Q8NB25 (F184A_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 29, 2013.
Version 83.
History...
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Protein FAM184A | ||||
| Gene names |
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| Organism | Homo sapiens (Human) [Reference proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo![]() |
Protein attributes
| Sequence length | 1140 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Sequence similarities | Belongs to the FAM184 family. |
| Sequence caution | The sequence BAB14769.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAC03719.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. |
Ontologies
| Keywords | |
|---|---|
| Coding sequence diversity | Alternative splicing Polymorphism |
| Domain | Coiled coil |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| None. [Check GOA] | |
Alternative products
| This entry describes 4 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q8NB25-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Note: No experimental confirmation available. | ||||||
| Isoform 2 (identifier: Q8NB25-2) The sequence of this isoform differs from the canonical sequence as follows: 924-972: Missing. 1012-1046: Missing. | ||||||
| Note: No experimental confirmation available. | ||||||
| Isoform 3 (identifier: Q8NB25-3) The sequence of this isoform differs from the canonical sequence as follows: 1114-1116: SPA → RYQ 1117-1140: Missing. | ||||||
| Isoform 4 (identifier: Q8NB25-4) The sequence of this isoform differs from the canonical sequence as follows: 1-120: Missing. 924-972: Missing. | ||||||
| Note: No experimental confirmation available. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 1140 | 1140 | Protein FAM184A | PRO_0000089512 | |||||
Regions | |||||||||
| Coiled coil | 57 – 256 | 200 | Potential | ||||||
| Coiled coil | 296 – 800 | 505 | Potential | ||||||
| Coiled coil | 868 – 907 | 40 | Potential | ||||||
Natural variations | |||||||||
| Alternative sequence | 1 – 120 | 120 | Missing in isoform 4. | VSP_044520 | |||||
| Alternative sequence | 924 – 972 | 49 | Missing in isoform 2 and isoform 4. | VSP_007446 | |||||
| Alternative sequence | 1012 – 1046 | 35 | Missing in isoform 2. | VSP_007447 | |||||
| Alternative sequence | 1114 – 1116 | 3 | SPA → RYQ in isoform 3. | VSP_039102 | |||||
| Alternative sequence | 1117 – 1140 | 24 | Missing in isoform 3. | VSP_039103 | |||||
| Natural variant | 174 | 1 | Q → H. Corresponds to variant rs34681930 [ dbSNP | Ensembl ]. | VAR_054101 | |||||
| Natural variant | 177 | 1 | V → G. Corresponds to variant rs34977570 [ dbSNP | Ensembl ]. | VAR_054102 | |||||
| Natural variant | 599 | 1 | D → N. Corresponds to variant rs17827619 [ dbSNP | Ensembl ]. | VAR_054103 | |||||
Experimental info | |||||||||
| Sequence conflict | 546 | 1 | N → D in CAD98058. Ref.1 | ||||||
| Sequence conflict | 620 | 1 | Missing in BAC03719. Ref.4 | ||||||
| Sequence conflict | 739 | 1 | Q → R in BAC03719. Ref.4 | ||||||
| Sequence conflict | 795 | 1 | F → L in CAD98058. Ref.1 | ||||||
| Sequence conflict | 882 | 1 | H → R in CAD98058. Ref.1 | ||||||
Sequences
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References
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | BX538186 mRNA. Translation: CAD98058.1. AL137009, AL132874, AL365275 Genomic DNA. Translation: CAI20344.1. AL365275, AL132874, AL137009 Genomic DNA. Translation: CAI40383.1. AL132874, AL137009, AL365275 Genomic DNA. Translation: CAX30830.1. CH471051 Genomic DNA. Translation: EAW48188.1. AK024004 mRNA. Translation: BAB14769.1. Different initiation. AK091682 mRNA. Translation: BAC03719.1. Different initiation. BC009055 mRNA. Translation: AAH09055.2. AL136767 mRNA. Translation: CAB66701.1. |
| IPI | IPI00647504. IPI00746850. IPI00874044. IPI00914049. |
| RefSeq | NP_001093881.1. NM_001100411.1. NP_078857.5. NM_024581.4. |
| UniGene | Hs.443789. |
3D structure databases | |
| ProteinModelPortal | Q8NB25. |
| ModBase | Search... |
Protein-protein interaction databases | |
| MINT | MINT-4712612. |
PTM databases | |
| PhosphoSite | Q8NB25. |
Polymorphism databases | |
| DMDM | 209572754. |
Proteomic databases | |
| PaxDb | Q8NB25. |
| PRIDE | Q8NB25. |
Protocols and materials databases | |
| DNASU | 79632. |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENST00000338891; ENSP00000342604; ENSG00000111879. ENST00000352896; ENSP00000326608; ENSG00000111879. ENST00000521531; ENSP00000430442; ENSG00000111879. |
| GeneID | 79632. |
| KEGG | hsa:79632. |
| UCSC | uc003pyj.3. human. uc003pyk.4. human. uc003pyl.4. human. |
Organism-specific databases | |
| CTD | 79632. |
| GeneCards | GC06M119280. |
| HGNC | HGNC:20991. FAM184A. |
| HPA | HPA034571. |
| neXtProt | NX_Q8NB25. |
| PharmGKB | PA164719768. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | NOG138283. |
| HOGENOM | HOG000090031. |
| HOVERGEN | HBG050909. |
| InParanoid | Q8NB25. |
| OMA | RQQHEET. |
| OrthoDB | EOG4ZGPBM. |
Gene expression databases | |
| ArrayExpress | Q8NB25. |
| Bgee | Q8NB25. |
| CleanEx | HS_FAM184A. |
| Genevestigator | Q8NB25. |
| GermOnline | ENSG00000111879. Homo sapiens. |
Family and domain databases | |
| ProtoNet | Search... |
Other | |
| ChiTaRS | FAM184A. human. |
| GenomeRNAi | 79632. |
| NextBio | 68735. |
Entry information
| Entry name | F184A_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q8NB25 Secondary accession number(s): B9DI75 Q9H851 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 6 Human chromosome 6: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| SIMILARITY comments Index of protein domains and families |

Clusters with
