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Protein

Phospholipid-transporting ATPase IG

Gene

ATP11C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. Required for B cell differentiation past the pro-B cell stage. Seems to mediate phosphatidylserine (PS) flipping in pro-B cells. May be involved in the transport of cholestatic bile acids (By similarity).By similarity

Catalytic activityi

ATP + H2O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei4124-aspartylphosphate intermediateBy similarity1
Metal bindingi819MagnesiumBy similarity1
Metal bindingi823MagnesiumBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid transport, Transport

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:HS02327-MONOMER.
ReactomeiR-HSA-936837. Ion transport by P-type ATPases.

Protein family/group databases

TCDBi3.A.3.8.14. the p-type atpase (p-atpase) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipid-transporting ATPase IG (EC:3.6.3.1)
Alternative name(s):
ATPase IQ
ATPase class VI type 11C
P4-ATPase flippase complex alpha subunit ATP11C
Gene namesi
Name:ATP11C
Synonyms:ATPIG, ATPIQ
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:13554. ATP11C.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 66CytoplasmicSequence analysisAdd BLAST66
Transmembranei67 – 85HelicalSequence analysisAdd BLAST19
Topological domaini86ExtracellularSequence analysis1
Transmembranei87 – 107HelicalSequence analysisAdd BLAST21
Topological domaini108 – 290CytoplasmicSequence analysisAdd BLAST183
Transmembranei291 – 311HelicalSequence analysisAdd BLAST21
Topological domaini312 – 346ExtracellularSequence analysisAdd BLAST35
Transmembranei347 – 367HelicalSequence analysisAdd BLAST21
Topological domaini368 – 879CytoplasmicSequence analysisAdd BLAST512
Transmembranei880 – 900HelicalSequence analysisAdd BLAST21
Topological domaini901 – 908ExtracellularSequence analysis8
Transmembranei909 – 929HelicalSequence analysisAdd BLAST21
Topological domaini930 – 955CytoplasmicSequence analysisAdd BLAST26
Transmembranei956 – 976HelicalSequence analysisAdd BLAST21
Topological domaini977 – 995ExtracellularSequence analysisAdd BLAST19
Transmembranei996 – 1016HelicalSequence analysisAdd BLAST21
Topological domaini1017 – 1026CytoplasmicSequence analysis10
Transmembranei1027 – 1047HelicalSequence analysisAdd BLAST21
Topological domaini1048 – 1069ExtracellularSequence analysisAdd BLAST22
Transmembranei1070 – 1090HelicalSequence analysisAdd BLAST21
Topological domaini1091 – 1132CytoplasmicSequence analysisAdd BLAST42

GO - Cellular componenti

  • endoplasmic reticulum Source: UniProtKB
  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
  • lysosomal membrane Source: UniProtKB
  • plasma membrane Source: UniProtKB
  • recycling endosome Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000101974.
PharmGKBiPA25103.

Polymorphism and mutation databases

BioMutaiATP11C.
DMDMi62512178.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000463731 – 1132Phospholipid-transporting ATPase IGAdd BLAST1132

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei445PhosphoserineCombined sources1
Modified residuei1108PhosphoserineCombined sources1
Modified residuei1116PhosphoserineCombined sources1
Modified residuei1126PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8NB49.
MaxQBiQ8NB49.
PaxDbiQ8NB49.
PeptideAtlasiQ8NB49.
PRIDEiQ8NB49.

PTM databases

iPTMnetiQ8NB49.
PhosphoSitePlusiQ8NB49.
SwissPalmiQ8NB49.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSG00000101974.
ExpressionAtlasiQ8NB49. baseline and differential.
GenevisibleiQ8NB49. HS.

Organism-specific databases

HPAiHPA030830.

Interactioni

Subunit structurei

Component of a P4-ATPase flippase complex which consists of a catalytic alpha subunit and an accessory beta subunit (Probable). Interacts with beta subunit TMEM30A.Curated1 Publication

Protein-protein interaction databases

BioGridi130370. 34 interactors.
IntActiQ8NB49. 4 interactors.
STRINGi9606.ENSP00000332756.

Structurei

3D structure databases

ProteinModelPortaliQ8NB49.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0206. Eukaryota.
COG0474. LUCA.
GeneTreeiENSGT00860000133712.
HOVERGENiHBG050601.
InParanoidiQ8NB49.
KOiK01530.
OMAiWDKDFYD.
OrthoDBiEOG091G03B1.
PhylomeDBiQ8NB49.
TreeFamiTF326897.

Family and domain databases

Gene3Di2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProiIPR030363. ATP11C.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006539. P-type_ATPase_IV.
IPR032631. P-type_ATPase_N.
IPR001757. P_typ_ATPase.
IPR032630. P_typ_ATPase_c.
[Graphical view]
PANTHERiPTHR24092. PTHR24092. 1 hit.
PTHR24092:SF38. PTHR24092:SF38. 1 hit.
PfamiPF00122. E1-E2_ATPase. 1 hit.
PF16212. PhoLip_ATPase_C. 1 hit.
PF16209. PhoLip_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01652. ATPase-Plipid. 1 hit.
TIGR01494. ATPase_P-type. 3 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NB49-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQMVPSLPPA SECAGEEKRV GTRTVFVGNH PVSETEAYIA QRFCDNRIVS
60 70 80 90 100
SKYTLWNFLP KNLFEQFRRI ANFYFLIIFL VQVTVDTPTS PVTSGLPLFF
110 120 130 140 150
VITVTAIKQG YEDCLRHRAD NEVNKSTVYI IENAKRVRKE SEKIKVGDVV
160 170 180 190 200
EVQADETFPC DLILLSSCTT DGTCYVTTAS LDGESNCKTH YAVRDTIALC
210 220 230 240 250
TAESIDTLRA AIECEQPQPD LYKFVGRINI YSNSLEAVAR SLGPENLLLK
260 270 280 290 300
GATLKNTEKI YGVAVYTGME TKMALNYQGK SQKRSAVEKS INAFLIVYLF
310 320 330 340 350
ILLTKAAVCT TLKYVWQSTP YNDEPWYNQK TQKERETLKV LKMFTDFLSF
360 370 380 390 400
MVLFNFIIPV SMYVTVEMQK FLGSFFISWD KDFYDEEINE GALVNTSDLN
410 420 430 440 450
EELGQVDYVF TDKTGTLTEN SMEFIECCID GHKYKGVTQE VDGLSQTDGT
460 470 480 490 500
LTYFDKVDKN REELFLRALC LCHTVEIKTN DAVDGATESA ELTYISSSPD
510 520 530 540 550
EIALVKGAKR YGFTFLGNRN GYMRVENQRK EIEEYELLHT LNFDAVRRRM
560 570 580 590 600
SVIVKTQEGD ILLFCKGADS AVFPRVQNHE IELTKVHVER NAMDGYRTLC
610 620 630 640 650
VAFKEIAPDD YERINRQLIE AKMALQDREE KMEKVFDDIE TNMNLIGATA
660 670 680 690 700
VEDKLQDQAA ETIEALHAAG LKVWVLTGDK METAKSTCYA CRLFQTNTEL
710 720 730 740 750
LELTTKTIEE SERKEDRLHE LLIEYRKKLL HEFPKSTRSF KKAWTEHQEY
760 770 780 790 800
GLIIDGSTLS LILNSSQDSS SNNYKSIFLQ ICMKCTAVLC CRMAPLQKAQ
810 820 830 840 850
IVRMVKNLKG SPITLSIGDG ANDVSMILES HVGIGIKGKE GRQAARNSDY
860 870 880 890 900
SVPKFKHLKK LLLAHGHLYY VRIAHLVQYF FYKNLCFILP QFLYQFFCGF
910 920 930 940 950
SQQPLYDAAY LTMYNICFTS LPILAYSLLE QHINIDTLTS DPRLYMKISG
960 970 980 990 1000
NAMLQLGPFL YWTFLAAFEG TVFFFGTYFL FQTASLEENG KVYGNWTFGT
1010 1020 1030 1040 1050
IVFTVLVFTV TLKLALDTRF WTWINHFVIW GSLAFYVFFS FFWGGIIWPF
1060 1070 1080 1090 1100
LKQQRMYFVF AQMLSSVSTW LAIILLIFIS LFPEILLIVL KNVRRRSARR
1110 1120 1130
NLSCRRASDS LSARPSVRPL LLRTFSDESN VL
Length:1,132
Mass (Da):129,477
Last modified:April 12, 2005 - v3
Checksum:i74B63B20A5C6E49D
GO
Isoform 2 (identifier: Q8NB49-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1100-1132: RNLSCRRASDSLSARPSVRPLLLRTFSDESNVL → VHHLISSSA

Note: No experimental confirmation available.
Show »
Length:1,108
Mass (Da):126,710
Checksum:iADC1995E368B8C4E
GO
Isoform 3 (identifier: Q8NB49-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1100-1132: RNLSCRRASDSLSARPSVRPLLLRTFSDESNVL → NPNLELPMLLSYKHTDSGYS

Show »
Length:1,119
Mass (Da):128,040
Checksum:i2F1EF15A73AB3947
GO
Isoform 4 (identifier: Q8NB49-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1100-1132: RNLSCRRASDSLSARPSVRPLLLRTFSDESNVL → VTKRLPSSGTSAIFMLSQTSSNHSFSWSE

Note: No experimental confirmation available.
Show »
Length:1,128
Mass (Da):128,933
Checksum:i5928DF8ED2988A7C
GO

Sequence cautioni

The sequence BAC03692 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC86172 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC86377 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAD18440 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAI39713 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI39714 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI39716 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI40418 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI41444 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI41445 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI41446 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI41447 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti537L → P in BAC86377 (PubMed:14702039).Curated1
Sequence conflicti873I → V in BAC86377 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_021827114C → W.1 PublicationCorresponds to variant rs2491014dbSNPEnsembl.1
Natural variantiVAR_036501157T → I in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_055546522Y → C.Corresponds to variant rs17281983dbSNPEnsembl.1
Natural variantiVAR_036502931Q → P in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_061036972V → M.Corresponds to variant rs55724992dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0073091100 – 1132RNLSC…ESNVL → VHHLISSSA in isoform 2. 1 PublicationAdd BLAST33
Alternative sequenceiVSP_0133731100 – 1132RNLSC…ESNVL → NPNLELPMLLSYKHTDSGYS in isoform 3. 1 PublicationAdd BLAST33
Alternative sequenceiVSP_0133741100 – 1132RNLSC…ESNVL → VTKRLPSSGTSAIFMLSQTS SNHSFSWSE in isoform 4. 1 PublicationAdd BLAST33

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ580093 mRNA. Translation: CAE30472.1.
AJ580094 mRNA. Translation: CAE30473.1.
AL161777, AL356785 Genomic DNA. Translation: CAI39713.1. Sequence problems.
AL161777, AL356785 Genomic DNA. Translation: CAI39714.1. Sequence problems.
AL161777, AL356785, AL590077 Genomic DNA. Translation: CAI39716.1. Sequence problems.
AL356785, AL161777 Genomic DNA. Translation: CAI41444.1. Sequence problems.
AL356785, AL161777 Genomic DNA. Translation: CAI41445.1. Sequence problems.
AL356785, AL161777, AL590077 Genomic DNA. Translation: CAI41446.1. Sequence problems.
AL356785 Genomic DNA. Translation: CAI41447.1. Sequence problems.
AL590077, AL356785, AL161777 Genomic DNA. Translation: CAI40418.1. Sequence problems.
AK091552 mRNA. Translation: BAC03692.1. Different initiation.
AK125474 mRNA. Translation: BAC86172.1. Different initiation.
AK125986 mRNA. Translation: BAC86377.1. Different initiation.
AK131262 mRNA. Translation: BAD18440.1. Different initiation.
CCDSiCCDS14668.1. [Q8NB49-1]
CCDS35410.1. [Q8NB49-3]
RefSeqiNP_001010986.1. NM_001010986.2.
NP_775965.2. NM_173694.4.
UniGeneiHs.88252.

Genome annotation databases

EnsembliENST00000327569; ENSP00000332756; ENSG00000101974. [Q8NB49-1]
ENST00000361648; ENSP00000355165; ENSG00000101974. [Q8NB49-3]
GeneIDi286410.
KEGGihsa:286410.
UCSCiuc004faz.4. human. [Q8NB49-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ580093 mRNA. Translation: CAE30472.1.
AJ580094 mRNA. Translation: CAE30473.1.
AL161777, AL356785 Genomic DNA. Translation: CAI39713.1. Sequence problems.
AL161777, AL356785 Genomic DNA. Translation: CAI39714.1. Sequence problems.
AL161777, AL356785, AL590077 Genomic DNA. Translation: CAI39716.1. Sequence problems.
AL356785, AL161777 Genomic DNA. Translation: CAI41444.1. Sequence problems.
AL356785, AL161777 Genomic DNA. Translation: CAI41445.1. Sequence problems.
AL356785, AL161777, AL590077 Genomic DNA. Translation: CAI41446.1. Sequence problems.
AL356785 Genomic DNA. Translation: CAI41447.1. Sequence problems.
AL590077, AL356785, AL161777 Genomic DNA. Translation: CAI40418.1. Sequence problems.
AK091552 mRNA. Translation: BAC03692.1. Different initiation.
AK125474 mRNA. Translation: BAC86172.1. Different initiation.
AK125986 mRNA. Translation: BAC86377.1. Different initiation.
AK131262 mRNA. Translation: BAD18440.1. Different initiation.
CCDSiCCDS14668.1. [Q8NB49-1]
CCDS35410.1. [Q8NB49-3]
RefSeqiNP_001010986.1. NM_001010986.2.
NP_775965.2. NM_173694.4.
UniGeneiHs.88252.

3D structure databases

ProteinModelPortaliQ8NB49.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130370. 34 interactors.
IntActiQ8NB49. 4 interactors.
STRINGi9606.ENSP00000332756.

Protein family/group databases

TCDBi3.A.3.8.14. the p-type atpase (p-atpase) superfamily.

PTM databases

iPTMnetiQ8NB49.
PhosphoSitePlusiQ8NB49.
SwissPalmiQ8NB49.

Polymorphism and mutation databases

BioMutaiATP11C.
DMDMi62512178.

Proteomic databases

EPDiQ8NB49.
MaxQBiQ8NB49.
PaxDbiQ8NB49.
PeptideAtlasiQ8NB49.
PRIDEiQ8NB49.

Protocols and materials databases

DNASUi286410.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000327569; ENSP00000332756; ENSG00000101974. [Q8NB49-1]
ENST00000361648; ENSP00000355165; ENSG00000101974. [Q8NB49-3]
GeneIDi286410.
KEGGihsa:286410.
UCSCiuc004faz.4. human. [Q8NB49-1]

Organism-specific databases

CTDi286410.
GeneCardsiATP11C.
HGNCiHGNC:13554. ATP11C.
HPAiHPA030830.
MIMi300516. gene.
neXtProtiNX_Q8NB49.
OpenTargetsiENSG00000101974.
PharmGKBiPA25103.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0206. Eukaryota.
COG0474. LUCA.
GeneTreeiENSGT00860000133712.
HOVERGENiHBG050601.
InParanoidiQ8NB49.
KOiK01530.
OMAiWDKDFYD.
OrthoDBiEOG091G03B1.
PhylomeDBiQ8NB49.
TreeFamiTF326897.

Enzyme and pathway databases

BioCyciZFISH:HS02327-MONOMER.
ReactomeiR-HSA-936837. Ion transport by P-type ATPases.

Miscellaneous databases

ChiTaRSiATP11C. human.
GenomeRNAii286410.
PROiQ8NB49.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000101974.
ExpressionAtlasiQ8NB49. baseline and differential.
GenevisibleiQ8NB49. HS.

Family and domain databases

Gene3Di2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProiIPR030363. ATP11C.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006539. P-type_ATPase_IV.
IPR032631. P-type_ATPase_N.
IPR001757. P_typ_ATPase.
IPR032630. P_typ_ATPase_c.
[Graphical view]
PANTHERiPTHR24092. PTHR24092. 1 hit.
PTHR24092:SF38. PTHR24092:SF38. 1 hit.
PfamiPF00122. E1-E2_ATPase. 1 hit.
PF16212. PhoLip_ATPase_C. 1 hit.
PF16209. PhoLip_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01652. ATPase-Plipid. 1 hit.
TIGR01494. ATPase_P-type. 3 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAT11C_HUMAN
AccessioniPrimary (citable) accession number: Q8NB49
Secondary accession number(s): Q5JT69
, Q5JT70, Q5JT71, Q5JT72, Q5JT73, Q6ZND5, Q6ZU50, Q6ZUP7, Q70IJ9, Q70IK0, Q8WX24
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: April 12, 2005
Last modified: November 30, 2016
This is version 142 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.