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Q8NBD8 (T229B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transmembrane protein 229B
Gene names
Name:TMEM229B
Synonyms:C14orf83
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length167 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the TMEM229 family.

Ontologies

Keywords
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 167167Transmembrane protein 229B
PRO_0000263681

Regions

Topological domain1 – 1414Cytoplasmic Potential
Transmembrane15 – 3521Helical; Potential
Topological domain36 – 405Extracellular Potential
Transmembrane41 – 6121Helical; Potential
Topological domain62 – 7312Cytoplasmic Potential
Transmembrane74 – 9421Helical; Potential
Topological domain95 – 10915Extracellular Potential
Transmembrane110 – 13021Helical; Potential
Topological domain131 – 16737Cytoplasmic Potential

Sequences

Sequence LengthMass (Da)Tools
Q8NBD8 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 0C7507C6F00F0D85

FASTA16719,531
        10         20         30         40         50         60 
MASAEPLTAL SRWYLYAIHG YFCEVMFTAA WEFVVNLNWK FPGVTSVWAL FIYGTSILIV 

        70         80         90        100        110        120 
ERMYLRLRGR CPLLLRCLIY TLWTYLWEFT TGFILRQFNA CPWDYSQFDF DFMGLITLEY 

       130        140        150        160 
AVPWFCGALI MEQFIIRNTL RLRFDKDAEP GEPSGALALA NGHVKTD 

« Hide

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Cerebellum.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK090706 mRNA. Translation: BAC03507.1.
BC104940 mRNA. Translation: AAI04941.1.
BC104942 mRNA. Translation: AAI04943.1.
CCDSCCDS9783.1.
RefSeqNP_872332.1. NM_182526.2.
XP_005267430.1. XM_005267373.1.
XP_005267431.1. XM_005267374.2.
XP_005267432.1. XM_005267375.1.
XP_006720125.1. XM_006720062.1.
UniGeneHs.509707.

3D structure databases

ProteinModelPortalQ8NBD8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000350050.

Polymorphism databases

DMDM74730125.

Proteomic databases

PaxDbQ8NBD8.
PRIDEQ8NBD8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000357461; ENSP00000350050; ENSG00000198133.
ENST00000555638; ENSP00000452201; ENSG00000198133.
ENST00000557006; ENSP00000451774; ENSG00000198133.
GeneID161145.
KEGGhsa:161145.
UCSCuc001xjk.3. human.

Organism-specific databases

CTD161145.
GeneCardsGC14M067914.
HGNCHGNC:20130. TMEM229B.
HPAHPA046562.
neXtProtNX_Q8NBD8.
PharmGKBPA165479330.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG45696.
HOGENOMHOG000007583.
HOVERGENHBG055272.
InParanoidQ8NBD8.
OMAWEFTTGY.
OrthoDBEOG7JHM6T.
PhylomeDBQ8NBD8.
TreeFamTF336481.

Gene expression databases

ArrayExpressQ8NBD8.
BgeeQ8NBD8.
CleanExHS_C14orf83.
GenevestigatorQ8NBD8.

Family and domain databases

InterProIPR010540. DUF1113_TMEM229.
[Graphical view]
PfamPF06541. DUF1113. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSTMEM229B. human.
GeneWikiTMEM229B.
GenomeRNAi161145.
NextBio88023.
PROQ8NBD8.

Entry information

Entry nameT229B_HUMAN
AccessionPrimary (citable) accession number: Q8NBD8
Entry history
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Uncharacterized protein families (UPF)

List of uncharacterized protein family (UPF) entries

SIMILARITY comments

Index of protein domains and families

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM