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Q8NB90

- SPAT5_HUMAN

UniProt

Q8NB90 - SPAT5_HUMAN

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Protein

Spermatogenesis-associated protein 5

Gene

SPATA5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

May be involved in morphological and functional mitochondrial transformations during spermatogenesis.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi394 – 4018ATP 1Sequence Analysis
Nucleotide bindingi668 – 6758ATP 2Sequence Analysis

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. multicellular organismal development Source: UniProtKB-KW
  3. spermatogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Spermatogenesis-associated protein 5
Alternative name(s):
ATPase family protein 2 homolog
Spermatogenesis-associated factor protein
Gene namesi
Name:SPATA5
Synonyms:AFG2, SPAF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:18119. SPATA5.

Subcellular locationi

Cytoplasm By similarity. Mitochondrion By similarity

GO - Cellular componenti

  1. cytoplasm Source: LIFEdb
  2. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38294.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 893893Spermatogenesis-associated protein 5PRO_0000330583Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei272 – 2721Phosphothreonine1 Publication
Modified residuei274 – 2741Phosphoserine1 Publication
Modified residuei279 – 2791Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8NB90.
PaxDbiQ8NB90.
PRIDEiQ8NB90.

PTM databases

PhosphoSiteiQ8NB90.

Expressioni

Gene expression databases

BgeeiQ8NB90.
CleanExiHS_SPATA5.
GenevestigatoriQ8NB90.

Organism-specific databases

HPAiHPA036450.
HPA036451.

Interactioni

Protein-protein interaction databases

BioGridi127927. 3 interactions.
IntActiQ8NB90. 3 interactions.
MINTiMINT-3041496.
STRINGi9606.ENSP00000274008.

Structurei

3D structure databases

ProteinModelPortaliQ8NB90.
SMRiQ8NB90. Positions 339-886.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AAA ATPase family. AFG2 subfamily.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0464.
GeneTreeiENSGT00740000115527.
HOGENOMiHOG000223225.
HOVERGENiHBG108504.
InParanoidiQ8NB90.
KOiK14575.
OMAiMNDIRPS.
OrthoDBiEOG7HF1HK.
PhylomeDBiQ8NB90.
TreeFamiTF314525.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR009010. Asp_de-COase-like_dom.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR003338. CDC4_N-term_subdom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00004. AAA. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
SM01073. CDC48_N. 1 hit.
[Graphical view]
SUPFAMiSSF50692. SSF50692. 1 hit.
SSF52540. SSF52540. 2 hits.
PROSITEiPS00674. AAA. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8NB90-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSKKNRKRL NQSAENGSSL PSAASSCAEA RAPSAGSDFA ATSGTLTVTN
60 70 80 90 100
LLEKVDDKIP KTFQNSLIHL GLNTMKSANI CIGRPVLLTS LNGKQEVYTA
110 120 130 140 150
WPMAGFPGGK VGLSEMAQKN VGVRPGDAIQ VQPLVGAVLQ AEEMDVALSD
160 170 180 190 200
KDMEINEEEL TGCILRKLDG KIVLPGNFLY CTFYGRPYKL QVLRVKGADG
210 220 230 240 250
MILGGPQSDS DTDAQRMAFE QSSMETSSLE LSLQLSQLDL EDTQIPTSRS
260 270 280 290 300
TPYKPIDDRI TNKASDVLLD VTQSPGDGSG LMLEEVTGLK CNFESAREGN
310 320 330 340 350
EQLTEEERLL KFSIGAKCNT DTFYFISSTT RVNFTEIDKN SKEQDNQFKV
360 370 380 390 400
TYDMIGGLSS QLKAIREIIE LPLKQPELFK SYGIPAPRGV LLYGPPGTGK
410 420 430 440 450
TMIARAVANE VGAYVSVING PEIISKFYGE TEAKLRQIFA EATLRHPSII
460 470 480 490 500
FIDELDALCP KREGAQNEVE KRVVASLLTL MDGIGSEVSE GQVLVLGATN
510 520 530 540 550
RPHALDAALR RPGRFDKEIE IGVPNAQDRL DILQKLLRRV PHLLTEAELL
560 570 580 590 600
QLANSAHGYV GADLKVLCNE AGLCALRRIL KKQPNLPDVK VAGLVKITLK
610 620 630 640 650
DFLQAMNDIR PSAMREIAID VPNVSWSDIG GLESIKLKLE QAVEWPLKHP
660 670 680 690 700
ESFIRMGIQP PKGVLLYGPP GCSKTMIAKA LANESGLNFL AIKGPELMNK
710 720 730 740 750
YVGESERAVR ETFRKARAVA PSIIFFDELD ALAVERGSSL GAGNVADRVL
760 770 780 790 800
AQLLTEMDGI EQLKDVTILA ATNRPDRIDK ALMRPGRIDR IIYVPLPDAA
810 820 830 840 850
TRREIFKLQF HSMPVSNEVD LDELILQTDA YSGAEIVAVC REAALLALEE
860 870 880 890
DIQANLIMKR HFTQALSTVT PRIPESLRRF YEDYQEKSGL HTL
Length:893
Mass (Da):97,904
Last modified:October 5, 2010 - v3
Checksum:i60214147CBB31F4A
GO
Isoform 2 (identifier: Q8NB90-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     781-790: ALMRPGRIDR → VPPSQTFLLL
     791-893: Missing.

Note: No experimental confirmation available.

Show »
Length:790
Mass (Da):86,077
Checksum:iFFFEED99D59D405F
GO
Isoform 3 (identifier: Q8NB90-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     694-696: GPE → VGC
     697-893: Missing.

Note: No experimental confirmation available.

Show »
Length:696
Mass (Da):75,727
Checksum:i5403422972A776F5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti55 – 551Missing in AAH48217. (PubMed:15489334)Curated
Sequence conflicti66 – 661S → P in AAM00262. 1 PublicationCurated
Sequence conflicti210 – 2101S → P in AAM00262. 1 PublicationCurated
Sequence conflicti568 – 5681C → Y in BAC03651. (PubMed:14702039)Curated
Sequence conflicti603 – 6031L → F in AAM00262. 1 PublicationCurated
Sequence conflicti614 – 6141M → T in BAC03651. (PubMed:14702039)Curated
Sequence conflicti695 – 6951P → S in AAM43608. 1 PublicationCurated
Sequence conflicti851 – 8511D → G in AAM00262. 1 PublicationCurated
Sequence conflicti891 – 8911H → R in AAM00262. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti27 – 271C → S.
Corresponds to variant rs35430470 [ dbSNP | Ensembl ].
VAR_042703
Natural varianti673 – 6731S → Y.
Corresponds to variant rs35133326 [ dbSNP | Ensembl ].
VAR_042704

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei694 – 6963GPE → VGC in isoform 3. 1 PublicationVSP_033046
Alternative sequencei697 – 893197Missing in isoform 3. 1 PublicationVSP_033047Add
BLAST
Alternative sequencei781 – 79010ALMRPGRIDR → VPPSQTFLLL in isoform 2. 1 PublicationVSP_033048
Alternative sequencei791 – 893103Missing in isoform 2. 1 PublicationVSP_033049Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF361489 mRNA. Translation: AAM00262.1.
AF479656 mRNA. Translation: AAM43608.1.
AK091384 mRNA. Translation: BAC03651.1.
AC021205 Genomic DNA. No translation available.
AC026402 Genomic DNA. No translation available.
AC097492 Genomic DNA. No translation available.
AC109357 Genomic DNA. No translation available.
BC048217 mRNA. Translation: AAH48217.1.
CCDSiCCDS3730.1. [Q8NB90-1]
RefSeqiNP_660208.2. NM_145207.2. [Q8NB90-1]
UniGeneiHs.709648.

Genome annotation databases

EnsembliENST00000274008; ENSP00000274008; ENSG00000145375. [Q8NB90-1]
GeneIDi166378.
KEGGihsa:166378.
UCSCiuc003iey.3. human. [Q8NB90-3]
uc003iez.4. human. [Q8NB90-1]

Polymorphism databases

DMDMi308153554.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF361489 mRNA. Translation: AAM00262.1 .
AF479656 mRNA. Translation: AAM43608.1 .
AK091384 mRNA. Translation: BAC03651.1 .
AC021205 Genomic DNA. No translation available.
AC026402 Genomic DNA. No translation available.
AC097492 Genomic DNA. No translation available.
AC109357 Genomic DNA. No translation available.
BC048217 mRNA. Translation: AAH48217.1 .
CCDSi CCDS3730.1. [Q8NB90-1 ]
RefSeqi NP_660208.2. NM_145207.2. [Q8NB90-1 ]
UniGenei Hs.709648.

3D structure databases

ProteinModelPortali Q8NB90.
SMRi Q8NB90. Positions 339-886.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 127927. 3 interactions.
IntActi Q8NB90. 3 interactions.
MINTi MINT-3041496.
STRINGi 9606.ENSP00000274008.

Chemistry

ChEMBLi CHEMBL2311230.

PTM databases

PhosphoSitei Q8NB90.

Polymorphism databases

DMDMi 308153554.

Proteomic databases

MaxQBi Q8NB90.
PaxDbi Q8NB90.
PRIDEi Q8NB90.

Protocols and materials databases

DNASUi 166378.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000274008 ; ENSP00000274008 ; ENSG00000145375 . [Q8NB90-1 ]
GeneIDi 166378.
KEGGi hsa:166378.
UCSCi uc003iey.3. human. [Q8NB90-3 ]
uc003iez.4. human. [Q8NB90-1 ]

Organism-specific databases

CTDi 166378.
GeneCardsi GC04P123844.
H-InvDB HIX0022056.
HGNCi HGNC:18119. SPATA5.
HPAi HPA036450.
HPA036451.
MIMi 613940. gene.
neXtProti NX_Q8NB90.
PharmGKBi PA38294.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0464.
GeneTreei ENSGT00740000115527.
HOGENOMi HOG000223225.
HOVERGENi HBG108504.
InParanoidi Q8NB90.
KOi K14575.
OMAi MNDIRPS.
OrthoDBi EOG7HF1HK.
PhylomeDBi Q8NB90.
TreeFami TF314525.

Miscellaneous databases

GeneWikii SPATA5.
GenomeRNAii 166378.
NextBioi 88589.
PROi Q8NB90.
SOURCEi Search...

Gene expression databases

Bgeei Q8NB90.
CleanExi HS_SPATA5.
Genevestigatori Q8NB90.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR003593. AAA+_ATPase.
IPR009010. Asp_de-COase-like_dom.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR003338. CDC4_N-term_subdom.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00004. AAA. 2 hits.
[Graphical view ]
SMARTi SM00382. AAA. 2 hits.
SM01073. CDC48_N. 1 hit.
[Graphical view ]
SUPFAMi SSF50692. SSF50692. 1 hit.
SSF52540. SSF52540. 2 hits.
PROSITEi PS00674. AAA. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of human SPAF, a new member of AAA-protein family associated with spermatogenesis and malignant conversion."
    Wang Z., Liu Y., Kulesz-Martin M.F.
    Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Cloning and characterization of a novel hSPAF gene."
    Xu J., Wang L., Ye X., Zeng L., Xie Y., Mao Y.
    Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Testis.
  6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-272; SER-274 AND SER-279, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSPAT5_HUMAN
AccessioniPrimary (citable) accession number: Q8NB90
Secondary accession number(s): C9JT97
, Q86XW1, Q8NI20, Q8TDL7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: October 5, 2010
Last modified: October 29, 2014
This is version 109 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3