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Protein

Transmembrane protein 229B

Gene

TMEM229B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 229B
Gene namesi
Name:TMEM229B
Synonyms:C14orf83
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:20130. TMEM229B.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1414CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei15 – 3521HelicalSequence AnalysisAdd
BLAST
Topological domaini36 – 405ExtracellularSequence Analysis
Transmembranei41 – 6121HelicalSequence AnalysisAdd
BLAST
Topological domaini62 – 7312CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei74 – 9421HelicalSequence AnalysisAdd
BLAST
Topological domaini95 – 10915ExtracellularSequence AnalysisAdd
BLAST
Transmembranei110 – 13021HelicalSequence AnalysisAdd
BLAST
Topological domaini131 – 16737CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165479330.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 167167Transmembrane protein 229BPRO_0000263681Add
BLAST

Proteomic databases

PaxDbiQ8NBD8.
PRIDEiQ8NBD8.

Expressioni

Gene expression databases

BgeeiQ8NBD8.
CleanExiHS_C14orf83.
ExpressionAtlasiQ8NBD8. baseline and differential.
GenevestigatoriQ8NBD8.

Organism-specific databases

HPAiHPA046562.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000350050.

Structurei

3D structure databases

ProteinModelPortaliQ8NBD8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM229 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG45696.
GeneTreeiENSGT00390000010899.
HOGENOMiHOG000007583.
HOVERGENiHBG055272.
InParanoidiQ8NBD8.
OMAiWEFTTGY.
OrthoDBiEOG7JHM6T.
PhylomeDBiQ8NBD8.
TreeFamiTF336481.

Family and domain databases

InterProiIPR010540. DUF1113_TMEM229.
[Graphical view]
PfamiPF06541. DUF1113. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NBD8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASAEPLTAL SRWYLYAIHG YFCEVMFTAA WEFVVNLNWK FPGVTSVWAL
60 70 80 90 100
FIYGTSILIV ERMYLRLRGR CPLLLRCLIY TLWTYLWEFT TGFILRQFNA
110 120 130 140 150
CPWDYSQFDF DFMGLITLEY AVPWFCGALI MEQFIIRNTL RLRFDKDAEP
160
GEPSGALALA NGHVKTD
Length:167
Mass (Da):19,531
Last modified:October 1, 2002 - v1
Checksum:i0C7507C6F00F0D85
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK090706 mRNA. Translation: BAC03507.1.
BC104940 mRNA. Translation: AAI04941.1.
BC104942 mRNA. Translation: AAI04943.1.
CCDSiCCDS9783.1.
RefSeqiNP_872332.1. NM_182526.2.
XP_005267430.1. XM_005267373.1.
XP_005267431.1. XM_005267374.2.
XP_005267432.1. XM_005267375.1.
XP_006720125.1. XM_006720062.1.
UniGeneiHs.509707.

Genome annotation databases

EnsembliENST00000357461; ENSP00000350050; ENSG00000198133.
ENST00000555638; ENSP00000452201; ENSG00000198133.
ENST00000557006; ENSP00000451774; ENSG00000198133.
GeneIDi161145.
KEGGihsa:161145.
UCSCiuc001xjk.3. human.

Polymorphism databases

DMDMi74730125.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK090706 mRNA. Translation: BAC03507.1.
BC104940 mRNA. Translation: AAI04941.1.
BC104942 mRNA. Translation: AAI04943.1.
CCDSiCCDS9783.1.
RefSeqiNP_872332.1. NM_182526.2.
XP_005267430.1. XM_005267373.1.
XP_005267431.1. XM_005267374.2.
XP_005267432.1. XM_005267375.1.
XP_006720125.1. XM_006720062.1.
UniGeneiHs.509707.

3D structure databases

ProteinModelPortaliQ8NBD8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000350050.

Polymorphism databases

DMDMi74730125.

Proteomic databases

PaxDbiQ8NBD8.
PRIDEiQ8NBD8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000357461; ENSP00000350050; ENSG00000198133.
ENST00000555638; ENSP00000452201; ENSG00000198133.
ENST00000557006; ENSP00000451774; ENSG00000198133.
GeneIDi161145.
KEGGihsa:161145.
UCSCiuc001xjk.3. human.

Organism-specific databases

CTDi161145.
GeneCardsiGC14M067914.
HGNCiHGNC:20130. TMEM229B.
HPAiHPA046562.
neXtProtiNX_Q8NBD8.
PharmGKBiPA165479330.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG45696.
GeneTreeiENSGT00390000010899.
HOGENOMiHOG000007583.
HOVERGENiHBG055272.
InParanoidiQ8NBD8.
OMAiWEFTTGY.
OrthoDBiEOG7JHM6T.
PhylomeDBiQ8NBD8.
TreeFamiTF336481.

Miscellaneous databases

ChiTaRSiTMEM229B. human.
GeneWikiiTMEM229B.
GenomeRNAii161145.
NextBioi88023.
PROiQ8NBD8.

Gene expression databases

BgeeiQ8NBD8.
CleanExiHS_C14orf83.
ExpressionAtlasiQ8NBD8. baseline and differential.
GenevestigatoriQ8NBD8.

Family and domain databases

InterProiIPR010540. DUF1113_TMEM229.
[Graphical view]
PfamiPF06541. DUF1113. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cerebellum.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiT229B_HUMAN
AccessioniPrimary (citable) accession number: Q8NBD8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: October 1, 2002
Last modified: January 7, 2015
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.