Q8NB59 (SYT14_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Synaptotagmin-14

Alternative name(s):
Synaptotagmin XIV
Short name=SytXIV

Gene names

Name:

SYT14

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	555 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Is Ca2+-independent.
Subunit structure	Homodimer. Can also form heterodimers By similarity.
Subcellular location	Membrane; Single-pass type III membrane protein. Note: Localized in perinuclear and submembranous regions. Ref.6
Tissue specificity	Highly expressed in fetal and adult brain tissue. Ref.6
Involvement in disease	Spinocerebellar ataxia, autosomal recessive, 11 (SCAR11) [MIM:614229]: Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAR11 is associated with psychomotor retardation. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.6
Sequence similarities	Belongs to the synaptotagmin family. Contains 2 C2 domains.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Disease mutation Neurodegeneration
Domain	Repeat Signal-anchor Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell death Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 7 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8NB59-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8NB59-2)

The sequence of this isoform differs from the canonical sequence as follows:
     450-457: PPNTYVKL → HPMDCSVV
     458-555: Missing.

Isoform 3 (identifier: Q8NB59-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-38: Missing.

Isoform 4 (identifier: Q8NB59-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-38: Missing.
     299-303: QVHLV → AVTPK
     304-555: Missing.

Isoform 5 (identifier: Q8NB59-5)

The sequence of this isoform differs from the canonical sequence as follows:
     452-452: N → TFHPLLSDGLFCCLKHLIGGQVYIIRD

Isoform 6 (identifier: Q8NB59-6)

The sequence of this isoform differs from the canonical sequence as follows:
     452-452: N → NGLFCCLKHLIGGQVYIIRD

Isoform 7 (identifier: Q8NB59-7)

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: MAIEGGERTCGVHELICIRK → MASASWRLKV...ASASQVTGTT
     452-452: N → NGLFCCLKHLIGGQVYIIRD

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 555	555	Synaptotagmin-14		PRO_0000183978
Regions
	Topological domain	1 – 24	24	Extracellular Potential
	Transmembrane	25 – 47	23	Helical; Signal-anchor for type III membrane protein; Potential
	Topological domain	48 – 555	508	Cytoplasmic Potential
	Domain	276 – 378	103	C2 1
	Domain	417 – 521	105	C2 2
Natural variations
	Alternative sequence	1 – 38	38	Missing in isoform 3 and isoform 4.		VSP_011602
	Alternative sequence	1 – 20	20	MAIEG…ICIRK → MASASWRLKVEREPVEYMNL SVLEKIGYFSVARLEYSGTI LAHCNFRLLGSNDSSASASQ VTGTT in isoform 7.		VSP_046124
	Alternative sequence	299 – 303	5	QVHLV → AVTPK in isoform 4.		VSP_011603
	Alternative sequence	304 – 555	252	Missing in isoform 4.		VSP_011604
	Alternative sequence	450 – 457	8	PPNTYVKL → HPMDCSVV in isoform 2.		VSP_011605
	Alternative sequence	452	1	N → TFHPLLSDGLFCCLKHLIGG QVYIIRD in isoform 5.		VSP_011607
	Alternative sequence	452	1	N → NGLFCCLKHLIGGQVYIIRD in isoform 6 and isoform 7.		VSP_011608
	Alternative sequence	458 – 555	98	Missing in isoform 2.		VSP_011606
	Natural variant	138	1	G → E. Ref.6		VAR_066663
	Natural variant	439	1	G → D in SCAR11; shows intracellular localization different from that of the wild-type protein; forms a reticular pattern in the cytoplasm; does not show submembranous distribution; is abnormally retained in the endoplasmic reticulum consistent to improper folding. Ref.6		VAR_066664
Experimental info
	Sequence conflict	195	1	S → N in CAE85112. Ref.2
	Sequence conflict	323	1	V → A in CAE85113. Ref.2
	Sequence conflict	514	1	K → E in BAC76809. Ref.1
	Sequence conflict	514	1	K → E in BAC03682. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 17, 2006. Version 2. Checksum: A7E7359DC3DEF5B9	FASTA	555	62,287
	10 20 30 40 50 60 MAIEGGERTC GVHELICIRK VSPEAVGFLS AVGVFIILML LLFLYINKKF CFENVGGFPD 70 80 90 100 110 120 LGSEYSTRKN SQDKIYNSYM DKDEHGSSSE SEDEALGKYH EALSRTHNSR LPLADSRQRN 130 140 150 160 170 180 YAWETRQKYS PLSAEYDGYS SEASIDEGNC IQRMRRTPPL DELQPPPYQD DSGSPHLSCT 190 200 210 220 230 240 PSEIGDSKCE FSHCSNSPRC SYNKCPSEGS TGHEIESFHN KGYEEDVPSD STAVLSPEDM 250 260 270 280 290 300 SAQGSSSQLP KPFDPEPEAK YGTLDVTFDY DSQEQKLLVT VTAVTDIPTY NRTGGNSWQV 310 320 330 340 350 360 HLVLLPIKKQ RAKTSIQRGP CPVFTETFKF NHVESEMIGN YAVRFRLYGV HRMKKEKIVG 370 380 390 400 410 420 EKIFYLTKLN LQGKMSLPVI LEPSYNHSGC DSQMSVSEMS CSESTSSCQS LEHGSVPEIL 430 440 450 460 470 480 IGLLYNATTG RLSAEVIKGS HFKNLAANRP PNTYVKLTLL NSMGQEMSKC KTSIRRGQPN 490 500 510 520 530 540 PVYKETFVFQ VALFQLSDVT LILSVYNKRS MKRKEMIGWI SLGLNSSGEE ELNHWTEMKE 550 SKGQQVCRWH ALLES
	Isoform 2 [UniParc]. Checksum: 6921572FE920B878	FASTA	457	50,923
	10 20 30 40 50 60 MAIEGGERTC GVHELICIRK VSPEAVGFLS AVGVFIILML LLFLYINKKF CFENVGGFPD 70 80 90 100 110 120 LGSEYSTRKN SQDKIYNSYM DKDEHGSSSE SEDEALGKYH EALSRTHNSR LPLADSRQRN 130 140 150 160 170 180 YAWETRQKYS PLSAEYDGYS SEASIDEGNC IQRMRRTPPL DELQPPPYQD DSGSPHLSCT 190 200 210 220 230 240 PSEIGDSKCE FSHCSNSPRC SYNKCPSEGS TGHEIESFHN KGYEEDVPSD STAVLSPEDM 250 260 270 280 290 300 SAQGSSSQLP KPFDPEPEAK YGTLDVTFDY DSQEQKLLVT VTAVTDIPTY NRTGGNSWQV 310 320 330 340 350 360 HLVLLPIKKQ RAKTSIQRGP CPVFTETFKF NHVESEMIGN YAVRFRLYGV HRMKKEKIVG 370 380 390 400 410 420 EKIFYLTKLN LQGKMSLPVI LEPSYNHSGC DSQMSVSEMS CSESTSSCQS LEHGSVPEIL 430 440 450 IGLLYNATTG RLSAEVIKGS HFKNLAANRH PMDCSVV
	Isoform 3 [UniParc]. Checksum: 4211CBB56E0E73EC	FASTA	517	58,289
	10 20 30 40 50 60 MLLLFLYINK KFCFENVGGF PDLGSEYSTR KNSQDKIYNS YMDKDEHGSS SESEDEALGK 70 80 90 100 110 120 YHEALSRTHN SRLPLADSRQ RNYAWETRQK YSPLSAEYDG YSSEASIDEG NCIQRMRRTP 130 140 150 160 170 180 PLDELQPPPY QDDSGSPHLS CTPSEIGDSK CEFSHCSNSP RCSYNKCPSE GSTGHEIESF 190 200 210 220 230 240 HNKGYEEDVP SDSTAVLSPE DMSAQGSSSQ LPKPFDPEPE AKYGTLDVTF DYDSQEQKLL 250 260 270 280 290 300 VTVTAVTDIP TYNRTGGNSW QVHLVLLPIK KQRAKTSIQR GPCPVFTETF KFNHVESEMI 310 320 330 340 350 360 GNYAVRFRLY GVHRMKKEKI VGEKIFYLTK LNLQGKMSLP VILEPSYNHS GCDSQMSVSE 370 380 390 400 410 420 MSCSESTSSC QSLEHGSVPE ILIGLLYNAT TGRLSAEVIK GSHFKNLAAN RPPNTYVKLT 430 440 450 460 470 480 LLNSMGQEMS KCKTSIRRGQ PNPVYKETFV FQVALFQLSD VTLILSVYNK RSMKRKEMIG 490 500 510 WISLGLNSSG EEELNHWTEM KESKGQQVCR WHALLES
	Isoform 4 [UniParc]. Checksum: FC80A0B09B5DE2BD	FASTA	265	29,654
	10 20 30 40 50 60 MLLLFLYINK KFCFENVGGF PDLGSEYSTR KNSQDKIYNS YMDKDEHGSS SESEDEALGK 70 80 90 100 110 120 YHEALSRTHN SRLPLADSRQ RNYAWETRQK YSPLSAEYDG YSSEASIDEG NCIQRMRRTP 130 140 150 160 170 180 PLDELQPPPY QDDSGSPHLS CTPSEIGDSK CEFSHCSNSP RCSYNKCPSE GSTGHEIESF 190 200 210 220 230 240 HNKGYEEDVP SDSTAVLSPE DMSAQGSSSQ LPKPFDPEPE AKYGTLDVTF DYDSQEQKLL 250 260 VTVTAVTDIP TYNRTGGNSW AVTPK
	Isoform 5 [UniParc]. Checksum: 96CAD81E55551FB5	FASTA	581	65,215
	10 20 30 40 50 60 MAIEGGERTC GVHELICIRK VSPEAVGFLS AVGVFIILML LLFLYINKKF CFENVGGFPD 70 80 90 100 110 120 LGSEYSTRKN SQDKIYNSYM DKDEHGSSSE SEDEALGKYH EALSRTHNSR LPLADSRQRN 130 140 150 160 170 180 YAWETRQKYS PLSAEYDGYS SEASIDEGNC IQRMRRTPPL DELQPPPYQD DSGSPHLSCT 190 200 210 220 230 240 PSEIGDSKCE FSHCSNSPRC SYNKCPSEGS TGHEIESFHN KGYEEDVPSD STAVLSPEDM 250 260 270 280 290 300 SAQGSSSQLP KPFDPEPEAK YGTLDVTFDY DSQEQKLLVT VTAVTDIPTY NRTGGNSWQV 310 320 330 340 350 360 HLVLLPIKKQ RAKTSIQRGP CPVFTETFKF NHVESEMIGN YAVRFRLYGV HRMKKEKIVG 370 380 390 400 410 420 EKIFYLTKLN LQGKMSLPVI LEPSYNHSGC DSQMSVSEMS CSESTSSCQS LEHGSVPEIL 430 440 450 460 470 480 IGLLYNATTG RLSAEVIKGS HFKNLAANRP PTFHPLLSDG LFCCLKHLIG GQVYIIRDTY 490 500 510 520 530 540 VKLTLLNSMG QEMSKCKTSI RRGQPNPVYK ETFVFQVALF QLSDVTLILS VYNKRSMKRK 550 560 570 580 EMIGWISLGL NSSGEEELNH WTEMKESKGQ QVCRWHALLE S
	Isoform 6 [UniParc]. Checksum: 0DA3491777CA1FF4	FASTA	574	64,418
	10 20 30 40 50 60 MAIEGGERTC GVHELICIRK VSPEAVGFLS AVGVFIILML LLFLYINKKF CFENVGGFPD 70 80 90 100 110 120 LGSEYSTRKN SQDKIYNSYM DKDEHGSSSE SEDEALGKYH EALSRTHNSR LPLADSRQRN 130 140 150 160 170 180 YAWETRQKYS PLSAEYDGYS SEASIDEGNC IQRMRRTPPL DELQPPPYQD DSGSPHLSCT 190 200 210 220 230 240 PSEIGDSKCE FSHCSNSPRC SYNKCPSEGS TGHEIESFHN KGYEEDVPSD STAVLSPEDM 250 260 270 280 290 300 SAQGSSSQLP KPFDPEPEAK YGTLDVTFDY DSQEQKLLVT VTAVTDIPTY NRTGGNSWQV 310 320 330 340 350 360 HLVLLPIKKQ RAKTSIQRGP CPVFTETFKF NHVESEMIGN YAVRFRLYGV HRMKKEKIVG 370 380 390 400 410 420 EKIFYLTKLN LQGKMSLPVI LEPSYNHSGC DSQMSVSEMS CSESTSSCQS LEHGSVPEIL 430 440 450 460 470 480 IGLLYNATTG RLSAEVIKGS HFKNLAANRP PNGLFCCLKH LIGGQVYIIR DTYVKLTLLN 490 500 510 520 530 540 SMGQEMSKCK TSIRRGQPNP VYKETFVFQV ALFQLSDVTL ILSVYNKRSM KRKEMIGWIS 550 560 570 LGLNSSGEEE LNHWTEMKES KGQQVCRWHA LLES
	Isoform 7 [UniParc]. Checksum: BD9AAB3F9D5F0AE4	FASTA	619	69,346
	10 20 30 40 50 60 MASASWRLKV EREPVEYMNL SVLEKIGYFS VARLEYSGTI LAHCNFRLLG SNDSSASASQ 70 80 90 100 110 120 VTGTTVSPEA VGFLSAVGVF IILMLLLFLY INKKFCFENV GGFPDLGSEY STRKNSQDKI 130 140 150 160 170 180 YNSYMDKDEH GSSSESEDEA LGKYHEALSR THNSRLPLAD SRQRNYAWET RQKYSPLSAE 190 200 210 220 230 240 YDGYSSEASI DEGNCIQRMR RTPPLDELQP PPYQDDSGSP HLSCTPSEIG DSKCEFSHCS 250 260 270 280 290 300 NSPRCSYNKC PSEGSTGHEI ESFHNKGYEE DVPSDSTAVL SPEDMSAQGS SSQLPKPFDP 310 320 330 340 350 360 EPEAKYGTLD VTFDYDSQEQ KLLVTVTAVT DIPTYNRTGG NSWQVHLVLL PIKKQRAKTS 370 380 390 400 410 420 IQRGPCPVFT ETFKFNHVES EMIGNYAVRF RLYGVHRMKK EKIVGEKIFY LTKLNLQGKM 430 440 450 460 470 480 SLPVILEPSY NHSGCDSQMS VSEMSCSEST SSCQSLEHGS VPEILIGLLY NATTGRLSAE 490 500 510 520 530 540 VIKGSHFKNL AANRPPNGLF CCLKHLIGGQ VYIIRDTYVK LTLLNSMGQE MSKCKTSIRR 550 560 570 580 590 600 GQPNPVYKET FVFQVALFQL SDVTLILSVY NKRSMKRKEM IGWISLGLNS SGEEELNHWT 610 EMKESKGQQV CRWHALLES

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning, expression, and characterization of a novel class of synaptotagmin (Syt XIV) conserved from Drosophila to humans." Fukuda M. J. Biochem. 133:641-649(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"Synaptotagmin gene content of the sequenced genomes." Craxton M.A. BMC Genomics 5:43-43(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3; 4; 5 AND 6).
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[4]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7). Tissue: Cerebellum.
[6]	"Exome sequencing reveals a homozygous SYT14 mutation in adult-onset, autosomal-recessive spinocerebellar ataxia with psychomotor retardation." Doi H., Yoshida K., Yasuda T., Fukuda M., Fukuda Y., Morita H., Ikeda S., Kato R., Tsurusaki Y., Miyake N., Saitsu H., Sakai H., Miyatake S., Shiina M., Nukina N., Koyano S., Tsuji S., Kuroiwa Y., Matsumoto N. Am. J. Hum. Genet. 89:320-327(2011) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION, VARIANT SCAR11 ASP-439, VARIANT GLU-138, CHARACTERIZATION OF VARIANT SCAR11 ASP-439.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB102948 mRNA. Translation: BAC76809.1. AJ617623 mRNA. Translation: CAE85109.1. AJ617624 mRNA. Translation: CAE85110.1. AJ617625 mRNA. Translation: CAE85111.1. AJ617626 mRNA. Translation: CAE85112.1. AJ617627 mRNA. Translation: CAE85113.1. AK091517 mRNA. Translation: BAC03682.1. AL513263, AL022397, AL022399 Genomic DNA. Translation: CAI17884.1. AL022397, AL022399, AL513263 Genomic DNA. Translation: CAI17887.1. AL022397, AL513263, AL022399 Genomic DNA. Translation: CAI17888.1. AL022397, AL513263 Genomic DNA. Translation: CAI17889.1. AL022399, AL513263, AL022397 Genomic DNA. Translation: CAI22770.1. AL513263, AL022399, AL022397 Genomic DNA. Translation: CAI17885.1. AL513263, AL022397 Genomic DNA. Translation: CAI17886.1. AL022399, AL022397, AL513263 Genomic DNA. Translation: CAI22771.1. BC144157 mRNA. No translation available.
IPI	IPI00168143. IPI00470677. IPI00470678. IPI00470679. IPI00470681. IPI00844485. IPI01010442.
RefSeq	NP_001139734.1. NM_001146262.2. NP_001242935.1. NM_001256006.1. NP_694994.2. NM_153262.3.
UniGene	Hs.658866.
3D structure databases
ProteinModelPortal	Q8NB59.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000418901.
PTM databases
PhosphoSite	Q8NB59.
Polymorphism databases
DMDM	116242810.
Proteomic databases
PaxDb	Q8NB59.
PRIDE	Q8NB59.
Protocols and materials databases
DNASU	255928.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000367015; ENSP00000355982; ENSG00000143469. ENST00000367019; ENSP00000355986; ENSG00000143469. ENST00000422431; ENSP00000389039; ENSG00000143469. ENST00000472886; ENSP00000418901; ENSG00000143469. ENST00000534859; ENSP00000442891; ENSG00000143469. ENST00000537238; ENSP00000437423; ENSG00000143469.
GeneID	255928.
KEGG	hsa:255928.
UCSC	uc001hht.4. human. uc009xcv.3. human.
Organism-specific databases
CTD	255928.
GeneCards	GC01P210112.
HGNC	HGNC:23143. SYT14.
HPA	HPA036963.
MIM	610949. gene. 614229. phenotype.
neXtProt	NX_Q8NB59.
Orphanet	284271. Autosomal recessive cerebellar ataxia - psychomotor retardation.
PharmGKB	PA134887689.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG305739.
HOVERGEN	HBG062897.
Gene expression databases
ArrayExpress	Q8NB59.
Bgee	Q8NB59.
CleanEx	HS_SYT14.
Genevestigator	Q8NB59.
GermOnline	ENSG00000143469. Homo sapiens.
Family and domain databases
InterPro	IPR000008. C2_Ca-dep. IPR008973. C2_Ca/lipid-bd_dom_CaLB. IPR018029. C2_membr_targeting. [Graphical view]
Pfam	PF00168. C2. 2 hits. [Graphical view]
SMART	SM00239. C2. 2 hits. [Graphical view]
SUPFAM	SSF49562. C2_CaLB. 2 hits.
PROSITE	PS50004. C2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	255928.
NextBio	92685.
SOURCE	Search...

Entry information

Entry name

SYT14_HUMAN

Accession

Primary (citable) accession number: Q8NB59
Secondary accession number(s): B1AJU0 , B1AJU1, F5H426, Q5THX7, Q707N3, Q707N4, Q707N5, Q707N6, Q707N7

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2004
Last sequence update:	October 17, 2006
Last modified:	May 1, 2013
This is version 92 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.