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Q8NB25 (F184A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein FAM184A
Gene names
Name:FAM184A
Synonyms:C6orf60
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1140 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the FAM184 family.

Sequence caution

The sequence BAB14769.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence BAC03719.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainCoiled coil
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentextracellular space

Inferred from direct assay PubMed 22664934. Source: UniProt

Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8NB25-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: No experimental confirmation available.
Isoform 2 (identifier: Q8NB25-2)

The sequence of this isoform differs from the canonical sequence as follows:
     924-972: Missing.
     1012-1046: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: Q8NB25-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1114-1116: SPA → RYQ
     1117-1140: Missing.
Isoform 4 (identifier: Q8NB25-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-120: Missing.
     924-972: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11401140Protein FAM184A
PRO_0000089512

Regions

Coiled coil57 – 256200 Potential
Coiled coil296 – 800505 Potential
Coiled coil868 – 90740 Potential

Natural variations

Alternative sequence1 – 120120Missing in isoform 4.
VSP_044520
Alternative sequence924 – 97249Missing in isoform 2 and isoform 4.
VSP_007446
Alternative sequence1012 – 104635Missing in isoform 2.
VSP_007447
Alternative sequence1114 – 11163SPA → RYQ in isoform 3.
VSP_039102
Alternative sequence1117 – 114024Missing in isoform 3.
VSP_039103
Natural variant1741Q → H.
Corresponds to variant rs34681930 [ dbSNP | Ensembl ].
VAR_054101
Natural variant1771V → G.
Corresponds to variant rs34977570 [ dbSNP | Ensembl ].
VAR_054102
Natural variant5991D → N.
Corresponds to variant rs17827619 [ dbSNP | Ensembl ].
VAR_054103

Experimental info

Sequence conflict5461N → D in CAD98058. Ref.1
Sequence conflict6201Missing in BAC03719. Ref.4
Sequence conflict7391Q → R in BAC03719. Ref.4
Sequence conflict7951F → L in CAD98058. Ref.1
Sequence conflict8821H → R in CAD98058. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 14, 2008. Version 3.
Checksum: 6565FD0C349B37E1

FASTA1,140132,965
        10         20         30         40         50         60 
MATPGMSWQQ HYYGGSAAKF APSPATAQLA GHSMDYSQEM HLKMSKKIAQ LTKVIYALNT 

        70         80         90        100        110        120 
KNDEHESAIQ ALKDAHEEEI QQILAETREK ILQYKSKVTE ELDLRRKIQV LESSLEDHIK 

       130        140        150        160        170        180 
MKQQALTEFE AYKHRVEDMQ LCAEAQHVQR IVTMSREVEE IRRKFEEKLR SFGQLQVQFE 

       190        200        210        220        230        240 
KDKRLALEDL QAAHRREIQE LLKSQQDHSA SVNKGQEKAE ELHRMEVESL NKMLEELRLE 

       250        260        270        280        290        300 
RKKLIEDYEG KLNKAQSFYE RELDTLKRSQ LFTAESLQAS KEKEADLRKE FQGQEAILRK 

       310        320        330        340        350        360 
TIGKLKTELQ MVQDEAGSLL DKCQKLQTAL AIAENNVQVL QKQLDDAKEG EMALLSKHKE 

       370        380        390        400        410        420 
VESELAAARE RLQQQASDLV LKASHIGMLQ ATQMTQEVTI KDLESEKSRV NERLSQLEEE 

       430        440        450        460        470        480 
RAFLRSKTQS LDEEQKQQIL ELEKKVNEAK RTQQEYYERE LKNLQSRLEE EVTQLNEAHS 

       490        500        510        520        530        540 
KTLEELAWKH HMAIEAVHSN AIRDKKKLQM DLEEQHNKDK LNLEEDKNQL QQELENLKEV 

       550        560        570        580        590        600 
LEDKLNTANQ EIGHLQDMVR KSEQGLGSAE GLIASLQDSQ ERLQNELDLT KDSLKETKDA 

       610        620        630        640        650        660 
LLNVEGELEQ ERQQHEETIA AMKEEEKLKV DKMAHDLEIK WTENLRQECS KLREELRLQH 

       670        680        690        700        710        720 
EEDKKSAMSQ LLQLKDREKN AARDSWQKKV EDLLNQISLL KQNLEIQLSQ SQTSLQQLQA 

       730        740        750        760        770        780 
QFTQERQRLT QELEELEEQH QQRHKSLKEA HVLAFQTMEE EKEKEQRALE NHLQQKHSAE 

       790        800        810        820        830        840 
LQSLKDAHRE SMEGFRIEME QELQTLRFEL EDEGKAMLAS LRSELNHQHA AAIDLLRHNH 

       850        860        870        880        890        900 
HQELAAAKME LERSIDISRR QSKEHICRIT DLQEELRHRE HHISELDKEV QHLHENISAL 

       910        920        930        940        950        960 
TKELEFKGKE ILRIRSESNQ QIRLHEQDLN KRLEKELDVM TADHLREKNI MRADFNKTNE 

       970        980        990       1000       1010       1020 
LLKEINAALQ VSLEEMEEKY LMRESKPEDI QMITELKAML TERDQIIKKL IEDNKFYQLE 

      1030       1040       1050       1060       1070       1080 
LVNRETNFNK VFNSSPTVGV INPLAKQKKK NDKSPTNRFV SVPNLSALES GGVGNGHPNR 

      1090       1100       1110       1120       1130       1140 
LDPIPNSPVH DIEFNSSKPL PQPVPPKGPK TFLSPAQSEA SPVASPDPQR QEWFARYFTF 

« Hide

Isoform 2 [UniParc].

Checksum: FE34CBA8D03122B3
Show »

FASTA1,056123,198
Isoform 3 [UniParc].

Checksum: 10F25BC6E913E5C9
Show »

FASTA1,116130,330
Isoform 4 [UniParc].

Checksum: 41A5C04C5F22A3CE
Show »

FASTA971113,569

References

[1]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
Tissue: Fetal brain.
[2]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 54-1140 (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 617-1140 (ISOFORM 1).
Tissue: Brain.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 688-1140 (ISOFORM 1).
Tissue: Eye.
[6]"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."
Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. expand/collapse author list , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A.
Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 847-1140 (ISOFORM 3).
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX538186 mRNA. Translation: CAD98058.1.
AL137009, AL132874, AL365275 Genomic DNA. Translation: CAI20344.1.
AL365275, AL132874, AL137009 Genomic DNA. Translation: CAI40383.1.
AL132874, AL137009, AL365275 Genomic DNA. Translation: CAX30830.1.
CH471051 Genomic DNA. Translation: EAW48188.1.
AK024004 mRNA. Translation: BAB14769.1. Different initiation.
AK091682 mRNA. Translation: BAC03719.1. Different initiation.
BC009055 mRNA. Translation: AAH09055.2.
AL136767 mRNA. Translation: CAB66701.1.
CCDSCCDS43499.1. [Q8NB25-1]
CCDS43500.1. [Q8NB25-4]
RefSeqNP_001093881.1. NM_001100411.2. [Q8NB25-4]
NP_001275505.1. NM_001288576.1.
NP_078857.5. NM_024581.5. [Q8NB25-1]
UniGeneHs.443789.

3D structure databases

ProteinModelPortalQ8NB25.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid122762. 4 interactions.
MINTMINT-4712612.

PTM databases

PhosphoSiteQ8NB25.

Polymorphism databases

DMDM209572754.

Proteomic databases

MaxQBQ8NB25.
PaxDbQ8NB25.
PRIDEQ8NB25.

Protocols and materials databases

DNASU79632.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000338891; ENSP00000342604; ENSG00000111879. [Q8NB25-1]
ENST00000352896; ENSP00000326608; ENSG00000111879. [Q8NB25-4]
ENST00000521531; ENSP00000430442; ENSG00000111879. [Q8NB25-2]
GeneID79632.
KEGGhsa:79632.
UCSCuc003pyj.3. human. [Q8NB25-1]
uc003pyk.4. human. [Q8NB25-4]

Organism-specific databases

CTD79632.
GeneCardsGC06M119280.
HGNCHGNC:20991. FAM184A.
HPAHPA034571.
neXtProtNX_Q8NB25.
PharmGKBPA164719768.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG138283.
HOGENOMHOG000090031.
HOVERGENHBG050909.
InParanoidQ8NB25.
OMAKKTQQEY.
OrthoDBEOG7JQBMM.
PhylomeDBQ8NB25.
TreeFamTF316006.

Gene expression databases

ArrayExpressQ8NB25.
BgeeQ8NB25.
CleanExHS_FAM184A.
GenevestigatorQ8NB25.

Family and domain databases

ProtoNetSearch...

Other

ChiTaRSFAM184A. human.
GenomeRNAi79632.
NextBio68735.
PROQ8NB25.

Entry information

Entry nameF184A_HUMAN
AccessionPrimary (citable) accession number: Q8NB25
Secondary accession number(s): B9DI75 expand/collapse secondary AC list , F8W8D6, Q5TBS9, Q7Z323, Q96GY8, Q9H0J8, Q9H851
Entry history
Integrated into UniProtKB/Swiss-Prot: May 16, 2003
Last sequence update: October 14, 2008
Last modified: July 9, 2014
This is version 93 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM