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Protein

Golgi membrane protein 1

Gene

GOLM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Unknown. Cellular response protein to viral infection.

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Golgi membrane protein 1
Alternative name(s):
Golgi membrane protein GP73
Golgi phosphoprotein 2
Gene namesi
Name:GOLM1
Synonyms:C9orf155, GOLPH2
ORF Names:PSEC0242, UNQ686/PRO1326
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:15451. GOLM1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 12CytoplasmicSequence analysisAdd BLAST12
Transmembranei13 – 35Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST23
Topological domaini36 – 401LumenalSequence analysisAdd BLAST366

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • extracellular space Source: UniProtKB
  • Golgi apparatus Source: ProtInc
  • integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi51280.
OpenTargetsiENSG00000135052.
PharmGKBiPA28811.

Polymorphism and mutation databases

BioMutaiGOLM1.
DMDMi51316027.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000213561 – 401Golgi membrane protein 1Add BLAST401

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi109N-linked (GlcNAc...) (complex)3 Publications1
Glycosylationi144N-linked (GlcNAc...)Sequence analysis1
Modified residuei187PhosphoserineCombined sources1
Modified residuei309Phosphoserine; by FAM20C1 Publication1
Glycosylationi398N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Glycosylated.4 Publications
Phosphorylation sites are present in the extracellular medium.

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ8NBJ4.
MaxQBiQ8NBJ4.
PaxDbiQ8NBJ4.
PeptideAtlasiQ8NBJ4.
PRIDEiQ8NBJ4.

PTM databases

iPTMnetiQ8NBJ4.
PhosphoSitePlusiQ8NBJ4.

Expressioni

Tissue specificityi

Widely expressed. Highly expressed in colon, prostate, trachea and stomach. Expressed at lower level in testis, muscle, lymphoid tissues, white blood cells and spleen. Predominantly expressed by cells of the epithelial lineage. Expressed at low level in normal liver. Expression significantly increases in virus (HBV, HCV) infected liver. Expression does not increase in liver disease due to non-viral causes (alcohol-induced liver disease, autoimmune hepatitis). Increased expression in hepatocytes appears to be a general feature of advanced liver disease. In liver tissue from patients with adult giant-cell hepatitis (GCH), it is strongly expressed in hepatocytes-derived syncytial giant cells. Constitutively expressed by biliary epithelial cells but not by hepatocytes.2 Publications

Inductioni

Up-regulated in response to viral infection. Induced by the E1A adenoviral protein.1 Publication

Gene expression databases

BgeeiENSG00000135052.
CleanExiHS_GOLM1.
ExpressionAtlasiQ8NBJ4. baseline and differential.
GenevisibleiQ8NBJ4. HS.

Organism-specific databases

HPAiCAB015341.
HPA010638.
HPA011929.

Interactioni

Subunit structurei

Interacts with DYM.1 Publication

Protein-protein interaction databases

BioGridi119432. 29 interactors.
IntActiQ8NBJ4. 31 interactors.
MINTiMINT-1378675.
STRINGi9606.ENSP00000373363.

Structurei

3D structure databases

ProteinModelPortaliQ8NBJ4.
SMRiQ8NBJ4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili40 – 205Sequence analysisAdd BLAST166

Sequence similaritiesi

Belongs to the GOLM1/CASC4 family.Curated

Keywords - Domaini

Coiled coil, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKCK. Eukaryota.
ENOG4111ZGQ. LUCA.
GeneTreeiENSGT00530000063675.
HOGENOMiHOG000065682.
HOVERGENiHBG062332.
InParanoidiQ8NBJ4.
OMAiNQETEGP.
OrthoDBiEOG091G0D2S.
PhylomeDBiQ8NBJ4.
TreeFamiTF331127.

Family and domain databases

InterProiIPR026143. GOLM1.
IPR026139. GOLM1/CASC4.
[Graphical view]
PANTHERiPTHR15896. PTHR15896. 1 hit.
PTHR15896:SF8. PTHR15896:SF8. 1 hit.
PRINTSiPR02084. GOLM1CASC4.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative initiation. AlignAdd to basket

Isoform 1 (identifier: Q8NBJ4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMGLGNGRRS MKSPPLVLAA LVACIIVLGF NYWIASSRSV DLQTRIMELE
60 70 80 90 100
GRVRRAAAER GAVELKKNEF QGELEKQREQ LDKIQSSHNF QLESVNKLYQ
110 120 130 140 150
DEKAVLVNNI TTGERLIRVL QDQLKTLQRN YGRLQQDVLQ FQKNQTNLER
160 170 180 190 200
KFSYDLSQCI NQMKEVKEQC EERIEEVTKK GNEAVASRDL SENNDQRQQL
210 220 230 240 250
QALSEPQPRL QAAGLPHTEV PQGKGNVLGN SKSQTPAPSS EVVLDSKRQV
260 270 280 290 300
EKEETNEIQV VNEEPQRDRL PQEPGREQVV EDRPVGGRGF GGAGELGQTP
310 320 330 340 350
QVQAALSVSQ ENPEMEGPER DQLVIPDGQE EEQEAAGEGR NQQKLRGEDD
360 370 380 390 400
YNMDENEAES ETDKQAALAG NDRNIDVFNV EDQKRDTINL LDQREKRNHT

L
Length:401
Mass (Da):45,333
Last modified:October 1, 2002 - v1
Checksum:i24C1DC31E47B5B77
GO
Isoform 2 (identifier: Q8NBJ4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: Missing.

Show »
Length:391
Mass (Da):44,273
Checksum:i5BCF2B6097DFA458
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti249Q → R in CAG33482 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053922217H → R.Corresponds to variant rs2297002dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0187821 – 10Missing in isoform 2. Curated10

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF236056 mRNA. Translation: AAF44663.1.
AY358593 mRNA. Translation: AAQ88956.1.
CR457201 mRNA. Translation: CAG33482.1.
AK075542 mRNA. Translation: BAC11685.1.
BC001740 mRNA. Translation: AAH01740.1.
CCDSiCCDS35054.1. [Q8NBJ4-1]
RefSeqiNP_057632.2. NM_016548.3. [Q8NBJ4-1]
NP_808800.1. NM_177937.2. [Q8NBJ4-1]
UniGeneiHs.494337.

Genome annotation databases

EnsembliENST00000388711; ENSP00000373363; ENSG00000135052. [Q8NBJ4-1]
ENST00000388712; ENSP00000373364; ENSG00000135052. [Q8NBJ4-1]
GeneIDi51280.
KEGGihsa:51280.
UCSCiuc004aol.4. human. [Q8NBJ4-1]

Keywords - Coding sequence diversityi

Alternative initiation, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF236056 mRNA. Translation: AAF44663.1.
AY358593 mRNA. Translation: AAQ88956.1.
CR457201 mRNA. Translation: CAG33482.1.
AK075542 mRNA. Translation: BAC11685.1.
BC001740 mRNA. Translation: AAH01740.1.
CCDSiCCDS35054.1. [Q8NBJ4-1]
RefSeqiNP_057632.2. NM_016548.3. [Q8NBJ4-1]
NP_808800.1. NM_177937.2. [Q8NBJ4-1]
UniGeneiHs.494337.

3D structure databases

ProteinModelPortaliQ8NBJ4.
SMRiQ8NBJ4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119432. 29 interactors.
IntActiQ8NBJ4. 31 interactors.
MINTiMINT-1378675.
STRINGi9606.ENSP00000373363.

PTM databases

iPTMnetiQ8NBJ4.
PhosphoSitePlusiQ8NBJ4.

Polymorphism and mutation databases

BioMutaiGOLM1.
DMDMi51316027.

Proteomic databases

EPDiQ8NBJ4.
MaxQBiQ8NBJ4.
PaxDbiQ8NBJ4.
PeptideAtlasiQ8NBJ4.
PRIDEiQ8NBJ4.

Protocols and materials databases

DNASUi51280.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000388711; ENSP00000373363; ENSG00000135052. [Q8NBJ4-1]
ENST00000388712; ENSP00000373364; ENSG00000135052. [Q8NBJ4-1]
GeneIDi51280.
KEGGihsa:51280.
UCSCiuc004aol.4. human. [Q8NBJ4-1]

Organism-specific databases

CTDi51280.
DisGeNETi51280.
GeneCardsiGOLM1.
H-InvDBHIX0153288.
HGNCiHGNC:15451. GOLM1.
HPAiCAB015341.
HPA010638.
HPA011929.
MIMi606804. gene.
neXtProtiNX_Q8NBJ4.
OpenTargetsiENSG00000135052.
PharmGKBiPA28811.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKCK. Eukaryota.
ENOG4111ZGQ. LUCA.
GeneTreeiENSGT00530000063675.
HOGENOMiHOG000065682.
HOVERGENiHBG062332.
InParanoidiQ8NBJ4.
OMAiNQETEGP.
OrthoDBiEOG091G0D2S.
PhylomeDBiQ8NBJ4.
TreeFamiTF331127.

Miscellaneous databases

ChiTaRSiGOLM1. human.
GeneWikiiGOLM1.
GenomeRNAii51280.
PROiQ8NBJ4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000135052.
CleanExiHS_GOLM1.
ExpressionAtlasiQ8NBJ4. baseline and differential.
GenevisibleiQ8NBJ4. HS.

Family and domain databases

InterProiIPR026143. GOLM1.
IPR026139. GOLM1/CASC4.
[Graphical view]
PANTHERiPTHR15896. PTHR15896. 1 hit.
PTHR15896:SF8. PTHR15896:SF8. 1 hit.
PRINTSiPR02084. GOLM1CASC4.
ProtoNetiSearch...

Entry informationi

Entry nameiGOLM1_HUMAN
AccessioniPrimary (citable) accession number: Q8NBJ4
Secondary accession number(s): Q6IAF4, Q9NRB9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-2 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.