Q8NBB4 (ZSCA1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger and SCAN domain-containing protein 1

Gene names

Name:

ZSCAN1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	408 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in transcriptional regulation.
Subcellular location	Nucleus Potential.
Sequence similarities	Contains 3 C2H2-type zinc fingers. Contains 1 SCAN box domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	viral reproduction Inferred from electronic annotation. Source: InterPro
Cellular_component	nucleus Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW sequence-specific DNA binding RNA polymerase II transcription factor activity Inferred from Biological aspect of Ancestor. Source: RefGenome transcription coactivator activity Inferred from Biological aspect of Ancestor. Source: RefGenome zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8NBB4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8NBB4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     124-178: VLVSLDSVEP...ALPEESEWLE → GERRRLRAPG...RGCVFNYFYI
     179-408: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 408	408	Zinc finger and SCAN domain-containing protein 1		PRO_0000047748
Regions
	Domain	38 – 120	83	SCAN box
	Zinc finger	292 – 314	23	C2H2-type 1
	Zinc finger	320 – 342	23	C2H2-type 2
	Zinc finger	380 – 402	23	C2H2-type 3
Natural variations
	Alternative sequence	124 – 178	55	VLVSL…SEWLE → GERRRLRAPGRARGPDVSED RTALLPAHIAPTPARPLPTS KPLLPRGCVFNYFYI in isoform 2.		VSP_011953
	Alternative sequence	179 – 408	230	Missing in isoform 2.		VSP_011954
Experimental info
	Sequence conflict	132	1	E → G in BAC03582. Ref.2
Isoform 2:
	Sequence conflict	130	1	R → P in AAQ16582. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 18, 2010. Version 2. Checksum: 95AB02559C6CA217	FASTA	408	45,286
	10 20 30 40 50 60 MLPRPKAPAS PRRPQTPTPS EQDADPGPAS PRDTEAQRLR FRQFQYHVAS GPHLALGQLW 70 80 90 100 110 120 TLCRQWLRPE ARSKEQMLEL LVLEQFLGAL PSKMRTWVQS QGPRSCREAA SLVEDLTQMC 130 140 150 160 170 180 QQEVLVSLDS VEPQDWSFGE EEDGKSPRSQ KEPSQASELI LDAVAAAPAL PEESEWLETT 190 200 210 220 230 240 QLQQSLHTRA EAEAPRAPGL LGSRARLPLK PSIWDEPEDL LAGPSSDLRA EGTVISSPKG 250 260 270 280 290 300 PSAQRISPRR RNRNTDQSGR HQPSLKHTKG GTQEAVAGIS VVPRGPRGGR PFQCADCGMV 310 320 330 340 350 360 FTWVTHFIEH QKTHREEGPF PCPECGKVFL HNSVLTEHGK IHLLEPPRKK APRSKGPRES 370 380 390 400 VPPRDGAQGP VAPRSPKRPF QCSVCGKAFP WMVHLIDHQK LHTAHGHM
	Isoform 2 [UniParc]. Checksum: 6B574D047929CE94	FASTA	178	20,139
	10 20 30 40 50 60 MLPRPKAPAS PRRPQTPTPS EQDADPGPAS PRDTEAQRLR FRQFQYHVAS GPHLALGQLW 70 80 90 100 110 120 TLCRQWLRPE ARSKEQMLEL LVLEQFLGAL PSKMRTWVQS QGPRSCREAA SLVEDLTQMC 130 140 150 160 170 QQEGERRRLR APGRARGPDV SEDRTALLPA HIAPTPARPL PTSKPLLPRG CVFNYFYI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of a novel scan box gene." Luo K.T., Yu L. Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Substantia nigra.
[3]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain and Lung.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY280370 mRNA. Translation: AAQ16582.1. AK091098 mRNA. Translation: BAC03582.1. AC008751 Genomic DNA. No translation available. AC008969 Genomic DNA. No translation available. CH471135 Genomic DNA. Translation: EAW72550.1. BC048099 mRNA. Translation: AAH48099.1. BC107729 mRNA. Translation: AAI07730.1.
IPI	IPI00301010. IPI00448936.
RefSeq	NP_872378.3. NM_182572.3.
UniGene	Hs.643437.
3D structure databases
ProteinModelPortal	Q8NBB4.
SMR	Q8NBB4. Positions 24-116, 282-406.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8NBB4. 2 interactions.
STRING	9606.ENSP00000282326.
Polymorphism databases
DMDM	296453061.
Proteomic databases
PaxDb	Q8NBB4.
PRIDE	Q8NBB4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000282326; ENSP00000282326; ENSG00000152467. ENST00000391700; ENSP00000375581; ENSG00000152467. ENST00000601162; ENSP00000470438; ENSG00000152467.
GeneID	284312.
KEGG	hsa:284312.
UCSC	uc002qra.1. human. uc002qrc.1. human.
Organism-specific databases
CTD	284312.
GeneCards	GC19P058547.
HGNC	HGNC:23712. ZSCAN1.
HPA	HPA007938.
neXtProt	NX_Q8NBB4.
PharmGKB	PA143485394.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG252815.
HOGENOM	HOG000170824.
InParanoid	Q8NBB4.
KO	K09230.
OMA	QKTHREE.
OrthoDB	EOG4HX515.
Gene expression databases
Bgee	Q8NBB4.
CleanEx	HS_ZSCAN1.
Genevestigator	Q8NBB4.
GermOnline	ENSG00000152467. Homo sapiens.
Family and domain databases
Gene3D	3.30.160.60. 3 hits.
InterPro	IPR008916. Retrov_capsid_C. IPR003309. Tscrpt_reg_SCAN. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Pfam	PF02023. SCAN. 1 hit. PF00096. zf-C2H2. 1 hit. [Graphical view]
SMART	SM00431. SCAN. 1 hit. SM00355. ZnF_C2H2. 3 hits. [Graphical view]
SUPFAM	SSF47353. Retrov_capsid_C. 1 hit.
PROSITE	PS50804. SCAN_BOX. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 3 hits. PS50157. ZINC_FINGER_C2H2_2. 3 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	284312.
NextBio	94719.

Entry information

Entry name

ZSCA1_HUMAN

Accession

Primary (citable) accession number: Q8NBB4
Secondary accession number(s): Q3B798, Q6WLH8, Q86WS8

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 23, 2004
Last sequence update:	May 18, 2010
Last modified:	May 1, 2013
This is version 91 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.