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Protein

Zinc finger protein 527

Gene

ZNF527

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri274 – 29623C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri302 – 32423C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri330 – 35223C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri358 – 38023C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri386 – 40823C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri414 – 43623C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri442 – 46423C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri470 – 49223C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri498 – 52023C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri526 – 54823C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri554 – 57623C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri582 – 60423C2H2-type 12PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 527
Gene namesi
Name:ZNF527
Synonyms:KIAA1829
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:29385. ZNF527.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Polymorphism and mutation databases

BioMutaiZNF527.
DMDMi317373306.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 609609Zinc finger protein 527PRO_0000047639Add
BLAST

Proteomic databases

EPDiQ8NB42.
PaxDbiQ8NB42.
PRIDEiQ8NB42.

PTM databases

iPTMnetiQ8NB42.
PhosphoSiteiQ8NB42.

Expressioni

Gene expression databases

BgeeiQ8NB42.
CleanExiHS_ZNF527.
ExpressionAtlasiQ8NB42. baseline and differential.
GenevisibleiQ8NB42. HS.

Organism-specific databases

HPAiHPA037740.
HPA037741.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000390179.

Structurei

3D structure databases

ProteinModelPortaliQ8NB42.
SMRiQ8NB42. Positions 14-54, 169-606.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 123110KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 12 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri274 – 29623C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri302 – 32423C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri330 – 35223C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri358 – 38023C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri386 – 40823C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri414 – 43623C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri442 – 46423C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri470 – 49223C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri498 – 52023C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri526 – 54823C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri554 – 57623C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri582 – 60423C2H2-type 12PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129704.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8NB42.
KOiK09228.
OMAiWESWCEI.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ8NB42.

Family and domain databases

Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 11 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NB42-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAVGLCKAMS QGLVTFRDVA LDFSQEEWEW LKPSQKDLYR DVMLENYRNL
60 70 80 90 100
VWLGLSISKP NMISLLEQGK EPWMVERKMS QGHCADWESW CEIEELSPKW
110 120 130 140 150
FIDEDEISQE MVMERLASHG LECSSFREAW KYKGEFELHQ GNAERHFMQV
160 170 180 190 200
TAVKEISTGK RDNEFSNSGR SIPLKSVFLT QQKVPTIQQV HKFDIYDKLF
210 220 230 240 250
PQNSVIIEYK RLHAEKESLI GNECEEFNQS TYLSKDIGIP PGEKPYESHD
260 270 280 290 300
FSKLLSFHSL FTQHQTTHFG KLPHGYDECG DAFSCYSFFT QPQRIHSGEK
310 320 330 340 350
PYACNDCGKA FSHDFFLSEH QRTHIGEKPY ECKECNKAFR QSAHLAQHQR
360 370 380 390 400
IHTGEKPFAC NECGKAFSRY AFLVEHQRIH TGEKPYECKE CNKAFRQSAH
410 420 430 440 450
LNQHQRIHTG EKPYECNQCG KAFSRRIALT LHQRIHTGEK PFKCSECGKT
460 470 480 490 500
FGYRSHLNQH QRIHTGEKPY ECIKCGKFFR TDSQLNRHHR IHTGERPFEC
510 520 530 540 550
SKCGKAFSDA LVLIHHKRSH AGEKPYECNK CGKAFSCGSY LNQHQRIHTG
560 570 580 590 600
EKPYECSECG KAFHQILSLR LHQRIHAGEK PYKCNECGNN FSCVSALRRH

QRIHNRETL
Length:609
Mass (Da):70,902
Last modified:January 11, 2011 - v2
Checksum:iD1FEBF1EB02D41FB
GO
Isoform 2 (identifier: Q8NB42-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     54-85: Missing.

Show »
Length:577
Mass (Da):67,334
Checksum:iA2B45C1DCCEE0484
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti57 – 571I → V in BAC03701 (PubMed:14702039).Curated
Sequence conflicti57 – 571I → V in BAG62727 (PubMed:14702039).Curated
Sequence conflicti287 – 2871S → P in BAG62727 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei54 – 8532Missing in isoform 2. 1 PublicationVSP_040341Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK301135 mRNA. Translation: BAG62727.1.
AK091585 mRNA. Translation: BAC03701.1.
AC008806 Genomic DNA. No translation available.
CCDSiCCDS42559.1. [Q8NB42-1]
RefSeqiNP_115829.1. NM_032453.1. [Q8NB42-1]
XP_005259386.1. XM_005259329.2. [Q8NB42-2]
UniGeneiHs.590940.

Genome annotation databases

EnsembliENST00000436120; ENSP00000390179; ENSG00000189164. [Q8NB42-1]
GeneIDi84503.
KEGGihsa:84503.
UCSCiuc010efk.2. human. [Q8NB42-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK301135 mRNA. Translation: BAG62727.1.
AK091585 mRNA. Translation: BAC03701.1.
AC008806 Genomic DNA. No translation available.
CCDSiCCDS42559.1. [Q8NB42-1]
RefSeqiNP_115829.1. NM_032453.1. [Q8NB42-1]
XP_005259386.1. XM_005259329.2. [Q8NB42-2]
UniGeneiHs.590940.

3D structure databases

ProteinModelPortaliQ8NB42.
SMRiQ8NB42. Positions 14-54, 169-606.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000390179.

PTM databases

iPTMnetiQ8NB42.
PhosphoSiteiQ8NB42.

Polymorphism and mutation databases

BioMutaiZNF527.
DMDMi317373306.

Proteomic databases

EPDiQ8NB42.
PaxDbiQ8NB42.
PRIDEiQ8NB42.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000436120; ENSP00000390179; ENSG00000189164. [Q8NB42-1]
GeneIDi84503.
KEGGihsa:84503.
UCSCiuc010efk.2. human. [Q8NB42-1]

Organism-specific databases

CTDi84503.
GeneCardsiZNF527.
HGNCiHGNC:29385. ZNF527.
HPAiHPA037740.
HPA037741.
neXtProtiNX_Q8NB42.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129704.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8NB42.
KOiK09228.
OMAiWESWCEI.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ8NB42.

Miscellaneous databases

GenomeRNAii84503.
NextBioi74294.
PROiQ8NB42.

Gene expression databases

BgeeiQ8NB42.
CleanExiHS_ZNF527.
ExpressionAtlasiQ8NB42. baseline and differential.
GenevisibleiQ8NB42. HS.

Family and domain databases

Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 11 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain and Spleen.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiZN527_HUMAN
AccessioniPrimary (citable) accession number: Q8NB42
Secondary accession number(s): B4DVL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: January 11, 2011
Last modified: May 11, 2016
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.