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Protein

Sulfatase-modifying factor 2

Gene

SUMF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Lacks formyl-glycine generating activity and is unable to convert newly synthesized inactive sulfatases to their active form. Inhibits the activation of sulfatases by SUMF1.3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi194Calcium 1; via carbonyl oxygen1
Metal bindingi195Calcium 1; via carbonyl oxygen1
Metal bindingi208Calcium 11
Metal bindingi210Calcium 1; via carbonyl oxygen1
Metal bindingi229Calcium 2; via carbonyl oxygen1
Metal bindingi232Calcium 2; via carbonyl oxygen1
Metal bindingi234Calcium 2; via carbonyl oxygen1
Metal bindingi236Calcium 21

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-1660662. Glycosphingolipid metabolism.
R-HSA-1663150. The activation of arylsulfatases.

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfatase-modifying factor 2
Alternative name(s):
C-alpha-formylglycine-generating enzyme 2
Gene namesi
Name:SUMF2
ORF Names:PSEC0171, UNQ1968/PRO4500
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:20415. SUMF2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi156C → A: Abolishes interaction with and inhibition of SUMF1. Can still form homodimers. 1 Publication1
Mutagenesisi290C → A: Abolishes interaction with and inhibition of SUMF1. Can still form homodimers. 1 Publication1

Organism-specific databases

DisGeNETi25870.
OpenTargetsiENSG00000129103.
PharmGKBiPA134921869.

Polymorphism and mutation databases

BioMutaiSUMF2.
DMDMi296452916.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000003345926 – 301Sulfatase-modifying factor 2Add BLAST276

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi156 ↔ 2902 Publications
Glycosylationi191N-linked (GlcNAc...)1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ8NBJ7.
MaxQBiQ8NBJ7.
PaxDbiQ8NBJ7.
PeptideAtlasiQ8NBJ7.
PRIDEiQ8NBJ7.

2D gel databases

REPRODUCTION-2DPAGEIPI00171412.

PTM databases

iPTMnetiQ8NBJ7.
PhosphoSitePlusiQ8NBJ7.

Miscellaneous databases

PMAP-CutDBQ8NBJ7.

Expressioni

Tissue specificityi

Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highest levels in kidney, liver and placenta.2 Publications

Gene expression databases

BgeeiENSG00000129103.
CleanExiHS_SUMF2.
ExpressionAtlasiQ8NBJ7. baseline and differential.
GenevisibleiQ8NBJ7. HS.

Organism-specific databases

HPAiCAB025743.
HPA024040.

Interactioni

Subunit structurei

Homodimer and heterodimer with SUMF1.2 Publications

Protein-protein interaction databases

BioGridi117386. 11 interactors.
IntActiQ8NBJ7. 6 interactors.
MINTiMINT-1196002.
STRINGi9606.ENSP00000341938.

Structurei

Secondary structure

1301
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi30 – 33Combined sources4
Beta strandi36 – 41Combined sources6
Beta strandi55 – 59Combined sources5
Beta strandi61 – 67Combined sources7
Helixi71 – 81Combined sources11
Helixi86 – 90Combined sources5
Beta strandi92 – 96Combined sources5
Helixi97 – 99Combined sources3
Helixi102 – 106Combined sources5
Beta strandi118 – 122Combined sources5
Helixi149 – 158Combined sources10
Helixi166 – 174Combined sources9
Beta strandi185 – 187Combined sources3
Turni200 – 202Combined sources3
Beta strandi231 – 241Combined sources11
Helixi245 – 247Combined sources3
Beta strandi250 – 254Combined sources5
Beta strandi263 – 268Combined sources6
Beta strandi274 – 277Combined sources4
Beta strandi291 – 293Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Y4JX-ray1.86A/B27-301[»]
ProteinModelPortaliQ8NBJ7.
SMRiQ8NBJ7.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8NBJ7.

Family & Domainsi

Sequence similaritiesi

Belongs to the sulfatase-modifying factor family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IFQ0. Eukaryota.
COG1262. LUCA.
GeneTreeiENSGT00390000008983.
HOVERGENiHBG054193.
InParanoidiQ8NBJ7.
PhylomeDBiQ8NBJ7.

Family and domain databases

Gene3Di3.90.1580.10. 1 hit.
InterProiIPR016187. CTDL_fold.
IPR005532. SUMF_dom.
[Graphical view]
PfamiPF03781. FGE-sulfatase. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NBJ7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARHGLPLLP LLSLLVGAWL KLGNGQATSM VQLQGGRFLM GTNSPDSRDG
60 70 80 90 100
DGPVREATVK PFAIDIFPVT NKDFRDFVRE KKYRTEAEMF GWSFVFEDFV
110 120 130 140 150
SDELRNKATQ PMKSVLWWLP VEKAFWRQPA GPGSGIRERL EHPVLHVSWN
160 170 180 190 200
DARAYCAWRG KRLPTEEEWE FAARGGLKGQ VYPWGNWFQP NRTNLWQGKF
210 220 230 240 250
PKGDKAEDGF HGVSPVNAFP AQNNYGLYDL LGNVWEWTAS PYQAAEQDMR
260 270 280 290 300
VLRGASWIDT ADGSANHRAR VTTRMGNTPD SASDNLGFRC AADAGRPPGE

L
Length:301
Mass (Da):33,843
Last modified:May 18, 2010 - v2
Checksum:i1E834CEA56922755
GO
Isoform 2 (identifier: Q8NBJ7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-88: Missing.

Show »
Length:213
Mass (Da):24,117
Checksum:iE8AF9A2220AEE11D
GO
Isoform 3 (identifier: Q8NBJ7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     227-301: LYDLLGNVWE...ADAGRPPGEL → WATLQIQPQT...QVFLLEAKYY

Note: No experimental confirmation available.
Show »
Length:339
Mass (Da):37,395
Checksum:i74E1DA4C9B85F276
GO
Isoform 5 (identifier: Q8NBJ7-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     114-197: Missing.

Show »
Length:217
Mass (Da):23,902
Checksum:i80822E9067E4E5C2
GO
Isoform 4 (identifier: Q8NBJ7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     114-301: SVLWWLPVEK...ADAGRPPGEL → VKFTHGGTGS...QVFLLEAKYY

Note: No experimental confirmation available.
Show »
Length:321
Mass (Da):34,187
Checksum:iA4B285CB52C41407
GO

Sequence cautioni

The sequence AAH00224 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAB43247 differs from that shown. Reason: Frameshift at positions 150 and 187.Curated
The sequence CAB43247 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04695151D → E.Combined sources6 PublicationsCorresponds to variant rs4245575dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0078781 – 88Missing in isoform 2. 2 PublicationsAdd BLAST88
Alternative sequenceiVSP_007880114 – 301SVLWW…PPGEL → VKFTHGGTGSSQTAPTCGRE SSPRETKLRMASMESPQMLS PPRTTTGSMTSWGTCGSGQH HRTRLLSRTCASSGGHPGST QLMALPITGPGSPPGWATLQ IQPQTTSVSAVLQTQAGRQG SCKQPGGDKEKSLLGSLSFP GHVANSAIPSSRASASGKNF PFPVSHPSVAGASHQGRRGL SLLCFGEGAQCVLTMAGGQV FLLEAKYY in isoform 4. 1 PublicationAdd BLAST188
Alternative sequenceiVSP_040878114 – 197Missing in isoform 5. CuratedAdd BLAST84
Alternative sequenceiVSP_007879227 – 301LYDLL…PPGEL → WATLQIQPQTTSVSAVLQTQ AGRQGSCKQPGGDKEKSLLG SLSFPGHVANSAIPSSRASA SGKNFPFPVSHPSVAGASHQ GRRGLSLLCFGEGAQCVLTM AGGQVFLLEAKYY in isoform 3. 1 PublicationAdd BLAST75

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY323911 mRNA. Translation: AAP86218.1.
AY359103 mRNA. Translation: AAQ89461.1.
AK300488 mRNA. Translation: BAG62203.1.
AK301627 mRNA. Translation: BAG63112.1.
AK075477 mRNA. Translation: BAC11643.1.
AL050037 mRNA. Translation: CAB43247.1. Sequence problems.
CH471140 Genomic DNA. Translation: EAX07980.1.
BC000224 mRNA. Translation: AAH00224.1. Different initiation.
BC006159 mRNA. Translation: AAH06159.1.
BC015600 mRNA. Translation: AAH15600.2.
BC084539 mRNA. Translation: AAH84539.1.
BC111092 mRNA. Translation: AAI11093.1.
CCDSiCCDS55111.1. [Q8NBJ7-2]
PIRiT08715.
RefSeqiNP_001035934.2. NM_001042469.1.
NP_001035935.2. NM_001042470.1.
NP_001123541.1. NM_001130069.2.
NP_001139805.1. NM_001146333.1. [Q8NBJ7-2]
NP_056226.2. NM_015411.2.
UniGeneiHs.279696.

Genome annotation databases

EnsembliENST00000275607; ENSP00000275607; ENSG00000129103. [Q8NBJ7-2]
GeneIDi25870.
KEGGihsa:25870.
UCSCiuc003trt.4. human. [Q8NBJ7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY323911 mRNA. Translation: AAP86218.1.
AY359103 mRNA. Translation: AAQ89461.1.
AK300488 mRNA. Translation: BAG62203.1.
AK301627 mRNA. Translation: BAG63112.1.
AK075477 mRNA. Translation: BAC11643.1.
AL050037 mRNA. Translation: CAB43247.1. Sequence problems.
CH471140 Genomic DNA. Translation: EAX07980.1.
BC000224 mRNA. Translation: AAH00224.1. Different initiation.
BC006159 mRNA. Translation: AAH06159.1.
BC015600 mRNA. Translation: AAH15600.2.
BC084539 mRNA. Translation: AAH84539.1.
BC111092 mRNA. Translation: AAI11093.1.
CCDSiCCDS55111.1. [Q8NBJ7-2]
PIRiT08715.
RefSeqiNP_001035934.2. NM_001042469.1.
NP_001035935.2. NM_001042470.1.
NP_001123541.1. NM_001130069.2.
NP_001139805.1. NM_001146333.1. [Q8NBJ7-2]
NP_056226.2. NM_015411.2.
UniGeneiHs.279696.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Y4JX-ray1.86A/B27-301[»]
ProteinModelPortaliQ8NBJ7.
SMRiQ8NBJ7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117386. 11 interactors.
IntActiQ8NBJ7. 6 interactors.
MINTiMINT-1196002.
STRINGi9606.ENSP00000341938.

PTM databases

iPTMnetiQ8NBJ7.
PhosphoSitePlusiQ8NBJ7.

Polymorphism and mutation databases

BioMutaiSUMF2.
DMDMi296452916.

2D gel databases

REPRODUCTION-2DPAGEIPI00171412.

Proteomic databases

EPDiQ8NBJ7.
MaxQBiQ8NBJ7.
PaxDbiQ8NBJ7.
PeptideAtlasiQ8NBJ7.
PRIDEiQ8NBJ7.

Protocols and materials databases

DNASUi25870.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000275607; ENSP00000275607; ENSG00000129103. [Q8NBJ7-2]
GeneIDi25870.
KEGGihsa:25870.
UCSCiuc003trt.4. human. [Q8NBJ7-1]

Organism-specific databases

CTDi25870.
DisGeNETi25870.
GeneCardsiSUMF2.
HGNCiHGNC:20415. SUMF2.
HPAiCAB025743.
HPA024040.
MIMi607940. gene.
neXtProtiNX_Q8NBJ7.
OpenTargetsiENSG00000129103.
PharmGKBiPA134921869.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFQ0. Eukaryota.
COG1262. LUCA.
GeneTreeiENSGT00390000008983.
HOVERGENiHBG054193.
InParanoidiQ8NBJ7.
PhylomeDBiQ8NBJ7.

Enzyme and pathway databases

ReactomeiR-HSA-1660662. Glycosphingolipid metabolism.
R-HSA-1663150. The activation of arylsulfatases.

Miscellaneous databases

EvolutionaryTraceiQ8NBJ7.
GeneWikiiSUMF2.
GenomeRNAii25870.
PMAP-CutDBQ8NBJ7.
PROiQ8NBJ7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000129103.
CleanExiHS_SUMF2.
ExpressionAtlasiQ8NBJ7. baseline and differential.
GenevisibleiQ8NBJ7. HS.

Family and domain databases

Gene3Di3.90.1580.10. 1 hit.
InterProiIPR016187. CTDL_fold.
IPR005532. SUMF_dom.
[Graphical view]
PfamiPF03781. FGE-sulfatase. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSUMF2_HUMAN
AccessioniPrimary (citable) accession number: Q8NBJ7
Secondary accession number(s): B4DU41
, B4DWQ0, Q14DW5, Q53ZE3, Q96BH2, Q9BRN3, Q9BWI1, Q9Y405
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: May 18, 2010
Last modified: November 30, 2016
This is version 149 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.