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Q8NB25

- F184A_HUMAN

UniProt

Q8NB25 - F184A_HUMAN

Protein

Protein FAM184A

Gene

FAM184A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 3 (14 Oct 2008)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein FAM184A
    Gene namesi
    Name:FAM184A
    Synonyms:C6orf60
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:20991. FAM184A.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProt

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA164719768.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11401140Protein FAM184APRO_0000089512Add
    BLAST

    Proteomic databases

    MaxQBiQ8NB25.
    PaxDbiQ8NB25.
    PRIDEiQ8NB25.

    PTM databases

    PhosphoSiteiQ8NB25.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8NB25.
    BgeeiQ8NB25.
    CleanExiHS_FAM184A.
    GenevestigatoriQ8NB25.

    Organism-specific databases

    HPAiHPA034571.

    Interactioni

    Protein-protein interaction databases

    BioGridi122762. 4 interactions.
    MINTiMINT-4712612.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NB25.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili57 – 256200Sequence AnalysisAdd
    BLAST
    Coiled coili296 – 800505Sequence AnalysisAdd
    BLAST
    Coiled coili868 – 90740Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the FAM184 family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG138283.
    HOGENOMiHOG000090031.
    HOVERGENiHBG050909.
    InParanoidiQ8NB25.
    OMAiKKTQQEY.
    OrthoDBiEOG7JQBMM.
    PhylomeDBiQ8NB25.
    TreeFamiTF316006.

    Family and domain databases

    InterProiIPR029605. FAM184.
    IPR029607. FAM184A.
    [Graphical view]
    PANTHERiPTHR18870. PTHR18870. 1 hit.
    PTHR18870:SF7. PTHR18870:SF7. 1 hit.

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8NB25-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MATPGMSWQQ HYYGGSAAKF APSPATAQLA GHSMDYSQEM HLKMSKKIAQ     50
    LTKVIYALNT KNDEHESAIQ ALKDAHEEEI QQILAETREK ILQYKSKVTE 100
    ELDLRRKIQV LESSLEDHIK MKQQALTEFE AYKHRVEDMQ LCAEAQHVQR 150
    IVTMSREVEE IRRKFEEKLR SFGQLQVQFE KDKRLALEDL QAAHRREIQE 200
    LLKSQQDHSA SVNKGQEKAE ELHRMEVESL NKMLEELRLE RKKLIEDYEG 250
    KLNKAQSFYE RELDTLKRSQ LFTAESLQAS KEKEADLRKE FQGQEAILRK 300
    TIGKLKTELQ MVQDEAGSLL DKCQKLQTAL AIAENNVQVL QKQLDDAKEG 350
    EMALLSKHKE VESELAAARE RLQQQASDLV LKASHIGMLQ ATQMTQEVTI 400
    KDLESEKSRV NERLSQLEEE RAFLRSKTQS LDEEQKQQIL ELEKKVNEAK 450
    RTQQEYYERE LKNLQSRLEE EVTQLNEAHS KTLEELAWKH HMAIEAVHSN 500
    AIRDKKKLQM DLEEQHNKDK LNLEEDKNQL QQELENLKEV LEDKLNTANQ 550
    EIGHLQDMVR KSEQGLGSAE GLIASLQDSQ ERLQNELDLT KDSLKETKDA 600
    LLNVEGELEQ ERQQHEETIA AMKEEEKLKV DKMAHDLEIK WTENLRQECS 650
    KLREELRLQH EEDKKSAMSQ LLQLKDREKN AARDSWQKKV EDLLNQISLL 700
    KQNLEIQLSQ SQTSLQQLQA QFTQERQRLT QELEELEEQH QQRHKSLKEA 750
    HVLAFQTMEE EKEKEQRALE NHLQQKHSAE LQSLKDAHRE SMEGFRIEME 800
    QELQTLRFEL EDEGKAMLAS LRSELNHQHA AAIDLLRHNH HQELAAAKME 850
    LERSIDISRR QSKEHICRIT DLQEELRHRE HHISELDKEV QHLHENISAL 900
    TKELEFKGKE ILRIRSESNQ QIRLHEQDLN KRLEKELDVM TADHLREKNI 950
    MRADFNKTNE LLKEINAALQ VSLEEMEEKY LMRESKPEDI QMITELKAML 1000
    TERDQIIKKL IEDNKFYQLE LVNRETNFNK VFNSSPTVGV INPLAKQKKK 1050
    NDKSPTNRFV SVPNLSALES GGVGNGHPNR LDPIPNSPVH DIEFNSSKPL 1100
    PQPVPPKGPK TFLSPAQSEA SPVASPDPQR QEWFARYFTF 1140

    Note: No experimental confirmation available.

    Length:1,140
    Mass (Da):132,965
    Last modified:October 14, 2008 - v3
    Checksum:i6565FD0C349B37E1
    GO
    Isoform 2 (identifier: Q8NB25-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         924-972: Missing.
         1012-1046: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,056
    Mass (Da):123,198
    Checksum:iFE34CBA8D03122B3
    GO
    Isoform 3 (identifier: Q8NB25-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1114-1116: SPA → RYQ
         1117-1140: Missing.

    Show »
    Length:1,116
    Mass (Da):130,330
    Checksum:i10F25BC6E913E5C9
    GO
    Isoform 4 (identifier: Q8NB25-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-120: Missing.
         924-972: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:971
    Mass (Da):113,569
    Checksum:i41A5C04C5F22A3CE
    GO

    Sequence cautioni

    The sequence BAB14769.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAC03719.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti546 – 5461N → D in CAD98058. (PubMed:17974005)Curated
    Sequence conflicti620 – 6201Missing in BAC03719. (PubMed:14702039)Curated
    Sequence conflicti739 – 7391Q → R in BAC03719. (PubMed:14702039)Curated
    Sequence conflicti795 – 7951F → L in CAD98058. (PubMed:17974005)Curated
    Sequence conflicti882 – 8821H → R in CAD98058. (PubMed:17974005)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti174 – 1741Q → H.
    Corresponds to variant rs34681930 [ dbSNP | Ensembl ].
    VAR_054101
    Natural varianti177 – 1771V → G.
    Corresponds to variant rs34977570 [ dbSNP | Ensembl ].
    VAR_054102
    Natural varianti599 – 5991D → N.
    Corresponds to variant rs17827619 [ dbSNP | Ensembl ].
    VAR_054103

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 120120Missing in isoform 4. 1 PublicationVSP_044520Add
    BLAST
    Alternative sequencei924 – 97249Missing in isoform 2 and isoform 4. 2 PublicationsVSP_007446Add
    BLAST
    Alternative sequencei1012 – 104635Missing in isoform 2. 1 PublicationVSP_007447Add
    BLAST
    Alternative sequencei1114 – 11163SPA → RYQ in isoform 3. 1 PublicationVSP_039102
    Alternative sequencei1117 – 114024Missing in isoform 3. 1 PublicationVSP_039103Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX538186 mRNA. Translation: CAD98058.1.
    AL137009, AL132874, AL365275 Genomic DNA. Translation: CAI20344.1.
    AL365275, AL132874, AL137009 Genomic DNA. Translation: CAI40383.1.
    AL132874, AL137009, AL365275 Genomic DNA. Translation: CAX30830.1.
    CH471051 Genomic DNA. Translation: EAW48188.1.
    AK024004 mRNA. Translation: BAB14769.1. Different initiation.
    AK091682 mRNA. Translation: BAC03719.1. Different initiation.
    BC009055 mRNA. Translation: AAH09055.2.
    AL136767 mRNA. Translation: CAB66701.1.
    CCDSiCCDS43499.1. [Q8NB25-1]
    CCDS43500.1. [Q8NB25-4]
    RefSeqiNP_001093881.1. NM_001100411.2. [Q8NB25-4]
    NP_001275505.1. NM_001288576.1.
    NP_078857.5. NM_024581.5. [Q8NB25-1]
    UniGeneiHs.443789.

    Genome annotation databases

    EnsembliENST00000338891; ENSP00000342604; ENSG00000111879. [Q8NB25-1]
    ENST00000352896; ENSP00000326608; ENSG00000111879. [Q8NB25-4]
    ENST00000521531; ENSP00000430442; ENSG00000111879. [Q8NB25-2]
    GeneIDi79632.
    KEGGihsa:79632.
    UCSCiuc003pyj.3. human. [Q8NB25-1]
    uc003pyk.4. human. [Q8NB25-4]

    Polymorphism databases

    DMDMi209572754.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX538186 mRNA. Translation: CAD98058.1 .
    AL137009 , AL132874 , AL365275 Genomic DNA. Translation: CAI20344.1 .
    AL365275 , AL132874 , AL137009 Genomic DNA. Translation: CAI40383.1 .
    AL132874 , AL137009 , AL365275 Genomic DNA. Translation: CAX30830.1 .
    CH471051 Genomic DNA. Translation: EAW48188.1 .
    AK024004 mRNA. Translation: BAB14769.1 . Different initiation.
    AK091682 mRNA. Translation: BAC03719.1 . Different initiation.
    BC009055 mRNA. Translation: AAH09055.2 .
    AL136767 mRNA. Translation: CAB66701.1 .
    CCDSi CCDS43499.1. [Q8NB25-1 ]
    CCDS43500.1. [Q8NB25-4 ]
    RefSeqi NP_001093881.1. NM_001100411.2. [Q8NB25-4 ]
    NP_001275505.1. NM_001288576.1.
    NP_078857.5. NM_024581.5. [Q8NB25-1 ]
    UniGenei Hs.443789.

    3D structure databases

    ProteinModelPortali Q8NB25.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122762. 4 interactions.
    MINTi MINT-4712612.

    PTM databases

    PhosphoSitei Q8NB25.

    Polymorphism databases

    DMDMi 209572754.

    Proteomic databases

    MaxQBi Q8NB25.
    PaxDbi Q8NB25.
    PRIDEi Q8NB25.

    Protocols and materials databases

    DNASUi 79632.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000338891 ; ENSP00000342604 ; ENSG00000111879 . [Q8NB25-1 ]
    ENST00000352896 ; ENSP00000326608 ; ENSG00000111879 . [Q8NB25-4 ]
    ENST00000521531 ; ENSP00000430442 ; ENSG00000111879 . [Q8NB25-2 ]
    GeneIDi 79632.
    KEGGi hsa:79632.
    UCSCi uc003pyj.3. human. [Q8NB25-1 ]
    uc003pyk.4. human. [Q8NB25-4 ]

    Organism-specific databases

    CTDi 79632.
    GeneCardsi GC06M119280.
    HGNCi HGNC:20991. FAM184A.
    HPAi HPA034571.
    neXtProti NX_Q8NB25.
    PharmGKBi PA164719768.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG138283.
    HOGENOMi HOG000090031.
    HOVERGENi HBG050909.
    InParanoidi Q8NB25.
    OMAi KKTQQEY.
    OrthoDBi EOG7JQBMM.
    PhylomeDBi Q8NB25.
    TreeFami TF316006.

    Miscellaneous databases

    ChiTaRSi FAM184A. human.
    GenomeRNAii 79632.
    NextBioi 68735.
    PROi Q8NB25.

    Gene expression databases

    ArrayExpressi Q8NB25.
    Bgeei Q8NB25.
    CleanExi HS_FAM184A.
    Genevestigatori Q8NB25.

    Family and domain databases

    InterProi IPR029605. FAM184.
    IPR029607. FAM184A.
    [Graphical view ]
    PANTHERi PTHR18870. PTHR18870. 1 hit.
    PTHR18870:SF7. PTHR18870:SF7. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
      Tissue: Fetal brain.
    2. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 54-1140 (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 617-1140 (ISOFORM 1).
      Tissue: Brain.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 688-1140 (ISOFORM 1).
      Tissue: Eye.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 847-1140 (ISOFORM 3).
      Tissue: Testis.

    Entry informationi

    Entry nameiF184A_HUMAN
    AccessioniPrimary (citable) accession number: Q8NB25
    Secondary accession number(s): B9DI75
    , F8W8D6, Q5TBS9, Q7Z323, Q96GY8, Q9H0J8, Q9H851
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 16, 2003
    Last sequence update: October 14, 2008
    Last modified: October 1, 2014
    This is version 95 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3