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Protein

Kelch-like protein 23

Gene

KLHL23

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch-like protein 23
Gene namesi
Name:KLHL23
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:27506. KLHL23.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671575.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 558558Kelch-like protein 23PRO_0000242157Add
BLAST

Proteomic databases

PaxDbiQ8NBE8.
PRIDEiQ8NBE8.

PTM databases

PhosphoSiteiQ8NBE8.

Expressioni

Gene expression databases

BgeeiQ8NBE8.
CleanExiHS_KLHL23.
ExpressionAtlasiQ8NBE8. baseline and differential.
GenevestigatoriQ8NBE8.

Organism-specific databases

HPAiHPA047593.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
NUDCD3Q8IVD92EBI-2512246,EBI-744342

Protein-protein interaction databases

BioGridi127354. 13 interactions.
1529322. 1 interaction.
IntActiQ8NBE8. 8 interactions.
MINTiMINT-8247345.
STRINGi9606.ENSP00000272797.

Structurei

3D structure databases

ProteinModelPortaliQ8NBE8.
SMRiQ8NBE8. Positions 18-252, 275-551.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini36 – 10469BTBPROSITE-ProRule annotationAdd
BLAST
Domaini139 – 240102BACKAdd
BLAST
Repeati274 – 32047Kelch 1Add
BLAST
Repeati321 – 36949Kelch 2Add
BLAST
Repeati370 – 41647Kelch 3Add
BLAST
Repeati418 – 46649Kelch 4Add
BLAST
Repeati467 – 50842Kelch 5Add
BLAST
Repeati510 – 55748Kelch 6Add
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 6 Kelch repeats.Curated

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiNOG319663.
GeneTreeiENSGT00770000120450.
HOGENOMiHOG000231807.
HOVERGENiHBG096077.
InParanoidiQ8NBE8.
KOiK10460.
OMAiKKACEQF.
OrthoDBiEOG72NRPN.
PhylomeDBiQ8NBE8.
TreeFamiTF329218.

Family and domain databases

Gene3Di2.130.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR015916. Gal_Oxidase_b-propeller.
IPR017096. Kelch-like_gigaxonin-typ.
IPR006652. Kelch_1.
[Graphical view]
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 6 hits.
[Graphical view]
PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 6 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NBE8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALKGQEDYI YLFKDSTHPV DFLDAFRTFY LDGLFTDITL QCPSGIIFHC
60 70 80 90 100
HRAVLAACSN YFKAMFTADM KEKFKNKIKL SGIHHDILEG LVNYAYTSQI
110 120 130 140 150
EITKRNVQSL LEAADLLQFL SVKKACERFL VRHLDIDNCI GMHSFAEFHV
160 170 180 190 200
CPELEKESRR ILCSKFKEVW QQEEFLEISL EKFLFILSRK NLSVWKEEAI
210 220 230 240 250
IEPVIKWTAH DVENRIECLY NLLSYINIDI DPVYLKTALG LQRSCLLTEN
260 270 280 290 300
KIRSLIYNAL NPMHKEISQR STATMYIIGG YYWHPLSEVH IWDPLTNVWI
310 320 330 340 350
QGAEIPDYTR ESYGVTCLGP NIYVTGGYRT DNIEALDTVW IYNSESDEWT
360 370 380 390 400
EGLPMLNARY YHCAVTLGGC VYALGGYRKG APAEEAEFYD PLKEKWIPIA
410 420 430 440 450
NMIKGVGNAT ACVLHDVIYV IGGHCGYRGS CTYDKVQSYN SDINEWSLIT
460 470 480 490 500
SSPHPEYGLC SVPFENKLYL VGGQTTITEC YDPEQNEWRE IAPMMERRME
510 520 530 540 550
CGAVIMNGCI YVTGGYSYSK GTYLQSIEKY DPDLNKWEIV GNLPSAMRSH

GCVCVYNV
Length:558
Mass (Da):63,923
Last modified:October 1, 2002 - v1
Checksum:i17DB1B8AD964549B
GO

Sequence cautioni

The sequence BAC04490.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK090653 mRNA. Translation: BAC03497.1.
AK095131 mRNA. Translation: BAC04490.1. Different initiation.
BC010437 mRNA. Translation: AAH10437.2.
CCDSiCCDS2236.1.
RefSeqiNP_001186219.1. NM_001199290.1.
NP_653312.2. NM_144711.5.
UniGeneiHs.655150.
Hs.745233.

Genome annotation databases

EnsembliENST00000272797; ENSP00000272797; ENSG00000213160.
ENST00000392647; ENSP00000376419; ENSG00000213160.
GeneIDi100526832.
151230.
KEGGihsa:100526832.
hsa:151230.
UCSCiuc002ufh.2. human.

Polymorphism databases

DMDMi74751169.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK090653 mRNA. Translation: BAC03497.1.
AK095131 mRNA. Translation: BAC04490.1. Different initiation.
BC010437 mRNA. Translation: AAH10437.2.
CCDSiCCDS2236.1.
RefSeqiNP_001186219.1. NM_001199290.1.
NP_653312.2. NM_144711.5.
UniGeneiHs.655150.
Hs.745233.

3D structure databases

ProteinModelPortaliQ8NBE8.
SMRiQ8NBE8. Positions 18-252, 275-551.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127354. 13 interactions.
1529322. 1 interaction.
IntActiQ8NBE8. 8 interactions.
MINTiMINT-8247345.
STRINGi9606.ENSP00000272797.

PTM databases

PhosphoSiteiQ8NBE8.

Polymorphism databases

DMDMi74751169.

Proteomic databases

PaxDbiQ8NBE8.
PRIDEiQ8NBE8.

Protocols and materials databases

DNASUi151230.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000272797; ENSP00000272797; ENSG00000213160.
ENST00000392647; ENSP00000376419; ENSG00000213160.
GeneIDi100526832.
151230.
KEGGihsa:100526832.
hsa:151230.
UCSCiuc002ufh.2. human.

Organism-specific databases

CTDi100526832.
151230.
GeneCardsiGC02P170551.
HGNCiHGNC:27506. KLHL23.
HPAiHPA047593.
neXtProtiNX_Q8NBE8.
PharmGKBiPA142671575.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG319663.
GeneTreeiENSGT00770000120450.
HOGENOMiHOG000231807.
HOVERGENiHBG096077.
InParanoidiQ8NBE8.
KOiK10460.
OMAiKKACEQF.
OrthoDBiEOG72NRPN.
PhylomeDBiQ8NBE8.
TreeFamiTF329218.

Miscellaneous databases

NextBioi86624.
PROiQ8NBE8.

Gene expression databases

BgeeiQ8NBE8.
CleanExiHS_KLHL23.
ExpressionAtlasiQ8NBE8. baseline and differential.
GenevestigatoriQ8NBE8.

Family and domain databases

Gene3Di2.130.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR015916. Gal_Oxidase_b-propeller.
IPR017096. Kelch-like_gigaxonin-typ.
IPR006652. Kelch_1.
[Graphical view]
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 6 hits.
[Graphical view]
PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 6 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cerebellum.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.

Entry informationi

Entry nameiKLH23_HUMAN
AccessioniPrimary (citable) accession number: Q8NBE8
Secondary accession number(s): Q8N9B9, Q96FT8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: October 1, 2002
Last modified: January 7, 2015
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.