Q8NBD8 (T229B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transmembrane protein 229B

Gene names

Name:	TMEM229B
Synonyms:	C14orf83

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	167 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the TMEM229 family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 167	167	Transmembrane protein 229B		PRO_0000263681
Regions
	Topological domain	1 – 14	14	Cytoplasmic Potential
	Transmembrane	15 – 35	21	Helical; Potential
	Topological domain	36 – 40	5	Extracellular Potential
	Transmembrane	41 – 61	21	Helical; Potential
	Topological domain	62 – 73	12	Cytoplasmic Potential
	Transmembrane	74 – 94	21	Helical; Potential
	Topological domain	95 – 109	15	Extracellular Potential
	Transmembrane	110 – 130	21	Helical; Potential
	Topological domain	131 – 167	37	Cytoplasmic Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8NBD8 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 0C7507C6F00F0D85	FASTA	167	19,531
	10 20 30 40 50 60 MASAEPLTAL SRWYLYAIHG YFCEVMFTAA WEFVVNLNWK FPGVTSVWAL FIYGTSILIV 70 80 90 100 110 120 ERMYLRLRGR CPLLLRCLIY TLWTYLWEFT TGFILRQFNA CPWDYSQFDF DFMGLITLEY 130 140 150 160 AVPWFCGALI MEQFIIRNTL RLRFDKDAEP GEPSGALALA NGHVKTD

References

[1]

"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Cerebellum.

[2]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK090706 mRNA. Translation: BAC03507.1. BC104940 mRNA. Translation: AAI04941.1. BC104942 mRNA. Translation: AAI04943.1.
IPI	IPI00184162.
RefSeq	NP_872332.1. NM_182526.2.
UniGene	Hs.509707.
3D structure databases
ProteinModelPortal	Q8NBD8.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000350050.
Polymorphism databases
DMDM	74730125.
Proteomic databases
PaxDb	Q8NBD8.
PRIDE	Q8NBD8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000357461; ENSP00000350050; ENSG00000198133. ENST00000555638; ENSP00000452201; ENSG00000198133. ENST00000557006; ENSP00000451774; ENSG00000198133.
GeneID	161145.
KEGG	hsa:161145.
UCSC	uc001xjk.3. human.
Organism-specific databases
CTD	161145.
GeneCards	GC14M067914.
HGNC	HGNC:20130. TMEM229B.
HPA	HPA046562.
neXtProt	NX_Q8NBD8.
PharmGKB	PA165479330.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG45696.
HOGENOM	HOG000007583.
HOVERGEN	HBG055272.
InParanoid	Q8NBD8.
OMA	WEFTTGY.
OrthoDB	EOG4640D2.
PhylomeDB	Q8NBD8.
Gene expression databases
ArrayExpress	Q8NBD8.
Bgee	Q8NBD8.
CleanEx	HS_C14orf83.
Genevestigator	Q8NBD8.
Family and domain databases
InterPro	IPR010540. DUF1113_TMEM229. [Graphical view]
Pfam	PF06541. DUF1113. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	TMEM229B. human.
GenomeRNAi	161145.
NextBio	88023.

Entry information

Entry name

T229B_HUMAN

Accession

Primary (citable) accession number: Q8NBD8

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	October 1, 2002
Last modified:	April 3, 2013
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.