Reviewed, UniProtKB/Swiss-Prot Q8NB46 (ANR52_HUMAN)

Names and origin

Protein names

Recommended name:
    Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C
      Short name=Serine/threonine-protein phosphatase 6 regulatory subunit ARS-C
      Short name=PP6-ARS-C
Alternative name(s):
    Ankyrin repeat domain-containing protein 52

Gene names

Name:

ANKRD52

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1076 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Putative regulatory subunit of protein phospatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates.
Subunit structure	Protein phospatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed by the catalytic subunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS). Interacts with SAPS1. Ref.4
Sequence similarities	Contains 28 ANK repeats.

Ontologies

Keywords
Domain	ANK repeat Repeat
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	protein binding Ref.4 Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
SAPS1	Q9UPN7	1	EBI-1996119,EBI-359745

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1076	1076	Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C		PRO_0000244587
Regions
	Repeat	7 – 36	30	ANK 1
	Repeat	40 – 69	30	ANK 2
	Repeat	73 – 102	30	ANK 3
	Repeat	106 – 135	30	ANK 4
	Repeat	139 – 168	30	ANK 5
	Repeat	172 – 201	30	ANK 6
	Repeat	205 – 234	30	ANK 7
	Repeat	238 – 267	30	ANK 8
	Repeat	271 – 301	31	ANK 9
	Repeat	305 – 334	30	ANK 10
	Repeat	338 – 367	30	ANK 11
	Repeat	371 – 400	30	ANK 12
	Repeat	422 – 451	30	ANK 13
	Repeat	455 – 484	30	ANK 14
	Repeat	488 – 545	58	ANK 15
	Repeat	549 – 579	31	ANK 16
	Repeat	584 – 613	30	ANK 17
	Repeat	617 – 646	30	ANK 18
	Repeat	651 – 680	30	ANK 19
	Repeat	687 – 716	30	ANK 20
	Repeat	720 – 749	30	ANK 21
	Repeat	753 – 782	30	ANK 22
	Repeat	790 – 819	30	ANK 23
	Repeat	822 – 852	31	ANK 24
	Repeat	857 – 886	30	ANK 25
	Repeat	890 – 920	31	ANK 26
	Repeat	924 – 953	30	ANK 27
	Repeat	960 – 989	30	ANK 28
Amino acid modifications
	Modified residue	1028	1	Phosphoserine Ref.3
Experimental info
	Sequence conflict	686	1	A → V in AK091555. Ref.2
	Sequence conflict	856	1	A → T in AK091555. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q8NB46-1 [UniParc]. Last modified June 27, 2006. Version 2. Checksum: 1C594FC6A569445E	FASTA	1,076	115,058
	10 20 30 40 50 60 MGILSITDQP PLVQAIFSRD VEEVRSLLSQ KENINVLDQE RRTPLHAAAY VGDVPILQLL 70 80 90 100 110 120 LMSGANVNAK DTLWLTPLHR AAASRNEKVL GLLLAHSADV NARDKLWQTP LHVAAANRAT 130 140 150 160 170 180 KCAEALAPLL SSLNVADRSG RSALHHAVHS GHLETVNLLL NKGASLNVCD KKERQPLHWA 190 200 210 220 230 240 AFLGHLEVLK LLVARGADLG CKDRKGYGLL HTAAASGQIE VVKYLLRMGA EIDEPNAFGN 250 260 270 280 290 300 TALHIACYLG QDAVAIELVN AGANVNQPND KGFTPLHVAA VSTNGALCLE LLVNNGADVN 310 320 330 340 350 360 YQVPEGKSPL HMAAIHGRFT RSQILIQNGS EIDCADKFGN TPLHVAARYG HELLISTLMT 370 380 390 400 410 420 NGADTARRGI HDMFPLHLAV LFGFSDCCRK LLSSGQLYSI VSSLSNEHVL SAGFDINTPD 430 440 450 460 470 480 NLGRTCLHAA ASGGNVECLN LLLSSGADLR RRDKFGRTPL HYAAANGSYQ CAVTLVTAGA 490 500 510 520 530 540 GVNEADCKGC SPLHYAAASD TYRRAEPHTP SSHDAEEDEP LKESRRKEAF FCLEFLLDNG 550 560 570 580 590 600 ADPSLRDRQG YTAVHYAAAY GNRQNLELLL EMSFNCLEDV ESTIPVSPLH LAAYNGHCEA 610 620 630 640 650 660 LKTLAETLVN LDVRDHKGRT ALFLATERGS TECVEVLTAH GASALIKERK RKWTPLHAAA 670 680 690 700 710 720 ASGHTDSLHL LIDSGERADI TDVMDAYGQT PLMLAIMNGH VDCVHLLLEK GSTADAADLR 730 740 750 760 770 780 GRTALHRGAV TGCEDCLAAL LDHDAFVLCR DFKGRTPIHL ASACGHTAVL RTLLQAALST 790 800 810 820 830 840 DPLDAGVDYS GYSPMHWASY TGHEDCLELL LEHSPFSYLE GNPFTPLHCA VINNQDSTTE 850 860 870 880 890 900 MLLGALGAKI VNSRDAKGRT PLHAAAFADN VSGLRMLLQH QAEVNATDHT GRTALMTAAE 910 920 930 940 950 960 NGQTAAVEFL LYRGKADLTV LDENKNTALH LACSKGHEKC ALMILAETQD LGLINATNSA 970 980 990 1000 1010 1020 LQMPLHIAAR NGLASVVQAL LSHGATVLAV DEEGHTPALA CAPNKDVADC LALILSTMKP 1030 1040 1050 1060 1070 FPPKDAVSPF SFSLLKNCSI AAAKTVGGCG ALPHGASCPY SQERPGAIGL DGCYSE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The finished DNA sequence of human chromosome 12." Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A. Nature 440:346-351(2006) [PubMed: 16541075] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 510-1076. Tissue: Brain.
[3]	"A probability-based approach for high-throughput protein phosphorylation analysis and site localization." Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P. Nat. Biotechnol. 24:1285-1292(2006) [PubMed: 16964243] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1028, MASS SPECTROMETRY. Tissue: Epithelium.
[4]	"Protein phosphatase 6 regulatory subunits composed of ankyrin repeat domains." Stefansson B., Ohama T., Daugherty A.E., Brautigan D.L. Biochemistry 47:1442-1451(2008) [PubMed: 18186651] [Abstract] Cited for: INTERACTION WITH SAPS1.
[5]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1028, MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AC073896 Genomic DNA. No translation available. AK091555 mRNA. No translation available.
IPI	IPI00398957.
UniGene	Hs.524506
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8NB46. 2 interactions.
STRING	Q8NB46.
PTM databases
PhosphoSite	Q8NB46.
Proteomic databases
PRIDE	Q8NB46.
Genome annotation databases
Ensembl	ENST00000417002; ENSP00000416967; ENSG00000139645; Homo sapiens. [Genome view]
Organism-specific databases
GeneCards	GC12M054920.
HGNC	HGNC:26614. ANKRD52.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q8NB46.
HOVERGEN	Q8NB46.
Gene expression databases
ArrayExpress	Q8NB46.
Bgee	Q8NB46.
CleanEx	HS_ANKRD52.
Genevestigator	Q8NB46.
GermOnline	ENSG00000139645. Homo sapiens.
Family and domain databases
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. [Graphical view]
Gene3D	G3DSA:1.25.40.20. ANK. 5 hits.
Pfam	PF00023. Ank. 28 hits. [Graphical view]
SMART	SM00248. ANK. 28 hits. [Graphical view]
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 21 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ANR52_HUMAN

Accession

Primary (citable) accession number: Q8NB46
Secondary accession number(s): A6NE79

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	June 27, 2006
Last modified:	November 24, 2009
This is version 46 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.