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Protein

Zinc finger protein GLIS1

Gene

GLIS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as both a repressor and activator of transcription. Binds to the consensus sequence 5'-GACCACCCAC-3' (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri195 – 22026C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri229 – 25628C2H2-type 2; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri262 – 28625C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri292 – 31625C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri322 – 34625C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein GLIS1
Alternative name(s):
GLI-similar 1
Gene namesi
Name:GLIS1Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:29525. GLIS1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134948186.

Polymorphism and mutation databases

BioMutaiGLIS1.
DMDMi209572624.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 620620Zinc finger protein GLIS1PRO_0000047209Add
BLAST

Proteomic databases

PaxDbiQ8NBF1.
PRIDEiQ8NBF1.

PTM databases

PhosphoSiteiQ8NBF1.

Expressioni

Gene expression databases

BgeeiQ8NBF1.
CleanExiHS_GLIS1.
GenevisibleiQ8NBF1. HS.

Organism-specific databases

HPAiHPA001409.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000309653.

Structurei

3D structure databases

ProteinModelPortaliQ8NBF1.
SMRiQ8NBF1. Positions 197-344.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi340 – 35617Bipartite nuclear localization signalSequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi456 – 51156Pro-richAdd
BLAST

Sequence similaritiesi

Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri195 – 22026C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri229 – 25628C2H2-type 2; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri262 – 28625C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri292 – 31625C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri322 – 34625C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000118771.
HOGENOMiHOG000231136.
HOVERGENiHBG051736.
InParanoidiQ8NBF1.
KOiK09232.
OMAiLRPNGYH.
OrthoDBiEOG70S75H.
PhylomeDBiQ8NBF1.
TreeFamiTF350216.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR030430. GLIS1.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR19818:SF75. PTHR19818:SF75. 1 hit.
SMARTiSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NBF1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEARTSLSA HCRGPLATGL HPDLDLPGRS LATPAPSCYL LGSEPSSGLG
60 70 80 90 100
LQPETHLPEG SLKRCCVLGL PPTSPASSSP CASSDVTSII RSSQTSLVTC
110 120 130 140 150
VNGLRSPPLT GDLGGPSKRA RPGPASTDSH EGSLQLEACR KASFLKQEPA
160 170 180 190 200
DEFSELFGPH QQGLPPPYPL SQLPPGPSLG GLGLGLAGRV VAGRQACRWV
210 220 230 240 250
DCCAAYEQQE ELVRHIEKSH IDQRKGEDFT CFWAGCVRRY KPFNARYKLL
260 270 280 290 300
IHMRVHSGEK PNKCMFEGCS KAFSRLENLK IHLRSHTGEK PYLCQHPGCQ
310 320 330 340 350
KAFSNSSDRA KHQRTHLDTK PYACQIPGCS KRYTDPSSLR KHVKAHSAKE
360 370 380 390 400
QQVRKKLHAG PDTEADVLTE CLVLQQLHTS TQLAASDGKG GCGLGQELLP
410 420 430 440 450
GVYPGSITPH NGLASGLLPP AHDVPSRHHP LDATTSSHHH LSPLPMAEST
460 470 480 490 500
RDGLGPGLLS PIVSPLKGLG PPPLPPSSQS HSPGGQPFPT LPSKPSYPPF
510 520 530 540 550
QSPPPPPLPS PQGYQGSFHS IQSCFPYGDC YRMAEPAAGG DGLVGETHGF
560 570 580 590 600
NPLRPNGYHS LSTPLPATGY EALAEASCPT ALPQQPSEDV VSSGPEDCGF
610 620
FPNGAFDHCL GHIPSIYTDT
Length:620
Mass (Da):65,976
Last modified:October 14, 2008 - v2
Checksum:iA07F61B35CF12EB7
GO

Sequence cautioni

The sequence BAC04178.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti221 – 2211I → T in BAC03494 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti110 – 1101T → A.1 Publication
Corresponds to variant rs4307514 [ dbSNP | Ensembl ].
VAR_047031
Natural varianti157 – 1571F → L.
Corresponds to variant rs34961060 [ dbSNP | Ensembl ].
VAR_033544
Natural varianti187 – 1871A → G.1 Publication
Corresponds to variant rs35227000 [ dbSNP | Ensembl ].
VAR_047032

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK090634 mRNA. Translation: BAC03494.1.
AK093474 mRNA. Translation: BAC04178.1. Different initiation.
AL591720, AC105280 Genomic DNA. Translation: CAH72026.1.
CH471059 Genomic DNA. Translation: EAX06734.1.
BC101799 mRNA. Translation: AAI01800.1.
BC104911 mRNA. Translation: AAI04912.1.
CCDSiCCDS582.1.
RefSeqiNP_671726.2. NM_147193.2.
UniGeneiHs.306691.

Genome annotation databases

EnsembliENST00000312233; ENSP00000309653; ENSG00000174332.
GeneIDi148979.
KEGGihsa:148979.
UCSCiuc001cvr.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK090634 mRNA. Translation: BAC03494.1.
AK093474 mRNA. Translation: BAC04178.1. Different initiation.
AL591720, AC105280 Genomic DNA. Translation: CAH72026.1.
CH471059 Genomic DNA. Translation: EAX06734.1.
BC101799 mRNA. Translation: AAI01800.1.
BC104911 mRNA. Translation: AAI04912.1.
CCDSiCCDS582.1.
RefSeqiNP_671726.2. NM_147193.2.
UniGeneiHs.306691.

3D structure databases

ProteinModelPortaliQ8NBF1.
SMRiQ8NBF1. Positions 197-344.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000309653.

PTM databases

PhosphoSiteiQ8NBF1.

Polymorphism and mutation databases

BioMutaiGLIS1.
DMDMi209572624.

Proteomic databases

PaxDbiQ8NBF1.
PRIDEiQ8NBF1.

Protocols and materials databases

DNASUi148979.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000312233; ENSP00000309653; ENSG00000174332.
GeneIDi148979.
KEGGihsa:148979.
UCSCiuc001cvr.1. human.

Organism-specific databases

CTDi148979.
GeneCardsiGC01M053971.
HGNCiHGNC:29525. GLIS1.
HPAiHPA001409.
MIMi610378. gene.
neXtProtiNX_Q8NBF1.
PharmGKBiPA134948186.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000118771.
HOGENOMiHOG000231136.
HOVERGENiHBG051736.
InParanoidiQ8NBF1.
KOiK09232.
OMAiLRPNGYH.
OrthoDBiEOG70S75H.
PhylomeDBiQ8NBF1.
TreeFamiTF350216.

Miscellaneous databases

ChiTaRSiGLIS1. human.
GeneWikiiGLIS1.
GenomeRNAii148979.
NextBioi86045.
PROiQ8NBF1.
SOURCEiSearch...

Gene expression databases

BgeeiQ8NBF1.
CleanExiHS_GLIS1.
GenevisibleiQ8NBF1. HS.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR030430. GLIS1.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR19818:SF75. PTHR19818:SF75. 1 hit.
SMARTiSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ALA-110 AND GLY-187.
    Tissue: Glial tumorImported and TestisImported.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung and Placenta.

Entry informationi

Entry nameiGLIS1_HUMAN
AccessioniPrimary (citable) accession number: Q8NBF1
Secondary accession number(s): Q2M3G9, Q8N9V9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: October 14, 2008
Last modified: June 24, 2015
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.