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Q8NB78

- KDM1B_HUMAN

UniProt

Q8NB78 - KDM1B_HUMAN

Protein

Lysine-specific histone demethylase 1B

Gene

KDM1B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 3 (11 Jan 2011)
      Previous versions | rss
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    Functioni

    Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of imprinted genes during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. Has no effect on tri-methylated 'Lys-4', mono-, di- or tri-methylated 'Lys-9', mono-, di- or tri-methylated 'Lys-27', mono-, di- or tri-methylated 'Lys-36' of histone H3, or on mono-, di- or tri-methylated 'Lys-20' of histone H4 By similarity.By similarity

    Cofactori

    FAD.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri133 – 19361CW-typePROSITE-ProRule annotationAdd
    BLAST
    Nucleotide bindingi383 – 43957FADSequence AnalysisAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: InterPro
    2. flavin adenine dinucleotide binding Source: Ensembl
    3. histone demethylase activity (H3-dimethyl-K4 specific) Source: UniProtKB
    4. histone demethylase activity (H3-monomethyl-K4 specific) Source: UniProtKB
    5. oxidoreductase activity Source: UniProtKB-KW
    6. zinc ion binding Source: Ensembl

    GO - Biological processi

    1. DNA methylation involved in gamete generation Source: Ensembl
    2. histone H3-K4 demethylation Source: UniProtKB
    3. multicellular organismal development Source: UniProtKB-KW
    4. regulation of DNA methylation Source: UniProtKB
    5. regulation of gene expression by genetic imprinting Source: UniProtKB
    6. regulation of transcription, DNA-templated Source: UniProtKB-KW
    7. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chromatin regulator, Developmental protein, Oxidoreductase, Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    FAD, Flavoprotein, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysine-specific histone demethylase 1B (EC:1.-.-.-)
    Alternative name(s):
    Flavin-containing amine oxidase domain-containing protein 1
    Lysine-specific histone demethylase 2
    Gene namesi
    Name:KDM1B
    Synonyms:AOF1, C6orf193, LSD2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:21577. KDM1B.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162379723.
    PA165617946.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 822822Lysine-specific histone demethylase 1BPRO_0000247336Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei17 – 171Phosphoserine3 Publications
    Modified residuei247 – 2471Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8NB78.
    PaxDbiQ8NB78.
    PRIDEiQ8NB78.

    PTM databases

    PhosphoSiteiQ8NB78.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8NB78.
    BgeeiQ8NB78.
    CleanExiHS_AOF1.
    GenevestigatoriQ8NB78.

    Organism-specific databases

    HPAiHPA031269.
    HPA055597.

    Interactioni

    Subunit structurei

    Does not form a complex with RCOR1/CoREST.By similarity

    Protein-protein interaction databases

    BioGridi128743. 9 interactions.
    IntActiQ8NB78. 1 interaction.
    STRINGi9606.ENSP00000297792.

    Structurei

    Secondary structure

    1
    822
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi51 – 555
    Beta strandi70 – 723
    Beta strandi75 – 773
    Beta strandi82 – 865
    Beta strandi89 – 924
    Helixi93 – 1008
    Helixi104 – 1063
    Helixi107 – 11610
    Turni117 – 1204
    Helixi127 – 1348
    Beta strandi139 – 1413
    Turni145 – 1473
    Beta strandi150 – 1523
    Helixi161 – 1666
    Beta strandi173 – 1753
    Beta strandi180 – 1823
    Helixi184 – 1863
    Helixi192 – 1954
    Helixi199 – 2035
    Beta strandi211 – 2133
    Helixi217 – 2193
    Helixi225 – 2273
    Helixi267 – 2693
    Beta strandi286 – 2883
    Helixi291 – 2966
    Helixi298 – 3003
    Helixi305 – 32016
    Helixi328 – 3314
    Helixi332 – 3343
    Helixi341 – 35818
    Beta strandi361 – 3633
    Helixi371 – 3733
    Helixi378 – 3803
    Beta strandi384 – 3885
    Helixi392 – 40413
    Beta strandi407 – 4115
    Beta strandi413 – 4175
    Beta strandi427 – 4304
    Beta strandi432 – 4354
    Beta strandi438 – 4403
    Helixi446 – 4549
    Beta strandi458 – 4603
    Beta strandi467 – 4693
    Helixi477 – 49721
    Helixi498 – 5003
    Helixi503 – 5053
    Helixi509 – 52315
    Helixi530 – 54718
    Turni551 – 5533
    Turni556 – 5605
    Helixi561 – 5644
    Beta strandi572 – 5743
    Helixi580 – 5878
    Beta strandi592 – 5954
    Beta strandi598 – 6025
    Beta strandi604 – 6129
    Beta strandi617 – 6259
    Helixi629 – 6346
    Beta strandi637 – 6415
    Helixi645 – 6539
    Beta strandi654 – 6574
    Beta strandi660 – 6656
    Helixi672 – 6754
    Beta strandi679 – 6835
    Beta strandi686 – 6883
    Turni689 – 6924
    Beta strandi693 – 7008
    Beta strandi708 – 7136
    Helixi716 – 7205
    Turni721 – 7233
    Helixi726 – 74015
    Turni741 – 7433
    Beta strandi750 – 7545
    Helixi757 – 7593
    Turni761 – 7633
    Beta strandi766 – 7716
    Helixi777 – 7837
    Turni787 – 7893
    Beta strandi790 – 7923
    Helixi795 – 7973
    Beta strandi799 – 8013
    Helixi805 – 82117

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4FWEX-ray2.13A30-822[»]
    4FWFX-ray2.70A30-822[»]
    4FWJX-ray2.90A/B30-822[»]
    4GU0X-ray3.10A/B/C/D51-822[»]
    4GU1X-ray2.94A/B51-822[»]
    4GURX-ray2.51A51-822[»]
    4GUSX-ray2.23A51-822[»]
    4GUTX-ray2.00A51-822[»]
    4GUUX-ray2.30A51-822[»]
    4HSUX-ray1.99A51-822[»]
    ProteinModelPortaliQ8NB78.
    SMRiQ8NB78. Positions 49-822.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini275 – 37399SWIRMPROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The SWIRM domain may act as an anchor site for a histone tail.By similarity

    Sequence similaritiesi

    Belongs to the flavin monoamine oxidase family.Curated
    Contains 1 CW-type zinc finger.PROSITE-ProRule annotation
    Contains 1 SWIRM domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri133 – 19361CW-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiCOG1231.
    HOGENOMiHOG000230870.
    HOVERGENiHBG079963.
    InParanoidiQ8NB78.
    OrthoDBiEOG7X9G66.
    PhylomeDBiQ8NB78.
    TreeFamiTF352593.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR002937. Amino_oxidase.
    IPR009057. Homeodomain-like.
    IPR007526. SWIRM.
    IPR011991. WHTH_DNA-bd_dom.
    IPR011124. Znf_CW.
    [Graphical view]
    PfamiPF01593. Amino_oxidase. 1 hit.
    PF07496. zf-CW. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS50934. SWIRM. 1 hit.
    PS51050. ZF_CW. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8NB78-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MATPRGRTKK KASFDHSPDS LPLRSSGRQA KKKATETTDE DEDGGSEKKY    50
    RKCEKAGCTA TCPVCFASAS ERCAKNGYTS RWYHLSCGEH FCNECFDHYY 100
    RSHKDGYDKY TTWKKIWTSN GKTEPSPKAF MADQQLPYWV QCTKPECRKW 150
    RQLTKEIQLT PQIAKTYRCG MKPNTAIKPE TSDHCSLPED LRVLEVSNHW 200
    WYSMLILPPL LKDSVAAPLL SAYYPDCVGM SPSCTSTNRA AATGNASPGK 250
    LEHSKAALSV HVPGMNRYFQ PFYQPNECGK ALCVRPDVME LDELYEFPEY 300
    SRDPTMYLAL RNLILALWYT NCKEALTPQK CIPHIIVRGL VRIRCVQEVE 350
    RILYFMTRKG LINTGVLSVG ADQYLLPKDY HNKSVIIIGA GPAGLAAARQ 400
    LHNFGIKVTV LEAKDRIGGR VWDDKSFKGV TVGRGAQIVN GCINNPVALM 450
    CEQLGISMHK FGERCDLIQE GGRITDPTID KRMDFHFNAL LDVVSEWRKD 500
    KTQLQDVPLG EKIEEIYKAF IKESGIQFSE LEGQVLQFHL SNLEYACGSN 550
    LHQVSARSWD HNEFFAQFAG DHTLLTPGYS VIIEKLAEGL DIQLKSPVQC 600
    IDYSGDEVQV TTTDGTGYSA QKVLVTVPLA LLQKGAIQFN PPLSEKKMKA 650
    INSLGAGIIE KIALQFPYRF WDSKVQGADF FGHVPPSASK RGLFAVFYDM 700
    DPQKKHSVLM SVIAGEAVAS VRTLDDKQVL QQCMATLREL FKEQEVPDPT 750
    KYFVTRWSTD PWIQMAYSFV KTGGSGEAYD IIAEDIQGTV FFAGEATNRH 800
    FPQTVTGAYL SGVREASKIA AF 822
    Length:822
    Mass (Da):92,098
    Last modified:January 11, 2011 - v3
    Checksum:i6C0A9BD6B2CEA2EA
    GO
    Isoform 2 (identifier: Q8NB78-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         192-323: Missing.
         453-552: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:590
    Mass (Da):65,717
    Checksum:iAFDC638DFD727A9E
    GO
    Isoform 4 (identifier: Q8NB78-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-647: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:175
    Mass (Da):19,428
    Checksum:i5571123B00CDE9E8
    GO

    Sequence cautioni

    The sequence BAC03663.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti651 – 6511I → T in BAC86124. (PubMed:14702039)Curated
    Sequence conflicti794 – 7952Missing in CAH10499. (PubMed:17974005)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 647647Missing in isoform 4. 1 PublicationVSP_019963Add
    BLAST
    Alternative sequencei192 – 323132Missing in isoform 2. 1 PublicationVSP_019964Add
    BLAST
    Alternative sequencei453 – 552100Missing in isoform 2. 1 PublicationVSP_019965Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK091217 mRNA. Translation: BAC03612.1.
    AK091428 mRNA. Translation: BAC03663.1. Different initiation.
    AK125318 mRNA. Translation: BAC86124.1.
    AL589723, AL031774 Genomic DNA. Translation: CAM14159.1.
    AL589723, AL031774 Genomic DNA. Translation: CAM14160.1.
    AL031774, AL589723 Genomic DNA. Translation: CAM28216.1.
    AL031774, AL589723 Genomic DNA. Translation: CAM28217.1.
    CH471087 Genomic DNA. Translation: EAW55401.1.
    CR627410 mRNA. Translation: CAH10499.1.
    CCDSiCCDS34343.1. [Q8NB78-2]
    RefSeqiNP_694587.3. NM_153042.3. [Q8NB78-2]
    XP_005248983.1. XM_005248926.1. [Q8NB78-1]
    UniGeneiHs.709336.

    Genome annotation databases

    EnsembliENST00000297792; ENSP00000297792; ENSG00000165097. [Q8NB78-2]
    GeneIDi221656.
    KEGGihsa:221656.
    UCSCiuc003ncn.1. human. [Q8NB78-2]
    uc003nco.1. human. [Q8NB78-1]
    uc003ncp.1. human. [Q8NB78-4]

    Polymorphism databases

    DMDMi317373434.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK091217 mRNA. Translation: BAC03612.1 .
    AK091428 mRNA. Translation: BAC03663.1 . Different initiation.
    AK125318 mRNA. Translation: BAC86124.1 .
    AL589723 , AL031774 Genomic DNA. Translation: CAM14159.1 .
    AL589723 , AL031774 Genomic DNA. Translation: CAM14160.1 .
    AL031774 , AL589723 Genomic DNA. Translation: CAM28216.1 .
    AL031774 , AL589723 Genomic DNA. Translation: CAM28217.1 .
    CH471087 Genomic DNA. Translation: EAW55401.1 .
    CR627410 mRNA. Translation: CAH10499.1 .
    CCDSi CCDS34343.1. [Q8NB78-2 ]
    RefSeqi NP_694587.3. NM_153042.3. [Q8NB78-2 ]
    XP_005248983.1. XM_005248926.1. [Q8NB78-1 ]
    UniGenei Hs.709336.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4FWE X-ray 2.13 A 30-822 [» ]
    4FWF X-ray 2.70 A 30-822 [» ]
    4FWJ X-ray 2.90 A/B 30-822 [» ]
    4GU0 X-ray 3.10 A/B/C/D 51-822 [» ]
    4GU1 X-ray 2.94 A/B 51-822 [» ]
    4GUR X-ray 2.51 A 51-822 [» ]
    4GUS X-ray 2.23 A 51-822 [» ]
    4GUT X-ray 2.00 A 51-822 [» ]
    4GUU X-ray 2.30 A 51-822 [» ]
    4HSU X-ray 1.99 A 51-822 [» ]
    ProteinModelPortali Q8NB78.
    SMRi Q8NB78. Positions 49-822.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 128743. 9 interactions.
    IntActi Q8NB78. 1 interaction.
    STRINGi 9606.ENSP00000297792.

    Chemistry

    BindingDBi Q8NB78.
    ChEMBLi CHEMBL1938208.

    PTM databases

    PhosphoSitei Q8NB78.

    Polymorphism databases

    DMDMi 317373434.

    Proteomic databases

    MaxQBi Q8NB78.
    PaxDbi Q8NB78.
    PRIDEi Q8NB78.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000297792 ; ENSP00000297792 ; ENSG00000165097 . [Q8NB78-2 ]
    GeneIDi 221656.
    KEGGi hsa:221656.
    UCSCi uc003ncn.1. human. [Q8NB78-2 ]
    uc003nco.1. human. [Q8NB78-1 ]
    uc003ncp.1. human. [Q8NB78-4 ]

    Organism-specific databases

    CTDi 221656.
    GeneCardsi GC06P018156.
    H-InvDB HIX0005608.
    HGNCi HGNC:21577. KDM1B.
    HPAi HPA031269.
    HPA055597.
    MIMi 613081. gene.
    neXtProti NX_Q8NB78.
    PharmGKBi PA162379723.
    PA165617946.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1231.
    HOGENOMi HOG000230870.
    HOVERGENi HBG079963.
    InParanoidi Q8NB78.
    OrthoDBi EOG7X9G66.
    PhylomeDBi Q8NB78.
    TreeFami TF352593.

    Miscellaneous databases

    GenomeRNAii 221656.
    NextBioi 91405.
    PROi Q8NB78.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8NB78.
    Bgeei Q8NB78.
    CleanExi HS_AOF1.
    Genevestigatori Q8NB78.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR002937. Amino_oxidase.
    IPR009057. Homeodomain-like.
    IPR007526. SWIRM.
    IPR011991. WHTH_DNA-bd_dom.
    IPR011124. Znf_CW.
    [Graphical view ]
    Pfami PF01593. Amino_oxidase. 1 hit.
    PF07496. zf-CW. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS50934. SWIRM. 1 hit.
    PS51050. ZF_CW. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 185-822 (ISOFORM 1).
      Tissue: Brain and Tongue.
    2. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 624-822 (ISOFORM 1).
      Tissue: Cervix.
    5. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
      J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-17, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-17, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-17 AND SER-247, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiKDM1B_HUMAN
    AccessioniPrimary (citable) accession number: Q8NB78
    Secondary accession number(s): A2A2C5
    , A2A2C6, Q5TGV3, Q6AI15, Q6ZUU4, Q8N258, Q96EL7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2006
    Last sequence update: January 11, 2011
    Last modified: October 1, 2014
    This is version 102 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3