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Q8NB25

- F184A_HUMAN

UniProt

Q8NB25 - F184A_HUMAN

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Protein
Protein FAM184A
Gene
FAM184A, C6orf60
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM184A
Gene namesi
Name:FAM184A
Synonyms:C6orf60
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:20991. FAM184A.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProt
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164719768.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11401140Protein FAM184A
PRO_0000089512Add
BLAST

Proteomic databases

MaxQBiQ8NB25.
PaxDbiQ8NB25.
PRIDEiQ8NB25.

PTM databases

PhosphoSiteiQ8NB25.

Expressioni

Gene expression databases

ArrayExpressiQ8NB25.
BgeeiQ8NB25.
CleanExiHS_FAM184A.
GenevestigatoriQ8NB25.

Organism-specific databases

HPAiHPA034571.

Interactioni

Protein-protein interaction databases

BioGridi122762. 4 interactions.
MINTiMINT-4712612.

Structurei

3D structure databases

ProteinModelPortaliQ8NB25.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili57 – 256200 Reviewed prediction
Add
BLAST
Coiled coili296 – 800505 Reviewed prediction
Add
BLAST
Coiled coili868 – 90740 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Belongs to the FAM184 family.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG138283.
HOGENOMiHOG000090031.
HOVERGENiHBG050909.
InParanoidiQ8NB25.
OMAiKKTQQEY.
OrthoDBiEOG7JQBMM.
PhylomeDBiQ8NB25.
TreeFamiTF316006.

Family and domain databases

InterProiIPR029605. FAM184.
IPR029607. FAM184A.
[Graphical view]
PANTHERiPTHR18870. PTHR18870. 1 hit.
PTHR18870:SF7. PTHR18870:SF7. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8NB25-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MATPGMSWQQ HYYGGSAAKF APSPATAQLA GHSMDYSQEM HLKMSKKIAQ     50
LTKVIYALNT KNDEHESAIQ ALKDAHEEEI QQILAETREK ILQYKSKVTE 100
ELDLRRKIQV LESSLEDHIK MKQQALTEFE AYKHRVEDMQ LCAEAQHVQR 150
IVTMSREVEE IRRKFEEKLR SFGQLQVQFE KDKRLALEDL QAAHRREIQE 200
LLKSQQDHSA SVNKGQEKAE ELHRMEVESL NKMLEELRLE RKKLIEDYEG 250
KLNKAQSFYE RELDTLKRSQ LFTAESLQAS KEKEADLRKE FQGQEAILRK 300
TIGKLKTELQ MVQDEAGSLL DKCQKLQTAL AIAENNVQVL QKQLDDAKEG 350
EMALLSKHKE VESELAAARE RLQQQASDLV LKASHIGMLQ ATQMTQEVTI 400
KDLESEKSRV NERLSQLEEE RAFLRSKTQS LDEEQKQQIL ELEKKVNEAK 450
RTQQEYYERE LKNLQSRLEE EVTQLNEAHS KTLEELAWKH HMAIEAVHSN 500
AIRDKKKLQM DLEEQHNKDK LNLEEDKNQL QQELENLKEV LEDKLNTANQ 550
EIGHLQDMVR KSEQGLGSAE GLIASLQDSQ ERLQNELDLT KDSLKETKDA 600
LLNVEGELEQ ERQQHEETIA AMKEEEKLKV DKMAHDLEIK WTENLRQECS 650
KLREELRLQH EEDKKSAMSQ LLQLKDREKN AARDSWQKKV EDLLNQISLL 700
KQNLEIQLSQ SQTSLQQLQA QFTQERQRLT QELEELEEQH QQRHKSLKEA 750
HVLAFQTMEE EKEKEQRALE NHLQQKHSAE LQSLKDAHRE SMEGFRIEME 800
QELQTLRFEL EDEGKAMLAS LRSELNHQHA AAIDLLRHNH HQELAAAKME 850
LERSIDISRR QSKEHICRIT DLQEELRHRE HHISELDKEV QHLHENISAL 900
TKELEFKGKE ILRIRSESNQ QIRLHEQDLN KRLEKELDVM TADHLREKNI 950
MRADFNKTNE LLKEINAALQ VSLEEMEEKY LMRESKPEDI QMITELKAML 1000
TERDQIIKKL IEDNKFYQLE LVNRETNFNK VFNSSPTVGV INPLAKQKKK 1050
NDKSPTNRFV SVPNLSALES GGVGNGHPNR LDPIPNSPVH DIEFNSSKPL 1100
PQPVPPKGPK TFLSPAQSEA SPVASPDPQR QEWFARYFTF 1140

Note: No experimental confirmation available.

Length:1,140
Mass (Da):132,965
Last modified:October 14, 2008 - v3
Checksum:i6565FD0C349B37E1
GO
Isoform 2 (identifier: Q8NB25-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     924-972: Missing.
     1012-1046: Missing.

Note: No experimental confirmation available.

Show »
Length:1,056
Mass (Da):123,198
Checksum:iFE34CBA8D03122B3
GO
Isoform 3 (identifier: Q8NB25-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1114-1116: SPA → RYQ
     1117-1140: Missing.

Show »
Length:1,116
Mass (Da):130,330
Checksum:i10F25BC6E913E5C9
GO
Isoform 4 (identifier: Q8NB25-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-120: Missing.
     924-972: Missing.

Note: No experimental confirmation available.

Show »
Length:971
Mass (Da):113,569
Checksum:i41A5C04C5F22A3CE
GO

Sequence cautioni

The sequence BAB14769.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAC03719.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti174 – 1741Q → H.
Corresponds to variant rs34681930 [ dbSNP | Ensembl ].
VAR_054101
Natural varianti177 – 1771V → G.
Corresponds to variant rs34977570 [ dbSNP | Ensembl ].
VAR_054102
Natural varianti599 – 5991D → N.
Corresponds to variant rs17827619 [ dbSNP | Ensembl ].
VAR_054103

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 120120Missing in isoform 4.
VSP_044520Add
BLAST
Alternative sequencei924 – 97249Missing in isoform 2 and isoform 4.
VSP_007446Add
BLAST
Alternative sequencei1012 – 104635Missing in isoform 2.
VSP_007447Add
BLAST
Alternative sequencei1114 – 11163SPA → RYQ in isoform 3.
VSP_039102
Alternative sequencei1117 – 114024Missing in isoform 3.
VSP_039103Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti546 – 5461N → D in CAD98058. 1 Publication
Sequence conflicti620 – 6201Missing in BAC03719. 1 Publication
Sequence conflicti739 – 7391Q → R in BAC03719. 1 Publication
Sequence conflicti795 – 7951F → L in CAD98058. 1 Publication
Sequence conflicti882 – 8821H → R in CAD98058. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX538186 mRNA. Translation: CAD98058.1.
AL137009, AL132874, AL365275 Genomic DNA. Translation: CAI20344.1.
AL365275, AL132874, AL137009 Genomic DNA. Translation: CAI40383.1.
AL132874, AL137009, AL365275 Genomic DNA. Translation: CAX30830.1.
CH471051 Genomic DNA. Translation: EAW48188.1.
AK024004 mRNA. Translation: BAB14769.1. Different initiation.
AK091682 mRNA. Translation: BAC03719.1. Different initiation.
BC009055 mRNA. Translation: AAH09055.2.
AL136767 mRNA. Translation: CAB66701.1.
CCDSiCCDS43499.1. [Q8NB25-1]
CCDS43500.1. [Q8NB25-4]
RefSeqiNP_001093881.1. NM_001100411.2. [Q8NB25-4]
NP_001275505.1. NM_001288576.1.
NP_078857.5. NM_024581.5. [Q8NB25-1]
UniGeneiHs.443789.

Genome annotation databases

EnsembliENST00000338891; ENSP00000342604; ENSG00000111879. [Q8NB25-1]
ENST00000352896; ENSP00000326608; ENSG00000111879. [Q8NB25-4]
ENST00000521531; ENSP00000430442; ENSG00000111879. [Q8NB25-2]
GeneIDi79632.
KEGGihsa:79632.
UCSCiuc003pyj.3. human. [Q8NB25-1]
uc003pyk.4. human. [Q8NB25-4]

Polymorphism databases

DMDMi209572754.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX538186 mRNA. Translation: CAD98058.1 .
AL137009 , AL132874 , AL365275 Genomic DNA. Translation: CAI20344.1 .
AL365275 , AL132874 , AL137009 Genomic DNA. Translation: CAI40383.1 .
AL132874 , AL137009 , AL365275 Genomic DNA. Translation: CAX30830.1 .
CH471051 Genomic DNA. Translation: EAW48188.1 .
AK024004 mRNA. Translation: BAB14769.1 . Different initiation.
AK091682 mRNA. Translation: BAC03719.1 . Different initiation.
BC009055 mRNA. Translation: AAH09055.2 .
AL136767 mRNA. Translation: CAB66701.1 .
CCDSi CCDS43499.1. [Q8NB25-1 ]
CCDS43500.1. [Q8NB25-4 ]
RefSeqi NP_001093881.1. NM_001100411.2. [Q8NB25-4 ]
NP_001275505.1. NM_001288576.1.
NP_078857.5. NM_024581.5. [Q8NB25-1 ]
UniGenei Hs.443789.

3D structure databases

ProteinModelPortali Q8NB25.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122762. 4 interactions.
MINTi MINT-4712612.

PTM databases

PhosphoSitei Q8NB25.

Polymorphism databases

DMDMi 209572754.

Proteomic databases

MaxQBi Q8NB25.
PaxDbi Q8NB25.
PRIDEi Q8NB25.

Protocols and materials databases

DNASUi 79632.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000338891 ; ENSP00000342604 ; ENSG00000111879 . [Q8NB25-1 ]
ENST00000352896 ; ENSP00000326608 ; ENSG00000111879 . [Q8NB25-4 ]
ENST00000521531 ; ENSP00000430442 ; ENSG00000111879 . [Q8NB25-2 ]
GeneIDi 79632.
KEGGi hsa:79632.
UCSCi uc003pyj.3. human. [Q8NB25-1 ]
uc003pyk.4. human. [Q8NB25-4 ]

Organism-specific databases

CTDi 79632.
GeneCardsi GC06M119280.
HGNCi HGNC:20991. FAM184A.
HPAi HPA034571.
neXtProti NX_Q8NB25.
PharmGKBi PA164719768.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG138283.
HOGENOMi HOG000090031.
HOVERGENi HBG050909.
InParanoidi Q8NB25.
OMAi KKTQQEY.
OrthoDBi EOG7JQBMM.
PhylomeDBi Q8NB25.
TreeFami TF316006.

Miscellaneous databases

ChiTaRSi FAM184A. human.
GenomeRNAii 79632.
NextBioi 68735.
PROi Q8NB25.

Gene expression databases

ArrayExpressi Q8NB25.
Bgeei Q8NB25.
CleanExi HS_FAM184A.
Genevestigatori Q8NB25.

Family and domain databases

InterProi IPR029605. FAM184.
IPR029607. FAM184A.
[Graphical view ]
PANTHERi PTHR18870. PTHR18870. 1 hit.
PTHR18870:SF7. PTHR18870:SF7. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Fetal brain.
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 54-1140 (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 617-1140 (ISOFORM 1).
    Tissue: Brain.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 688-1140 (ISOFORM 1).
    Tissue: Eye.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 847-1140 (ISOFORM 3).
    Tissue: Testis.

Entry informationi

Entry nameiF184A_HUMAN
AccessioniPrimary (citable) accession number: Q8NB25
Secondary accession number(s): B9DI75
, F8W8D6, Q5TBS9, Q7Z323, Q96GY8, Q9H0J8, Q9H851
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2003
Last sequence update: October 14, 2008
Last modified: September 3, 2014
This is version 94 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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