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Q8NBD8

- T229B_HUMAN

UniProt

Q8NBD8 - T229B_HUMAN

Protein

Transmembrane protein 229B

Gene

TMEM229B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
  1. Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transmembrane protein 229B
    Gene namesi
    Name:TMEM229B
    Synonyms:C14orf83
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:20130. TMEM229B.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA165479330.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 167167Transmembrane protein 229BPRO_0000263681Add
    BLAST

    Proteomic databases

    PaxDbiQ8NBD8.
    PRIDEiQ8NBD8.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8NBD8.
    BgeeiQ8NBD8.
    CleanExiHS_C14orf83.
    GenevestigatoriQ8NBD8.

    Organism-specific databases

    HPAiHPA046562.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000350050.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NBD8.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1414CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini36 – 405ExtracellularSequence Analysis
    Topological domaini62 – 7312CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini95 – 10915ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini131 – 16737CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei15 – 3521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei41 – 6121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei74 – 9421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei110 – 13021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TMEM229 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG45696.
    HOGENOMiHOG000007583.
    HOVERGENiHBG055272.
    InParanoidiQ8NBD8.
    OMAiWEFTTGY.
    OrthoDBiEOG7JHM6T.
    PhylomeDBiQ8NBD8.
    TreeFamiTF336481.

    Family and domain databases

    InterProiIPR010540. DUF1113_TMEM229.
    [Graphical view]
    PfamiPF06541. DUF1113. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NBD8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASAEPLTAL SRWYLYAIHG YFCEVMFTAA WEFVVNLNWK FPGVTSVWAL    50
    FIYGTSILIV ERMYLRLRGR CPLLLRCLIY TLWTYLWEFT TGFILRQFNA 100
    CPWDYSQFDF DFMGLITLEY AVPWFCGALI MEQFIIRNTL RLRFDKDAEP 150
    GEPSGALALA NGHVKTD 167
    Length:167
    Mass (Da):19,531
    Last modified:October 1, 2002 - v1
    Checksum:i0C7507C6F00F0D85
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK090706 mRNA. Translation: BAC03507.1.
    BC104940 mRNA. Translation: AAI04941.1.
    BC104942 mRNA. Translation: AAI04943.1.
    CCDSiCCDS9783.1.
    RefSeqiNP_872332.1. NM_182526.2.
    XP_005267430.1. XM_005267373.1.
    XP_005267431.1. XM_005267374.2.
    XP_005267432.1. XM_005267375.1.
    XP_006720125.1. XM_006720062.1.
    UniGeneiHs.509707.

    Genome annotation databases

    EnsembliENST00000357461; ENSP00000350050; ENSG00000198133.
    ENST00000555638; ENSP00000452201; ENSG00000198133.
    ENST00000557006; ENSP00000451774; ENSG00000198133.
    GeneIDi161145.
    KEGGihsa:161145.
    UCSCiuc001xjk.3. human.

    Polymorphism databases

    DMDMi74730125.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK090706 mRNA. Translation: BAC03507.1 .
    BC104940 mRNA. Translation: AAI04941.1 .
    BC104942 mRNA. Translation: AAI04943.1 .
    CCDSi CCDS9783.1.
    RefSeqi NP_872332.1. NM_182526.2.
    XP_005267430.1. XM_005267373.1.
    XP_005267431.1. XM_005267374.2.
    XP_005267432.1. XM_005267375.1.
    XP_006720125.1. XM_006720062.1.
    UniGenei Hs.509707.

    3D structure databases

    ProteinModelPortali Q8NBD8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000350050.

    Polymorphism databases

    DMDMi 74730125.

    Proteomic databases

    PaxDbi Q8NBD8.
    PRIDEi Q8NBD8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000357461 ; ENSP00000350050 ; ENSG00000198133 .
    ENST00000555638 ; ENSP00000452201 ; ENSG00000198133 .
    ENST00000557006 ; ENSP00000451774 ; ENSG00000198133 .
    GeneIDi 161145.
    KEGGi hsa:161145.
    UCSCi uc001xjk.3. human.

    Organism-specific databases

    CTDi 161145.
    GeneCardsi GC14M067914.
    HGNCi HGNC:20130. TMEM229B.
    HPAi HPA046562.
    neXtProti NX_Q8NBD8.
    PharmGKBi PA165479330.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG45696.
    HOGENOMi HOG000007583.
    HOVERGENi HBG055272.
    InParanoidi Q8NBD8.
    OMAi WEFTTGY.
    OrthoDBi EOG7JHM6T.
    PhylomeDBi Q8NBD8.
    TreeFami TF336481.

    Miscellaneous databases

    ChiTaRSi TMEM229B. human.
    GeneWikii TMEM229B.
    GenomeRNAii 161145.
    NextBioi 88023.
    PROi Q8NBD8.

    Gene expression databases

    ArrayExpressi Q8NBD8.
    Bgeei Q8NBD8.
    CleanExi HS_C14orf83.
    Genevestigatori Q8NBD8.

    Family and domain databases

    InterProi IPR010540. DUF1113_TMEM229.
    [Graphical view ]
    Pfami PF06541. DUF1113. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Cerebellum.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiT229B_HUMAN
    AccessioniPrimary (citable) accession number: Q8NBD8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 12, 2006
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families
    3. Uncharacterized protein families (UPF)
      List of uncharacterized protein family (UPF) entries

    External Data

    Dasty 3