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Protein

Protein FAM184A

Gene

FAM184A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM184A
Gene namesi
Name:FAM184A
Synonyms:C6orf60
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000111879.18
HGNCiHGNC:20991 FAM184A
neXtProtiNX_Q8NB25

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi79632
OpenTargetsiENSG00000111879
PharmGKBiPA164719768

Polymorphism and mutation databases

BioMutaiFAM184A
DMDMi209572754

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000895121 – 1140Protein FAM184AAdd BLAST1140

Proteomic databases

EPDiQ8NB25
MaxQBiQ8NB25
PaxDbiQ8NB25
PeptideAtlasiQ8NB25
PRIDEiQ8NB25
ProteomicsDBi72720
72721 [Q8NB25-2]
72722 [Q8NB25-3]

PTM databases

iPTMnetiQ8NB25
PhosphoSitePlusiQ8NB25
SwissPalmiQ8NB25

Expressioni

Gene expression databases

BgeeiENSG00000111879
CleanExiHS_FAM184A
ExpressionAtlasiQ8NB25 baseline and differential
GenevisibleiQ8NB25 HS

Organism-specific databases

HPAiHPA034571
HPA034572
HPA041955

Interactioni

Protein-protein interaction databases

BioGridi122762, 14 interactors
IntActiQ8NB25, 9 interactors
MINTiQ8NB25

Structurei

3D structure databases

ProteinModelPortaliQ8NB25
SMRiQ8NB25
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili57 – 256Sequence analysisAdd BLAST200
Coiled coili296 – 800Sequence analysisAdd BLAST505
Coiled coili868 – 907Sequence analysisAdd BLAST40

Sequence similaritiesi

Belongs to the FAM184 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IFYF Eukaryota
ENOG410ZNZK LUCA
GeneTreeiENSGT00530000063669
HOGENOMiHOG000090031
HOVERGENiHBG050909
InParanoidiQ8NB25
OMAiDVMTADH
OrthoDBiEOG091G017V
PhylomeDBiQ8NB25
TreeFamiTF316006

Family and domain databases

InterProiView protein in InterPro
IPR029605 FAM184
IPR029607 FAM184A
PANTHERiPTHR18870 PTHR18870, 1 hit
PTHR18870:SF7 PTHR18870:SF7, 1 hit

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8NB25-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATPGMSWQQ HYYGGSAAKF APSPATAQLA GHSMDYSQEM HLKMSKKIAQ
60 70 80 90 100
LTKVIYALNT KNDEHESAIQ ALKDAHEEEI QQILAETREK ILQYKSKVTE
110 120 130 140 150
ELDLRRKIQV LESSLEDHIK MKQQALTEFE AYKHRVEDMQ LCAEAQHVQR
160 170 180 190 200
IVTMSREVEE IRRKFEEKLR SFGQLQVQFE KDKRLALEDL QAAHRREIQE
210 220 230 240 250
LLKSQQDHSA SVNKGQEKAE ELHRMEVESL NKMLEELRLE RKKLIEDYEG
260 270 280 290 300
KLNKAQSFYE RELDTLKRSQ LFTAESLQAS KEKEADLRKE FQGQEAILRK
310 320 330 340 350
TIGKLKTELQ MVQDEAGSLL DKCQKLQTAL AIAENNVQVL QKQLDDAKEG
360 370 380 390 400
EMALLSKHKE VESELAAARE RLQQQASDLV LKASHIGMLQ ATQMTQEVTI
410 420 430 440 450
KDLESEKSRV NERLSQLEEE RAFLRSKTQS LDEEQKQQIL ELEKKVNEAK
460 470 480 490 500
RTQQEYYERE LKNLQSRLEE EVTQLNEAHS KTLEELAWKH HMAIEAVHSN
510 520 530 540 550
AIRDKKKLQM DLEEQHNKDK LNLEEDKNQL QQELENLKEV LEDKLNTANQ
560 570 580 590 600
EIGHLQDMVR KSEQGLGSAE GLIASLQDSQ ERLQNELDLT KDSLKETKDA
610 620 630 640 650
LLNVEGELEQ ERQQHEETIA AMKEEEKLKV DKMAHDLEIK WTENLRQECS
660 670 680 690 700
KLREELRLQH EEDKKSAMSQ LLQLKDREKN AARDSWQKKV EDLLNQISLL
710 720 730 740 750
KQNLEIQLSQ SQTSLQQLQA QFTQERQRLT QELEELEEQH QQRHKSLKEA
760 770 780 790 800
HVLAFQTMEE EKEKEQRALE NHLQQKHSAE LQSLKDAHRE SMEGFRIEME
810 820 830 840 850
QELQTLRFEL EDEGKAMLAS LRSELNHQHA AAIDLLRHNH HQELAAAKME
860 870 880 890 900
LERSIDISRR QSKEHICRIT DLQEELRHRE HHISELDKEV QHLHENISAL
910 920 930 940 950
TKELEFKGKE ILRIRSESNQ QIRLHEQDLN KRLEKELDVM TADHLREKNI
960 970 980 990 1000
MRADFNKTNE LLKEINAALQ VSLEEMEEKY LMRESKPEDI QMITELKAML
1010 1020 1030 1040 1050
TERDQIIKKL IEDNKFYQLE LVNRETNFNK VFNSSPTVGV INPLAKQKKK
1060 1070 1080 1090 1100
NDKSPTNRFV SVPNLSALES GGVGNGHPNR LDPIPNSPVH DIEFNSSKPL
1110 1120 1130 1140
PQPVPPKGPK TFLSPAQSEA SPVASPDPQR QEWFARYFTF
Note: No experimental confirmation available.
Length:1,140
Mass (Da):132,965
Last modified:October 14, 2008 - v3
Checksum:i6565FD0C349B37E1
GO
Isoform 2 (identifier: Q8NB25-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     924-972: Missing.
     1012-1046: Missing.

Note: No experimental confirmation available.
Show »
Length:1,056
Mass (Da):123,198
Checksum:iFE34CBA8D03122B3
GO
Isoform 3 (identifier: Q8NB25-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1114-1116: SPA → RYQ
     1117-1140: Missing.

Show »
Length:1,116
Mass (Da):130,330
Checksum:i10F25BC6E913E5C9
GO
Isoform 4 (identifier: Q8NB25-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-120: Missing.
     924-972: Missing.

Note: No experimental confirmation available.
Show »
Length:971
Mass (Da):113,569
Checksum:i41A5C04C5F22A3CE
GO

Sequence cautioni

The sequence BAB14769 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC03719 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti546N → D in CAD98058 (PubMed:17974005).Curated1
Sequence conflicti620Missing in BAC03719 (PubMed:14702039).Curated1
Sequence conflicti739Q → R in BAC03719 (PubMed:14702039).Curated1
Sequence conflicti795F → L in CAD98058 (PubMed:17974005).Curated1
Sequence conflicti882H → R in CAD98058 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_054101174Q → H. Corresponds to variant dbSNP:rs34681930Ensembl.1
Natural variantiVAR_054102177V → G. Corresponds to variant dbSNP:rs34977570Ensembl.1
Natural variantiVAR_054103599D → N. Corresponds to variant dbSNP:rs17827619Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0445201 – 120Missing in isoform 4. 1 PublicationAdd BLAST120
Alternative sequenceiVSP_007446924 – 972Missing in isoform 2 and isoform 4. 2 PublicationsAdd BLAST49
Alternative sequenceiVSP_0074471012 – 1046Missing in isoform 2. 1 PublicationAdd BLAST35
Alternative sequenceiVSP_0391021114 – 1116SPA → RYQ in isoform 3. 1 Publication3
Alternative sequenceiVSP_0391031117 – 1140Missing in isoform 3. 1 PublicationAdd BLAST24

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX538186 mRNA Translation: CAD98058.1
AL132874 Genomic DNA No translation available.
AL137009 Genomic DNA No translation available.
AL365275 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48188.1
AK024004 mRNA Translation: BAB14769.1 Different initiation.
AK091682 mRNA Translation: BAC03719.1 Different initiation.
BC009055 mRNA Translation: AAH09055.2
AL136767 mRNA Translation: CAB66701.1
CCDSiCCDS43499.1 [Q8NB25-1]
CCDS43500.1 [Q8NB25-4]
RefSeqiNP_001093881.1, NM_001100411.2 [Q8NB25-4]
NP_001275505.1, NM_001288576.1
NP_078857.5, NM_024581.5 [Q8NB25-1]
UniGeneiHs.443789

Genome annotation databases

EnsembliENST00000338891; ENSP00000342604; ENSG00000111879 [Q8NB25-1]
ENST00000352896; ENSP00000326608; ENSG00000111879 [Q8NB25-4]
ENST00000521531; ENSP00000430442; ENSG00000111879 [Q8NB25-2]
GeneIDi79632
KEGGihsa:79632
UCSCiuc003pyj.5 human [Q8NB25-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiF184A_HUMAN
AccessioniPrimary (citable) accession number: Q8NB25
Secondary accession number(s): B9DI75
, F8W8D6, Q5TBS9, Q7Z323, Q96GY8, Q9H0J8, Q9H851
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2003
Last sequence update: October 14, 2008
Last modified: June 20, 2018
This is version 125 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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