Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C

Gene

ANKRD52

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000139645-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C
Short name:
PP6-ARS-C
Short name:
Serine/threonine-protein phosphatase 6 regulatory subunit ARS-C
Alternative name(s):
Ankyrin repeat domain-containing protein 52
Gene namesi
Name:ANKRD52
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:26614. ANKRD52.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000139645.
PharmGKBiPA143485302.

Polymorphism and mutation databases

BioMutaiANKRD52.
DMDMi296439443.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002445871 – 1076Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit CAdd BLAST1076

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1028PhosphoserineCombined sources1
Modified residuei1075PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8NB46.
MaxQBiQ8NB46.
PaxDbiQ8NB46.
PeptideAtlasiQ8NB46.
PRIDEiQ8NB46.

PTM databases

iPTMnetiQ8NB46.
PhosphoSitePlusiQ8NB46.

Expressioni

Gene expression databases

BgeeiENSG00000139645.
CleanExiHS_ANKRD52.
GenevisibleiQ8NB46. HS.

Organism-specific databases

HPAiHPA043815.

Interactioni

Subunit structurei

Protein phosphatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed by the catalytic subunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS). Interacts with PPP6R1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PPP6R1Q9UPN74EBI-1996119,EBI-359745

Protein-protein interaction databases

BioGridi129540. 35 interactors.
IntActiQ8NB46. 18 interactors.
MINTiMINT-8287684.
STRINGi9606.ENSP00000267116.

Structurei

3D structure databases

ProteinModelPortaliQ8NB46.
SMRiQ8NB46.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati7 – 36ANK 1Add BLAST30
Repeati40 – 69ANK 2Add BLAST30
Repeati73 – 102ANK 3Add BLAST30
Repeati106 – 135ANK 4Add BLAST30
Repeati139 – 168ANK 5Add BLAST30
Repeati172 – 201ANK 6Add BLAST30
Repeati205 – 234ANK 7Add BLAST30
Repeati238 – 267ANK 8Add BLAST30
Repeati271 – 301ANK 9Add BLAST31
Repeati305 – 334ANK 10Add BLAST30
Repeati338 – 367ANK 11Add BLAST30
Repeati371 – 400ANK 12Add BLAST30
Repeati422 – 451ANK 13Add BLAST30
Repeati455 – 484ANK 14Add BLAST30
Repeati488 – 545ANK 15Add BLAST58
Repeati549 – 579ANK 16Add BLAST31
Repeati584 – 613ANK 17Add BLAST30
Repeati617 – 646ANK 18Add BLAST30
Repeati651 – 680ANK 19Add BLAST30
Repeati687 – 716ANK 20Add BLAST30
Repeati720 – 749ANK 21Add BLAST30
Repeati753 – 782ANK 22Add BLAST30
Repeati790 – 819ANK 23Add BLAST30
Repeati822 – 852ANK 24Add BLAST31
Repeati857 – 886ANK 25Add BLAST30
Repeati890 – 920ANK 26Add BLAST31
Repeati924 – 953ANK 27Add BLAST30
Repeati960 – 989ANK 28Add BLAST30

Sequence similaritiesi

Contains 28 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00840000129677.
HOGENOMiHOG000033959.
HOVERGENiHBG067697.
InParanoidiQ8NB46.
KOiK15504.
OMAiKNCGIAA.
OrthoDBiEOG091G02S4.
PhylomeDBiQ8NB46.
TreeFamiTF312824.

Family and domain databases

Gene3Di1.25.40.20. 4 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF00023. Ank. 3 hits.
PF12796. Ank_2. 9 hits.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 28 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 3 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 21 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NB46-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGILSITDQP PLVQAIFSRD VEEVRSLLSQ KENINVLDQE RRTPLHAAAY
60 70 80 90 100
VGDVPILQLL LMSGANVNAK DTLWLTPLHR AAASRNEKVL GLLLAHSADV
110 120 130 140 150
NARDKLWQTP LHVAAANRAT KCAEALAPLL SSLNVADRSG RSALHHAVHS
160 170 180 190 200
GHLETVNLLL NKGASLNVCD KKERQPLHWA AFLGHLEVLK LLVARGADLG
210 220 230 240 250
CKDRKGYGLL HTAAASGQIE VVKYLLRMGA EIDEPNAFGN TALHIACYLG
260 270 280 290 300
QDAVAIELVN AGANVNQPND KGFTPLHVAA VSTNGALCLE LLVNNGADVN
310 320 330 340 350
YQSKEGKSPL HMAAIHGRFT RSQILIQNGS EIDCADKFGN TPLHVAARYG
360 370 380 390 400
HELLISTLMT NGADTARRGI HDMFPLHLAV LFGFSDCCRK LLSSGQLYSI
410 420 430 440 450
VSSLSNEHVL SAGFDINTPD NLGRTCLHAA ASGGNVECLN LLLSSGADLR
460 470 480 490 500
RRDKFGRTPL HYAAANGSYQ CAVTLVTAGA GVNEADCKGC SPLHYAAASD
510 520 530 540 550
TYRRAEPHTP SSHDAEEDEP LKESRRKEAF FCLEFLLDNG ADPSLRDRQG
560 570 580 590 600
YTAVHYAAAY GNRQNLELLL EMSFNCLEDV ESTIPVSPLH LAAYNGHCEA
610 620 630 640 650
LKTLAETLVN LDVRDHKGRT ALFLATERGS TECVEVLTAH GASALIKERK
660 670 680 690 700
RKWTPLHAAA ASGHTDSLHL LIDSGERADI TDVMDAYGQT PLMLAIMNGH
710 720 730 740 750
VDCVHLLLEK GSTADAADLR GRTALHRGAV TGCEDCLAAL LDHDAFVLCR
760 770 780 790 800
DFKGRTPIHL ASACGHTAVL RTLLQAALST DPLDAGVDYS GYSPMHWASY
810 820 830 840 850
TGHEDCLELL LEHSPFSYLE GNPFTPLHCA VINNQDSTTE MLLGALGAKI
860 870 880 890 900
VNSRDAKGRT PLHAAAFADN VSGLRMLLQH QAEVNATDHT GRTALMTAAE
910 920 930 940 950
NGQTAAVEFL LYRGKADLTV LDENKNTALH LACSKGHEKC ALMILAETQD
960 970 980 990 1000
LGLINATNSA LQMPLHIAAR NGLASVVQAL LSHGATVLAV DEEGHTPALA
1010 1020 1030 1040 1050
CAPNKDVADC LALILSTMKP FPPKDAVSPF SFSLLKNCSI AAAKTVGGCG
1060 1070
ALPHGASCPY SQERPGAIGL DGCYSE
Length:1,076
Mass (Da):115,077
Last modified:May 18, 2010 - v3
Checksum:i8CEE6E151956EAFE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti686A → V in AK091555 (PubMed:14702039).Curated1
Sequence conflicti856A → T in AK091555 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB190990 mRNA. Translation: BAG16262.1.
AC073896 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW96919.1.
AK091555 mRNA. No translation available.
CCDSiCCDS44920.1.
RefSeqiNP_775866.2. NM_173595.3.
UniGeneiHs.524506.

Genome annotation databases

EnsembliENST00000267116; ENSP00000267116; ENSG00000139645.
GeneIDi283373.
KEGGihsa:283373.
UCSCiuc001skm.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB190990 mRNA. Translation: BAG16262.1.
AC073896 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW96919.1.
AK091555 mRNA. No translation available.
CCDSiCCDS44920.1.
RefSeqiNP_775866.2. NM_173595.3.
UniGeneiHs.524506.

3D structure databases

ProteinModelPortaliQ8NB46.
SMRiQ8NB46.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129540. 35 interactors.
IntActiQ8NB46. 18 interactors.
MINTiMINT-8287684.
STRINGi9606.ENSP00000267116.

PTM databases

iPTMnetiQ8NB46.
PhosphoSitePlusiQ8NB46.

Polymorphism and mutation databases

BioMutaiANKRD52.
DMDMi296439443.

Proteomic databases

EPDiQ8NB46.
MaxQBiQ8NB46.
PaxDbiQ8NB46.
PeptideAtlasiQ8NB46.
PRIDEiQ8NB46.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000267116; ENSP00000267116; ENSG00000139645.
GeneIDi283373.
KEGGihsa:283373.
UCSCiuc001skm.5. human.

Organism-specific databases

CTDi283373.
GeneCardsiANKRD52.
H-InvDBHIX0010731.
HGNCiHGNC:26614. ANKRD52.
HPAiHPA043815.
neXtProtiNX_Q8NB46.
OpenTargetsiENSG00000139645.
PharmGKBiPA143485302.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0504. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00840000129677.
HOGENOMiHOG000033959.
HOVERGENiHBG067697.
InParanoidiQ8NB46.
KOiK15504.
OMAiKNCGIAA.
OrthoDBiEOG091G02S4.
PhylomeDBiQ8NB46.
TreeFamiTF312824.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000139645-MONOMER.

Miscellaneous databases

ChiTaRSiANKRD52. human.
GenomeRNAii283373.
PROiQ8NB46.

Gene expression databases

BgeeiENSG00000139645.
CleanExiHS_ANKRD52.
GenevisibleiQ8NB46. HS.

Family and domain databases

Gene3Di1.25.40.20. 4 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF00023. Ank. 3 hits.
PF12796. Ank_2. 9 hits.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 28 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 3 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 21 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiANR52_HUMAN
AccessioniPrimary (citable) accession number: Q8NB46
Secondary accession number(s): A6NE79, B1Q2K2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: May 18, 2010
Last modified: November 30, 2016
This is version 115 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.