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Q8NBJ4

- GOLM1_HUMAN

UniProt

Q8NBJ4 - GOLM1_HUMAN

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Protein
Golgi membrane protein 1
Gene
GOLM1, C9orf155, GOLPH2, PSEC0242, UNQ686/PRO1326
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Unknown. Cellular response protein to viral infection.

GO - Molecular functioni

  1. protein binding Source: UniProtKB

GO - Biological processi

  1. nucleus organization Source: Ensembl
  2. regulation of lipid metabolic process Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Golgi membrane protein 1
Alternative name(s):
Golgi membrane protein GP73
Golgi phosphoprotein 2
Gene namesi
Name:GOLM1
Synonyms:C9orf155, GOLPH2
ORF Names:PSEC0242, UNQ686/PRO1326
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:15451. GOLM1.

Subcellular locationi

Golgi apparatuscis-Golgi network membrane; Single-pass type II membrane protein
Note: Early Golgi. Cycles via the cell surface and endosomes upon lumenal pH disruption.2 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1212Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei13 – 3523Helical; Signal-anchor for type II membrane protein; Reviewed prediction
Add
BLAST
Topological domaini36 – 401366Lumenal Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: HPA
  2. extracellular space Source: UniProt
  3. extracellular vesicular exosome Source: UniProt
  4. integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28811.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 401401Golgi membrane protein 1
PRO_0000021356Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi109 – 1091N-linked (GlcNAc...) (complex)3 Publications
Glycosylationi144 – 1441N-linked (GlcNAc...) Reviewed prediction
Glycosylationi398 – 3981N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

Glycosylated.2 Publications
Phosphorylation sites are present in the extracellular medium.

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ8NBJ4.
PaxDbiQ8NBJ4.
PRIDEiQ8NBJ4.

PTM databases

PhosphoSiteiQ8NBJ4.

Expressioni

Tissue specificityi

Widely expressed. Highly expressed in colon, prostate, trachea and stomach. Expressed at lower level in testis, muscle, lymphoid tissues, white blood cells and spleen. Predominantly expressed by cells of the epithelial lineage. Expressed at low level in normal liver. Expression significantly increases in virus (HBV, HCV) infected liver. Expression does not increase in liver disease due to non-viral causes (alcohol-induced liver disease, autoimmune hepatitis). Increased expression in hepatocytes appears to be a general feature of advanced liver disease. In liver tissue from patients with adult giant-cell hepatitis (GCH), it is strongly expressed in hepatocytes-derived syncytial giant cells. Constitutively expressed by biliary epithelial cells but not by hepatocytes.2 Publications

Inductioni

Up-regulated in response to viral infection. Induced by the E1A adenoviral protein.1 Publication

Gene expression databases

ArrayExpressiQ8NBJ4.
BgeeiQ8NBJ4.
CleanExiHS_GOLM1.
GenevestigatoriQ8NBJ4.

Organism-specific databases

HPAiCAB015341.
HPA010638.
HPA011929.

Interactioni

Subunit structurei

Interacts with DYM.1 Publication

Protein-protein interaction databases

BioGridi119432. 13 interactions.
IntActiQ8NBJ4. 27 interactions.
MINTiMINT-1378675.

Structurei

3D structure databases

ProteinModelPortaliQ8NBJ4.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili40 – 205166 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Belongs to the GOLM1/CASC4 family.

Keywords - Domaini

Coiled coil, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG39658.
HOGENOMiHOG000065682.
HOVERGENiHBG062332.
OMAiKFSYDLN.
OrthoDBiEOG7992QP.
PhylomeDBiQ8NBJ4.
TreeFamiTF331127.

Family and domain databases

InterProiIPR026143. GOLM1.
IPR026139. GOLM1/CASC4.
[Graphical view]
PANTHERiPTHR15896. PTHR15896. 1 hit.
PTHR15896:SF8. PTHR15896:SF8. 1 hit.
PRINTSiPR02084. GOLM1CASC4.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative initiation. Align

Isoform 1 (identifier: Q8NBJ4-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MMGLGNGRRS MKSPPLVLAA LVACIIVLGF NYWIASSRSV DLQTRIMELE    50
GRVRRAAAER GAVELKKNEF QGELEKQREQ LDKIQSSHNF QLESVNKLYQ 100
DEKAVLVNNI TTGERLIRVL QDQLKTLQRN YGRLQQDVLQ FQKNQTNLER 150
KFSYDLSQCI NQMKEVKEQC EERIEEVTKK GNEAVASRDL SENNDQRQQL 200
QALSEPQPRL QAAGLPHTEV PQGKGNVLGN SKSQTPAPSS EVVLDSKRQV 250
EKEETNEIQV VNEEPQRDRL PQEPGREQVV EDRPVGGRGF GGAGELGQTP 300
QVQAALSVSQ ENPEMEGPER DQLVIPDGQE EEQEAAGEGR NQQKLRGEDD 350
YNMDENEAES ETDKQAALAG NDRNIDVFNV EDQKRDTINL LDQREKRNHT 400
L 401
Length:401
Mass (Da):45,333
Last modified:October 1, 2002 - v1
Checksum:i24C1DC31E47B5B77
GO
Isoform 2 (identifier: Q8NBJ4-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: Missing.

Show »
Length:391
Mass (Da):44,273
Checksum:i5BCF2B6097DFA458
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti217 – 2171H → R.
Corresponds to variant rs2297002 [ dbSNP | Ensembl ].
VAR_053922

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1010Missing in isoform 2.
VSP_018782

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti249 – 2491Q → R in CAG33482. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF236056 mRNA. Translation: AAF44663.1.
AY358593 mRNA. Translation: AAQ88956.1.
CR457201 mRNA. Translation: CAG33482.1.
AK075542 mRNA. Translation: BAC11685.1.
BC001740 mRNA. Translation: AAH01740.1.
CCDSiCCDS35054.1. [Q8NBJ4-1]
RefSeqiNP_057632.2. NM_016548.3. [Q8NBJ4-1]
NP_808800.1. NM_177937.2. [Q8NBJ4-1]
UniGeneiHs.494337.

Genome annotation databases

EnsembliENST00000388711; ENSP00000373363; ENSG00000135052. [Q8NBJ4-1]
ENST00000388712; ENSP00000373364; ENSG00000135052. [Q8NBJ4-1]
GeneIDi51280.
KEGGihsa:51280.
UCSCiuc004aol.3. human. [Q8NBJ4-1]

Polymorphism databases

DMDMi51316027.

Keywords - Coding sequence diversityi

Alternative initiation, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF236056 mRNA. Translation: AAF44663.1 .
AY358593 mRNA. Translation: AAQ88956.1 .
CR457201 mRNA. Translation: CAG33482.1 .
AK075542 mRNA. Translation: BAC11685.1 .
BC001740 mRNA. Translation: AAH01740.1 .
CCDSi CCDS35054.1. [Q8NBJ4-1 ]
RefSeqi NP_057632.2. NM_016548.3. [Q8NBJ4-1 ]
NP_808800.1. NM_177937.2. [Q8NBJ4-1 ]
UniGenei Hs.494337.

3D structure databases

ProteinModelPortali Q8NBJ4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119432. 13 interactions.
IntActi Q8NBJ4. 27 interactions.
MINTi MINT-1378675.

PTM databases

PhosphoSitei Q8NBJ4.

Polymorphism databases

DMDMi 51316027.

Proteomic databases

MaxQBi Q8NBJ4.
PaxDbi Q8NBJ4.
PRIDEi Q8NBJ4.

Protocols and materials databases

DNASUi 51280.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000388711 ; ENSP00000373363 ; ENSG00000135052 . [Q8NBJ4-1 ]
ENST00000388712 ; ENSP00000373364 ; ENSG00000135052 . [Q8NBJ4-1 ]
GeneIDi 51280.
KEGGi hsa:51280.
UCSCi uc004aol.3. human. [Q8NBJ4-1 ]

Organism-specific databases

CTDi 51280.
GeneCardsi GC09M088641.
H-InvDB HIX0153288.
HGNCi HGNC:15451. GOLM1.
HPAi CAB015341.
HPA010638.
HPA011929.
MIMi 606804. gene.
neXtProti NX_Q8NBJ4.
PharmGKBi PA28811.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG39658.
HOGENOMi HOG000065682.
HOVERGENi HBG062332.
OMAi KFSYDLN.
OrthoDBi EOG7992QP.
PhylomeDBi Q8NBJ4.
TreeFami TF331127.

Miscellaneous databases

ChiTaRSi GOLM1. human.
GeneWikii GOLM1.
GenomeRNAii 51280.
NextBioi 54505.
PROi Q8NBJ4.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8NBJ4.
Bgeei Q8NBJ4.
CleanExi HS_GOLM1.
Genevestigatori Q8NBJ4.

Family and domain databases

InterProi IPR026143. GOLM1.
IPR026139. GOLM1/CASC4.
[Graphical view ]
PANTHERi PTHR15896. PTHR15896. 1 hit.
PTHR15896:SF8. PTHR15896:SF8. 1 hit.
PRINTSi PR02084. GOLM1CASC4.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "GP73, a novel Golgi-localized protein upregulated by viral infection."
    Kladney R.D., Bulla G.A., Guo L., Mason A.L., Tollefson A.E., Simon D.J., Koutoubi Z., Fimmel C.J.
    Gene 249:53-65(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE INITIATION, GLYCOSYLATION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    Tissue: Liver.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
    Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
    , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
    DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Teratocarcinoma.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  6. "Cycling of early Golgi proteins via the cell surface and endosomes upon lumenal pH disruption."
    Puri S., Bachert C., Fimmel C.J., Linstedt A.D.
    Traffic 3:641-653(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  7. "Expression of GP73, a resident Golgi membrane protein, in viral and nonviral liver disease."
    Kladney R.D., Cui X., Bulla G.A., Brunt E.M., Fimmel C.J.
    Hepatology 35:1431-1440(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  8. "Upregulation of the Golgi protein GP73 by adenovirus infection requires the E1A CtBP interaction domain."
    Kladney R.D., Tollefson A.E., Wold W.S., Fimmel C.J.
    Virology 301:236-246(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION BY VIRAL INFECTION.
  9. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-109.
    Tissue: Plasma.
  10. "Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry."
    Ramachandran P., Boontheung P., Xie Y., Sondej M., Wong D.T., Loo J.A.
    J. Proteome Res. 5:1493-1503(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-109.
    Tissue: Saliva.
  11. Cited for: GLYCOSYLATION AT ASN-109.
  12. "Dymeclin, the gene underlying Dyggve-Melchior-Clausen syndrome, encodes a protein integral to extracellular matrix and Golgi organization and is associated with protein secretion pathways critical in bone development."
    Denais C., Dent C.L., Southgate L., Hoyle J., Dafou D., Trembath R.C., Machado R.D.
    Hum. Mutat. 32:231-239(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DYM.

Entry informationi

Entry nameiGOLM1_HUMAN
AccessioniPrimary (citable) accession number: Q8NBJ4
Secondary accession number(s): Q6IAF4, Q9NRB9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: October 1, 2002
Last modified: September 3, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-2 is the initiator.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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