ID   SYT14_HUMAN             Reviewed;         555 AA.
AC   Q8NB59; B1AJU0; B1AJU1; F5H426; Q5THX7; Q707N3; Q707N4; Q707N5; Q707N6;
AC   Q707N7;
DT   27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT   17-OCT-2006, sequence version 2.
DT   24-JAN-2024, entry version 162.
DE   RecName: Full=Synaptotagmin-14;
DE   AltName: Full=Synaptotagmin XIV;
DE            Short=SytXIV;
GN   Name=SYT14;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX   PubMed=12801916; DOI=10.1093/jb/mvg082;
RA   Fukuda M.;
RT   "Molecular cloning, expression, and characterization of a novel class of
RT   synaptotagmin (Syt XIV) conserved from Drosophila to humans.";
RL   J. Biochem. 133:641-649(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3; 4; 5 AND 6).
RX   PubMed=15238157; DOI=10.1186/1471-2164-5-43;
RA   Craxton M.A.;
RT   "Synaptotagmin gene content of the sequenced genomes.";
RL   BMC Genomics 5:43-43(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Brain;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA   Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA   Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA   Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA   Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA   Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA   Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA   Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA   Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA   Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA   Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA   Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA   Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA   McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA   Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA   White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA   Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA   Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA   Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7).
RC   TISSUE=Cerebellum;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   TISSUE SPECIFICITY, SUBCELLULAR LOCATION, VARIANT SCAR11 ASP-439, VARIANT
RP   GLU-138, AND CHARACTERIZATION OF VARIANT SCAR11 ASP-439.
RX   PubMed=21835308; DOI=10.1016/j.ajhg.2011.07.012;
RA   Doi H., Yoshida K., Yasuda T., Fukuda M., Fukuda Y., Morita H., Ikeda S.,
RA   Kato R., Tsurusaki Y., Miyake N., Saitsu H., Sakai H., Miyatake S.,
RA   Shiina M., Nukina N., Koyano S., Tsuji S., Kuroiwa Y., Matsumoto N.;
RT   "Exome sequencing reveals a homozygous SYT14 mutation in adult-onset,
RT   autosomal-recessive spinocerebellar ataxia with psychomotor retardation.";
RL   Am. J. Hum. Genet. 89:320-327(2011).
CC   -!- FUNCTION: May be involved in the trafficking and exocytosis of
CC       secretory vesicles in non-neuronal tissues. Is Ca(2+)-independent.
CC   -!- SUBUNIT: Homodimer. Can also form heterodimers (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:21835308}; Single-
CC       pass type III membrane protein {ECO:0000269|PubMed:21835308}.
CC       Note=Localized in perinuclear and submembranous regions.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=7;
CC       Name=1;
CC         IsoId=Q8NB59-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8NB59-2; Sequence=VSP_011605, VSP_011606;
CC       Name=3;
CC         IsoId=Q8NB59-3; Sequence=VSP_011602;
CC       Name=4;
CC         IsoId=Q8NB59-4; Sequence=VSP_011602, VSP_011603, VSP_011604;
CC       Name=5;
CC         IsoId=Q8NB59-5; Sequence=VSP_011607;
CC       Name=6;
CC         IsoId=Q8NB59-6; Sequence=VSP_011608;
CC       Name=7;
CC         IsoId=Q8NB59-7; Sequence=VSP_046124, VSP_011608;
CC   -!- TISSUE SPECIFICITY: Highly expressed in fetal and adult brain tissue.
CC       {ECO:0000269|PubMed:21835308}.
CC   -!- DISEASE: Spinocerebellar ataxia, autosomal recessive, 11 (SCAR11)
CC       [MIM:614229]: A form of spinocerebellar ataxia, a clinically and
CC       genetically heterogeneous group of cerebellar disorders. Patients show
CC       progressive incoordination of gait and often poor coordination of
CC       hands, speech and eye movements, due to degeneration of the cerebellum
CC       with variable involvement of the brainstem and spinal cord. SCAR11 is
CC       associated with psychomotor retardation. {ECO:0000269|PubMed:21835308}.
CC       Note=The disease is caused by variants affecting the gene represented
CC       in this entry.
CC   -!- SIMILARITY: Belongs to the synaptotagmin family. {ECO:0000305}.
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DR   EMBL; AB102948; BAC76809.1; -; mRNA.
DR   EMBL; AJ617623; CAE85109.1; -; mRNA.
DR   EMBL; AJ617624; CAE85110.1; -; mRNA.
DR   EMBL; AJ617625; CAE85111.1; -; mRNA.
DR   EMBL; AJ617626; CAE85112.1; -; mRNA.
DR   EMBL; AJ617627; CAE85113.1; -; mRNA.
DR   EMBL; AK091517; BAC03682.1; -; mRNA.
DR   EMBL; AL513263; CAI17884.1; -; Genomic_DNA.
DR   EMBL; AL022397; CAI17884.1; JOINED; Genomic_DNA.
DR   EMBL; AL022399; CAI17884.1; JOINED; Genomic_DNA.
DR   EMBL; AL022397; CAI17887.1; -; Genomic_DNA.
DR   EMBL; AL022399; CAI17887.1; JOINED; Genomic_DNA.
DR   EMBL; AL513263; CAI17887.1; JOINED; Genomic_DNA.
DR   EMBL; AL022397; CAI17888.1; -; Genomic_DNA.
DR   EMBL; AL513263; CAI17888.1; JOINED; Genomic_DNA.
DR   EMBL; AL022399; CAI17888.1; JOINED; Genomic_DNA.
DR   EMBL; AL022397; CAI17889.1; -; Genomic_DNA.
DR   EMBL; AL513263; CAI17889.1; JOINED; Genomic_DNA.
DR   EMBL; AL022399; CAI22770.1; -; Genomic_DNA.
DR   EMBL; AL513263; CAI22770.1; JOINED; Genomic_DNA.
DR   EMBL; AL022397; CAI22770.1; JOINED; Genomic_DNA.
DR   EMBL; AL513263; CAI17885.1; -; Genomic_DNA.
DR   EMBL; AL022399; CAI17885.1; JOINED; Genomic_DNA.
DR   EMBL; AL022397; CAI17885.1; JOINED; Genomic_DNA.
DR   EMBL; AL513263; CAI17886.1; -; Genomic_DNA.
DR   EMBL; AL022397; CAI17886.1; JOINED; Genomic_DNA.
DR   EMBL; AL022399; CAI22771.1; -; Genomic_DNA.
DR   EMBL; AL022397; CAI22771.1; JOINED; Genomic_DNA.
DR   EMBL; AL513263; CAI22771.1; JOINED; Genomic_DNA.
DR   EMBL; BC144157; -; NOT_ANNOTATED_CDS; mRNA.
DR   CCDS; CCDS31014.1; -. [Q8NB59-1]
DR   CCDS; CCDS53470.1; -. [Q8NB59-6]
DR   CCDS; CCDS58058.1; -. [Q8NB59-3]
DR   RefSeq; NP_001139734.1; NM_001146262.2. [Q8NB59-6]
DR   RefSeq; NP_001242935.1; NM_001256006.1. [Q8NB59-3]
DR   RefSeq; NP_694994.2; NM_153262.3. [Q8NB59-1]
DR   AlphaFoldDB; Q8NB59; -.
DR   SMR; Q8NB59; -.
DR   BioGRID; 129128; 4.
DR   IntAct; Q8NB59; 1.
DR   STRING; 9606.ENSP00000486230; -.
DR   iPTMnet; Q8NB59; -.
DR   PhosphoSitePlus; Q8NB59; -.
DR   BioMuta; SYT14; -.
DR   DMDM; 116242810; -.
DR   jPOST; Q8NB59; -.
DR   MassIVE; Q8NB59; -.
DR   MaxQB; Q8NB59; -.
DR   PaxDb; 9606-ENSP00000355986; -.
DR   PeptideAtlas; Q8NB59; -.
DR   Antibodypedia; 51697; 33 antibodies from 15 providers.
DR   DNASU; 255928; -.
DR   Ensembl; ENST00000367015.5; ENSP00000355982.1; ENSG00000143469.21. [Q8NB59-3]
DR   Ensembl; ENST00000367019.6; ENSP00000355986.1; ENSG00000143469.21. [Q8NB59-6]
DR   Ensembl; ENST00000399639.6; ENSP00000445837.2; ENSG00000143469.21. [Q8NB59-4]
DR   Ensembl; ENST00000472886.5; ENSP00000418901.1; ENSG00000143469.21. [Q8NB59-1]
DR   Ensembl; ENST00000537238.5; ENSP00000437423.1; ENSG00000143469.21. [Q8NB59-3]
DR   GeneID; 255928; -.
DR   KEGG; hsa:255928; -.
DR   MANE-Select; ENST00000367019.6; ENSP00000355986.1; NM_001146262.4; NP_001139734.1. [Q8NB59-6]
DR   UCSC; uc001hht.6; human. [Q8NB59-1]
DR   AGR; HGNC:23143; -.
DR   CTD; 255928; -.
DR   DisGeNET; 255928; -.
DR   GeneCards; SYT14; -.
DR   HGNC; HGNC:23143; SYT14.
DR   HPA; ENSG00000143469; Tissue enhanced (retina, testis, thyroid gland).
DR   MalaCards; SYT14; -.
DR   MIM; 610949; gene.
DR   MIM; 614229; phenotype.
DR   neXtProt; NX_Q8NB59; -.
DR   OpenTargets; ENSG00000143469; -.
DR   Orphanet; 284271; Autosomal recessive cerebellar ataxia-psychomotor delay syndrome.
DR   PharmGKB; PA134887689; -.
DR   VEuPathDB; HostDB:ENSG00000143469; -.
DR   eggNOG; KOG1028; Eukaryota.
DR   GeneTree; ENSGT00940000159420; -.
DR   HOGENOM; CLU_1049555_0_0_1; -.
DR   InParanoid; Q8NB59; -.
DR   OMA; MTFLFWY; -.
DR   OrthoDB; 2875354at2759; -.
DR   PhylomeDB; Q8NB59; -.
DR   TreeFam; TF351132; -.
DR   PathwayCommons; Q8NB59; -.
DR   BioGRID-ORCS; 255928; 15 hits in 1146 CRISPR screens.
DR   ChiTaRS; SYT14; human.
DR   GeneWiki; SYT14; -.
DR   GenomeRNAi; 255928; -.
DR   Pharos; Q8NB59; Tbio.
DR   PRO; PR:Q8NB59; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   RNAct; Q8NB59; Protein.
DR   Bgee; ENSG00000143469; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 66 other cell types or tissues.
DR   ExpressionAtlas; Q8NB59; baseline and differential.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005543; F:phospholipid binding; IBA:GO_Central.
DR   CDD; cd08389; C2A_Synaptotagmin-14_16; 1.
DR   CDD; cd08408; C2B_Synaptotagmin-14_16; 1.
DR   Gene3D; 2.60.40.150; C2 domain; 2.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR043541; SYT14/14L/16.
DR   PANTHER; PTHR46129; SYNAPTOTAGMIN 14, ISOFORM D; 1.
DR   PANTHER; PTHR46129:SF3; SYNAPTOTAGMIN-14-RELATED; 1.
DR   Pfam; PF00168; C2; 2.
DR   SMART; SM00239; C2; 2.
DR   SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR   PROSITE; PS50004; C2; 2.
DR   Genevisible; Q8NB59; HS.
PE   1: Evidence at protein level;
KW   Alternative splicing; Disease variant; Membrane; Neurodegeneration;
KW   Reference proteome; Repeat; Signal-anchor; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..555
FT                   /note="Synaptotagmin-14"
FT                   /id="PRO_0000183978"
FT   TOPO_DOM        1..24
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        25..47
FT                   /note="Helical; Signal-anchor for type III membrane
FT                   protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        48..555
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          260..379
FT                   /note="C2 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT   DOMAIN          415..550
FT                   /note="C2 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT   REGION          157..179
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          222..257
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        234..250
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         1..38
FT                   /note="Missing (in isoform 3 and isoform 4)"
FT                   /evidence="ECO:0000303|PubMed:15238157"
FT                   /id="VSP_011602"
FT   VAR_SEQ         1..20
FT                   /note="MAIEGGERTCGVHELICIRK -> MASASWRLKVEREPVEYMNLSVLEKIGY
FT                   FSVARLEYSGTILAHCNFRLLGSNDSSASASQVTGTT (in isoform 7)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_046124"
FT   VAR_SEQ         299..303
FT                   /note="QVHLV -> AVTPK (in isoform 4)"
FT                   /evidence="ECO:0000303|PubMed:15238157"
FT                   /id="VSP_011603"
FT   VAR_SEQ         304..555
FT                   /note="Missing (in isoform 4)"
FT                   /evidence="ECO:0000303|PubMed:15238157"
FT                   /id="VSP_011604"
FT   VAR_SEQ         450..457
FT                   /note="PPNTYVKL -> HPMDCSVV (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15238157"
FT                   /id="VSP_011605"
FT   VAR_SEQ         452
FT                   /note="N -> TFHPLLSDGLFCCLKHLIGGQVYIIRD (in isoform 5)"
FT                   /evidence="ECO:0000303|PubMed:15238157"
FT                   /id="VSP_011607"
FT   VAR_SEQ         452
FT                   /note="N -> NGLFCCLKHLIGGQVYIIRD (in isoform 6 and isoform
FT                   7)"
FT                   /evidence="ECO:0000303|PubMed:15238157,
FT                   ECO:0000303|PubMed:15489334"
FT                   /id="VSP_011608"
FT   VAR_SEQ         458..555
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15238157"
FT                   /id="VSP_011606"
FT   VARIANT         138
FT                   /note="G -> E (in dbSNP:rs759296305)"
FT                   /evidence="ECO:0000269|PubMed:21835308"
FT                   /id="VAR_066663"
FT   VARIANT         439
FT                   /note="G -> D (in SCAR11; shows intracellular localization
FT                   different from that of the wild-type protein; forms a
FT                   reticular pattern in the cytoplasm; does not show
FT                   submembranous distribution; is abnormally retained in the
FT                   endoplasmic reticulum consistent to improper folding;
FT                   dbSNP:rs387907033)"
FT                   /evidence="ECO:0000269|PubMed:21835308"
FT                   /id="VAR_066664"
FT   CONFLICT        195
FT                   /note="S -> N (in Ref. 2; CAE85112)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        323
FT                   /note="V -> A (in Ref. 2; CAE85113)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        514
FT                   /note="K -> E (in Ref. 1; BAC76809 and 3; BAC03682)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   555 AA;  62287 MW;  A7E7359DC3DEF5B9 CRC64;
     MAIEGGERTC GVHELICIRK VSPEAVGFLS AVGVFIILML LLFLYINKKF CFENVGGFPD
     LGSEYSTRKN SQDKIYNSYM DKDEHGSSSE SEDEALGKYH EALSRTHNSR LPLADSRQRN
     YAWETRQKYS PLSAEYDGYS SEASIDEGNC IQRMRRTPPL DELQPPPYQD DSGSPHLSCT
     PSEIGDSKCE FSHCSNSPRC SYNKCPSEGS TGHEIESFHN KGYEEDVPSD STAVLSPEDM
     SAQGSSSQLP KPFDPEPEAK YGTLDVTFDY DSQEQKLLVT VTAVTDIPTY NRTGGNSWQV
     HLVLLPIKKQ RAKTSIQRGP CPVFTETFKF NHVESEMIGN YAVRFRLYGV HRMKKEKIVG
     EKIFYLTKLN LQGKMSLPVI LEPSYNHSGC DSQMSVSEMS CSESTSSCQS LEHGSVPEIL
     IGLLYNATTG RLSAEVIKGS HFKNLAANRP PNTYVKLTLL NSMGQEMSKC KTSIRRGQPN
     PVYKETFVFQ VALFQLSDVT LILSVYNKRS MKRKEMIGWI SLGLNSSGEE ELNHWTEMKE
     SKGQQVCRWH ALLES
//