Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8NBE8

- KLH23_HUMAN

UniProt

Q8NBE8 - KLH23_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Kelch-like protein 23

Gene

KLHL23

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch-like protein 23
Gene namesi
Name:KLHL23
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:27506. KLHL23.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671575.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 558558Kelch-like protein 23PRO_0000242157Add
BLAST

Proteomic databases

PaxDbiQ8NBE8.
PRIDEiQ8NBE8.

PTM databases

PhosphoSiteiQ8NBE8.

Expressioni

Gene expression databases

BgeeiQ8NBE8.
CleanExiHS_KLHL23.
ExpressionAtlasiQ8NBE8. baseline and differential.
GenevestigatoriQ8NBE8.

Organism-specific databases

HPAiHPA047593.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
NUDCD3Q8IVD92EBI-2512246,EBI-744342

Protein-protein interaction databases

BioGridi127354. 13 interactions.
1529322. 1 interaction.
IntActiQ8NBE8. 8 interactions.
MINTiMINT-8247345.
STRINGi9606.ENSP00000272797.

Structurei

3D structure databases

ProteinModelPortaliQ8NBE8.
SMRiQ8NBE8. Positions 18-252, 275-551.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini36 – 10469BTBPROSITE-ProRule annotationAdd
BLAST
Domaini139 – 240102BACKAdd
BLAST
Repeati274 – 32047Kelch 1Add
BLAST
Repeati321 – 36949Kelch 2Add
BLAST
Repeati370 – 41647Kelch 3Add
BLAST
Repeati418 – 46649Kelch 4Add
BLAST
Repeati467 – 50842Kelch 5Add
BLAST
Repeati510 – 55748Kelch 6Add
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 6 Kelch repeats.Curated

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiNOG319663.
GeneTreeiENSGT00760000118865.
HOGENOMiHOG000231807.
HOVERGENiHBG096077.
InParanoidiQ8NBE8.
KOiK10460.
OMAiKKACEQF.
OrthoDBiEOG72NRPN.
PhylomeDBiQ8NBE8.
TreeFamiTF329218.

Family and domain databases

Gene3Di2.130.10.80. 1 hit.
3.30.710.10. 1 hit.
InterProiIPR011705. BACK.
IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR015916. Gal_Oxidase_b-propeller.
IPR017096. Kelch-like_gigaxonin-typ.
IPR006652. Kelch_1.
[Graphical view]
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 6 hits.
[Graphical view]
PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 6 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NBE8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALKGQEDYI YLFKDSTHPV DFLDAFRTFY LDGLFTDITL QCPSGIIFHC
60 70 80 90 100
HRAVLAACSN YFKAMFTADM KEKFKNKIKL SGIHHDILEG LVNYAYTSQI
110 120 130 140 150
EITKRNVQSL LEAADLLQFL SVKKACERFL VRHLDIDNCI GMHSFAEFHV
160 170 180 190 200
CPELEKESRR ILCSKFKEVW QQEEFLEISL EKFLFILSRK NLSVWKEEAI
210 220 230 240 250
IEPVIKWTAH DVENRIECLY NLLSYINIDI DPVYLKTALG LQRSCLLTEN
260 270 280 290 300
KIRSLIYNAL NPMHKEISQR STATMYIIGG YYWHPLSEVH IWDPLTNVWI
310 320 330 340 350
QGAEIPDYTR ESYGVTCLGP NIYVTGGYRT DNIEALDTVW IYNSESDEWT
360 370 380 390 400
EGLPMLNARY YHCAVTLGGC VYALGGYRKG APAEEAEFYD PLKEKWIPIA
410 420 430 440 450
NMIKGVGNAT ACVLHDVIYV IGGHCGYRGS CTYDKVQSYN SDINEWSLIT
460 470 480 490 500
SSPHPEYGLC SVPFENKLYL VGGQTTITEC YDPEQNEWRE IAPMMERRME
510 520 530 540 550
CGAVIMNGCI YVTGGYSYSK GTYLQSIEKY DPDLNKWEIV GNLPSAMRSH

GCVCVYNV
Length:558
Mass (Da):63,923
Last modified:October 1, 2002 - v1
Checksum:i17DB1B8AD964549B
GO

Sequence cautioni

The sequence BAC04490.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK090653 mRNA. Translation: BAC03497.1.
AK095131 mRNA. Translation: BAC04490.1. Different initiation.
BC010437 mRNA. Translation: AAH10437.2.
CCDSiCCDS2236.1.
RefSeqiNP_001186219.1. NM_001199290.1.
NP_653312.2. NM_144711.5.
UniGeneiHs.655150.
Hs.745233.

Genome annotation databases

EnsembliENST00000272797; ENSP00000272797; ENSG00000213160.
ENST00000392647; ENSP00000376419; ENSG00000213160.
GeneIDi100526832.
151230.
KEGGihsa:100526832.
hsa:151230.
UCSCiuc002ufh.2. human.

Polymorphism databases

DMDMi74751169.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK090653 mRNA. Translation: BAC03497.1 .
AK095131 mRNA. Translation: BAC04490.1 . Different initiation.
BC010437 mRNA. Translation: AAH10437.2 .
CCDSi CCDS2236.1.
RefSeqi NP_001186219.1. NM_001199290.1.
NP_653312.2. NM_144711.5.
UniGenei Hs.655150.
Hs.745233.

3D structure databases

ProteinModelPortali Q8NBE8.
SMRi Q8NBE8. Positions 18-252, 275-551.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 127354. 13 interactions.
1529322. 1 interaction.
IntActi Q8NBE8. 8 interactions.
MINTi MINT-8247345.
STRINGi 9606.ENSP00000272797.

PTM databases

PhosphoSitei Q8NBE8.

Polymorphism databases

DMDMi 74751169.

Proteomic databases

PaxDbi Q8NBE8.
PRIDEi Q8NBE8.

Protocols and materials databases

DNASUi 151230.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000272797 ; ENSP00000272797 ; ENSG00000213160 .
ENST00000392647 ; ENSP00000376419 ; ENSG00000213160 .
GeneIDi 100526832.
151230.
KEGGi hsa:100526832.
hsa:151230.
UCSCi uc002ufh.2. human.

Organism-specific databases

CTDi 100526832.
151230.
GeneCardsi GC02P170551.
HGNCi HGNC:27506. KLHL23.
HPAi HPA047593.
neXtProti NX_Q8NBE8.
PharmGKBi PA142671575.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG319663.
GeneTreei ENSGT00760000118865.
HOGENOMi HOG000231807.
HOVERGENi HBG096077.
InParanoidi Q8NBE8.
KOi K10460.
OMAi KKACEQF.
OrthoDBi EOG72NRPN.
PhylomeDBi Q8NBE8.
TreeFami TF329218.

Miscellaneous databases

NextBioi 86624.
PROi Q8NBE8.

Gene expression databases

Bgeei Q8NBE8.
CleanExi HS_KLHL23.
ExpressionAtlasi Q8NBE8. baseline and differential.
Genevestigatori Q8NBE8.

Family and domain databases

Gene3Di 2.130.10.80. 1 hit.
3.30.710.10. 1 hit.
InterProi IPR011705. BACK.
IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR015916. Gal_Oxidase_b-propeller.
IPR017096. Kelch-like_gigaxonin-typ.
IPR006652. Kelch_1.
[Graphical view ]
Pfami PF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 6 hits.
[Graphical view ]
PIRSFi PIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
SMARTi SM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 6 hits.
[Graphical view ]
SUPFAMi SSF54695. SSF54695. 1 hit.
PROSITEi PS50097. BTB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cerebellum.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.

Entry informationi

Entry nameiKLH23_HUMAN
AccessioniPrimary (citable) accession number: Q8NBE8
Secondary accession number(s): Q8N9B9, Q96FT8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3