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Q8NBB4

- ZSCA1_HUMAN

UniProt

Q8NBB4 - ZSCA1_HUMAN

Protein

Zinc finger and SCAN domain-containing protein 1

Gene

ZSCAN1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 2 (18 May 2010)
      Previous versions | rss
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    Functioni

    May be involved in transcriptional regulation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri292 – 31423C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri320 – 34223C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri380 – 40223C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: RefGenome
    4. transcription coactivator activity Source: RefGenome

    GO - Biological processi

    1. regulation of transcription from RNA polymerase II promoter Source: GOC
    2. transcription from RNA polymerase II promoter Source: GOC

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger and SCAN domain-containing protein 1
    Gene namesi
    Name:ZSCAN1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:23712. ZSCAN1.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: RefGenome

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA143485394.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 408408Zinc finger and SCAN domain-containing protein 1PRO_0000047748Add
    BLAST

    Proteomic databases

    PaxDbiQ8NBB4.
    PRIDEiQ8NBB4.

    Expressioni

    Gene expression databases

    BgeeiQ8NBB4.
    CleanExiHS_ZSCAN1.
    GenevestigatoriQ8NBB4.

    Organism-specific databases

    HPAiHPA007938.

    Interactioni

    Protein-protein interaction databases

    BioGridi129825. 37 interactions.
    IntActiQ8NBB4. 2 interactions.
    STRINGi9606.ENSP00000282326.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NBB4.
    SMRiQ8NBB4. Positions 24-116, 261-407.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini38 – 12083SCAN boxPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 SCAN box domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri292 – 31423C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri320 – 34223C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri380 – 40223C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG252815.
    HOGENOMiHOG000170824.
    InParanoidiQ8NBB4.
    KOiK09230.
    OMAiQKTHREE.
    OrthoDBiEOG75J0M6.
    PhylomeDBiQ8NBB4.
    TreeFamiTF336839.

    Family and domain databases

    Gene3Di3.30.160.60. 3 hits.
    InterProiIPR027775. C2H2_Znf_fam.
    IPR008916. Retrov_capsid_C.
    IPR003309. Tscrpt_reg_SCAN.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PANTHERiPTHR10032. PTHR10032. 1 hit.
    PfamiPF02023. SCAN. 1 hit.
    PF00096. zf-C2H2. 1 hit.
    [Graphical view]
    SMARTiSM00431. SCAN. 1 hit.
    SM00355. ZnF_C2H2. 3 hits.
    [Graphical view]
    SUPFAMiSSF47353. SSF47353. 1 hit.
    PROSITEiPS50804. SCAN_BOX. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8NBB4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLPRPKAPAS PRRPQTPTPS EQDADPGPAS PRDTEAQRLR FRQFQYHVAS    50
    GPHLALGQLW TLCRQWLRPE ARSKEQMLEL LVLEQFLGAL PSKMRTWVQS 100
    QGPRSCREAA SLVEDLTQMC QQEVLVSLDS VEPQDWSFGE EEDGKSPRSQ 150
    KEPSQASELI LDAVAAAPAL PEESEWLETT QLQQSLHTRA EAEAPRAPGL 200
    LGSRARLPLK PSIWDEPEDL LAGPSSDLRA EGTVISSPKG PSAQRISPRR 250
    RNRNTDQSGR HQPSLKHTKG GTQEAVAGIS VVPRGPRGGR PFQCADCGMV 300
    FTWVTHFIEH QKTHREEGPF PCPECGKVFL HNSVLTEHGK IHLLEPPRKK 350
    APRSKGPRES VPPRDGAQGP VAPRSPKRPF QCSVCGKAFP WMVHLIDHQK 400
    LHTAHGHM 408
    Length:408
    Mass (Da):45,286
    Last modified:May 18, 2010 - v2
    Checksum:i95AB02559C6CA217
    GO
    Isoform 2 (identifier: Q8NBB4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         124-178: VLVSLDSVEP...ALPEESEWLE → GERRRLRAPG...RGCVFNYFYI
         179-408: Missing.

    Show »
    Length:178
    Mass (Da):20,139
    Checksum:i6B574D047929CE94
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti132 – 1321E → G in BAC03582. (PubMed:14702039)Curated
    Isoform 2 (identifier: Q8NBB4-2)
    Sequence conflicti130 – 1301R → P in AAQ16582. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei124 – 17855VLVSL…SEWLE → GERRRLRAPGRARGPDVSED RTALLPAHIAPTPARPLPTS KPLLPRGCVFNYFYI in isoform 2. 2 PublicationsVSP_011953Add
    BLAST
    Alternative sequencei179 – 408230Missing in isoform 2. 2 PublicationsVSP_011954Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY280370 mRNA. Translation: AAQ16582.1.
    AK091098 mRNA. Translation: BAC03582.1.
    AC008751 Genomic DNA. No translation available.
    AC008969 Genomic DNA. No translation available.
    CH471135 Genomic DNA. Translation: EAW72550.1.
    BC048099 mRNA. Translation: AAH48099.1.
    BC107729 mRNA. Translation: AAI07730.1.
    CCDSiCCDS12969.1. [Q8NBB4-1]
    RefSeqiNP_872378.3. NM_182572.3. [Q8NBB4-1]
    UniGeneiHs.643437.

    Genome annotation databases

    EnsembliENST00000282326; ENSP00000282326; ENSG00000152467. [Q8NBB4-1]
    ENST00000391700; ENSP00000375581; ENSG00000152467.
    ENST00000601162; ENSP00000470438; ENSG00000152467.
    GeneIDi284312.
    KEGGihsa:284312.
    UCSCiuc002qra.1. human. [Q8NBB4-2]
    uc002qrc.1. human. [Q8NBB4-1]

    Polymorphism databases

    DMDMi296453061.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY280370 mRNA. Translation: AAQ16582.1 .
    AK091098 mRNA. Translation: BAC03582.1 .
    AC008751 Genomic DNA. No translation available.
    AC008969 Genomic DNA. No translation available.
    CH471135 Genomic DNA. Translation: EAW72550.1 .
    BC048099 mRNA. Translation: AAH48099.1 .
    BC107729 mRNA. Translation: AAI07730.1 .
    CCDSi CCDS12969.1. [Q8NBB4-1 ]
    RefSeqi NP_872378.3. NM_182572.3. [Q8NBB4-1 ]
    UniGenei Hs.643437.

    3D structure databases

    ProteinModelPortali Q8NBB4.
    SMRi Q8NBB4. Positions 24-116, 261-407.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 129825. 37 interactions.
    IntActi Q8NBB4. 2 interactions.
    STRINGi 9606.ENSP00000282326.

    Polymorphism databases

    DMDMi 296453061.

    Proteomic databases

    PaxDbi Q8NBB4.
    PRIDEi Q8NBB4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000282326 ; ENSP00000282326 ; ENSG00000152467 . [Q8NBB4-1 ]
    ENST00000391700 ; ENSP00000375581 ; ENSG00000152467 .
    ENST00000601162 ; ENSP00000470438 ; ENSG00000152467 .
    GeneIDi 284312.
    KEGGi hsa:284312.
    UCSCi uc002qra.1. human. [Q8NBB4-2 ]
    uc002qrc.1. human. [Q8NBB4-1 ]

    Organism-specific databases

    CTDi 284312.
    GeneCardsi GC19P058547.
    HGNCi HGNC:23712. ZSCAN1.
    HPAi HPA007938.
    neXtProti NX_Q8NBB4.
    PharmGKBi PA143485394.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG252815.
    HOGENOMi HOG000170824.
    InParanoidi Q8NBB4.
    KOi K09230.
    OMAi QKTHREE.
    OrthoDBi EOG75J0M6.
    PhylomeDBi Q8NBB4.
    TreeFami TF336839.

    Miscellaneous databases

    GenomeRNAii 284312.
    NextBioi 94719.
    PROi Q8NBB4.

    Gene expression databases

    Bgeei Q8NBB4.
    CleanExi HS_ZSCAN1.
    Genevestigatori Q8NBB4.

    Family and domain databases

    Gene3Di 3.30.160.60. 3 hits.
    InterProi IPR027775. C2H2_Znf_fam.
    IPR008916. Retrov_capsid_C.
    IPR003309. Tscrpt_reg_SCAN.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    PANTHERi PTHR10032. PTHR10032. 1 hit.
    Pfami PF02023. SCAN. 1 hit.
    PF00096. zf-C2H2. 1 hit.
    [Graphical view ]
    SMARTi SM00431. SCAN. 1 hit.
    SM00355. ZnF_C2H2. 3 hits.
    [Graphical view ]
    SUPFAMi SSF47353. SSF47353. 1 hit.
    PROSITEi PS50804. SCAN_BOX. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of a novel scan box gene."
      Luo K.T., Yu L.
      Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Substantia nigra.
    3. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain and Lung.

    Entry informationi

    Entry nameiZSCA1_HUMAN
    AccessioniPrimary (citable) accession number: Q8NBB4
    Secondary accession number(s): Q3B798, Q6WLH8, Q86WS8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 23, 2004
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 103 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3