ID   ZSCA1_HUMAN             Reviewed;         408 AA.
AC   Q8NBB4; Q3B798; Q6WLH8; Q86WS8;
DT   23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 2.
DT   27-MAR-2024, entry version 168.
DE   RecName: Full=Zinc finger and SCAN domain-containing protein 1;
GN   Name=ZSCAN1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RA   Luo K.T., Yu L.;
RT   "Cloning and characterization of a novel scan box gene.";
RL   Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Substantia nigra;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA   Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA   Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA   Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA   Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA   Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA   Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA   Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA   Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA   McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA   Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA   Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA   She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA   Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Brain, and Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC   -!- INTERACTION:
CC       Q8NBB4; Q9HD26: GOPC; NbExp=3; IntAct=EBI-5292994, EBI-349832;
CC       Q8NBB4; O60437: PPL; NbExp=3; IntAct=EBI-5292994, EBI-368321;
CC       Q8NBB4-2; P54253: ATXN1; NbExp=6; IntAct=EBI-12021938, EBI-930964;
CC       Q8NBB4-2; O75190: DNAJB6; NbExp=3; IntAct=EBI-12021938, EBI-1053164;
CC       Q8NBB4-2; Q01658: DR1; NbExp=3; IntAct=EBI-12021938, EBI-750300;
CC       Q8NBB4-2; Q00403: GTF2B; NbExp=3; IntAct=EBI-12021938, EBI-389564;
CC       Q8NBB4-2; Q9Y5Q9: GTF3C3; NbExp=3; IntAct=EBI-12021938, EBI-1054873;
CC       Q8NBB4-2; O14901: KLF11; NbExp=3; IntAct=EBI-12021938, EBI-948266;
CC       Q8NBB4-2; Q13952-2: NFYC; NbExp=3; IntAct=EBI-12021938, EBI-11956831;
CC       Q8NBB4-2; O60437: PPL; NbExp=3; IntAct=EBI-12021938, EBI-368321;
CC       Q8NBB4-2; P49810: PSEN2; NbExp=3; IntAct=EBI-12021938, EBI-2010251;
CC       Q8NBB4-2; P37840: SNCA; NbExp=3; IntAct=EBI-12021938, EBI-985879;
CC       Q8NBB4-2; P00441: SOD1; NbExp=3; IntAct=EBI-12021938, EBI-990792;
CC       Q8NBB4-2; Q13148: TARDBP; NbExp=6; IntAct=EBI-12021938, EBI-372899;
CC       Q8NBB4-2; P10073: ZSCAN22; NbExp=3; IntAct=EBI-12021938, EBI-10178224;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00187}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q8NBB4-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8NBB4-2; Sequence=VSP_011953, VSP_011954;
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DR   EMBL; AY280370; AAQ16582.1; -; mRNA.
DR   EMBL; AK091098; BAC03582.1; -; mRNA.
DR   EMBL; AC008751; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC008969; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471135; EAW72550.1; -; Genomic_DNA.
DR   EMBL; BC048099; AAH48099.1; -; mRNA.
DR   EMBL; BC107729; AAI07730.1; -; mRNA.
DR   CCDS; CCDS12969.1; -. [Q8NBB4-1]
DR   RefSeq; NP_872378.3; NM_182572.3. [Q8NBB4-1]
DR   AlphaFoldDB; Q8NBB4; -.
DR   SMR; Q8NBB4; -.
DR   BioGRID; 129825; 55.
DR   IntAct; Q8NBB4; 59.
DR   STRING; 9606.ENSP00000282326; -.
DR   GlyGen; Q8NBB4; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; Q8NBB4; -.
DR   PhosphoSitePlus; Q8NBB4; -.
DR   BioMuta; ZSCAN1; -.
DR   DMDM; 296453061; -.
DR   jPOST; Q8NBB4; -.
DR   MassIVE; Q8NBB4; -.
DR   PaxDb; 9606-ENSP00000282326; -.
DR   PeptideAtlas; Q8NBB4; -.
DR   ABCD; Q8NBB4; 4 sequenced antibodies.
DR   Antibodypedia; 1802; 134 antibodies from 20 providers.
DR   DNASU; 284312; -.
DR   Ensembl; ENST00000282326.6; ENSP00000282326.1; ENSG00000152467.10. [Q8NBB4-1]
DR   GeneID; 284312; -.
DR   KEGG; hsa:284312; -.
DR   MANE-Select; ENST00000282326.6; ENSP00000282326.1; NM_182572.4; NP_872378.3.
DR   UCSC; uc002qra.2; human. [Q8NBB4-1]
DR   AGR; HGNC:23712; -.
DR   CTD; 284312; -.
DR   DisGeNET; 284312; -.
DR   GeneCards; ZSCAN1; -.
DR   HGNC; HGNC:23712; ZSCAN1.
DR   HPA; ENSG00000152467; Tissue enhanced (brain, pituitary gland, testis).
DR   MIM; 620026; gene.
DR   neXtProt; NX_Q8NBB4; -.
DR   PharmGKB; PA143485394; -.
DR   VEuPathDB; HostDB:ENSG00000152467; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   GeneTree; ENSGT00940000164008; -.
DR   HOGENOM; CLU_002678_49_8_1; -.
DR   InParanoid; Q8NBB4; -.
DR   OMA; HTVHGHM; -.
DR   OrthoDB; 5123279at2759; -.
DR   PhylomeDB; Q8NBB4; -.
DR   TreeFam; TF336839; -.
DR   PathwayCommons; Q8NBB4; -.
DR   SignaLink; Q8NBB4; -.
DR   BioGRID-ORCS; 284312; 11 hits in 1171 CRISPR screens.
DR   GenomeRNAi; 284312; -.
DR   Pharos; Q8NBB4; Tbio.
DR   PRO; PR:Q8NBB4; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; Q8NBB4; Protein.
DR   Bgee; ENSG00000152467; Expressed in adenohypophysis and 90 other cell types or tissues.
DR   ExpressionAtlas; Q8NBB4; baseline and differential.
DR   GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd07936; SCAN; 1.
DR   Gene3D; 3.30.160.60; Classic Zinc Finger; 3.
DR   Gene3D; 1.10.4020.10; DNA breaking-rejoining enzymes; 1.
DR   InterPro; IPR003309; SCAN_dom.
DR   InterPro; IPR038269; SCAN_sf.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   PANTHER; PTHR45935; PROTEIN ZBED8-RELATED; 1.
DR   PANTHER; PTHR45935:SF26; SCAN DOMAIN-CONTAINING PROTEIN SCAND2P-RELATED; 1.
DR   Pfam; PF02023; SCAN; 1.
DR   Pfam; PF00096; zf-C2H2; 2.
DR   SMART; SM00431; SCAN; 1.
DR   SMART; SM00355; ZnF_C2H2; 3.
DR   SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 2.
DR   SUPFAM; SSF47353; Retrovirus capsid dimerization domain-like; 1.
DR   PROSITE; PS50804; SCAN_BOX; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
DR   Genevisible; Q8NBB4; HS.
PE   1: Evidence at protein level;
KW   Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW   Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..408
FT                   /note="Zinc finger and SCAN domain-containing protein 1"
FT                   /id="PRO_0000047748"
FT   DOMAIN          38..120
FT                   /note="SCAN box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00187"
FT   ZN_FING         292..314
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         320..342
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         380..402
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          1..34
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          136..155
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          177..203
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          215..273
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          344..379
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..15
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        249..263
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        344..360
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         124..178
FT                   /note="VLVSLDSVEPQDWSFGEEEDGKSPRSQKEPSQASELILDAVAAAPALPEESE
FT                   WLE -> GERRRLRAPGRARGPDVSEDRTALLPAHIAPTPARPLPTSKPLLPRGCVFNY
FT                   FYI (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334, ECO:0000303|Ref.1"
FT                   /id="VSP_011953"
FT   VAR_SEQ         179..408
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334, ECO:0000303|Ref.1"
FT                   /id="VSP_011954"
FT   CONFLICT        132
FT                   /note="E -> G (in Ref. 2; BAC03582)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        Q8NBB4-2:130
FT                   /note="R -> P (in Ref. 1; AAQ16582)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   408 AA;  45286 MW;  95AB02559C6CA217 CRC64;
     MLPRPKAPAS PRRPQTPTPS EQDADPGPAS PRDTEAQRLR FRQFQYHVAS GPHLALGQLW
     TLCRQWLRPE ARSKEQMLEL LVLEQFLGAL PSKMRTWVQS QGPRSCREAA SLVEDLTQMC
     QQEVLVSLDS VEPQDWSFGE EEDGKSPRSQ KEPSQASELI LDAVAAAPAL PEESEWLETT
     QLQQSLHTRA EAEAPRAPGL LGSRARLPLK PSIWDEPEDL LAGPSSDLRA EGTVISSPKG
     PSAQRISPRR RNRNTDQSGR HQPSLKHTKG GTQEAVAGIS VVPRGPRGGR PFQCADCGMV
     FTWVTHFIEH QKTHREEGPF PCPECGKVFL HNSVLTEHGK IHLLEPPRKK APRSKGPRES
     VPPRDGAQGP VAPRSPKRPF QCSVCGKAFP WMVHLIDHQK LHTAHGHM
//