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Q8NBJ4

- GOLM1_HUMAN

UniProt

Q8NBJ4 - GOLM1_HUMAN

Protein

Golgi membrane protein 1

Gene

GOLM1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Unknown. Cellular response protein to viral infection.

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. nucleus organization Source: Ensembl
    2. regulation of lipid metabolic process Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Golgi membrane protein 1
    Alternative name(s):
    Golgi membrane protein GP73
    Golgi phosphoprotein 2
    Gene namesi
    Name:GOLM1
    Synonyms:C9orf155, GOLPH2
    ORF Names:PSEC0242, UNQ686/PRO1326
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:15451. GOLM1.

    Subcellular locationi

    Golgi apparatuscis-Golgi network membrane 2 Publications; Single-pass type II membrane protein 2 Publications
    Note: Early Golgi. Cycles via the cell surface and endosomes upon lumenal pH disruption.

    GO - Cellular componenti

    1. extracellular space Source: UniProt
    2. extracellular vesicular exosome Source: UniProt
    3. Golgi apparatus Source: HPA
    4. integral component of plasma membrane Source: ProtInc

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28811.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 401401Golgi membrane protein 1PRO_0000021356Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi109 – 1091N-linked (GlcNAc...) (complex)4 Publications
    Glycosylationi144 – 1441N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi398 – 3981N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Glycosylated.4 Publications
    Phosphorylation sites are present in the extracellular medium.

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiQ8NBJ4.
    PaxDbiQ8NBJ4.
    PRIDEiQ8NBJ4.

    PTM databases

    PhosphoSiteiQ8NBJ4.

    Expressioni

    Tissue specificityi

    Widely expressed. Highly expressed in colon, prostate, trachea and stomach. Expressed at lower level in testis, muscle, lymphoid tissues, white blood cells and spleen. Predominantly expressed by cells of the epithelial lineage. Expressed at low level in normal liver. Expression significantly increases in virus (HBV, HCV) infected liver. Expression does not increase in liver disease due to non-viral causes (alcohol-induced liver disease, autoimmune hepatitis). Increased expression in hepatocytes appears to be a general feature of advanced liver disease. In liver tissue from patients with adult giant-cell hepatitis (GCH), it is strongly expressed in hepatocytes-derived syncytial giant cells. Constitutively expressed by biliary epithelial cells but not by hepatocytes.2 Publications

    Inductioni

    Up-regulated in response to viral infection. Induced by the E1A adenoviral protein.1 Publication

    Gene expression databases

    ArrayExpressiQ8NBJ4.
    BgeeiQ8NBJ4.
    CleanExiHS_GOLM1.
    GenevestigatoriQ8NBJ4.

    Organism-specific databases

    HPAiCAB015341.
    HPA010638.
    HPA011929.

    Interactioni

    Subunit structurei

    Interacts with DYM.1 Publication

    Protein-protein interaction databases

    BioGridi119432. 13 interactions.
    IntActiQ8NBJ4. 27 interactions.
    MINTiMINT-1378675.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NBJ4.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1212CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini36 – 401366LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei13 – 3523Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili40 – 205166Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the GOLM1/CASC4 family.Curated

    Keywords - Domaini

    Coiled coil, Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG39658.
    HOGENOMiHOG000065682.
    HOVERGENiHBG062332.
    OMAiKFSYDLN.
    OrthoDBiEOG7992QP.
    PhylomeDBiQ8NBJ4.
    TreeFamiTF331127.

    Family and domain databases

    InterProiIPR026143. GOLM1.
    IPR026139. GOLM1/CASC4.
    [Graphical view]
    PANTHERiPTHR15896. PTHR15896. 1 hit.
    PTHR15896:SF8. PTHR15896:SF8. 1 hit.
    PRINTSiPR02084. GOLM1CASC4.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative initiation. Align

    Isoform 1 (identifier: Q8NBJ4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MMGLGNGRRS MKSPPLVLAA LVACIIVLGF NYWIASSRSV DLQTRIMELE    50
    GRVRRAAAER GAVELKKNEF QGELEKQREQ LDKIQSSHNF QLESVNKLYQ 100
    DEKAVLVNNI TTGERLIRVL QDQLKTLQRN YGRLQQDVLQ FQKNQTNLER 150
    KFSYDLSQCI NQMKEVKEQC EERIEEVTKK GNEAVASRDL SENNDQRQQL 200
    QALSEPQPRL QAAGLPHTEV PQGKGNVLGN SKSQTPAPSS EVVLDSKRQV 250
    EKEETNEIQV VNEEPQRDRL PQEPGREQVV EDRPVGGRGF GGAGELGQTP 300
    QVQAALSVSQ ENPEMEGPER DQLVIPDGQE EEQEAAGEGR NQQKLRGEDD 350
    YNMDENEAES ETDKQAALAG NDRNIDVFNV EDQKRDTINL LDQREKRNHT 400
    L 401
    Length:401
    Mass (Da):45,333
    Last modified:October 1, 2002 - v1
    Checksum:i24C1DC31E47B5B77
    GO
    Isoform 2 (identifier: Q8NBJ4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-10: Missing.

    Show »
    Length:391
    Mass (Da):44,273
    Checksum:i5BCF2B6097DFA458
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti249 – 2491Q → R in CAG33482. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti217 – 2171H → R.
    Corresponds to variant rs2297002 [ dbSNP | Ensembl ].
    VAR_053922

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 1010Missing in isoform 2. CuratedVSP_018782

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF236056 mRNA. Translation: AAF44663.1.
    AY358593 mRNA. Translation: AAQ88956.1.
    CR457201 mRNA. Translation: CAG33482.1.
    AK075542 mRNA. Translation: BAC11685.1.
    BC001740 mRNA. Translation: AAH01740.1.
    CCDSiCCDS35054.1. [Q8NBJ4-1]
    RefSeqiNP_057632.2. NM_016548.3. [Q8NBJ4-1]
    NP_808800.1. NM_177937.2. [Q8NBJ4-1]
    UniGeneiHs.494337.

    Genome annotation databases

    EnsembliENST00000388711; ENSP00000373363; ENSG00000135052. [Q8NBJ4-1]
    ENST00000388712; ENSP00000373364; ENSG00000135052. [Q8NBJ4-1]
    GeneIDi51280.
    KEGGihsa:51280.
    UCSCiuc004aol.3. human. [Q8NBJ4-1]

    Polymorphism databases

    DMDMi51316027.

    Keywords - Coding sequence diversityi

    Alternative initiation, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF236056 mRNA. Translation: AAF44663.1 .
    AY358593 mRNA. Translation: AAQ88956.1 .
    CR457201 mRNA. Translation: CAG33482.1 .
    AK075542 mRNA. Translation: BAC11685.1 .
    BC001740 mRNA. Translation: AAH01740.1 .
    CCDSi CCDS35054.1. [Q8NBJ4-1 ]
    RefSeqi NP_057632.2. NM_016548.3. [Q8NBJ4-1 ]
    NP_808800.1. NM_177937.2. [Q8NBJ4-1 ]
    UniGenei Hs.494337.

    3D structure databases

    ProteinModelPortali Q8NBJ4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119432. 13 interactions.
    IntActi Q8NBJ4. 27 interactions.
    MINTi MINT-1378675.

    PTM databases

    PhosphoSitei Q8NBJ4.

    Polymorphism databases

    DMDMi 51316027.

    Proteomic databases

    MaxQBi Q8NBJ4.
    PaxDbi Q8NBJ4.
    PRIDEi Q8NBJ4.

    Protocols and materials databases

    DNASUi 51280.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000388711 ; ENSP00000373363 ; ENSG00000135052 . [Q8NBJ4-1 ]
    ENST00000388712 ; ENSP00000373364 ; ENSG00000135052 . [Q8NBJ4-1 ]
    GeneIDi 51280.
    KEGGi hsa:51280.
    UCSCi uc004aol.3. human. [Q8NBJ4-1 ]

    Organism-specific databases

    CTDi 51280.
    GeneCardsi GC09M088641.
    H-InvDB HIX0153288.
    HGNCi HGNC:15451. GOLM1.
    HPAi CAB015341.
    HPA010638.
    HPA011929.
    MIMi 606804. gene.
    neXtProti NX_Q8NBJ4.
    PharmGKBi PA28811.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG39658.
    HOGENOMi HOG000065682.
    HOVERGENi HBG062332.
    OMAi KFSYDLN.
    OrthoDBi EOG7992QP.
    PhylomeDBi Q8NBJ4.
    TreeFami TF331127.

    Miscellaneous databases

    ChiTaRSi GOLM1. human.
    GeneWikii GOLM1.
    GenomeRNAii 51280.
    NextBioi 54505.
    PROi Q8NBJ4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8NBJ4.
    Bgeei Q8NBJ4.
    CleanExi HS_GOLM1.
    Genevestigatori Q8NBJ4.

    Family and domain databases

    InterProi IPR026143. GOLM1.
    IPR026139. GOLM1/CASC4.
    [Graphical view ]
    PANTHERi PTHR15896. PTHR15896. 1 hit.
    PTHR15896:SF8. PTHR15896:SF8. 1 hit.
    PRINTSi PR02084. GOLM1CASC4.
    ProtoNeti Search...

    Publicationsi

    1. "GP73, a novel Golgi-localized protein upregulated by viral infection."
      Kladney R.D., Bulla G.A., Guo L., Mason A.L., Tollefson A.E., Simon D.J., Koutoubi Z., Fimmel C.J.
      Gene 249:53-65(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE INITIATION, GLYCOSYLATION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
      Tissue: Liver.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
      Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
      , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
      DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Teratocarcinoma.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye.
    6. "Cycling of early Golgi proteins via the cell surface and endosomes upon lumenal pH disruption."
      Puri S., Bachert C., Fimmel C.J., Linstedt A.D.
      Traffic 3:641-653(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    7. "Expression of GP73, a resident Golgi membrane protein, in viral and nonviral liver disease."
      Kladney R.D., Cui X., Bulla G.A., Brunt E.M., Fimmel C.J.
      Hepatology 35:1431-1440(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    8. "Upregulation of the Golgi protein GP73 by adenovirus infection requires the E1A CtBP interaction domain."
      Kladney R.D., Tollefson A.E., Wold W.S., Fimmel C.J.
      Virology 301:236-246(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION BY VIRAL INFECTION.
    9. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
      J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-109.
      Tissue: Plasma.
    10. "Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry."
      Ramachandran P., Boontheung P., Xie Y., Sondej M., Wong D.T., Loo J.A.
      J. Proteome Res. 5:1493-1503(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-109.
      Tissue: Saliva.
    11. Cited for: GLYCOSYLATION AT ASN-109.
    12. "Dymeclin, the gene underlying Dyggve-Melchior-Clausen syndrome, encodes a protein integral to extracellular matrix and Golgi organization and is associated with protein secretion pathways critical in bone development."
      Denais C., Dent C.L., Southgate L., Hoyle J., Dafou D., Trembath R.C., Machado R.D.
      Hum. Mutat. 32:231-239(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH DYM.

    Entry informationi

    Entry nameiGOLM1_HUMAN
    AccessioniPrimary (citable) accession number: Q8NBJ4
    Secondary accession number(s): Q6IAF4, Q9NRB9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2004
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    It is uncertain whether Met-1 or Met-2 is the initiator.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3