ID F184A_HUMAN Reviewed; 1140 AA. AC Q8NB25; B9DI75; F8W8D6; Q5TBS9; Q7Z323; Q96GY8; Q9H0J8; Q9H851; DT 16-MAY-2003, integrated into UniProtKB/Swiss-Prot. DT 14-OCT-2008, sequence version 3. DT 24-JAN-2024, entry version 157. DE RecName: Full=Protein FAM184A {ECO:0000305}; GN Name=FAM184A {ECO:0000312|HGNC:HGNC:20991}; Synonyms=C6orf60; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). RC TISSUE=Fetal brain; RX PubMed=17974005; DOI=10.1186/1471-2164-8-399; RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., RA Wiemann S., Schupp I.; RT "The full-ORF clone resource of the German cDNA consortium."; RL BMC Genomics 8:399-399(2007). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., RA Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 54-1140 (ISOFORM 2), AND RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 617-1140 (ISOFORM 1). RC TISSUE=Brain; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 688-1140 (ISOFORM 1). RC TISSUE=Eye; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 847-1140 (ISOFORM 3). RC TISSUE=Testis; RX PubMed=11230166; DOI=10.1101/gr.gr1547r; RA Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., RA Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., RA Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., RA Ottenwaelder B., Obermaier B., Tampe J., Heubner D., Wambutt R., Korn B., RA Klein M., Poustka A.; RT "Towards a catalog of human genes and proteins: sequencing and analysis of RT 500 novel complete protein coding human cDNAs."; RL Genome Res. 11:422-435(2001). RN [7] RP SUBCELLULAR LOCATION. RX PubMed=33957083; DOI=10.1016/j.molcel.2021.04.012; RA Piette B.L., Alerasool N., Lin Z.Y., Lacoste J., Lam M.H.Y., Qian W.W., RA Tran S., Larsen B., Campos E., Peng J., Gingras A.C., Taipale M.; RT "Comprehensive interactome profiling of the human Hsp70 network highlights RT functional differentiation of J domains."; RL Mol. Cell 81:2549-2565(2021). CC -!- INTERACTION: CC Q8NB25; P22607: FGFR3; NbExp=3; IntAct=EBI-9917523, EBI-348399; CC Q8NB25; P06396: GSN; NbExp=3; IntAct=EBI-9917523, EBI-351506; CC Q8NB25; P01112: HRAS; NbExp=3; IntAct=EBI-9917523, EBI-350145; CC Q8NB25; Q96KQ4: PPP1R13B; NbExp=3; IntAct=EBI-9917523, EBI-1105153; CC Q8NB25; Q9UMX0: UBQLN1; NbExp=3; IntAct=EBI-9917523, EBI-741480; CC -!- SUBCELLULAR LOCATION: Cytoplasm, P-body {ECO:0000269|PubMed:33957083}. CC Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, CC centriolar satellite. Note=Localizes to cytoplasmic foci in both CC interphase and mitotic cells. {ECO:0000269|PubMed:33957083}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=4; CC Name=1; CC IsoId=Q8NB25-1; Sequence=Displayed; CC Name=2; CC IsoId=Q8NB25-2; Sequence=VSP_007446, VSP_007447; CC Name=3; CC IsoId=Q8NB25-3; Sequence=VSP_039102, VSP_039103; CC Name=4; CC IsoId=Q8NB25-4; Sequence=VSP_044520, VSP_007446; CC -!- SIMILARITY: Belongs to the FAM184 family. {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=BAB14769.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; CC Sequence=BAC03719.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BX538186; CAD98058.1; -; mRNA. DR EMBL; AL132874; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL137009; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL365275; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471051; EAW48188.1; -; Genomic_DNA. DR EMBL; AK024004; BAB14769.1; ALT_INIT; mRNA. DR EMBL; AK091682; BAC03719.1; ALT_INIT; mRNA. DR EMBL; BC009055; AAH09055.2; -; mRNA. DR EMBL; AL136767; CAB66701.1; -; mRNA. DR CCDS; CCDS43499.1; -. [Q8NB25-1] DR CCDS; CCDS43500.1; -. [Q8NB25-4] DR RefSeq; NP_001093881.1; NM_001100411.2. [Q8NB25-4] DR RefSeq; NP_001275505.1; NM_001288576.1. DR RefSeq; NP_078857.5; NM_024581.5. [Q8NB25-1] DR AlphaFoldDB; Q8NB25; -. DR SMR; Q8NB25; -. DR BioGRID; 122762; 69. DR IntAct; Q8NB25; 22. DR MINT; Q8NB25; -. DR STRING; 9606.ENSP00000342604; -. DR GlyGen; Q8NB25; 1 site, 1 O-linked glycan (1 site). DR iPTMnet; Q8NB25; -. DR PhosphoSitePlus; Q8NB25; -. DR SwissPalm; Q8NB25; -. DR BioMuta; FAM184A; -. DR DMDM; 209572754; -. DR EPD; Q8NB25; -. DR jPOST; Q8NB25; -. DR MassIVE; Q8NB25; -. DR MaxQB; Q8NB25; -. DR PaxDb; 9606-ENSP00000342604; -. DR PeptideAtlas; Q8NB25; -. DR ProteomicsDB; 30129; -. DR ProteomicsDB; 72720; -. [Q8NB25-1] DR ProteomicsDB; 72721; -. [Q8NB25-2] DR ProteomicsDB; 72722; -. [Q8NB25-3] DR Pumba; Q8NB25; -. DR Antibodypedia; 32589; 28 antibodies from 10 providers. DR DNASU; 79632; -. DR Ensembl; ENST00000338891.12; ENSP00000342604.7; ENSG00000111879.20. [Q8NB25-1] DR Ensembl; ENST00000352896.9; ENSP00000326608.6; ENSG00000111879.20. [Q8NB25-4] DR Ensembl; ENST00000521531.5; ENSP00000430442.1; ENSG00000111879.20. [Q8NB25-2] DR GeneID; 79632; -. DR KEGG; hsa:79632; -. DR MANE-Select; ENST00000338891.12; ENSP00000342604.7; NM_024581.6; NP_078857.5. DR UCSC; uc003pyj.5; human. [Q8NB25-1] DR AGR; HGNC:20991; -. DR CTD; 79632; -. DR DisGeNET; 79632; -. DR GeneCards; FAM184A; -. DR HGNC; HGNC:20991; FAM184A. DR HPA; ENSG00000111879; Tissue enhanced (placenta). DR neXtProt; NX_Q8NB25; -. DR OpenTargets; ENSG00000111879; -. DR PharmGKB; PA164719768; -. DR VEuPathDB; HostDB:ENSG00000111879; -. DR eggNOG; ENOG502R5KC; Eukaryota. DR GeneTree; ENSGT00530000063669; -. DR InParanoid; Q8NB25; -. DR OMA; MCKKVAQ; -. DR OrthoDB; 55155at2759; -. DR PhylomeDB; Q8NB25; -. DR TreeFam; TF316006; -. DR PathwayCommons; Q8NB25; -. DR SignaLink; Q8NB25; -. DR BioGRID-ORCS; 79632; 7 hits in 1156 CRISPR screens. DR ChiTaRS; FAM184A; human. DR GenomeRNAi; 79632; -. DR Pharos; Q8NB25; Tdark. DR PRO; PR:Q8NB25; -. DR Proteomes; UP000005640; Chromosome 6. DR RNAct; Q8NB25; Protein. DR Bgee; ENSG00000111879; Expressed in caudate nucleus and 152 other cell types or tissues. DR ExpressionAtlas; Q8NB25; baseline and differential. DR GO; GO:0034451; C:centriolar satellite; IDA:UniProtKB. DR GO; GO:0005615; C:extracellular space; HDA:UniProtKB. DR GO; GO:0000932; C:P-body; IDA:UniProtKB. DR InterPro; IPR039478; FAM184A/B_N. DR PANTHER; PTHR18870:SF7; PROTEIN FAM184A; 1. DR PANTHER; PTHR18870; PROTEIN TAG-278-RELATED; 1. DR Pfam; PF15665; FAM184; 1. DR Genevisible; Q8NB25; HS. PE 1: Evidence at protein level; KW Alternative splicing; Coiled coil; Cytoplasm; Cytoskeleton; KW Reference proteome. FT CHAIN 1..1140 FT /note="Protein FAM184A" FT /id="PRO_0000089512" FT REGION 1063..1128 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 57..256 FT /evidence="ECO:0000255" FT COILED 296..800 FT /evidence="ECO:0000255" FT COILED 868..907 FT /evidence="ECO:0000255" FT VAR_SEQ 1..120 FT /note="Missing (in isoform 4)" FT /evidence="ECO:0000303|PubMed:17974005" FT /id="VSP_044520" FT VAR_SEQ 924..972 FT /note="Missing (in isoform 2 and isoform 4)" FT /evidence="ECO:0000303|PubMed:14702039, FT ECO:0000303|PubMed:17974005" FT /id="VSP_007446" FT VAR_SEQ 1012..1046 FT /note="Missing (in isoform 2)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_007447" FT VAR_SEQ 1114..1116 FT /note="SPA -> RYQ (in isoform 3)" FT /evidence="ECO:0000303|PubMed:11230166" FT /id="VSP_039102" FT VAR_SEQ 1117..1140 FT /note="Missing (in isoform 3)" FT /evidence="ECO:0000303|PubMed:11230166" FT /id="VSP_039103" FT VARIANT 174 FT /note="Q -> H (in dbSNP:rs34681930)" FT /id="VAR_054101" FT VARIANT 177 FT /note="V -> G (in dbSNP:rs34977570)" FT /id="VAR_054102" FT VARIANT 599 FT /note="D -> N (in dbSNP:rs17827619)" FT /id="VAR_054103" FT CONFLICT 546 FT /note="N -> D (in Ref. 1; CAD98058)" FT /evidence="ECO:0000305" FT CONFLICT 620 FT /note="Missing (in Ref. 4; BAC03719)" FT /evidence="ECO:0000305" FT CONFLICT 739 FT /note="Q -> R (in Ref. 4; BAC03719)" FT /evidence="ECO:0000305" FT CONFLICT 795 FT /note="F -> L (in Ref. 1; CAD98058)" FT /evidence="ECO:0000305" FT CONFLICT 882 FT /note="H -> R (in Ref. 1; CAD98058)" FT /evidence="ECO:0000305" SQ SEQUENCE 1140 AA; 132965 MW; 6565FD0C349B37E1 CRC64; MATPGMSWQQ HYYGGSAAKF APSPATAQLA GHSMDYSQEM HLKMSKKIAQ LTKVIYALNT KNDEHESAIQ ALKDAHEEEI QQILAETREK ILQYKSKVTE ELDLRRKIQV LESSLEDHIK MKQQALTEFE AYKHRVEDMQ LCAEAQHVQR IVTMSREVEE IRRKFEEKLR SFGQLQVQFE KDKRLALEDL QAAHRREIQE LLKSQQDHSA SVNKGQEKAE ELHRMEVESL NKMLEELRLE RKKLIEDYEG KLNKAQSFYE RELDTLKRSQ LFTAESLQAS KEKEADLRKE FQGQEAILRK TIGKLKTELQ MVQDEAGSLL DKCQKLQTAL AIAENNVQVL QKQLDDAKEG EMALLSKHKE VESELAAARE RLQQQASDLV LKASHIGMLQ ATQMTQEVTI KDLESEKSRV NERLSQLEEE RAFLRSKTQS LDEEQKQQIL ELEKKVNEAK RTQQEYYERE LKNLQSRLEE EVTQLNEAHS KTLEELAWKH HMAIEAVHSN AIRDKKKLQM DLEEQHNKDK LNLEEDKNQL QQELENLKEV LEDKLNTANQ EIGHLQDMVR KSEQGLGSAE GLIASLQDSQ ERLQNELDLT KDSLKETKDA LLNVEGELEQ ERQQHEETIA AMKEEEKLKV DKMAHDLEIK WTENLRQECS KLREELRLQH EEDKKSAMSQ LLQLKDREKN AARDSWQKKV EDLLNQISLL KQNLEIQLSQ SQTSLQQLQA QFTQERQRLT QELEELEEQH QQRHKSLKEA HVLAFQTMEE EKEKEQRALE NHLQQKHSAE LQSLKDAHRE SMEGFRIEME QELQTLRFEL EDEGKAMLAS LRSELNHQHA AAIDLLRHNH HQELAAAKME LERSIDISRR QSKEHICRIT DLQEELRHRE HHISELDKEV QHLHENISAL TKELEFKGKE ILRIRSESNQ QIRLHEQDLN KRLEKELDVM TADHLREKNI MRADFNKTNE LLKEINAALQ VSLEEMEEKY LMRESKPEDI QMITELKAML TERDQIIKKL IEDNKFYQLE LVNRETNFNK VFNSSPTVGV INPLAKQKKK NDKSPTNRFV SVPNLSALES GGVGNGHPNR LDPIPNSPVH DIEFNSSKPL PQPVPPKGPK TFLSPAQSEA SPVASPDPQR QEWFARYFTF //