Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Golgi membrane protein 1

Gene

GOLM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Unknown. Cellular response protein to viral infection.

Caution

It is uncertain whether Met-1 or Met-2 is the initiator.Curated

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275 Post-translational protein phosphorylation

Names & Taxonomyi

Protein namesi
Recommended name:
Golgi membrane protein 1
Alternative name(s):
Golgi membrane protein GP73
Golgi phosphoprotein 2
Gene namesi
Name:GOLM1
Synonyms:C9orf155, GOLPH2
ORF Names:PSEC0242, UNQ686/PRO1326
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000135052.16
HGNCiHGNC:15451 GOLM1
MIMi606804 gene
neXtProtiNX_Q8NBJ4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 12CytoplasmicSequence analysisAdd BLAST12
Transmembranei13 – 35Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST23
Topological domaini36 – 401LumenalSequence analysisAdd BLAST366

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi51280
OpenTargetsiENSG00000135052
PharmGKBiPA28811

Polymorphism and mutation databases

BioMutaiGOLM1
DMDMi51316027

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000213561 – 401Golgi membrane protein 1Add BLAST401

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionine1 Publication1
Glycosylationi109N-linked (GlcNAc...) (complex) asparagine3 Publications1
Glycosylationi144N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei187PhosphoserineCombined sources1
Modified residuei309Phosphoserine; by FAM20C1 Publication1
Glycosylationi398N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Glycosylated.4 Publications
Phosphorylation sites are present in the extracellular medium.

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ8NBJ4
MaxQBiQ8NBJ4
PaxDbiQ8NBJ4
PeptideAtlasiQ8NBJ4
PRIDEiQ8NBJ4

PTM databases

iPTMnetiQ8NBJ4
PhosphoSitePlusiQ8NBJ4

Expressioni

Tissue specificityi

Widely expressed. Highly expressed in colon, prostate, trachea and stomach. Expressed at lower level in testis, muscle, lymphoid tissues, white blood cells and spleen. Predominantly expressed by cells of the epithelial lineage. Expressed at low level in normal liver. Expression significantly increases in virus (HBV, HCV) infected liver. Expression does not increase in liver disease due to non-viral causes (alcohol-induced liver disease, autoimmune hepatitis). Increased expression in hepatocytes appears to be a general feature of advanced liver disease. In liver tissue from patients with adult giant-cell hepatitis (GCH), it is strongly expressed in hepatocytes-derived syncytial giant cells. Constitutively expressed by biliary epithelial cells but not by hepatocytes.2 Publications

Inductioni

Up-regulated in response to viral infection. Induced by the E1A adenoviral protein.1 Publication

Gene expression databases

BgeeiENSG00000135052
CleanExiHS_GOLM1
ExpressionAtlasiQ8NBJ4 baseline and differential
GenevisibleiQ8NBJ4 HS

Organism-specific databases

HPAiCAB015341
HPA010638
HPA011929

Interactioni

Subunit structurei

Interacts with DYM.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
EGFRP0053313EBI-712073,EBI-297353

Protein-protein interaction databases

BioGridi11943239 interactors.
IntActiQ8NBJ4 58 interactors.
MINTiQ8NBJ4
STRINGi9606.ENSP00000373363

Structurei

3D structure databases

ProteinModelPortaliQ8NBJ4
SMRiQ8NBJ4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili40 – 205Sequence analysisAdd BLAST166

Sequence similaritiesi

Belongs to the GOLM1/CASC4 family.Curated

Keywords - Domaini

Coiled coil, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKCK Eukaryota
ENOG4111ZGQ LUCA
GeneTreeiENSGT00530000063675
HOGENOMiHOG000065682
HOVERGENiHBG062332
InParanoidiQ8NBJ4
OMAiREKRNHT
OrthoDBiEOG091G0D2S
PhylomeDBiQ8NBJ4
TreeFamiTF331127

Family and domain databases

InterProiView protein in InterPro
IPR026143 GOLM1
IPR026139 GOLM1/CASC4
PANTHERiPTHR15896 PTHR15896, 1 hit
PTHR15896:SF8 PTHR15896:SF8, 1 hit
PRINTSiPR02084 GOLM1CASC4

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative initiation. AlignAdd to basket

Isoform 1 (identifier: Q8NBJ4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMGLGNGRRS MKSPPLVLAA LVACIIVLGF NYWIASSRSV DLQTRIMELE
60 70 80 90 100
GRVRRAAAER GAVELKKNEF QGELEKQREQ LDKIQSSHNF QLESVNKLYQ
110 120 130 140 150
DEKAVLVNNI TTGERLIRVL QDQLKTLQRN YGRLQQDVLQ FQKNQTNLER
160 170 180 190 200
KFSYDLSQCI NQMKEVKEQC EERIEEVTKK GNEAVASRDL SENNDQRQQL
210 220 230 240 250
QALSEPQPRL QAAGLPHTEV PQGKGNVLGN SKSQTPAPSS EVVLDSKRQV
260 270 280 290 300
EKEETNEIQV VNEEPQRDRL PQEPGREQVV EDRPVGGRGF GGAGELGQTP
310 320 330 340 350
QVQAALSVSQ ENPEMEGPER DQLVIPDGQE EEQEAAGEGR NQQKLRGEDD
360 370 380 390 400
YNMDENEAES ETDKQAALAG NDRNIDVFNV EDQKRDTINL LDQREKRNHT

L
Length:401
Mass (Da):45,333
Last modified:October 1, 2002 - v1
Checksum:i24C1DC31E47B5B77
GO
Isoform 2 (identifier: Q8NBJ4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: Missing.

Show »
Length:391
Mass (Da):44,273
Checksum:i5BCF2B6097DFA458
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti249Q → R in CAG33482 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053922217H → R. Corresponds to variant dbSNP:rs2297002Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0187821 – 10Missing in isoform 2. Curated10

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF236056 mRNA Translation: AAF44663.1
AY358593 mRNA Translation: AAQ88956.1
CR457201 mRNA Translation: CAG33482.1
AK075542 mRNA Translation: BAC11685.1
BC001740 mRNA Translation: AAH01740.1
CCDSiCCDS35054.1 [Q8NBJ4-1]
RefSeqiNP_057632.2, NM_016548.3 [Q8NBJ4-1]
NP_808800.1, NM_177937.2 [Q8NBJ4-1]
UniGeneiHs.494337

Genome annotation databases

EnsembliENST00000388711; ENSP00000373363; ENSG00000135052 [Q8NBJ4-1]
ENST00000388712; ENSP00000373364; ENSG00000135052 [Q8NBJ4-1]
GeneIDi51280
KEGGihsa:51280
UCSCiuc004aol.4 human [Q8NBJ4-1]

Keywords - Coding sequence diversityi

Alternative initiation, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiGOLM1_HUMAN
AccessioniPrimary (citable) accession number: Q8NBJ4
Secondary accession number(s): Q6IAF4, Q9NRB9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: October 1, 2002
Last modified: March 28, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome