ID   KLH23_HUMAN             Reviewed;         558 AA.
AC   Q8NBE8; Q8N9B9; Q96FT8;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   27-MAR-2024, entry version 158.
DE   RecName: Full=Kelch-like protein 23;
GN   Name=KLHL23;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Cerebellum;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- INTERACTION:
CC       Q8NBE8; Q8IVD9: NUDCD3; NbExp=2; IntAct=EBI-2512246, EBI-744342;
CC       Q8NBE8; P40337-2: VHL; NbExp=3; IntAct=EBI-2512246, EBI-12157263;
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC04490.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AK090653; BAC03497.1; -; mRNA.
DR   EMBL; AK095131; BAC04490.1; ALT_INIT; mRNA.
DR   EMBL; BC010437; AAH10437.2; -; mRNA.
DR   RefSeq; NP_001186219.1; NM_001199290.2.
DR   RefSeq; NP_653312.2; NM_144711.5.
DR   AlphaFoldDB; Q8NBE8; -.
DR   SMR; Q8NBE8; -.
DR   BioGRID; 127354; 33.
DR   BioGRID; 1529322; 1.
DR   ComplexPortal; CPX-8123; CRL3 E3 ubiquitin ligase complex, KLHL23 variant.
DR   IntAct; Q8NBE8; 27.
DR   MINT; Q8NBE8; -.
DR   STRING; 9606.ENSP00000376419; -.
DR   iPTMnet; Q8NBE8; -.
DR   PhosphoSitePlus; Q8NBE8; -.
DR   SwissPalm; Q8NBE8; -.
DR   BioMuta; KLHL23; -.
DR   DMDM; 74751169; -.
DR   MassIVE; Q8NBE8; -.
DR   PaxDb; 9606-ENSP00000376419; -.
DR   PeptideAtlas; Q8NBE8; -.
DR   ProteomicsDB; 72759; -.
DR   Pumba; Q8NBE8; -.
DR   Antibodypedia; 33817; 84 antibodies from 17 providers.
DR   DNASU; 151230; -.
DR   Ensembl; ENST00000272797.8; ENSP00000272797.4; ENSG00000213160.10.
DR   Ensembl; ENST00000392647.7; ENSP00000376419.2; ENSG00000213160.10.
DR   GeneID; 100526832; -.
DR   GeneID; 151230; -.
DR   KEGG; hsa:100526832; -.
DR   KEGG; hsa:151230; -.
DR   MANE-Select; ENST00000392647.7; ENSP00000376419.2; NM_144711.6; NP_653312.2.
DR   UCSC; uc002ufh.3; human.
DR   AGR; HGNC:27506; -.
DR   CTD; 100526832; -.
DR   CTD; 151230; -.
DR   DisGeNET; 100526832; -.
DR   DisGeNET; 151230; -.
DR   GeneCards; KLHL23; -.
DR   HGNC; HGNC:27506; KLHL23.
DR   HPA; ENSG00000213160; Low tissue specificity.
DR   neXtProt; NX_Q8NBE8; -.
DR   OpenTargets; ENSG00000213160; -.
DR   PharmGKB; PA142671575; -.
DR   VEuPathDB; HostDB:ENSG00000213160; -.
DR   eggNOG; KOG4441; Eukaryota.
DR   GeneTree; ENSGT00940000159106; -.
DR   HOGENOM; CLU_004253_14_6_1; -.
DR   InParanoid; Q8NBE8; -.
DR   OMA; HIWDPIS; -.
DR   OrthoDB; 5472491at2759; -.
DR   PhylomeDB; Q8NBE8; -.
DR   TreeFam; TF329218; -.
DR   PathwayCommons; Q8NBE8; -.
DR   SignaLink; Q8NBE8; -.
DR   BioGRID-ORCS; 100526832; 5 hits in 185 CRISPR screens.
DR   BioGRID-ORCS; 151230; 12 hits in 1175 CRISPR screens.
DR   Pharos; Q8NBE8; Tdark.
DR   PRO; PR:Q8NBE8; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   RNAct; Q8NBE8; Protein.
DR   Bgee; ENSG00000213160; Expressed in cortical plate and 195 other cell types or tissues.
DR   ExpressionAtlas; Q8NBE8; baseline and differential.
DR   CDD; cd18462; BACK_KLHL23; 1.
DR   CDD; cd18252; BTB_POZ_KLHL23; 1.
DR   Gene3D; 1.25.40.420; -; 1.
DR   Gene3D; 2.120.10.80; Kelch-type beta propeller; 2.
DR   InterPro; IPR011705; BACK.
DR   InterPro; IPR017096; BTB-kelch_protein.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR030566; BTB_POZ_KLHL23.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   InterPro; IPR006652; Kelch_1.
DR   InterPro; IPR047068; KLHL23_BACK.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   PANTHER; PTHR24412; KELCH PROTEIN; 1.
DR   PANTHER; PTHR24412:SF304; KELCH-LIKE PROTEIN 23; 1.
DR   Pfam; PF07707; BACK; 1.
DR   Pfam; PF00651; BTB; 1.
DR   Pfam; PF01344; Kelch_1; 6.
DR   PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1.
DR   SMART; SM00875; BACK; 1.
DR   SMART; SM00225; BTB; 1.
DR   SMART; SM00612; Kelch; 6.
DR   SUPFAM; SSF117281; Kelch motif; 1.
DR   SUPFAM; SSF54695; POZ domain; 1.
DR   PROSITE; PS50097; BTB; 1.
DR   Genevisible; Q8NBE8; HS.
PE   1: Evidence at protein level;
KW   Kelch repeat; Reference proteome; Repeat.
FT   CHAIN           1..558
FT                   /note="Kelch-like protein 23"
FT                   /id="PRO_0000242157"
FT   DOMAIN          36..104
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   DOMAIN          139..240
FT                   /note="BACK"
FT   REPEAT          274..320
FT                   /note="Kelch 1"
FT   REPEAT          321..369
FT                   /note="Kelch 2"
FT   REPEAT          370..416
FT                   /note="Kelch 3"
FT   REPEAT          418..466
FT                   /note="Kelch 4"
FT   REPEAT          467..508
FT                   /note="Kelch 5"
FT   REPEAT          510..557
FT                   /note="Kelch 6"
SQ   SEQUENCE   558 AA;  63923 MW;  17DB1B8AD964549B CRC64;
     MALKGQEDYI YLFKDSTHPV DFLDAFRTFY LDGLFTDITL QCPSGIIFHC HRAVLAACSN
     YFKAMFTADM KEKFKNKIKL SGIHHDILEG LVNYAYTSQI EITKRNVQSL LEAADLLQFL
     SVKKACERFL VRHLDIDNCI GMHSFAEFHV CPELEKESRR ILCSKFKEVW QQEEFLEISL
     EKFLFILSRK NLSVWKEEAI IEPVIKWTAH DVENRIECLY NLLSYINIDI DPVYLKTALG
     LQRSCLLTEN KIRSLIYNAL NPMHKEISQR STATMYIIGG YYWHPLSEVH IWDPLTNVWI
     QGAEIPDYTR ESYGVTCLGP NIYVTGGYRT DNIEALDTVW IYNSESDEWT EGLPMLNARY
     YHCAVTLGGC VYALGGYRKG APAEEAEFYD PLKEKWIPIA NMIKGVGNAT ACVLHDVIYV
     IGGHCGYRGS CTYDKVQSYN SDINEWSLIT SSPHPEYGLC SVPFENKLYL VGGQTTITEC
     YDPEQNEWRE IAPMMERRME CGAVIMNGCI YVTGGYSYSK GTYLQSIEKY DPDLNKWEIV
     GNLPSAMRSH GCVCVYNV
//