GERIKLIPLL
760 770 780 790 800
CIVCTSVVWG FALFFFFQGL STWQKTPAES REHNRDCILL DFFDDHDIWH
810 820 830
FLSSIAMFGS FLVLLTLDDD LDTVQRDKIY VF
Length:832
Mass (Da):94,454
Last modified:April 26, 2005 - v2
Checksum:i5DDA17E7DC5A33FD
GO
Isoform 2 (identifier: Q8NBJ9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     387-387: G → GHDQFKRRLPSGQMRQLCIAMG
     814-832: LLTLDDDLDTVQRDKIYVF → SGPPGAALRIT

Note: No experimental confirmation available.
Show »
Length:845
Mass (Da):95,666
Checksum:i3FA58A2CA2C512D3
GO

Sequence cautioni

The sequence BAC11427 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC11641 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti450F → L in BAC11427 (PubMed:14702039).Curated1
Sequence conflicti596Q → R in BAC11641 (PubMed:16303743).Curated1
Sequence conflicti794D → N in BAC11641 (PubMed:16303743).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034493631T → M.Corresponds to variant rs12285035dbSNPEnsembl.1
Natural variantiVAR_034494636V → I.Corresponds to variant rs17120425dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_013523387G → GHDQFKRRLPSGQMRQLCIA MG in isoform 2. 1 Publication1
Alternative sequenceiVSP_013524814 – 832LLTLD…KIYVF → SGPPGAALRIT in isoform 2. 1 PublicationAdd BLAST19

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151799 mRNA. Translation: AAD34036.1.
AY358442 mRNA. Translation: AAQ88807.1.
AK075137 mRNA. Translation: BAC11427.1. Different initiation.
AK075471 mRNA. Translation: BAC11641.1. Different initiation.
CCDSiCCDS31682.1. [Q8NBJ9-1]
RefSeqiNP_001035545.1. NM_001040455.1. [Q8NBJ9-1]
UniGeneiHs.712144.

Genome annotation databases

EnsembliENST00000324225; ENSP00000314023; ENSG00000149577. [Q8NBJ9-1]
ENST00000620360; ENSP00000482762; ENSG00000149577. [Q8NBJ9-1]
GeneIDi51092.
KEGGihsa:51092.
UCSCiuc001pqh.2. human. [Q8NBJ9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151799 mRNA. Translation: AAD34036.1.
AY358442 mRNA. Translation: AAQ88807.1.
AK075137 mRNA. Translation: BAC11427.1. Different initiation.
AK075471 mRNA. Translation: BAC11641.1. Different initiation.
CCDSiCCDS31682.1. [Q8NBJ9-1]
RefSeqiNP_001035545.1. NM_001040455.1. [Q8NBJ9-1]
UniGeneiHs.712144.

3D structure databases

ProteinModelPortaliQ8NBJ9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119281. 16 interactors.
IntActiQ8NBJ9. 2 interactors.
STRINGi9606.ENSP00000314023.

Protein family/group databases

TCDBi1.A.79.1.3. the cholesterol uptake protein (chup) or double stranded rna uptake family.

PTM databases

iPTMnetiQ8NBJ9.
PhosphoSitePlusiQ8NBJ9.
SwissPalmiQ8NBJ9.

Polymorphism and mutation databases

BioMutaiSIDT2.
DMDMi62901098.

Proteomic databases

EPDiQ8NBJ9.
MaxQBiQ8NBJ9.
PaxDbiQ8NBJ9.
PeptideAtlasiQ8NBJ9.
PRIDEiQ8NBJ9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000324225; ENSP00000314023; ENSG00000149577. [Q8NBJ9-1]
ENST00000620360; ENSP00000482762; ENSG00000149577. [Q8NBJ9-1]
GeneIDi51092.
KEGGihsa:51092.
UCSCiuc001pqh.2. human. [Q8NBJ9-1]

Organism-specific databases

CTDi51092.
DisGeNETi51092.
GeneCardsiSIDT2.
H-InvDBHIX0010161.
HGNCiHGNC:24272. SIDT2.
HPAiHPA052352.
neXtProtiNX_Q8NBJ9.
OpenTargetsiENSG00000149577.
PharmGKBiPA134910333.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF6Z. Eukaryota.
ENOG410XPBN. LUCA.
GeneTreeiENSGT00390000010091.
HOGENOMiHOG000020635.
HOVERGENiHBG079188.
InParanoidiQ8NBJ9.
PhylomeDBiQ8NBJ9.
TreeFamiTF313076.

Miscellaneous databases

ChiTaRSiSIDT2. human.
GenomeRNAii51092.
PROiQ8NBJ9.

Gene expression databases

BgeeiENSG00000149577.
CleanExiHS_SIDT2.
ExpressionAtlasiQ8NBJ9. baseline and differential.
GenevisibleiQ8NBJ9. HS.

Family and domain databases

InterProiIPR025958. SID1_TM_fam.
[Graphical view]
PfamiPF13965. SID-1_RNA_chan. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSIDT2_HUMAN
AccessioniPrimary (citable) accession number: Q8NBJ9
Secondary accession number(s): Q8NBY7, Q9Y357
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: April 26, 2005
Last modified: November 2, 2016
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.