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Q8NBE8

- KLH23_HUMAN

UniProt

Q8NBE8 - KLH23_HUMAN

Protein

Kelch-like protein 23

Gene

KLHL23

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Kelch-like protein 23
    Gene namesi
    Name:KLHL23
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:27506. KLHL23.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142671575.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 558558Kelch-like protein 23PRO_0000242157Add
    BLAST

    Proteomic databases

    PaxDbiQ8NBE8.
    PRIDEiQ8NBE8.

    PTM databases

    PhosphoSiteiQ8NBE8.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8NBE8.
    BgeeiQ8NBE8.
    CleanExiHS_KLHL23.
    GenevestigatoriQ8NBE8.

    Organism-specific databases

    HPAiHPA047593.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    NUDCD3Q8IVD92EBI-2512246,EBI-744342

    Protein-protein interaction databases

    BioGridi127354. 11 interactions.
    1529322. 1 interaction.
    IntActiQ8NBE8. 8 interactions.
    MINTiMINT-8247345.
    STRINGi9606.ENSP00000272797.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NBE8.
    SMRiQ8NBE8. Positions 18-252, 272-551.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini36 – 10469BTBPROSITE-ProRule annotationAdd
    BLAST
    Domaini139 – 240102BACKAdd
    BLAST
    Repeati274 – 32047Kelch 1Add
    BLAST
    Repeati321 – 36949Kelch 2Add
    BLAST
    Repeati370 – 41647Kelch 3Add
    BLAST
    Repeati418 – 46649Kelch 4Add
    BLAST
    Repeati467 – 50842Kelch 5Add
    BLAST
    Repeati510 – 55748Kelch 6Add
    BLAST

    Sequence similaritiesi

    Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
    Contains 6 Kelch repeats.Curated

    Keywords - Domaini

    Kelch repeat, Repeat

    Phylogenomic databases

    eggNOGiNOG319663.
    HOGENOMiHOG000231807.
    HOVERGENiHBG096077.
    InParanoidiQ8NBE8.
    KOiK10460.
    OMAiKKACEQF.
    OrthoDBiEOG72NRPN.
    PhylomeDBiQ8NBE8.
    TreeFamiTF329218.

    Family and domain databases

    Gene3Di2.130.10.80. 1 hit.
    3.30.710.10. 1 hit.
    InterProiIPR011705. BACK.
    IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR013069. BTB_POZ.
    IPR015916. Gal_Oxidase_b-propeller.
    IPR017096. Kelch-like_gigaxonin-typ.
    IPR006652. Kelch_1.
    [Graphical view]
    PfamiPF07707. BACK. 1 hit.
    PF00651. BTB. 1 hit.
    PF01344. Kelch_1. 6 hits.
    [Graphical view]
    PIRSFiPIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
    SMARTiSM00875. BACK. 1 hit.
    SM00225. BTB. 1 hit.
    SM00612. Kelch. 6 hits.
    [Graphical view]
    SUPFAMiSSF54695. SSF54695. 1 hit.
    PROSITEiPS50097. BTB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NBE8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALKGQEDYI YLFKDSTHPV DFLDAFRTFY LDGLFTDITL QCPSGIIFHC    50
    HRAVLAACSN YFKAMFTADM KEKFKNKIKL SGIHHDILEG LVNYAYTSQI 100
    EITKRNVQSL LEAADLLQFL SVKKACERFL VRHLDIDNCI GMHSFAEFHV 150
    CPELEKESRR ILCSKFKEVW QQEEFLEISL EKFLFILSRK NLSVWKEEAI 200
    IEPVIKWTAH DVENRIECLY NLLSYINIDI DPVYLKTALG LQRSCLLTEN 250
    KIRSLIYNAL NPMHKEISQR STATMYIIGG YYWHPLSEVH IWDPLTNVWI 300
    QGAEIPDYTR ESYGVTCLGP NIYVTGGYRT DNIEALDTVW IYNSESDEWT 350
    EGLPMLNARY YHCAVTLGGC VYALGGYRKG APAEEAEFYD PLKEKWIPIA 400
    NMIKGVGNAT ACVLHDVIYV IGGHCGYRGS CTYDKVQSYN SDINEWSLIT 450
    SSPHPEYGLC SVPFENKLYL VGGQTTITEC YDPEQNEWRE IAPMMERRME 500
    CGAVIMNGCI YVTGGYSYSK GTYLQSIEKY DPDLNKWEIV GNLPSAMRSH 550
    GCVCVYNV 558
    Length:558
    Mass (Da):63,923
    Last modified:October 1, 2002 - v1
    Checksum:i17DB1B8AD964549B
    GO

    Sequence cautioni

    The sequence BAC04490.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK090653 mRNA. Translation: BAC03497.1.
    AK095131 mRNA. Translation: BAC04490.1. Different initiation.
    BC010437 mRNA. Translation: AAH10437.2.
    CCDSiCCDS2236.1.
    RefSeqiNP_001186219.1. NM_001199290.1.
    NP_653312.2. NM_144711.5.
    UniGeneiHs.655150.
    Hs.745233.

    Genome annotation databases

    EnsembliENST00000272797; ENSP00000272797; ENSG00000213160.
    ENST00000392647; ENSP00000376419; ENSG00000213160.
    GeneIDi100526832.
    151230.
    KEGGihsa:100526832.
    hsa:151230.
    UCSCiuc002ufh.2. human.

    Polymorphism databases

    DMDMi74751169.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK090653 mRNA. Translation: BAC03497.1 .
    AK095131 mRNA. Translation: BAC04490.1 . Different initiation.
    BC010437 mRNA. Translation: AAH10437.2 .
    CCDSi CCDS2236.1.
    RefSeqi NP_001186219.1. NM_001199290.1.
    NP_653312.2. NM_144711.5.
    UniGenei Hs.655150.
    Hs.745233.

    3D structure databases

    ProteinModelPortali Q8NBE8.
    SMRi Q8NBE8. Positions 18-252, 272-551.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 127354. 11 interactions.
    1529322. 1 interaction.
    IntActi Q8NBE8. 8 interactions.
    MINTi MINT-8247345.
    STRINGi 9606.ENSP00000272797.

    PTM databases

    PhosphoSitei Q8NBE8.

    Polymorphism databases

    DMDMi 74751169.

    Proteomic databases

    PaxDbi Q8NBE8.
    PRIDEi Q8NBE8.

    Protocols and materials databases

    DNASUi 151230.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000272797 ; ENSP00000272797 ; ENSG00000213160 .
    ENST00000392647 ; ENSP00000376419 ; ENSG00000213160 .
    GeneIDi 100526832.
    151230.
    KEGGi hsa:100526832.
    hsa:151230.
    UCSCi uc002ufh.2. human.

    Organism-specific databases

    CTDi 100526832.
    151230.
    GeneCardsi GC02P170551.
    HGNCi HGNC:27506. KLHL23.
    HPAi HPA047593.
    neXtProti NX_Q8NBE8.
    PharmGKBi PA142671575.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG319663.
    HOGENOMi HOG000231807.
    HOVERGENi HBG096077.
    InParanoidi Q8NBE8.
    KOi K10460.
    OMAi KKACEQF.
    OrthoDBi EOG72NRPN.
    PhylomeDBi Q8NBE8.
    TreeFami TF329218.

    Miscellaneous databases

    NextBioi 86624.
    PROi Q8NBE8.

    Gene expression databases

    ArrayExpressi Q8NBE8.
    Bgeei Q8NBE8.
    CleanExi HS_KLHL23.
    Genevestigatori Q8NBE8.

    Family and domain databases

    Gene3Di 2.130.10.80. 1 hit.
    3.30.710.10. 1 hit.
    InterProi IPR011705. BACK.
    IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR013069. BTB_POZ.
    IPR015916. Gal_Oxidase_b-propeller.
    IPR017096. Kelch-like_gigaxonin-typ.
    IPR006652. Kelch_1.
    [Graphical view ]
    Pfami PF07707. BACK. 1 hit.
    PF00651. BTB. 1 hit.
    PF01344. Kelch_1. 6 hits.
    [Graphical view ]
    PIRSFi PIRSF037037. Kelch-like_protein_gigaxonin. 1 hit.
    SMARTi SM00875. BACK. 1 hit.
    SM00225. BTB. 1 hit.
    SM00612. Kelch. 6 hits.
    [Graphical view ]
    SUPFAMi SSF54695. SSF54695. 1 hit.
    PROSITEi PS50097. BTB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Cerebellum.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye.

    Entry informationi

    Entry nameiKLH23_HUMAN
    AccessioniPrimary (citable) accession number: Q8NBE8
    Secondary accession number(s): Q8N9B9, Q96FT8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3