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Protein

Protein FAM184A

Gene

FAM184A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM184A
Gene namesi
Name:FAM184A
Synonyms:C6orf60
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:20991. FAM184A.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164719768.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11401140Protein FAM184APRO_0000089512Add
BLAST

Proteomic databases

MaxQBiQ8NB25.
PaxDbiQ8NB25.
PRIDEiQ8NB25.

PTM databases

PhosphoSiteiQ8NB25.

Expressioni

Gene expression databases

BgeeiQ8NB25.
CleanExiHS_FAM184A.
ExpressionAtlasiQ8NB25. baseline and differential.
GenevestigatoriQ8NB25.

Organism-specific databases

HPAiHPA034571.

Interactioni

Protein-protein interaction databases

BioGridi122762. 10 interactions.
IntActiQ8NB25. 4 interactions.
MINTiMINT-4712612.

Structurei

3D structure databases

ProteinModelPortaliQ8NB25.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili57 – 256200Sequence AnalysisAdd
BLAST
Coiled coili296 – 800505Sequence AnalysisAdd
BLAST
Coiled coili868 – 90740Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the FAM184 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG138283.
GeneTreeiENSGT00530000063669.
HOGENOMiHOG000090031.
HOVERGENiHBG050909.
InParanoidiQ8NB25.
OMAiKKTQQEY.
OrthoDBiEOG7JQBMM.
PhylomeDBiQ8NB25.
TreeFamiTF316006.

Family and domain databases

InterProiIPR029605. FAM184.
IPR029607. FAM184A.
[Graphical view]
PANTHERiPTHR18870. PTHR18870. 1 hit.
PTHR18870:SF7. PTHR18870:SF7. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NB25-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATPGMSWQQ HYYGGSAAKF APSPATAQLA GHSMDYSQEM HLKMSKKIAQ
60 70 80 90 100
LTKVIYALNT KNDEHESAIQ ALKDAHEEEI QQILAETREK ILQYKSKVTE
110 120 130 140 150
ELDLRRKIQV LESSLEDHIK MKQQALTEFE AYKHRVEDMQ LCAEAQHVQR
160 170 180 190 200
IVTMSREVEE IRRKFEEKLR SFGQLQVQFE KDKRLALEDL QAAHRREIQE
210 220 230 240 250
LLKSQQDHSA SVNKGQEKAE ELHRMEVESL NKMLEELRLE RKKLIEDYEG
260 270 280 290 300
KLNKAQSFYE RELDTLKRSQ LFTAESLQAS KEKEADLRKE FQGQEAILRK
310 320 330 340 350
TIGKLKTELQ MVQDEAGSLL DKCQKLQTAL AIAENNVQVL QKQLDDAKEG
360 370 380 390 400
EMALLSKHKE VESELAAARE RLQQQASDLV LKASHIGMLQ ATQMTQEVTI
410 420 430 440 450
KDLESEKSRV NERLSQLEEE RAFLRSKTQS LDEEQKQQIL ELEKKVNEAK
460 470 480 490 500
RTQQEYYERE LKNLQSRLEE EVTQLNEAHS KTLEELAWKH HMAIEAVHSN
510 520 530 540 550
AIRDKKKLQM DLEEQHNKDK LNLEEDKNQL QQELENLKEV LEDKLNTANQ
560 570 580 590 600
EIGHLQDMVR KSEQGLGSAE GLIASLQDSQ ERLQNELDLT KDSLKETKDA
610 620 630 640 650
LLNVEGELEQ ERQQHEETIA AMKEEEKLKV DKMAHDLEIK WTENLRQECS
660 670 680 690 700
KLREELRLQH EEDKKSAMSQ LLQLKDREKN AARDSWQKKV EDLLNQISLL
710 720 730 740 750
KQNLEIQLSQ SQTSLQQLQA QFTQERQRLT QELEELEEQH QQRHKSLKEA
760 770 780 790 800
HVLAFQTMEE EKEKEQRALE NHLQQKHSAE LQSLKDAHRE SMEGFRIEME
810 820 830 840 850
QELQTLRFEL EDEGKAMLAS LRSELNHQHA AAIDLLRHNH HQELAAAKME
860 870 880 890 900
LERSIDISRR QSKEHICRIT DLQEELRHRE HHISELDKEV QHLHENISAL
910 920 930 940 950
TKELEFKGKE ILRIRSESNQ QIRLHEQDLN KRLEKELDVM TADHLREKNI
960 970 980 990 1000
MRADFNKTNE LLKEINAALQ VSLEEMEEKY LMRESKPEDI QMITELKAML
1010 1020 1030 1040 1050
TERDQIIKKL IEDNKFYQLE LVNRETNFNK VFNSSPTVGV INPLAKQKKK
1060 1070 1080 1090 1100
NDKSPTNRFV SVPNLSALES GGVGNGHPNR LDPIPNSPVH DIEFNSSKPL
1110 1120 1130 1140
PQPVPPKGPK TFLSPAQSEA SPVASPDPQR QEWFARYFTF

Note: No experimental confirmation available.

Length:1,140
Mass (Da):132,965
Last modified:October 14, 2008 - v3
Checksum:i6565FD0C349B37E1
GO
Isoform 2 (identifier: Q8NB25-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     924-972: Missing.
     1012-1046: Missing.

Note: No experimental confirmation available.

Show »
Length:1,056
Mass (Da):123,198
Checksum:iFE34CBA8D03122B3
GO
Isoform 3 (identifier: Q8NB25-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1114-1116: SPA → RYQ
     1117-1140: Missing.

Show »
Length:1,116
Mass (Da):130,330
Checksum:i10F25BC6E913E5C9
GO
Isoform 4 (identifier: Q8NB25-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-120: Missing.
     924-972: Missing.

Note: No experimental confirmation available.

Show »
Length:971
Mass (Da):113,569
Checksum:i41A5C04C5F22A3CE
GO

Sequence cautioni

The sequence BAB14769.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC03719.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti546 – 5461N → D in CAD98058 (PubMed:17974005).Curated
Sequence conflicti620 – 6201Missing in BAC03719 (PubMed:14702039).Curated
Sequence conflicti739 – 7391Q → R in BAC03719 (PubMed:14702039).Curated
Sequence conflicti795 – 7951F → L in CAD98058 (PubMed:17974005).Curated
Sequence conflicti882 – 8821H → R in CAD98058 (PubMed:17974005).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti174 – 1741Q → H.
Corresponds to variant rs34681930 [ dbSNP | Ensembl ].
VAR_054101
Natural varianti177 – 1771V → G.
Corresponds to variant rs34977570 [ dbSNP | Ensembl ].
VAR_054102
Natural varianti599 – 5991D → N.
Corresponds to variant rs17827619 [ dbSNP | Ensembl ].
VAR_054103

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 120120Missing in isoform 4. 1 PublicationVSP_044520Add
BLAST
Alternative sequencei924 – 97249Missing in isoform 2 and isoform 4. 2 PublicationsVSP_007446Add
BLAST
Alternative sequencei1012 – 104635Missing in isoform 2. 1 PublicationVSP_007447Add
BLAST
Alternative sequencei1114 – 11163SPA → RYQ in isoform 3. 1 PublicationVSP_039102
Alternative sequencei1117 – 114024Missing in isoform 3. 1 PublicationVSP_039103Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX538186 mRNA. Translation: CAD98058.1.
AL137009, AL132874, AL365275 Genomic DNA. Translation: CAI20344.1.
AL365275, AL132874, AL137009 Genomic DNA. Translation: CAI40383.1.
AL132874, AL137009, AL365275 Genomic DNA. Translation: CAX30830.1.
CH471051 Genomic DNA. Translation: EAW48188.1.
AK024004 mRNA. Translation: BAB14769.1. Different initiation.
AK091682 mRNA. Translation: BAC03719.1. Different initiation.
BC009055 mRNA. Translation: AAH09055.2.
AL136767 mRNA. Translation: CAB66701.1.
CCDSiCCDS43499.1. [Q8NB25-1]
CCDS43500.1. [Q8NB25-4]
RefSeqiNP_001093881.1. NM_001100411.2. [Q8NB25-4]
NP_001275505.1. NM_001288576.1.
NP_078857.5. NM_024581.5. [Q8NB25-1]
UniGeneiHs.443789.

Genome annotation databases

EnsembliENST00000338891; ENSP00000342604; ENSG00000111879. [Q8NB25-1]
ENST00000352896; ENSP00000326608; ENSG00000111879. [Q8NB25-4]
ENST00000521531; ENSP00000430442; ENSG00000111879. [Q8NB25-2]
GeneIDi79632.
KEGGihsa:79632.
UCSCiuc003pyj.3. human. [Q8NB25-1]
uc003pyk.4. human. [Q8NB25-4]

Polymorphism databases

DMDMi209572754.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX538186 mRNA. Translation: CAD98058.1.
AL137009, AL132874, AL365275 Genomic DNA. Translation: CAI20344.1.
AL365275, AL132874, AL137009 Genomic DNA. Translation: CAI40383.1.
AL132874, AL137009, AL365275 Genomic DNA. Translation: CAX30830.1.
CH471051 Genomic DNA. Translation: EAW48188.1.
AK024004 mRNA. Translation: BAB14769.1. Different initiation.
AK091682 mRNA. Translation: BAC03719.1. Different initiation.
BC009055 mRNA. Translation: AAH09055.2.
AL136767 mRNA. Translation: CAB66701.1.
CCDSiCCDS43499.1. [Q8NB25-1]
CCDS43500.1. [Q8NB25-4]
RefSeqiNP_001093881.1. NM_001100411.2. [Q8NB25-4]
NP_001275505.1. NM_001288576.1.
NP_078857.5. NM_024581.5. [Q8NB25-1]
UniGeneiHs.443789.

3D structure databases

ProteinModelPortaliQ8NB25.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122762. 10 interactions.
IntActiQ8NB25. 4 interactions.
MINTiMINT-4712612.

PTM databases

PhosphoSiteiQ8NB25.

Polymorphism databases

DMDMi209572754.

Proteomic databases

MaxQBiQ8NB25.
PaxDbiQ8NB25.
PRIDEiQ8NB25.

Protocols and materials databases

DNASUi79632.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338891; ENSP00000342604; ENSG00000111879. [Q8NB25-1]
ENST00000352896; ENSP00000326608; ENSG00000111879. [Q8NB25-4]
ENST00000521531; ENSP00000430442; ENSG00000111879. [Q8NB25-2]
GeneIDi79632.
KEGGihsa:79632.
UCSCiuc003pyj.3. human. [Q8NB25-1]
uc003pyk.4. human. [Q8NB25-4]

Organism-specific databases

CTDi79632.
GeneCardsiGC06M119280.
HGNCiHGNC:20991. FAM184A.
HPAiHPA034571.
neXtProtiNX_Q8NB25.
PharmGKBiPA164719768.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG138283.
GeneTreeiENSGT00530000063669.
HOGENOMiHOG000090031.
HOVERGENiHBG050909.
InParanoidiQ8NB25.
OMAiKKTQQEY.
OrthoDBiEOG7JQBMM.
PhylomeDBiQ8NB25.
TreeFamiTF316006.

Miscellaneous databases

ChiTaRSiFAM184A. human.
GenomeRNAii79632.
NextBioi68735.
PROiQ8NB25.

Gene expression databases

BgeeiQ8NB25.
CleanExiHS_FAM184A.
ExpressionAtlasiQ8NB25. baseline and differential.
GenevestigatoriQ8NB25.

Family and domain databases

InterProiIPR029605. FAM184.
IPR029607. FAM184A.
[Graphical view]
PANTHERiPTHR18870. PTHR18870. 1 hit.
PTHR18870:SF7. PTHR18870:SF7. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Fetal brain.
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 54-1140 (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 617-1140 (ISOFORM 1).
    Tissue: Brain.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 688-1140 (ISOFORM 1).
    Tissue: Eye.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 847-1140 (ISOFORM 3).
    Tissue: Testis.

Entry informationi

Entry nameiF184A_HUMAN
AccessioniPrimary (citable) accession number: Q8NB25
Secondary accession number(s): B9DI75
, F8W8D6, Q5TBS9, Q7Z323, Q96GY8, Q9H0J8, Q9H851
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2003
Last sequence update: October 14, 2008
Last modified: March 4, 2015
This is version 99 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.