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Q8NBE8 (KLH23_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Kelch-like protein 23
Gene names
Name:KLHL23
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length558 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 BACK (BTB/Kelch associated) domain.

Contains 1 BTB (POZ) domain.

Contains 6 Kelch repeats.

Sequence caution

The sequence BAC04490.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   DomainKelch repeat
Repeat
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 558558Kelch-like protein 23
PRO_0000242157

Regions

Domain36 – 10469BTB
Domain139 – 240102BACK
Repeat274 – 32047Kelch 1
Repeat321 – 36949Kelch 2
Repeat370 – 41647Kelch 3
Repeat418 – 46649Kelch 4
Repeat467 – 50842Kelch 5
Repeat510 – 55748Kelch 6

Sequences

Sequence LengthMass (Da)Tools
Q8NBE8 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 17DB1B8AD964549B

FASTA55863,923
        10         20         30         40         50         60 
MALKGQEDYI YLFKDSTHPV DFLDAFRTFY LDGLFTDITL QCPSGIIFHC HRAVLAACSN 

        70         80         90        100        110        120 
YFKAMFTADM KEKFKNKIKL SGIHHDILEG LVNYAYTSQI EITKRNVQSL LEAADLLQFL 

       130        140        150        160        170        180 
SVKKACERFL VRHLDIDNCI GMHSFAEFHV CPELEKESRR ILCSKFKEVW QQEEFLEISL 

       190        200        210        220        230        240 
EKFLFILSRK NLSVWKEEAI IEPVIKWTAH DVENRIECLY NLLSYINIDI DPVYLKTALG 

       250        260        270        280        290        300 
LQRSCLLTEN KIRSLIYNAL NPMHKEISQR STATMYIIGG YYWHPLSEVH IWDPLTNVWI 

       310        320        330        340        350        360 
QGAEIPDYTR ESYGVTCLGP NIYVTGGYRT DNIEALDTVW IYNSESDEWT EGLPMLNARY 

       370        380        390        400        410        420 
YHCAVTLGGC VYALGGYRKG APAEEAEFYD PLKEKWIPIA NMIKGVGNAT ACVLHDVIYV 

       430        440        450        460        470        480 
IGGHCGYRGS CTYDKVQSYN SDINEWSLIT SSPHPEYGLC SVPFENKLYL VGGQTTITEC 

       490        500        510        520        530        540 
YDPEQNEWRE IAPMMERRME CGAVIMNGCI YVTGGYSYSK GTYLQSIEKY DPDLNKWEIV 

       550 
GNLPSAMRSH GCVCVYNV 

« Hide

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Cerebellum.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Eye.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK090653 mRNA. Translation: BAC03497.1.
AK095131 mRNA. Translation: BAC04490.1. Different initiation.
BC010437 mRNA. Translation: AAH10437.2.
RefSeqNP_001186219.1. NM_001199290.1.
NP_653312.2. NM_144711.5.
UniGeneHs.655150.
Hs.745233.

3D structure databases

ProteinModelPortalQ8NBE8.
SMRQ8NBE8. Positions 18-252, 272-551.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid127354. 11 interactions.
1529322. 1 interaction.
IntActQ8NBE8. 7 interactions.
MINTMINT-8247345.
STRING9606.ENSP00000272797.

PTM databases

PhosphoSiteQ8NBE8.

Polymorphism databases

DMDM74751169.

Proteomic databases

PaxDbQ8NBE8.
PRIDEQ8NBE8.

Protocols and materials databases

DNASU151230.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000272797; ENSP00000272797; ENSG00000213160.
ENST00000392647; ENSP00000376419; ENSG00000213160.
GeneID100526832.
151230.
KEGGhsa:100526832.
hsa:151230.
UCSCuc002ufh.2. human.

Organism-specific databases

CTD100526832.
151230.
GeneCardsGC02P170551.
HGNCHGNC:27506. KLHL23.
HPAHPA047593.
neXtProtNX_Q8NBE8.
PharmGKBPA142671575.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG319663.
HOGENOMHOG000231807.
HOVERGENHBG096077.
InParanoidQ8NBE8.
KOK10460.
OMAKKACEQF.
OrthoDBEOG72NRPN.
PhylomeDBQ8NBE8.
TreeFamTF329218.

Gene expression databases

ArrayExpressQ8NBE8.
BgeeQ8NBE8.
CleanExHS_KLHL23.
GenevestigatorQ8NBE8.

Family and domain databases

Gene3D2.130.10.80. 1 hit.
3.30.710.10. 1 hit.
InterProIPR011705. BACK.
IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR015916. Gal_Oxidase_b-propeller.
IPR017096. Kelch-like_gigaxonin-typ.
IPR006652. Kelch_1.
[Graphical view]
PfamPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 6 hits.
[Graphical view]
PIRSFPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 6 hits.
[Graphical view]
SUPFAMSSF54695. SSF54695. 1 hit.
PROSITEPS50097. BTB. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio86624.
PROQ8NBE8.

Entry information

Entry nameKLH23_HUMAN
AccessionPrimary (citable) accession number: Q8NBE8
Secondary accession number(s): Q8N9B9, Q96FT8
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: October 1, 2002
Last modified: April 16, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM