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Q8NBB4 (ZSCA1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger and SCAN domain-containing protein 1
Gene names
Name:ZSCAN1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length408 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in transcriptional regulation.

Subcellular location

Nucleus Potential.

Sequence similarities

Contains 3 C2H2-type zinc fingers.

Contains 1 SCAN box domain.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8NBB4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8NBB4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     124-178: VLVSLDSVEP...ALPEESEWLE → GERRRLRAPG...RGCVFNYFYI
     179-408: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 408408Zinc finger and SCAN domain-containing protein 1
PRO_0000047748

Regions

Domain38 – 12083SCAN box
Zinc finger292 – 31423C2H2-type 1
Zinc finger320 – 34223C2H2-type 2
Zinc finger380 – 40223C2H2-type 3

Natural variations

Alternative sequence124 – 17855VLVSL…SEWLE → GERRRLRAPGRARGPDVSED RTALLPAHIAPTPARPLPTS KPLLPRGCVFNYFYI in isoform 2.
VSP_011953
Alternative sequence179 – 408230Missing in isoform 2.
VSP_011954

Experimental info

Sequence conflict1321E → G in BAC03582. Ref.2
Isoform 2:
Sequence conflict1301R → P in AAQ16582. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 18, 2010. Version 2.
Checksum: 95AB02559C6CA217

FASTA40845,286
        10         20         30         40         50         60 
MLPRPKAPAS PRRPQTPTPS EQDADPGPAS PRDTEAQRLR FRQFQYHVAS GPHLALGQLW 

        70         80         90        100        110        120 
TLCRQWLRPE ARSKEQMLEL LVLEQFLGAL PSKMRTWVQS QGPRSCREAA SLVEDLTQMC 

       130        140        150        160        170        180 
QQEVLVSLDS VEPQDWSFGE EEDGKSPRSQ KEPSQASELI LDAVAAAPAL PEESEWLETT 

       190        200        210        220        230        240 
QLQQSLHTRA EAEAPRAPGL LGSRARLPLK PSIWDEPEDL LAGPSSDLRA EGTVISSPKG 

       250        260        270        280        290        300 
PSAQRISPRR RNRNTDQSGR HQPSLKHTKG GTQEAVAGIS VVPRGPRGGR PFQCADCGMV 

       310        320        330        340        350        360 
FTWVTHFIEH QKTHREEGPF PCPECGKVFL HNSVLTEHGK IHLLEPPRKK APRSKGPRES 

       370        380        390        400 
VPPRDGAQGP VAPRSPKRPF QCSVCGKAFP WMVHLIDHQK LHTAHGHM 

« Hide

Isoform 2 [UniParc].

Checksum: 6B574D047929CE94
Show »

FASTA17820,139

References

« Hide 'large scale' references
[1]"Cloning and characterization of a novel scan box gene."
Luo K.T., Yu L.
Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Substantia nigra.
[3]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Brain and Lung.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY280370 mRNA. Translation: AAQ16582.1.
AK091098 mRNA. Translation: BAC03582.1.
AC008751 Genomic DNA. No translation available.
AC008969 Genomic DNA. No translation available.
CH471135 Genomic DNA. Translation: EAW72550.1.
BC048099 mRNA. Translation: AAH48099.1.
BC107729 mRNA. Translation: AAI07730.1.
RefSeqNP_872378.3. NM_182572.3.
UniGeneHs.643437.

3D structure databases

ProteinModelPortalQ8NBB4.
SMRQ8NBB4. Positions 24-116, 263-407.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid129825. 37 interactions.
IntActQ8NBB4. 2 interactions.
STRING9606.ENSP00000282326.

Polymorphism databases

DMDM296453061.

Proteomic databases

PaxDbQ8NBB4.
PRIDEQ8NBB4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000282326; ENSP00000282326; ENSG00000152467. [Q8NBB4-1]
ENST00000391700; ENSP00000375581; ENSG00000152467.
ENST00000601162; ENSP00000470438; ENSG00000152467.
GeneID284312.
KEGGhsa:284312.
UCSCuc002qra.1. human. [Q8NBB4-2]
uc002qrc.1. human. [Q8NBB4-1]

Organism-specific databases

CTD284312.
GeneCardsGC19P058547.
HGNCHGNC:23712. ZSCAN1.
HPAHPA007938.
neXtProtNX_Q8NBB4.
PharmGKBPA143485394.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG252815.
HOGENOMHOG000170824.
InParanoidQ8NBB4.
KOK09230.
OMAQKTHREE.
OrthoDBEOG75J0M6.
PhylomeDBQ8NBB4.
TreeFamTF336839.

Gene expression databases

BgeeQ8NBB4.
CleanExHS_ZSCAN1.
GenevestigatorQ8NBB4.

Family and domain databases

Gene3D3.30.160.60. 3 hits.
InterProIPR027775. C2H2_Znf_fam.
IPR008916. Retrov_capsid_C.
IPR003309. Tscrpt_reg_SCAN.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERPTHR10032. PTHR10032. 1 hit.
PfamPF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTSM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 3 hits.
[Graphical view]
SUPFAMSSF47353. SSF47353. 1 hit.
PROSITEPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi284312.
NextBio94719.
PROQ8NBB4.

Entry information

Entry nameZSCA1_HUMAN
AccessionPrimary (citable) accession number: Q8NBB4
Secondary accession number(s): Q3B798, Q6WLH8, Q86WS8
Entry history
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: May 18, 2010
Last modified: April 16, 2014
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM