Q8NBE8 (KLH23_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Kelch-like protein 23

Gene names

Name:

KLHL23

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	558 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities	Contains 1 BACK (BTB/Kelch associated) domain. Contains 1 BTB (POZ) domain. Contains 6 Kelch repeats.
Sequence caution	The sequence BAC04490.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Domain	Kelch repeat Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 558	558	Kelch-like protein 23		PRO_0000242157
Regions
	Domain	36 – 104	69	BTB
	Domain	139 – 240	102	BACK
	Repeat	274 – 320	47	Kelch 1
	Repeat	321 – 369	49	Kelch 2
	Repeat	370 – 416	47	Kelch 3
	Repeat	418 – 466	49	Kelch 4
	Repeat	467 – 508	42	Kelch 5
	Repeat	510 – 557	48	Kelch 6

Sequences

	Sequence		Length	Mass (Da)
	Q8NBE8 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 17DB1B8AD964549B	FASTA	558	63,923
	10 20 30 40 50 60 MALKGQEDYI YLFKDSTHPV DFLDAFRTFY LDGLFTDITL QCPSGIIFHC HRAVLAACSN 70 80 90 100 110 120 YFKAMFTADM KEKFKNKIKL SGIHHDILEG LVNYAYTSQI EITKRNVQSL LEAADLLQFL 130 140 150 160 170 180 SVKKACERFL VRHLDIDNCI GMHSFAEFHV CPELEKESRR ILCSKFKEVW QQEEFLEISL 190 200 210 220 230 240 EKFLFILSRK NLSVWKEEAI IEPVIKWTAH DVENRIECLY NLLSYINIDI DPVYLKTALG 250 260 270 280 290 300 LQRSCLLTEN KIRSLIYNAL NPMHKEISQR STATMYIIGG YYWHPLSEVH IWDPLTNVWI 310 320 330 340 350 360 QGAEIPDYTR ESYGVTCLGP NIYVTGGYRT DNIEALDTVW IYNSESDEWT EGLPMLNARY 370 380 390 400 410 420 YHCAVTLGGC VYALGGYRKG APAEEAEFYD PLKEKWIPIA NMIKGVGNAT ACVLHDVIYV 430 440 450 460 470 480 IGGHCGYRGS CTYDKVQSYN SDINEWSLIT SSPHPEYGLC SVPFENKLYL VGGQTTITEC 490 500 510 520 530 540 YDPEQNEWRE IAPMMERRME CGAVIMNGCI YVTGGYSYSK GTYLQSIEKY DPDLNKWEIV 550 GNLPSAMRSH GCVCVYNV

References

[1]

"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Cerebellum.

[2]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Eye.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK090653 mRNA. Translation: BAC03497.1. AK095131 mRNA. Translation: BAC04490.1. Different initiation. BC010437 mRNA. Translation: AAH10437.2.
IPI	IPI00062213.
RefSeq	NP_001186219.1. NM_001199290.1. NP_653312.2. NM_144711.5.
UniGene	Hs.655150. Hs.733554.
3D structure databases
ProteinModelPortal	Q8NBE8.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8NBE8. 2 interactions.
MINT	MINT-8247345.
STRING	9606.ENSP00000272797.
PTM databases
PhosphoSite	Q8NBE8.
Polymorphism databases
DMDM	74751169.
Proteomic databases
PaxDb	Q8NBE8.
PRIDE	Q8NBE8.
Protocols and materials databases
DNASU	151230.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000272797; ENSP00000272797; ENSG00000213160. ENST00000392647; ENSP00000376419; ENSG00000213160.
GeneID	100526832. 151230.
KEGG	hsa:100526832. hsa:151230.
UCSC	uc002ufh.2. human.
Organism-specific databases
CTD	100526832. 151230.
GeneCards	GC02P170551.
HGNC	HGNC:27506. KLHL23.
HPA	HPA047593.
neXtProt	NX_Q8NBE8.
PharmGKB	PA142671575.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG319663.
HOGENOM	HOG000231807.
HOVERGEN	HBG096077.
InParanoid	Q8NBE8.
KO	K10460.
OMA	KKACEQF.
OrthoDB	EOG43FGWG.
Gene expression databases
ArrayExpress	Q8NBE8.
Bgee	Q8NBE8.
CleanEx	HS_KLHL23.
Genevestigator	Q8NBE8.
GermOnline	ENSG00000144362. Homo sapiens.
Family and domain databases
Gene3D	2.130.10.80. 1 hit. 3.30.710.10. 1 hit.
InterPro	IPR011705. BACK. IPR000210. BTB/POZ-like. IPR011333. BTB/POZ_fold. IPR013069. BTB_POZ. IPR015916. Gal_Oxidase_b-propeller. IPR017096. Kelch-like_gigaxonin. IPR006652. Kelch_1. [Graphical view]
Pfam	PF07707. BACK. 1 hit. PF00651. BTB. 1 hit. PF01344. Kelch_1. 6 hits. [Graphical view]
PIRSF	PIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMART	SM00875. BACK. 1 hit. SM00225. BTB. 1 hit. SM00612. Kelch. 6 hits. [Graphical view]
SUPFAM	SSF54695. BTB/POZ_fold. 1 hit.
PROSITE	PS50097. BTB. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	86624.

Entry information

Entry name

KLH23_HUMAN

Accession

Primary (citable) accession number: Q8NBE8
Secondary accession number(s): Q8N9B9, Q96FT8

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	October 1, 2002
Last modified:	May 29, 2013
This is version 85 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.