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Protein

Zinc finger protein 62 homolog

Gene

ZFP62

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in differentiating skeletal muscle.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri225 – 247C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri253 – 275C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri281 – 303C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri309 – 331C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri337 – 359C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri365 – 387C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri393 – 415C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri421 – 443C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri449 – 471C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri477 – 499C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri505 – 527C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri533 – 555C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri561 – 583C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri589 – 611C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri617 – 639C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri645 – 667C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri673 – 695C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri701 – 723C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri729 – 751C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri757 – 779C2H2-type 20PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri785 – 807C2H2-type 21PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri813 – 834C2H2-type 22PROSITE-ProRule annotationAdd BLAST22
Zinc fingeri840 – 862C2H2-type 23PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:G66-33165-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 62 homolog
Short name:
Zfp-62
Gene namesi
Name:ZFP62
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:23241. ZFP62.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi643836.
OpenTargetsiENSG00000196670.
PharmGKBiPA134969387.

Polymorphism and mutation databases

BioMutaiZFP62.
DMDMi327478553.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000473051 – 900Zinc finger protein 62 homologAdd BLAST900

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki65Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki82Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiQ8NB50.
PaxDbiQ8NB50.
PeptideAtlasiQ8NB50.
PRIDEiQ8NB50.

PTM databases

iPTMnetiQ8NB50.
PhosphoSitePlusiQ8NB50.

Expressioni

Gene expression databases

BgeeiENSG00000196670.
CleanExiHS_ZFP62.
ExpressionAtlasiQ8NB50. baseline and differential.
GenevisibleiQ8NB50. HS.

Organism-specific databases

HPAiHPA048629.

Interactioni

Protein-protein interaction databases

BioGridi569091. 17 interactors.
STRINGi9606.ENSP00000423820.

Structurei

3D structure databases

ProteinModelPortaliQ8NB50.
SMRiQ8NB50.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 23 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri225 – 247C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri253 – 275C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri281 – 303C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri309 – 331C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri337 – 359C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri365 – 387C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri393 – 415C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri421 – 443C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri449 – 471C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri477 – 499C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri505 – 527C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri533 – 555C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri561 – 583C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri589 – 611C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri617 – 639C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri645 – 667C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri673 – 695C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri701 – 723C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri729 – 751C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri757 – 779C2H2-type 20PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri785 – 807C2H2-type 21PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri813 – 834C2H2-type 22PROSITE-ProRule annotationAdd BLAST22
Zinc fingeri840 – 862C2H2-type 23PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00850000132243.
HOVERGENiHBG018163.
InParanoidiQ8NB50.
OMAiQHKIMHT.
OrthoDBiEOG091G02KC.
PhylomeDBiQ8NB50.
TreeFamiTF343410.

Family and domain databases

Gene3Di3.30.160.60. 26 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 4 hits.
PF13912. zf-C2H2_6. 15 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 26 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 25 hits.
PS50157. ZINC_FINGER_C2H2_2. 26 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NB50-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSHLKTSTED EEPTEEYENV GNAASKWPKV EDPMPESKVG DTCVWDSKVE
60 70 80 90 100
NQQKKPVENR MKEDKSSIRE AISKAKSTAN IKTEQEGEAS EKSLHLSPQH
110 120 130 140 150
ITHQTMPIGQ RGSEQGKRVE NINGTSYPSL QQKTNAVKKL HKCDECGKSF
160 170 180 190 200
KYNSRLVQHK IMHTGEKRYE CDDCGGTFRS SSSLRVHKRI HTGEKPYKCE
210 220 230 240 250
ECGKAYMSYS SLINHKSTHS GEKNCKCDEC GKSFNYSSVL DQHKRIHTGE
260 270 280 290 300
KPYECGECGK AFRNSSGLRV HKRIHTGEKP YECDICGKTF SNSSGLRVHK
310 320 330 340 350
RIHTGEKPYE CDECGKAFIT CRTLLNHKSI HFGDKPYKCD ECEKSFNYSS
360 370 380 390 400
LLIQHKVIHT GEKPYECDEC GKAFRNSSGL IVHKRIHTGE KPYKCDVCGK
410 420 430 440 450
AFSYSSGLAV HKSIHPGKKA HECKECGKSF SYNSLLLQHR TIHTGERPYV
460 470 480 490 500
CDVCGKTFRN NAGLKVHRRL HTGEKPYKCD VCGKAYISRS SLKNHKGIHL
510 520 530 540 550
GEKPYKCSYC EKSFNYSSAL EQHKRIHTRE KPFGCDECGK AFRNNSGLKV
560 570 580 590 600
HKRIHTGERP YKCEECGKAY ISLSSLINHK SVHPGEKPFK CDECEKAFIT
610 620 630 640 650
YRTLTNHKKV HLGEKPYKCD VCEKSFNYTS LLSQHRRVHT REKPYECDRC
660 670 680 690 700
EKVFRNNSSL KVHKRIHTGE RPYECDVCGK AYISHSSLIN HKSTHPGRTP
710 720 730 740 750
HTCDECGKAF FSSRTLISHK RVHLGEKPFK CVECGKSFSY SSLLSQHKRI
760 770 780 790 800
HTGEKPYVCD RCGKAFRNSS GLTVHKRIHT GEKPYECDEC GKAYISHSSL
810 820 830 840 850
INHKSVHQGK QPYNCECGKS FNYRSVLDQH KRIHTGKKPY RCNECGKAFN
860 870 880 890 900
IRSNLTKHKR THTGEESLNV IYVGSYSGTS QKRTYEGGNA LDGGRMRMPL
Length:900
Mass (Da):102,511
Last modified:April 5, 2011 - v3
Checksum:i0C1D915D03FBBE67
GO
Isoform 2 (identifier: Q8NB50-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     339-534: Missing.

Note: No experimental confirmation available.
Show »
Length:704
Mass (Da):80,231
Checksum:iB482C854BD712B8E
GO
Isoform 3 (identifier: Q8NB50-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-33: Missing.

Note: No experimental confirmation available.
Show »
Length:867
Mass (Da):98,780
Checksum:iE8BB0BD0D5E2AB87
GO

Sequence cautioni

The sequence AAI40762 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC03691 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAG58558 differs from that shown. Unusual initiator. The initiator methionine is coded by a non-canonical GTG valine codon.Curated
The sequence CAI46133 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti321C → R in BAC03691 (PubMed:14702039).Curated1
Sequence conflicti690N → I in BAG64495 (PubMed:14702039).Curated1
Sequence conflicti800L → F in BAG58558 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06488134M → I.1 PublicationCorresponds to variant rs705441dbSNPEnsembl.1
Natural variantiVAR_064882698R → K.3 PublicationsCorresponds to variant rs168726dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0452571 – 33Missing in isoform 3. 1 PublicationAdd BLAST33
Alternative sequenceiVSP_010136339 – 534Missing in isoform 2. 1 PublicationAdd BLAST196

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091550 mRNA. Translation: BAC03691.1. Different initiation.
AK295714 mRNA. Translation: BAG58558.1. Sequence problems.
AK303450 mRNA. Translation: BAG64495.1.
DA323041 mRNA. No translation available.
AC022413 Genomic DNA. No translation available.
AL832408 Transcribed RNA. Translation: CAI46133.1. Different initiation.
BC140761 mRNA. Translation: AAI40762.1. Different initiation.
BC171780 mRNA. Translation: AAI71780.1.
CCDSiCCDS47357.2. [Q8NB50-3]
CCDS54955.1. [Q8NB50-1]
RefSeqiNP_001166109.1. NM_001172638.1. [Q8NB50-1]
NP_689496.4. NM_152283.4. [Q8NB50-3]
XP_016865199.1. XM_017009710.1. [Q8NB50-3]
XP_016865200.1. XM_017009711.1. [Q8NB50-3]
XP_016865201.1. XM_017009712.1. [Q8NB50-3]
XP_016865202.1. XM_017009713.1. [Q8NB50-3]
XP_016865203.1. XM_017009714.1. [Q8NB50-3]
XP_016865204.1. XM_017009715.1. [Q8NB50-3]
XP_016865206.1. XM_017009717.1. [Q8NB50-1]
UniGeneiHs.509227.
Hs.638558.
Hs.735373.

Genome annotation databases

EnsembliENST00000502412; ENSP00000423820; ENSG00000196670. [Q8NB50-1]
ENST00000512132; ENSP00000426193; ENSG00000196670. [Q8NB50-3]
GeneIDi643836.
KEGGihsa:643836.
UCSCiuc011dhe.3. human. [Q8NB50-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091550 mRNA. Translation: BAC03691.1. Different initiation.
AK295714 mRNA. Translation: BAG58558.1. Sequence problems.
AK303450 mRNA. Translation: BAG64495.1.
DA323041 mRNA. No translation available.
AC022413 Genomic DNA. No translation available.
AL832408 Transcribed RNA. Translation: CAI46133.1. Different initiation.
BC140761 mRNA. Translation: AAI40762.1. Different initiation.
BC171780 mRNA. Translation: AAI71780.1.
CCDSiCCDS47357.2. [Q8NB50-3]
CCDS54955.1. [Q8NB50-1]
RefSeqiNP_001166109.1. NM_001172638.1. [Q8NB50-1]
NP_689496.4. NM_152283.4. [Q8NB50-3]
XP_016865199.1. XM_017009710.1. [Q8NB50-3]
XP_016865200.1. XM_017009711.1. [Q8NB50-3]
XP_016865201.1. XM_017009712.1. [Q8NB50-3]
XP_016865202.1. XM_017009713.1. [Q8NB50-3]
XP_016865203.1. XM_017009714.1. [Q8NB50-3]
XP_016865204.1. XM_017009715.1. [Q8NB50-3]
XP_016865206.1. XM_017009717.1. [Q8NB50-1]
UniGeneiHs.509227.
Hs.638558.
Hs.735373.

3D structure databases

ProteinModelPortaliQ8NB50.
SMRiQ8NB50.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi569091. 17 interactors.
STRINGi9606.ENSP00000423820.

PTM databases

iPTMnetiQ8NB50.
PhosphoSitePlusiQ8NB50.

Polymorphism and mutation databases

BioMutaiZFP62.
DMDMi327478553.

Proteomic databases

MaxQBiQ8NB50.
PaxDbiQ8NB50.
PeptideAtlasiQ8NB50.
PRIDEiQ8NB50.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000502412; ENSP00000423820; ENSG00000196670. [Q8NB50-1]
ENST00000512132; ENSP00000426193; ENSG00000196670. [Q8NB50-3]
GeneIDi643836.
KEGGihsa:643836.
UCSCiuc011dhe.3. human. [Q8NB50-1]

Organism-specific databases

CTDi643836.
DisGeNETi643836.
GeneCardsiZFP62.
HGNCiHGNC:23241. ZFP62.
HPAiHPA048629.
MIMi610281. gene.
neXtProtiNX_Q8NB50.
OpenTargetsiENSG00000196670.
PharmGKBiPA134969387.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00850000132243.
HOVERGENiHBG018163.
InParanoidiQ8NB50.
OMAiQHKIMHT.
OrthoDBiEOG091G02KC.
PhylomeDBiQ8NB50.
TreeFamiTF343410.

Enzyme and pathway databases

BioCyciZFISH:G66-33165-MONOMER.

Miscellaneous databases

GenomeRNAii643836.
PROiQ8NB50.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000196670.
CleanExiHS_ZFP62.
ExpressionAtlasiQ8NB50. baseline and differential.
GenevisibleiQ8NB50. HS.

Family and domain databases

Gene3Di3.30.160.60. 26 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 4 hits.
PF13912. zf-C2H2_6. 15 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 26 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 25 hits.
PS50157. ZINC_FINGER_C2H2_2. 26 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZFP62_HUMAN
AccessioniPrimary (citable) accession number: Q8NB50
Secondary accession number(s): B4DIP6
, B4E0N3, B5MDX6, B7ZVZ2, B9EIP6, E9PFT8, J3QTA9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: April 5, 2011
Last modified: November 2, 2016
This is version 133 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.