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Q8NBD8

- T229B_HUMAN

UniProt

Q8NBD8 - T229B_HUMAN

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Protein

Transmembrane protein 229B

Gene
TMEM229B, C14orf83
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 229B
Gene namesi
Synonyms:C14orf83
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:20130. TMEM229B.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1414Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei15 – 3521Helical; Reviewed predictionAdd
BLAST
Topological domaini36 – 405Extracellular Reviewed prediction
Transmembranei41 – 6121Helical; Reviewed predictionAdd
BLAST
Topological domaini62 – 7312Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei74 – 9421Helical; Reviewed predictionAdd
BLAST
Topological domaini95 – 10915Extracellular Reviewed predictionAdd
BLAST
Transmembranei110 – 13021Helical; Reviewed predictionAdd
BLAST
Topological domaini131 – 16737Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165479330.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 167167Transmembrane protein 229BPRO_0000263681Add
BLAST

Proteomic databases

PaxDbiQ8NBD8.
PRIDEiQ8NBD8.

Expressioni

Gene expression databases

ArrayExpressiQ8NBD8.
BgeeiQ8NBD8.
CleanExiHS_C14orf83.
GenevestigatoriQ8NBD8.

Organism-specific databases

HPAiHPA046562.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000350050.

Structurei

3D structure databases

ProteinModelPortaliQ8NBD8.

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM229 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG45696.
HOGENOMiHOG000007583.
HOVERGENiHBG055272.
InParanoidiQ8NBD8.
OMAiWEFTTGY.
OrthoDBiEOG7JHM6T.
PhylomeDBiQ8NBD8.
TreeFamiTF336481.

Family and domain databases

InterProiIPR010540. DUF1113_TMEM229.
[Graphical view]
PfamiPF06541. DUF1113. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NBD8-1 [UniParc]FASTAAdd to Basket

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MASAEPLTAL SRWYLYAIHG YFCEVMFTAA WEFVVNLNWK FPGVTSVWAL    50
FIYGTSILIV ERMYLRLRGR CPLLLRCLIY TLWTYLWEFT TGFILRQFNA 100
CPWDYSQFDF DFMGLITLEY AVPWFCGALI MEQFIIRNTL RLRFDKDAEP 150
GEPSGALALA NGHVKTD 167
Length:167
Mass (Da):19,531
Last modified:October 1, 2002 - v1
Checksum:i0C7507C6F00F0D85
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK090706 mRNA. Translation: BAC03507.1.
BC104940 mRNA. Translation: AAI04941.1.
BC104942 mRNA. Translation: AAI04943.1.
CCDSiCCDS9783.1.
RefSeqiNP_872332.1. NM_182526.2.
XP_005267430.1. XM_005267373.1.
XP_005267431.1. XM_005267374.2.
XP_005267432.1. XM_005267375.1.
XP_006720125.1. XM_006720062.1.
UniGeneiHs.509707.

Genome annotation databases

EnsembliENST00000357461; ENSP00000350050; ENSG00000198133.
ENST00000555638; ENSP00000452201; ENSG00000198133.
ENST00000557006; ENSP00000451774; ENSG00000198133.
GeneIDi161145.
KEGGihsa:161145.
UCSCiuc001xjk.3. human.

Polymorphism databases

DMDMi74730125.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK090706 mRNA. Translation: BAC03507.1 .
BC104940 mRNA. Translation: AAI04941.1 .
BC104942 mRNA. Translation: AAI04943.1 .
CCDSi CCDS9783.1.
RefSeqi NP_872332.1. NM_182526.2.
XP_005267430.1. XM_005267373.1.
XP_005267431.1. XM_005267374.2.
XP_005267432.1. XM_005267375.1.
XP_006720125.1. XM_006720062.1.
UniGenei Hs.509707.

3D structure databases

ProteinModelPortali Q8NBD8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000350050.

Polymorphism databases

DMDMi 74730125.

Proteomic databases

PaxDbi Q8NBD8.
PRIDEi Q8NBD8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000357461 ; ENSP00000350050 ; ENSG00000198133 .
ENST00000555638 ; ENSP00000452201 ; ENSG00000198133 .
ENST00000557006 ; ENSP00000451774 ; ENSG00000198133 .
GeneIDi 161145.
KEGGi hsa:161145.
UCSCi uc001xjk.3. human.

Organism-specific databases

CTDi 161145.
GeneCardsi GC14M067914.
HGNCi HGNC:20130. TMEM229B.
HPAi HPA046562.
neXtProti NX_Q8NBD8.
PharmGKBi PA165479330.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG45696.
HOGENOMi HOG000007583.
HOVERGENi HBG055272.
InParanoidi Q8NBD8.
OMAi WEFTTGY.
OrthoDBi EOG7JHM6T.
PhylomeDBi Q8NBD8.
TreeFami TF336481.

Miscellaneous databases

ChiTaRSi TMEM229B. human.
GeneWikii TMEM229B.
GenomeRNAii 161145.
NextBioi 88023.
PROi Q8NBD8.

Gene expression databases

ArrayExpressi Q8NBD8.
Bgeei Q8NBD8.
CleanExi HS_C14orf83.
Genevestigatori Q8NBD8.

Family and domain databases

InterProi IPR010540. DUF1113_TMEM229.
[Graphical view ]
Pfami PF06541. DUF1113. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cerebellum.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiT229B_HUMAN
AccessioniPrimary (citable) accession number: Q8NBD8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

External Data

Dasty 3

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