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Protein

Zinc finger protein GLIS1

Gene

GLIS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as both a repressor and activator of transcription. Binds to the consensus sequence 5'-GACCACCCAC-3' (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri195 – 220C2H2-type 1PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri229 – 256C2H2-type 2; atypicalPROSITE-ProRule annotationAdd BLAST28
Zinc fingeri262 – 286C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri292 – 316C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri322 – 346C2H2-type 5PROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000174332-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein GLIS1
Alternative name(s):
GLI-similar 1
Gene namesi
Name:GLIS1Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:29525. GLIS1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi148979.
OpenTargetsiENSG00000174332.
PharmGKBiPA134948186.

Polymorphism and mutation databases

BioMutaiGLIS1.
DMDMi209572624.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000472091 – 620Zinc finger protein GLIS1Add BLAST620

Proteomic databases

EPDiQ8NBF1.
MaxQBiQ8NBF1.
PaxDbiQ8NBF1.
PeptideAtlasiQ8NBF1.
PRIDEiQ8NBF1.

PTM databases

iPTMnetiQ8NBF1.
PhosphoSitePlusiQ8NBF1.

Expressioni

Gene expression databases

BgeeiENSG00000174332.
CleanExiHS_GLIS1.
ExpressionAtlasiQ8NBF1. baseline and differential.
GenevisibleiQ8NBF1. HS.

Organism-specific databases

HPAiHPA001409.

Interactioni

Protein-protein interaction databases

IntActiQ8NBF1. 2 interactors.
STRINGi9606.ENSP00000309653.

Structurei

3D structure databases

ProteinModelPortaliQ8NBF1.
SMRiQ8NBF1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi340 – 356Bipartite nuclear localization signalSequence analysisAdd BLAST17

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi456 – 511Pro-richAdd BLAST56

Sequence similaritiesi

Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri195 – 220C2H2-type 1PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri229 – 256C2H2-type 2; atypicalPROSITE-ProRule annotationAdd BLAST28
Zinc fingeri262 – 286C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri292 – 316C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri322 – 346C2H2-type 5PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118771.
HOGENOMiHOG000231136.
HOVERGENiHBG051736.
InParanoidiQ8NBF1.
KOiK09232.
PhylomeDBiQ8NBF1.
TreeFamiTF350216.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR030430. GLIS1.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR19818:SF93. PTHR19818:SF93. 1 hit.
SMARTiSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NBF1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEARTSLSA HCRGPLATGL HPDLDLPGRS LATPAPSCYL LGSEPSSGLG
60 70 80 90 100
LQPETHLPEG SLKRCCVLGL PPTSPASSSP CASSDVTSII RSSQTSLVTC
110 120 130 140 150
VNGLRSPPLT GDLGGPSKRA RPGPASTDSH EGSLQLEACR KASFLKQEPA
160 170 180 190 200
DEFSELFGPH QQGLPPPYPL SQLPPGPSLG GLGLGLAGRV VAGRQACRWV
210 220 230 240 250
DCCAAYEQQE ELVRHIEKSH IDQRKGEDFT CFWAGCVRRY KPFNARYKLL
260 270 280 290 300
IHMRVHSGEK PNKCMFEGCS KAFSRLENLK IHLRSHTGEK PYLCQHPGCQ
310 320 330 340 350
KAFSNSSDRA KHQRTHLDTK PYACQIPGCS KRYTDPSSLR KHVKAHSAKE
360 370 380 390 400
QQVRKKLHAG PDTEADVLTE CLVLQQLHTS TQLAASDGKG GCGLGQELLP
410 420 430 440 450
GVYPGSITPH NGLASGLLPP AHDVPSRHHP LDATTSSHHH LSPLPMAEST
460 470 480 490 500
RDGLGPGLLS PIVSPLKGLG PPPLPPSSQS HSPGGQPFPT LPSKPSYPPF
510 520 530 540 550
QSPPPPPLPS PQGYQGSFHS IQSCFPYGDC YRMAEPAAGG DGLVGETHGF
560 570 580 590 600
NPLRPNGYHS LSTPLPATGY EALAEASCPT ALPQQPSEDV VSSGPEDCGF
610 620
FPNGAFDHCL GHIPSIYTDT
Length:620
Mass (Da):65,976
Last modified:October 14, 2008 - v2
Checksum:iA07F61B35CF12EB7
GO

Sequence cautioni

The sequence BAC04178 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti221I → T in BAC03494 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_047031110T → A.1 PublicationCorresponds to variant rs4307514dbSNPEnsembl.1
Natural variantiVAR_033544157F → L.Corresponds to variant rs34961060dbSNPEnsembl.1
Natural variantiVAR_047032187A → G.1 PublicationCorresponds to variant rs35227000dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK090634 mRNA. Translation: BAC03494.1.
AK093474 mRNA. Translation: BAC04178.1. Different initiation.
AL591720, AC105280 Genomic DNA. Translation: CAH72026.1.
CH471059 Genomic DNA. Translation: EAX06734.1.
BC101799 mRNA. Translation: AAI01800.1.
BC104911 mRNA. Translation: AAI04912.1.
CCDSiCCDS582.1.
RefSeqiNP_671726.2. NM_147193.2.
UniGeneiHs.306691.

Genome annotation databases

EnsembliENST00000312233; ENSP00000309653; ENSG00000174332.
GeneIDi148979.
KEGGihsa:148979.
UCSCiuc001cvr.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK090634 mRNA. Translation: BAC03494.1.
AK093474 mRNA. Translation: BAC04178.1. Different initiation.
AL591720, AC105280 Genomic DNA. Translation: CAH72026.1.
CH471059 Genomic DNA. Translation: EAX06734.1.
BC101799 mRNA. Translation: AAI01800.1.
BC104911 mRNA. Translation: AAI04912.1.
CCDSiCCDS582.1.
RefSeqiNP_671726.2. NM_147193.2.
UniGeneiHs.306691.

3D structure databases

ProteinModelPortaliQ8NBF1.
SMRiQ8NBF1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8NBF1. 2 interactors.
STRINGi9606.ENSP00000309653.

PTM databases

iPTMnetiQ8NBF1.
PhosphoSitePlusiQ8NBF1.

Polymorphism and mutation databases

BioMutaiGLIS1.
DMDMi209572624.

Proteomic databases

EPDiQ8NBF1.
MaxQBiQ8NBF1.
PaxDbiQ8NBF1.
PeptideAtlasiQ8NBF1.
PRIDEiQ8NBF1.

Protocols and materials databases

DNASUi148979.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000312233; ENSP00000309653; ENSG00000174332.
GeneIDi148979.
KEGGihsa:148979.
UCSCiuc001cvr.2. human.

Organism-specific databases

CTDi148979.
DisGeNETi148979.
GeneCardsiGLIS1.
HGNCiHGNC:29525. GLIS1.
HPAiHPA001409.
MIMi610378. gene.
neXtProtiNX_Q8NBF1.
OpenTargetsiENSG00000174332.
PharmGKBiPA134948186.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118771.
HOGENOMiHOG000231136.
HOVERGENiHBG051736.
InParanoidiQ8NBF1.
KOiK09232.
PhylomeDBiQ8NBF1.
TreeFamiTF350216.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000174332-MONOMER.

Miscellaneous databases

ChiTaRSiGLIS1. human.
GeneWikiiGLIS1.
GenomeRNAii148979.
PROiQ8NBF1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000174332.
CleanExiHS_GLIS1.
ExpressionAtlasiQ8NBF1. baseline and differential.
GenevisibleiQ8NBF1. HS.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR030430. GLIS1.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR19818:SF93. PTHR19818:SF93. 1 hit.
SMARTiSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGLIS1_HUMAN
AccessioniPrimary (citable) accession number: Q8NBF1
Secondary accession number(s): Q2M3G9, Q8N9V9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: October 14, 2008
Last modified: November 30, 2016
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.