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Q8NBF1

- GLIS1_HUMAN

UniProt

Q8NBF1 - GLIS1_HUMAN

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Protein
Zinc finger protein GLIS1
Gene
GLIS1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Acts as both a repressor and activator of transcription. Binds to the consensus sequence 5'-GACCACCCAC-3' By similarity.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri195 – 22026C2H2-type 1
Add
BLAST
Zinc fingeri229 – 25628C2H2-type 2; atypical
Add
BLAST
Zinc fingeri262 – 28625C2H2-type 3
Add
BLAST
Zinc fingeri292 – 31625C2H2-type 4
Add
BLAST
Zinc fingeri322 – 34625C2H2-type 5
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  2. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  3. transcription from RNA polymerase II promoter Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein GLIS1
Alternative name(s):
GLI-similar 1
Gene namesi
Name:GLIS1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:29525. GLIS1.

Subcellular locationi

Nucleus By similarity By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134948186.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 620620Zinc finger protein GLIS1
PRO_0000047209Add
BLAST

Proteomic databases

PaxDbiQ8NBF1.
PRIDEiQ8NBF1.

PTM databases

PhosphoSiteiQ8NBF1.

Expressioni

Gene expression databases

BgeeiQ8NBF1.
CleanExiHS_GLIS1.
GenevestigatoriQ8NBF1.

Organism-specific databases

HPAiHPA001409.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000309653.

Structurei

3D structure databases

ProteinModelPortaliQ8NBF1.
SMRiQ8NBF1. Positions 197-370.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi340 – 35617Bipartite nuclear localization signal Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi456 – 51156Pro-rich
Add
BLAST

Sequence similaritiesi

Belongs to the GLI C2H2-type zinc-finger protein family.By similarity

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
HOGENOMiHOG000231136.
HOVERGENiHBG051736.
InParanoidiQ8NBF1.
KOiK09232.
OMAiLRPNGYH.
OrthoDBiEOG70S75H.
PhylomeDBiQ8NBF1.
TreeFamiTF350216.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NBF1-1 [UniParc]FASTAAdd to Basket

« Hide

MAEARTSLSA HCRGPLATGL HPDLDLPGRS LATPAPSCYL LGSEPSSGLG    50
LQPETHLPEG SLKRCCVLGL PPTSPASSSP CASSDVTSII RSSQTSLVTC 100
VNGLRSPPLT GDLGGPSKRA RPGPASTDSH EGSLQLEACR KASFLKQEPA 150
DEFSELFGPH QQGLPPPYPL SQLPPGPSLG GLGLGLAGRV VAGRQACRWV 200
DCCAAYEQQE ELVRHIEKSH IDQRKGEDFT CFWAGCVRRY KPFNARYKLL 250
IHMRVHSGEK PNKCMFEGCS KAFSRLENLK IHLRSHTGEK PYLCQHPGCQ 300
KAFSNSSDRA KHQRTHLDTK PYACQIPGCS KRYTDPSSLR KHVKAHSAKE 350
QQVRKKLHAG PDTEADVLTE CLVLQQLHTS TQLAASDGKG GCGLGQELLP 400
GVYPGSITPH NGLASGLLPP AHDVPSRHHP LDATTSSHHH LSPLPMAEST 450
RDGLGPGLLS PIVSPLKGLG PPPLPPSSQS HSPGGQPFPT LPSKPSYPPF 500
QSPPPPPLPS PQGYQGSFHS IQSCFPYGDC YRMAEPAAGG DGLVGETHGF 550
NPLRPNGYHS LSTPLPATGY EALAEASCPT ALPQQPSEDV VSSGPEDCGF 600
FPNGAFDHCL GHIPSIYTDT 620
Length:620
Mass (Da):65,976
Last modified:October 14, 2008 - v2
Checksum:iA07F61B35CF12EB7
GO

Sequence cautioni

The sequence BAC04178.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti110 – 1101T → A.1 Publication
Corresponds to variant rs4307514 [ dbSNP | Ensembl ].
VAR_047031
Natural varianti157 – 1571F → L.
Corresponds to variant rs34961060 [ dbSNP | Ensembl ].
VAR_033544
Natural varianti187 – 1871A → G.1 Publication
Corresponds to variant rs35227000 [ dbSNP | Ensembl ].
VAR_047032

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti221 – 2211I → T in BAC03494. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK090634 mRNA. Translation: BAC03494.1.
AK093474 mRNA. Translation: BAC04178.1. Different initiation.
AL591720, AC105280 Genomic DNA. Translation: CAH72026.1.
CH471059 Genomic DNA. Translation: EAX06734.1.
BC101799 mRNA. Translation: AAI01800.1.
BC104911 mRNA. Translation: AAI04912.1.
CCDSiCCDS582.1.
RefSeqiNP_671726.2. NM_147193.2.
UniGeneiHs.306691.

Genome annotation databases

EnsembliENST00000312233; ENSP00000309653; ENSG00000174332.
GeneIDi148979.
KEGGihsa:148979.
UCSCiuc001cvr.1. human.

Polymorphism databases

DMDMi209572624.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK090634 mRNA. Translation: BAC03494.1 .
AK093474 mRNA. Translation: BAC04178.1 . Different initiation.
AL591720 , AC105280 Genomic DNA. Translation: CAH72026.1 .
CH471059 Genomic DNA. Translation: EAX06734.1 .
BC101799 mRNA. Translation: AAI01800.1 .
BC104911 mRNA. Translation: AAI04912.1 .
CCDSi CCDS582.1.
RefSeqi NP_671726.2. NM_147193.2.
UniGenei Hs.306691.

3D structure databases

ProteinModelPortali Q8NBF1.
SMRi Q8NBF1. Positions 197-370.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000309653.

PTM databases

PhosphoSitei Q8NBF1.

Polymorphism databases

DMDMi 209572624.

Proteomic databases

PaxDbi Q8NBF1.
PRIDEi Q8NBF1.

Protocols and materials databases

DNASUi 148979.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000312233 ; ENSP00000309653 ; ENSG00000174332 .
GeneIDi 148979.
KEGGi hsa:148979.
UCSCi uc001cvr.1. human.

Organism-specific databases

CTDi 148979.
GeneCardsi GC01M053971.
HGNCi HGNC:29525. GLIS1.
HPAi HPA001409.
MIMi 610378. gene.
neXtProti NX_Q8NBF1.
PharmGKBi PA134948186.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
HOGENOMi HOG000231136.
HOVERGENi HBG051736.
InParanoidi Q8NBF1.
KOi K09232.
OMAi LRPNGYH.
OrthoDBi EOG70S75H.
PhylomeDBi Q8NBF1.
TreeFami TF350216.

Miscellaneous databases

ChiTaRSi GLIS1. human.
GeneWikii GLIS1.
GenomeRNAii 148979.
NextBioi 86045.
PROi Q8NBF1.
SOURCEi Search...

Gene expression databases

Bgeei Q8NBF1.
CleanExi HS_GLIS1.
Genevestigatori Q8NBF1.

Family and domain databases

Gene3Di 3.30.160.60. 5 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 5 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ALA-110 AND GLY-187.
    Tissue: Glial tumor and Testis.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung and Placenta.

Entry informationi

Entry nameiGLIS1_HUMAN
AccessioniPrimary (citable) accession number: Q8NBF1
Secondary accession number(s): Q2M3G9, Q8N9V9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: October 14, 2008
Last modified: July 9, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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