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Protein

Solute carrier family 43 member 3

Gene

SLC43A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Putative transporter.By similarity

GO - Biological processi

Complete GO annotation...

Protein family/group databases

TCDBi2.A.1.44.3. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 43 member 3
Alternative name(s):
Protein FOAP-13
Gene namesi
Name:SLC43A3
ORF Names:PSEC0252
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:17466. SLC43A3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei17 – 3721HelicalSequence analysisAdd
BLAST
Transmembranei72 – 9221HelicalSequence analysisAdd
BLAST
Transmembranei102 – 12221HelicalSequence analysisAdd
BLAST
Transmembranei123 – 14321HelicalSequence analysisAdd
BLAST
Transmembranei156 – 17621HelicalSequence analysisAdd
BLAST
Transmembranei188 – 20821HelicalSequence analysisAdd
BLAST
Transmembranei279 – 29921HelicalSequence analysisAdd
BLAST
Transmembranei319 – 33921HelicalSequence analysisAdd
BLAST
Transmembranei356 – 37621HelicalSequence analysisAdd
BLAST
Transmembranei396 – 41823HelicalSequence analysisAdd
BLAST
Transmembranei427 – 44721HelicalSequence analysisAdd
BLAST
Transmembranei456 – 47621HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134924689.

Polymorphism and mutation databases

BioMutaiSLC43A3.
DMDMi158706361.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 491491Solute carrier family 43 member 3PRO_0000305036Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi56 – 561N-linked (GlcNAc...)Sequence analysis
Glycosylationi220 – 2201N-linked (GlcNAc...)Sequence analysis
Glycosylationi229 – 2291N-linked (GlcNAc...)Sequence analysis
Modified residuei253 – 2531PhosphoserineCombined sources
Modified residuei258 – 2581PhosphothreonineCombined sources

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ8NBI5.
MaxQBiQ8NBI5.
PaxDbiQ8NBI5.
PeptideAtlasiQ8NBI5.
PRIDEiQ8NBI5.

PTM databases

iPTMnetiQ8NBI5.
PhosphoSiteiQ8NBI5.
SwissPalmiQ8NBI5.

Expressioni

Tissue specificityi

Highly expressed in macrophages.1 Publication

Gene expression databases

BgeeiQ8NBI5.
CleanExiHS_SLC43A3.
ExpressionAtlasiQ8NBI5. baseline and differential.
GenevisibleiQ8NBI5. HS.

Organism-specific databases

HPAiHPA030551.

Interactioni

Protein-protein interaction databases

BioGridi118823. 14 interactions.
IntActiQ8NBI5. 10 interactions.
STRINGi9606.ENSP00000337561.

Structurei

3D structure databases

ProteinModelPortaliQ8NBI5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IENT. Eukaryota.
ENOG410XSRN. LUCA.
GeneTreeiENSGT00530000063043.
HOGENOMiHOG000154238.
HOVERGENiHBG102974.
InParanoidiQ8NBI5.
KOiK08230.
OMAiQHVSAID.
OrthoDBiEOG712TWX.
PhylomeDBiQ8NBI5.
TreeFamiTF328358.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR027197. SLC43A3.
[Graphical view]
PANTHERiPTHR20765. PTHR20765. 1 hit.
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NBI5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGQGLPLHV ATLLTGLLEC LGFAGVLFGW PSLVFVFKNE DYFKDLCGPD
60 70 80 90 100
AGPIGNATGQ ADCKAQDERF SLIFTLGSFM NNFMTFPTGY IFDRFKTTVA
110 120 130 140 150
RLIAIFFYTT ATLIIAFTSA GSAVLLFLAM PMLTIGGILF LITNLQIGNL
160 170 180 190 200
FGQHRSTIIT LYNGAFDSSS AVFLIIKLLY EKGISLRASF IFISVCSTWH
210 220 230 240 250
VARTFLLMPR GHIPYPLPPN YSYGLCPGNG TTKEEKETAE HENRELQSKE
260 270 280 290 300
FLSAKEETPG AGQKQELRSF WSYAFSRRFA WHLVWLSVIQ LWHYLFIGTL
310 320 330 340 350
NSLLTNMAGG DMARVSTYTN AFAFTQFGVL CAPWNGLLMD RLKQKYQKEA
360 370 380 390 400
RKTGSSTLAV ALCSTVPSLA LTSLLCLGFA LCASVPILPL QYLTFILQVI
410 420 430 440 450
SRSFLYGSNA AFLTLAFPSE HFGKLFGLVM ALSAVVSLLQ FPIFTLIKGS
460 470 480 490
LQNDPFYVNV MFMLAILLTF FHPFLVYREC RTWKESPSAI A
Length:491
Mass (Da):54,529
Last modified:October 2, 2007 - v2
Checksum:iC6BC8E48F38B1D8C
GO
Isoform 2 (identifier: Q8NBI5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     61-61: A → AGRLGCMGDLFSTP

Note: No experimental confirmation available.
Show »
Length:504
Mass (Da):55,864
Checksum:i93D0EBFC39DAC502
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti172 – 1721V → A in BAG60330 (PubMed:14702039).Curated
Sequence conflicti459 – 4591N → D in BAC11695 (PubMed:16303743).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti53 – 531P → L.
Corresponds to variant rs34799622 [ dbSNP | Ensembl ].
VAR_035156

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei61 – 611A → AGRLGCMGDLFSTP in isoform 2. 1 PublicationVSP_055620

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028927 mRNA. Translation: BAB82466.1.
AK298028 mRNA. Translation: BAG60330.1.
CR457391 mRNA. Translation: CAG33672.1.
AK075552 mRNA. Translation: BAC11695.1.
AL157431 mRNA. Translation: CAB75655.1.
AP000781 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW73741.1.
BC003163 mRNA. Translation: AAH03163.1.
CCDSiCCDS60784.1. [Q8NBI5-2]
CCDS7956.1. [Q8NBI5-1]
PIRiT46915.
RefSeqiNP_001265130.1. NM_001278201.1. [Q8NBI5-1]
NP_001265135.1. NM_001278206.1. [Q8NBI5-2]
NP_054815.2. NM_014096.3. [Q8NBI5-1]
NP_060081.1. NM_017611.2. [Q8NBI5-1]
NP_955361.1. NM_199329.2. [Q8NBI5-1]
UniGeneiHs.99962.

Genome annotation databases

EnsembliENST00000352187; ENSP00000337561; ENSG00000134802. [Q8NBI5-1]
ENST00000395123; ENSP00000378555; ENSG00000134802. [Q8NBI5-1]
ENST00000395124; ENSP00000378556; ENSG00000134802. [Q8NBI5-1]
ENST00000529554; ENSP00000436254; ENSG00000134802. [Q8NBI5-1]
ENST00000533524; ENSP00000434515; ENSG00000134802. [Q8NBI5-2]
GeneIDi29015.
KEGGihsa:29015.
UCSCiuc001nkg.5. human. [Q8NBI5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB028927 mRNA. Translation: BAB82466.1.
AK298028 mRNA. Translation: BAG60330.1.
CR457391 mRNA. Translation: CAG33672.1.
AK075552 mRNA. Translation: BAC11695.1.
AL157431 mRNA. Translation: CAB75655.1.
AP000781 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW73741.1.
BC003163 mRNA. Translation: AAH03163.1.
CCDSiCCDS60784.1. [Q8NBI5-2]
CCDS7956.1. [Q8NBI5-1]
PIRiT46915.
RefSeqiNP_001265130.1. NM_001278201.1. [Q8NBI5-1]
NP_001265135.1. NM_001278206.1. [Q8NBI5-2]
NP_054815.2. NM_014096.3. [Q8NBI5-1]
NP_060081.1. NM_017611.2. [Q8NBI5-1]
NP_955361.1. NM_199329.2. [Q8NBI5-1]
UniGeneiHs.99962.

3D structure databases

ProteinModelPortaliQ8NBI5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118823. 14 interactions.
IntActiQ8NBI5. 10 interactions.
STRINGi9606.ENSP00000337561.

Protein family/group databases

TCDBi2.A.1.44.3. the major facilitator superfamily (mfs).

PTM databases

iPTMnetiQ8NBI5.
PhosphoSiteiQ8NBI5.
SwissPalmiQ8NBI5.

Polymorphism and mutation databases

BioMutaiSLC43A3.
DMDMi158706361.

Proteomic databases

EPDiQ8NBI5.
MaxQBiQ8NBI5.
PaxDbiQ8NBI5.
PeptideAtlasiQ8NBI5.
PRIDEiQ8NBI5.

Protocols and materials databases

DNASUi29015.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000352187; ENSP00000337561; ENSG00000134802. [Q8NBI5-1]
ENST00000395123; ENSP00000378555; ENSG00000134802. [Q8NBI5-1]
ENST00000395124; ENSP00000378556; ENSG00000134802. [Q8NBI5-1]
ENST00000529554; ENSP00000436254; ENSG00000134802. [Q8NBI5-1]
ENST00000533524; ENSP00000434515; ENSG00000134802. [Q8NBI5-2]
GeneIDi29015.
KEGGihsa:29015.
UCSCiuc001nkg.5. human. [Q8NBI5-1]

Organism-specific databases

CTDi29015.
GeneCardsiSLC43A3.
H-InvDBHIX0079404.
HGNCiHGNC:17466. SLC43A3.
HPAiHPA030551.
neXtProtiNX_Q8NBI5.
PharmGKBiPA134924689.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IENT. Eukaryota.
ENOG410XSRN. LUCA.
GeneTreeiENSGT00530000063043.
HOGENOMiHOG000154238.
HOVERGENiHBG102974.
InParanoidiQ8NBI5.
KOiK08230.
OMAiQHVSAID.
OrthoDBiEOG712TWX.
PhylomeDBiQ8NBI5.
TreeFamiTF328358.

Miscellaneous databases

ChiTaRSiSLC43A3. human.
GenomeRNAii29015.
PROiQ8NBI5.

Gene expression databases

BgeeiQ8NBI5.
CleanExiHS_SLC43A3.
ExpressionAtlasiQ8NBI5. baseline and differential.
GenevisibleiQ8NBI5. HS.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR027197. SLC43A3.
[Graphical view]
PANTHERiPTHR20765. PTHR20765. 1 hit.
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of a human novel gene, FOAP-13, which are highly expressed in macrophages."
    Fujii Y., Tsuritani K., Yajima Y., Amemiya T., Ukai Y., Naito K., Kawaguchi A., Takayama K.
    Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Lung.
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
    Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
    , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
    DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Melanoma.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Kidney.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-258, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-258, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-253 AND THR-258, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Erythroleukemia.

Entry informationi

Entry nameiS43A3_HUMAN
AccessioniPrimary (citable) accession number: Q8NBI5
Secondary accession number(s): B4DNR8, E7EQD2, Q9NSS4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: July 6, 2016
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.