Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger and SCAN domain-containing protein 1

Gene

ZSCAN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri292 – 31423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri320 – 34223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri380 – 40223C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: GO_Central
  4. transcription coactivator activity Source: GO_Central

GO - Biological processi

  1. regulation of transcription from RNA polymerase II promoter Source: GOC
  2. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and SCAN domain-containing protein 1
Gene namesi
Name:ZSCAN1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:23712. ZSCAN1.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA143485394.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 408408Zinc finger and SCAN domain-containing protein 1PRO_0000047748Add
BLAST

Proteomic databases

PaxDbiQ8NBB4.
PRIDEiQ8NBB4.

Expressioni

Gene expression databases

BgeeiQ8NBB4.
CleanExiHS_ZSCAN1.
GenevestigatoriQ8NBB4.

Organism-specific databases

HPAiHPA007938.

Interactioni

Protein-protein interaction databases

BioGridi129825. 49 interactions.
IntActiQ8NBB4. 2 interactions.
STRINGi9606.ENSP00000282326.

Structurei

3D structure databases

ProteinModelPortaliQ8NBB4.
SMRiQ8NBB4. Positions 24-116, 281-407.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini38 – 12083SCAN boxPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 SCAN box domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri292 – 31423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri320 – 34223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri380 – 40223C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG252815.
GeneTreeiENSGT00680000099963.
HOGENOMiHOG000170824.
InParanoidiQ8NBB4.
KOiK09230.
OMAiQKTHREE.
OrthoDBiEOG75J0M6.
PhylomeDBiQ8NBB4.
TreeFamiTF336839.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR027775. C2H2_Znf_fam.
IPR008916. Retrov_capsid_C.
IPR003309. Tscrpt_reg_SCAN.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR10032. PTHR10032. 1 hit.
PfamiPF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 3 hits.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
PROSITEiPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8NBB4-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLPRPKAPAS PRRPQTPTPS EQDADPGPAS PRDTEAQRLR FRQFQYHVAS
60 70 80 90 100
GPHLALGQLW TLCRQWLRPE ARSKEQMLEL LVLEQFLGAL PSKMRTWVQS
110 120 130 140 150
QGPRSCREAA SLVEDLTQMC QQEVLVSLDS VEPQDWSFGE EEDGKSPRSQ
160 170 180 190 200
KEPSQASELI LDAVAAAPAL PEESEWLETT QLQQSLHTRA EAEAPRAPGL
210 220 230 240 250
LGSRARLPLK PSIWDEPEDL LAGPSSDLRA EGTVISSPKG PSAQRISPRR
260 270 280 290 300
RNRNTDQSGR HQPSLKHTKG GTQEAVAGIS VVPRGPRGGR PFQCADCGMV
310 320 330 340 350
FTWVTHFIEH QKTHREEGPF PCPECGKVFL HNSVLTEHGK IHLLEPPRKK
360 370 380 390 400
APRSKGPRES VPPRDGAQGP VAPRSPKRPF QCSVCGKAFP WMVHLIDHQK

LHTAHGHM
Length:408
Mass (Da):45,286
Last modified:May 18, 2010 - v2
Checksum:i95AB02559C6CA217
GO
Isoform 2 (identifier: Q8NBB4-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     124-178: VLVSLDSVEP...ALPEESEWLE → GERRRLRAPG...RGCVFNYFYI
     179-408: Missing.

Show »
Length:178
Mass (Da):20,139
Checksum:i6B574D047929CE94
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti132 – 1321E → G in BAC03582. (PubMed:14702039)Curated
Isoform 2 (identifier: Q8NBB4-2)
Sequence conflicti130 – 1301R → P in AAQ16582. 1 PublicationCurated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei124 – 17855VLVSL…SEWLE → GERRRLRAPGRARGPDVSED RTALLPAHIAPTPARPLPTS KPLLPRGCVFNYFYI in isoform 2. 2 PublicationsVSP_011953Add
BLAST
Alternative sequencei179 – 408230Missing in isoform 2. 2 PublicationsVSP_011954Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY280370 mRNA. Translation: AAQ16582.1.
AK091098 mRNA. Translation: BAC03582.1.
AC008751 Genomic DNA. No translation available.
AC008969 Genomic DNA. No translation available.
CH471135 Genomic DNA. Translation: EAW72550.1.
BC048099 mRNA. Translation: AAH48099.1.
BC107729 mRNA. Translation: AAI07730.1.
CCDSiCCDS12969.1. [Q8NBB4-1]
RefSeqiNP_872378.3. NM_182572.3. [Q8NBB4-1]
UniGeneiHs.643437.

Genome annotation databases

EnsembliENST00000282326; ENSP00000282326; ENSG00000152467. [Q8NBB4-1]
ENST00000391700; ENSP00000375581; ENSG00000152467.
ENST00000601162; ENSP00000470438; ENSG00000152467.
GeneIDi284312.
KEGGihsa:284312.
UCSCiuc002qra.1. human. [Q8NBB4-2]
uc002qrc.1. human. [Q8NBB4-1]

Polymorphism databases

DMDMi296453061.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY280370 mRNA. Translation: AAQ16582.1.
AK091098 mRNA. Translation: BAC03582.1.
AC008751 Genomic DNA. No translation available.
AC008969 Genomic DNA. No translation available.
CH471135 Genomic DNA. Translation: EAW72550.1.
BC048099 mRNA. Translation: AAH48099.1.
BC107729 mRNA. Translation: AAI07730.1.
CCDSiCCDS12969.1. [Q8NBB4-1]
RefSeqiNP_872378.3. NM_182572.3. [Q8NBB4-1]
UniGeneiHs.643437.

3D structure databases

ProteinModelPortaliQ8NBB4.
SMRiQ8NBB4. Positions 24-116, 281-407.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129825. 49 interactions.
IntActiQ8NBB4. 2 interactions.
STRINGi9606.ENSP00000282326.

Polymorphism databases

DMDMi296453061.

Proteomic databases

PaxDbiQ8NBB4.
PRIDEiQ8NBB4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000282326; ENSP00000282326; ENSG00000152467. [Q8NBB4-1]
ENST00000391700; ENSP00000375581; ENSG00000152467.
ENST00000601162; ENSP00000470438; ENSG00000152467.
GeneIDi284312.
KEGGihsa:284312.
UCSCiuc002qra.1. human. [Q8NBB4-2]
uc002qrc.1. human. [Q8NBB4-1]

Organism-specific databases

CTDi284312.
GeneCardsiGC19P058547.
HGNCiHGNC:23712. ZSCAN1.
HPAiHPA007938.
neXtProtiNX_Q8NBB4.
PharmGKBiPA143485394.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG252815.
GeneTreeiENSGT00680000099963.
HOGENOMiHOG000170824.
InParanoidiQ8NBB4.
KOiK09230.
OMAiQKTHREE.
OrthoDBiEOG75J0M6.
PhylomeDBiQ8NBB4.
TreeFamiTF336839.

Miscellaneous databases

GenomeRNAii284312.
NextBioi94719.
PROiQ8NBB4.

Gene expression databases

BgeeiQ8NBB4.
CleanExiHS_ZSCAN1.
GenevestigatoriQ8NBB4.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR027775. C2H2_Znf_fam.
IPR008916. Retrov_capsid_C.
IPR003309. Tscrpt_reg_SCAN.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR10032. PTHR10032. 1 hit.
PfamiPF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 3 hits.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
PROSITEiPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a novel scan box gene."
    Luo K.T., Yu L.
    Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Substantia nigra.
  3. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain and Lung.

Entry informationi

Entry nameiZSCA1_HUMAN
AccessioniPrimary (citable) accession number: Q8NBB4
Secondary accession number(s): Q3B798, Q6WLH8, Q86WS8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: May 18, 2010
Last modified: February 4, 2015
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.