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Protein

Draxin

Gene

DRAXIN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway.UniRule annotation

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
DraxinUniRule annotation
Alternative name(s):
Dorsal inhibitory axon guidance proteinUniRule annotation
Dorsal repulsive axon guidance proteinUniRule annotation
Neucrin
Gene namesi
Name:DRAXINUniRule annotation
Synonyms:C1orf187
ORF Names:PSEC0258, UNQ3119/PRO10268
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:25054. DRAXIN.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672435.

Polymorphism and mutation databases

BioMutaiDRAXIN.
DMDMi124007126.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525UniRule annotation1 PublicationAdd
BLAST
Chaini26 – 349324DraxinPRO_0000273243Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi264 – 2641N-linked (GlcNAc...)UniRule annotation

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8NBI3.
PRIDEiQ8NBI3.

PTM databases

iPTMnetiQ8NBI3.
PhosphoSiteiQ8NBI3.

Expressioni

Gene expression databases

BgeeiQ8NBI3.
CleanExiHS_C1orf187.
GenevisibleiQ8NBI3. HS.

Organism-specific databases

HPAiHPA014302.

Interactioni

Subunit structurei

Interacts with LRP6.UniRule annotation

Binary interactionsi

WithEntry#Exp.IntActNotes
NTN1O956313EBI-10827752,EBI-2678626
NTN3O006342EBI-10827752,EBI-10831998

Protein-protein interaction databases

IntActiQ8NBI3. 3 interactions.
STRINGi9606.ENSP00000294485.

Structurei

3D structure databases

ProteinModelPortaliQ8NBI3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the draxin family.UniRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IKDT. Eukaryota.
ENOG4111MNU. LUCA.
GeneTreeiENSGT00390000013828.
HOGENOMiHOG000112267.
HOVERGENiHBG107824.
InParanoidiQ8NBI3.
OMAiCMEGLRC.
OrthoDBiEOG7R2BK0.
PhylomeDBiQ8NBI3.
TreeFamiTF333255.

Family and domain databases

HAMAPiMF_03060. Draxin.
InterProiIPR029094. Draxin.
[Graphical view]
PfamiPF15550. Draxin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8NBI3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGPAIHTAP MLFLVLLLPL ELSLAGALAP GTPARNLPEN HIDLPGPALW
60 70 80 90 100
TPQASHHRRR GPGKKEWGPG LPSQAQDGAV VTATRQASRL PEAEGLLPEQ
110 120 130 140 150
SPAGLLQDKD LLLGLALPYP EKENRPPGWE RTRKRSREHK RRRDRLRLHQ
160 170 180 190 200
GRALVRGPSS LMKKAELSEA QVLDAAMEES STSLAPTMFF LTTFEAAPAT
210 220 230 240 250
EESLILPVTS LRPQQAQPRS DGEVMPTLDM ALFDWTDYED LKPDGWPSAK
260 270 280 290 300
KKEKHRGKLS SDGNETSPAE GEPCDHHQDC LPGTCCDLRE HLCTPHNRGL
310 320 330 340
NNKCFDDCMC VEGLRCYAKF HRNRRVTRRK GRCVEPETAN GDQGSFINV
Length:349
Mass (Da):38,650
Last modified:January 23, 2007 - v2
Checksum:i8AC00A42A1AFB105
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti20 – 212LE → Q in AAQ89110 (PubMed:19857465).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti37 – 371L → F.3 Publications
Corresponds to variant rs11121804 [ dbSNP | Ensembl ].
VAR_030114

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB301919 mRNA. Translation: BAG80561.1.
AY358750 mRNA. Translation: AAQ89110.1.
AK075558 mRNA. Translation: BAC11697.1.
AL953897, AL031731 Genomic DNA. Translation: CAI15884.1.
AL031731, AL953897 Genomic DNA. Translation: CAI20222.1.
BC111064 mRNA. Translation: AAI11065.1.
CCDSiCCDS135.1.
RefSeqiNP_940947.3. NM_198545.3.
UniGeneiHs.632364.
Hs.733197.

Genome annotation databases

EnsembliENST00000294485; ENSP00000294485; ENSG00000162490.
GeneIDi374946.
KEGGihsa:374946.
UCSCiuc001ass.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB301919 mRNA. Translation: BAG80561.1.
AY358750 mRNA. Translation: AAQ89110.1.
AK075558 mRNA. Translation: BAC11697.1.
AL953897, AL031731 Genomic DNA. Translation: CAI15884.1.
AL031731, AL953897 Genomic DNA. Translation: CAI20222.1.
BC111064 mRNA. Translation: AAI11065.1.
CCDSiCCDS135.1.
RefSeqiNP_940947.3. NM_198545.3.
UniGeneiHs.632364.
Hs.733197.

3D structure databases

ProteinModelPortaliQ8NBI3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8NBI3. 3 interactions.
STRINGi9606.ENSP00000294485.

PTM databases

iPTMnetiQ8NBI3.
PhosphoSiteiQ8NBI3.

Polymorphism and mutation databases

BioMutaiDRAXIN.
DMDMi124007126.

Proteomic databases

PaxDbiQ8NBI3.
PRIDEiQ8NBI3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000294485; ENSP00000294485; ENSG00000162490.
GeneIDi374946.
KEGGihsa:374946.
UCSCiuc001ass.4. human.

Organism-specific databases

CTDi374946.
GeneCardsiDRAXIN.
HGNCiHGNC:25054. DRAXIN.
HPAiHPA014302.
MIMi612682. gene.
neXtProtiNX_Q8NBI3.
PharmGKBiPA142672435.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKDT. Eukaryota.
ENOG4111MNU. LUCA.
GeneTreeiENSGT00390000013828.
HOGENOMiHOG000112267.
HOVERGENiHBG107824.
InParanoidiQ8NBI3.
OMAiCMEGLRC.
OrthoDBiEOG7R2BK0.
PhylomeDBiQ8NBI3.
TreeFamiTF333255.

Miscellaneous databases

GenomeRNAii374946.
NextBioi100344.
PROiQ8NBI3.
SOURCEiSearch...

Gene expression databases

BgeeiQ8NBI3.
CleanExiHS_C1orf187.
GenevisibleiQ8NBI3. HS.

Family and domain databases

HAMAPiMF_03060. Draxin.
InterProiIPR029094. Draxin.
[Graphical view]
PfamiPF15550. Draxin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Neucrin is a novel neural-specific secreted antagonist to canonical Wnt signaling."
    Miyake A., Takahashi Y., Miwa H., Shimada A., Konishi M., Itoh N.
    Biochem. Biophys. Res. Commun. 390:1051-1055(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT PHE-37.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
    Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J., Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S., Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.
    , Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S., Isogai T.
    DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PHE-37.
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Fetal brain.
  6. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 26-40, VARIANT PHE-37.

Entry informationi

Entry nameiDRAXI_HUMAN
AccessioniPrimary (citable) accession number: Q8NBI3
Secondary accession number(s): B6EV15, Q5SNX0, Q6UWK8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: January 23, 2007
Last modified: March 16, 2016
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.