ID   CT203_HUMAN             Reviewed;         194 AA.
AC   Q8NBC4; B8JHY2;
DT   15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT   15-JUN-2010, sequence version 2.
DT   27-MAR-2024, entry version 91.
DE   RecName: Full=Uncharacterized protein C20orf203;
GN   Name=C20orf203;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX   PubMed=20376170; DOI=10.1371/journal.pcbi.1000734;
RA   Li C.Y., Zhang Y., Wang Z., Zhang Y., Cao C., Zhang P.W., Lu S.J., Li X.M.,
RA   Yu Q., Zheng X., Du Q., Uhl G.R., Liu Q.R., Wei L.;
RT   "A human-specific de novo protein-coding gene associated with human brain
RT   functions.";
RL   PLoS Comput. Biol. 6:E1000734-E1000734(2010).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=11780052; DOI=10.1038/414865a;
RA   Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA   Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA   Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA   Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA   Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA   Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA   Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA   Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA   Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA   Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA   Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA   Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA   Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA   Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA   Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA   Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA   Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA   Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA   Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA   Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA   Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA   Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 20.";
RL   Nature 414:865-871(2001).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20376170}.
CC   -!- TISSUE SPECIFICITY: Expressed most abundantly in the brain at protein
CC       level. Present in cortex, cerebellum and midbrain. Found in neurons.
CC       Elevated expressions detected in Alzheimer brain samples. Also
CC       expressed in testis. {ECO:0000269|PubMed:20376170}.
CC   -!- MISCELLANEOUS: Originated from non-coding DNA sequences (insertion of
CC       repeat elements especially Alu). Seems to exist only in human.
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DR   EMBL; GU931819; ADF32072.1; -; mRNA.
DR   EMBL; GU931820; ADF32073.1; -; mRNA.
DR   EMBL; AK091025; BAC03569.1; -; mRNA.
DR   EMBL; FO393400; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC105014; -; NOT_ANNOTATED_CDS; mRNA.
DR   CCDS; CCDS13203.1; -.
DR   RefSeq; NP_872390.2; NM_182584.2.
DR   AlphaFoldDB; Q8NBC4; -.
DR   BioGRID; 129958; 6.
DR   IntAct; Q8NBC4; 2.
DR   STRING; 9606.ENSP00000495424; -.
DR   BioMuta; HGNC:26592; -.
DR   jPOST; Q8NBC4; -.
DR   ProteomicsDB; 72757; -.
DR   Antibodypedia; 78238; 7 antibodies from 6 providers.
DR   DNASU; 284805; -.
DR   Ensembl; ENST00000360785.6; ENSP00000495162.1; ENSG00000198547.10.
DR   Ensembl; ENST00000608990.6; ENSP00000495424.1; ENSG00000198547.10.
DR   GeneID; 284805; -.
DR   KEGG; hsa:284805; -.
DR   MANE-Select; ENST00000608990.6; ENSP00000495424.1; NM_182584.4; NP_872390.2.
DR   AGR; HGNC:26592; -.
DR   DisGeNET; 284805; -.
DR   GeneCards; C20orf203; -.
DR   HGNC; HGNC:26592; C20orf203.
DR   HPA; ENSG00000198547; Low tissue specificity.
DR   neXtProt; NX_Q8NBC4; -.
DR   OpenTargets; ENSG00000198547; -.
DR   PharmGKB; PA165392347; -.
DR   VEuPathDB; HostDB:ENSG00000198547; -.
DR   GeneTree; ENSGT00920000150801; -.
DR   InParanoid; Q8NBC4; -.
DR   OMA; AWPSTWF; -.
DR   OrthoDB; 5121788at2759; -.
DR   PathwayCommons; Q8NBC4; -.
DR   SignaLink; Q8NBC4; -.
DR   BioGRID-ORCS; 284805; 5 hits in 158 CRISPR screens.
DR   ChiTaRS; C20orf203; human.
DR   GenomeRNAi; 284805; -.
DR   Pharos; Q8NBC4; Tdark.
DR   PRO; PR:Q8NBC4; -.
DR   Proteomes; UP000005640; Chromosome 20.
DR   RNAct; Q8NBC4; Protein.
DR   Bgee; ENSG00000198547; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 84 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   InterPro; IPR040965; DUF5559.
DR   Pfam; PF17714; DUF5559; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Reference proteome.
FT   CHAIN           1..194
FT                   /note="Uncharacterized protein C20orf203"
FT                   /id="PRO_0000394501"
FT   REGION          62..93
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        123
FT                   /note="G -> R (in Ref. 1; ADF32072/ADF32073 and 2;
FT                   BAC03569)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   194 AA;  21159 MW;  4C0D18500B820F22 CRC64;
     MFPRPVLNSR AQAILLPQPP NMLDHRQWPP RLASFPFTKT GMLSRATSVL AGLTAHLWDL
     GGGAGRRTSK AQRVHPQPSH QRQPPPPQHP GPYQERIWVG GEGWGEVGGL RLSKVGRRDR
     EVGRGLRAPA GRGRAMGGMP RMGTVGDFGQ ALSSLAWTST CFQDFCLPSL PGKLPAPLIS
     KQQFLSNSSR SLFN
//