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Protein

SID1 transmembrane family member 2

Gene

SIDT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Protein family/group databases

TCDBi1.A.79.1.3. the cholesterol uptake protein (chup) or double stranded rna uptake family.

Names & Taxonomyi

Protein namesi
Recommended name:
SID1 transmembrane family member 2
Gene namesi
Name:SIDT2
ORF Names:CGI-40, PSEC0072, UNQ685/PRO1325
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:24272. SIDT2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 296278ExtracellularSequence analysisAdd
BLAST
Transmembranei297 – 31721HelicalSequence analysisAdd
BLAST
Topological domaini318 – 447130CytoplasmicSequence analysisAdd
BLAST
Transmembranei448 – 46821HelicalSequence analysisAdd
BLAST
Topological domaini469 – 49931ExtracellularSequence analysisAdd
BLAST
Transmembranei500 – 52021HelicalSequence analysisAdd
BLAST
Topological domaini521 – 54626CytoplasmicSequence analysisAdd
BLAST
Transmembranei547 – 56721HelicalSequence analysisAdd
BLAST
Topological domaini568 – 60538ExtracellularSequence analysisAdd
BLAST
Transmembranei606 – 62621HelicalSequence analysisAdd
BLAST
Topological domaini627 – 6315CytoplasmicSequence analysis
Transmembranei632 – 65221HelicalSequence analysisAdd
BLAST
Topological domaini653 – 68836ExtracellularSequence analysisAdd
BLAST
Transmembranei689 – 70921HelicalSequence analysisAdd
BLAST
Topological domaini710 – 7156CytoplasmicSequence analysis
Transmembranei716 – 73621HelicalSequence analysisAdd
BLAST
Topological domaini737 – 74610ExtracellularSequence analysis
Transmembranei747 – 76721HelicalSequence analysisAdd
BLAST
Topological domaini768 – 79629CytoplasmicSequence analysisAdd
BLAST
Transmembranei797 – 81721HelicalSequence analysisAdd
BLAST
Topological domaini818 – 83215ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • lysosomal membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Lysosome, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134910333.

Polymorphism and mutation databases

BioMutaiSIDT2.
DMDMi62901098.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 18181 PublicationAdd
BLAST
Chaini19 – 832814SID1 transmembrane family member 2PRO_0000032578Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi27 – 271N-linked (GlcNAc...)Sequence analysis
Glycosylationi54 – 541N-linked (GlcNAc...)Sequence analysis
Glycosylationi60 – 601N-linked (GlcNAc...)Sequence analysis
Glycosylationi123 – 1231N-linked (GlcNAc...)Sequence analysis
Glycosylationi141 – 1411N-linked (GlcNAc...)Sequence analysis
Glycosylationi165 – 1651N-linked (GlcNAc...)Sequence analysis
Modified residuei401 – 4011PhosphoserineCombined sources
Modified residuei403 – 4031PhosphoserineCombined sources
Modified residuei404 – 4041PhosphoserineCombined sources
Glycosylationi476 – 4761N-linked (GlcNAc...)Sequence analysis
Glycosylationi496 – 4961N-linked (GlcNAc...)Sequence analysis
Glycosylationi572 – 5721N-linked (GlcNAc...)Sequence analysis
Glycosylationi603 – 6031N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

Glycosylated.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ8NBJ9.
PaxDbiQ8NBJ9.
PRIDEiQ8NBJ9.

PTM databases

iPTMnetiQ8NBJ9.
PhosphoSiteiQ8NBJ9.
SwissPalmiQ8NBJ9.

Expressioni

Gene expression databases

BgeeiQ8NBJ9.
CleanExiHS_SIDT2.
ExpressionAtlasiQ8NBJ9. baseline and differential.
GenevisibleiQ8NBJ9. HS.

Organism-specific databases

HPAiHPA052352.

Interactioni

Protein-protein interaction databases

BioGridi119281. 16 interactions.
STRINGi9606.ENSP00000314023.

Structurei

3D structure databases

ProteinModelPortaliQ8NBJ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi764 – 7674Poly-Phe

Sequence similaritiesi

Belongs to the SID1 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF6Z. Eukaryota.
ENOG410XPBN. LUCA.
GeneTreeiENSGT00390000010091.
HOGENOMiHOG000020635.
HOVERGENiHBG079188.
InParanoidiQ8NBJ9.
OrthoDBiEOG7K3TKF.
PhylomeDBiQ8NBJ9.
TreeFamiTF313076.

Family and domain databases

InterProiIPR025958. SID1_TM_fam.
[Graphical view]
PfamiPF13965. SID-1_RNA_chan. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NBJ9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFALGLPFLV LLVASVESHL GVLGPKNVSQ KDAEFERTYV DEVNSELVNI
60 70 80 90 100
YTFNHTVTRN RTEGVRVSVN VLNKQKGAPL LFVVRQKEAV VSFQVPLILR
110 120 130 140 150
GMFQRKYLYQ KVERTLCQPP TKNESEIQFF YVDVSTLSPV NTTYQLRVSR
160 170 180 190 200
MDDFVLRTGE QFSFNTTAAQ PQYFKYEFPE GVDSVIVKVT SNKAFPCSVI
210 220 230 240 250
SIQDVLCPVY DLDNNVAFIG MYQTMTKKAA ITVQRKDFPS NSFYVVVVVK
260 270 280 290 300
TEDQACGGSL PFYPFAEDEP VDQGHRQKTL SVLVSQAVTS EAYVSGMLFC
310 320 330 340 350
LGIFLSFYLL TVLLACWENW RQKKKTLLVA IDRACPESGH PRVLADSFPG
360 370 380 390 400
SSPYEGYNYG SFENVSGSTD GLVDSAGTGD LSYGYQGRSF EPVGTRPRVD
410 420 430 440 450
SMSSVEEDDY DTLTDIDSDK NVIRTKQYLY VADLARKDKR VLRKKYQIYF
460 470 480 490 500
WNIATIAVFY ALPVVQLVIT YQTVVNVTGN QDICYYNFLC AHPLGNLSAF
510 520 530 540 550
NNILSNLGYI LLGLLFLLII LQREINHNRA LLRNDLCALE CGIPKHFGLF
560 570 580 590 600
YAMGTALMME GLLSACYHVC PNYTNFQFDT SFMYMIAGLC MLKLYQKRHP
610 620 630 640 650
DINASAYSAY ACLAIVIFFS VLGVVFGKGN TAFWIVFSII HIIATLLLST
660 670 680 690 700
QLYYMGRWKL DSGIFRRILH VLYTDCIRQC SGPLYVDRMV LLVMGNVINW
710 720 730 740 750
SLAAYGLIMR PNDFASYLLA IGICNLLLYF AFYIIMKLRS GERIKLIPLL
760 770 780 790 800
CIVCTSVVWG FALFFFFQGL STWQKTPAES REHNRDCILL DFFDDHDIWH
810 820 830
FLSSIAMFGS FLVLLTLDDD LDTVQRDKIY VF
Length:832
Mass (Da):94,454
Last modified:April 26, 2005 - v2
Checksum:i5DDA17E7DC5A33FD
GO
Isoform 2 (identifier: Q8NBJ9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     387-387: G → GHDQFKRRLPSGQMRQLCIAMG
     814-832: LLTLDDDLDTVQRDKIYVF → SGPPGAALRIT

Note: No experimental confirmation available.
Show »
Length:845
Mass (Da):95,666
Checksum:i3FA58A2CA2C512D3
GO

Sequence cautioni

The sequence BAC11427.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC11641.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti450 – 4501F → L in BAC11427 (PubMed:14702039).Curated
Sequence conflicti596 – 5961Q → R in BAC11641 (PubMed:16303743).Curated
Sequence conflicti794 – 7941D → N in BAC11641 (PubMed:16303743).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti631 – 6311T → M.
Corresponds to variant rs12285035 [ dbSNP | Ensembl ].
VAR_034493
Natural varianti636 – 6361V → I.
Corresponds to variant rs17120425 [ dbSNP | Ensembl ].
VAR_034494

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei387 – 3871G → GHDQFKRRLPSGQMRQLCIA MG in isoform 2. 1 PublicationVSP_013523
Alternative sequencei814 – 83219LLTLD…KIYVF → SGPPGAALRIT in isoform 2. 1 PublicationVSP_013524Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151799 mRNA. Translation: AAD34036.1.
AY358442 mRNA. Translation: AAQ88807.1.
AK075137 mRNA. Translation: BAC11427.1. Different initiation.
AK075471 mRNA. Translation: BAC11641.1. Different initiation.
CCDSiCCDS31682.1. [Q8NBJ9-1]
RefSeqiNP_001035545.1. NM_001040455.1. [Q8NBJ9-1]
UniGeneiHs.712144.

Genome annotation databases

EnsembliENST00000324225; ENSP00000314023; ENSG00000149577. [Q8NBJ9-1]
ENST00000620360; ENSP00000482762; ENSG00000149577. [Q8NBJ9-1]
GeneIDi51092.
KEGGihsa:51092.
UCSCiuc001pqh.2. human. [Q8NBJ9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151799 mRNA. Translation: AAD34036.1.
AY358442 mRNA. Translation: AAQ88807.1.
AK075137 mRNA. Translation: BAC11427.1. Different initiation.
AK075471 mRNA. Translation: BAC11641.1. Different initiation.
CCDSiCCDS31682.1. [Q8NBJ9-1]
RefSeqiNP_001035545.1. NM_001040455.1. [Q8NBJ9-1]
UniGeneiHs.712144.

3D structure databases

ProteinModelPortaliQ8NBJ9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119281. 16 interactions.
STRINGi9606.ENSP00000314023.

Protein family/group databases

TCDBi1.A.79.1.3. the cholesterol uptake protein (chup) or double stranded rna uptake family.

PTM databases

iPTMnetiQ8NBJ9.
PhosphoSiteiQ8NBJ9.
SwissPalmiQ8NBJ9.

Polymorphism and mutation databases

BioMutaiSIDT2.
DMDMi62901098.

Proteomic databases

MaxQBiQ8NBJ9.
PaxDbiQ8NBJ9.
PRIDEiQ8NBJ9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000324225; ENSP00000314023; ENSG00000149577. [Q8NBJ9-1]
ENST00000620360; ENSP00000482762; ENSG00000149577. [Q8NBJ9-1]
GeneIDi51092.
KEGGihsa:51092.
UCSCiuc001pqh.2. human. [Q8NBJ9-1]

Organism-specific databases

CTDi51092.
GeneCardsiSIDT2.
H-InvDBHIX0010161.
HGNCiHGNC:24272. SIDT2.
HPAiHPA052352.
neXtProtiNX_Q8NBJ9.
PharmGKBiPA134910333.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF6Z. Eukaryota.
ENOG410XPBN. LUCA.
GeneTreeiENSGT00390000010091.
HOGENOMiHOG000020635.
HOVERGENiHBG079188.
InParanoidiQ8NBJ9.
OrthoDBiEOG7K3TKF.
PhylomeDBiQ8NBJ9.
TreeFamiTF313076.

Miscellaneous databases

ChiTaRSiSIDT2. human.
GenomeRNAii51092.
NextBioi53777.
PROiQ8NBJ9.

Gene expression databases

BgeeiQ8NBJ9.
CleanExiHS_SIDT2.
ExpressionAtlasiQ8NBJ9. baseline and differential.
GenevisibleiQ8NBJ9. HS.

Family and domain databases

InterProiIPR025958. SID1_TM_fam.
[Graphical view]
PfamiPF13965. SID-1_RNA_chan. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
    Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
    Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 19-33.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 328-832.
    Tissue: Placenta.
  5. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
    Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
    , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
    DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 590-832.
    Tissue: Placenta.
  6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-401; SER-403 AND SER-404, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiSIDT2_HUMAN
AccessioniPrimary (citable) accession number: Q8NBJ9
Secondary accession number(s): Q8NBY7, Q9Y357
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: April 26, 2005
Last modified: March 16, 2016
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.