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Q8NB14

- UBP38_HUMAN

UniProt

Q8NB14 - UBP38_HUMAN

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Protein
Ubiquitin carboxyl-terminal hydrolase 38
Gene
USP38, KIAA1891
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Deubiquitinating enzyme exhibiting a preference towards 'Lys-63'-linked Ubiquitin chains.1 Publication

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei454 – 4541Nucleophile By similarity
Active sitei857 – 8571Proton acceptor By similarity

GO - Molecular functioni

  1. ubiquitin-specific protease activity Source: FlyBase

GO - Biological processi

  1. protein deubiquitination Source: FlyBase
  2. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Protein family/group databases

MEROPSiC19.056.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 38 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 38
HP43.8KD
Ubiquitin thioesterase 38
Ubiquitin-specific-processing protease 38
Gene namesi
Name:USP38
Synonyms:KIAA1891
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:20067. USP38.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134880611.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10421042Ubiquitin carboxyl-terminal hydrolase 38
PRO_0000080668Add
BLAST

Proteomic databases

MaxQBiQ8NB14.
PaxDbiQ8NB14.
PRIDEiQ8NB14.

PTM databases

PhosphoSiteiQ8NB14.

Expressioni

Tissue specificityi

Highly expressed in skeletal muscle. Expressed in adrenal gland.2 Publications

Gene expression databases

ArrayExpressiQ8NB14.
BgeeiQ8NB14.
CleanExiHS_USP38.
GenevestigatoriQ8NB14.

Organism-specific databases

HPAiHPA047948.

Interactioni

Protein-protein interaction databases

BioGridi124165. 7 interactions.
IntActiQ8NB14. 6 interactions.
STRINGi9606.ENSP00000303434.

Structurei

3D structure databases

ProteinModelPortaliQ8NB14.
SMRiQ8NB14. Positions 433-633, 717-946.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini445 – 949505USP
Add
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.
Contains 1 USP domain.

Phylogenomic databases

eggNOGiCOG5560.
HOGENOMiHOG000007432.
HOVERGENiHBG060424.
InParanoidiQ8NB14.
KOiK11854.
OMAiHYYSYAR.
PhylomeDBiQ8NB14.
TreeFamiTF324529.

Family and domain databases

InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8NB14-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MDKILEGLVS SSHPLPLKRV IVRKVVESAE HWLDEAQCEA MFDLTTRLIL     50
EGQDPFQRQV GHQVLEAYAR YHRPEFESFF NKTFVLGLLH QGYHSLDRKD 100
VAILDYIHNG LKLIMSCPSV LDLFSLLQVE VLRMVCERPE PQLCARLSDL 150
LTDFVQCIPK GKLSITFCQQ LVRTIGHFQC VSTQERELRE YVSQVTKVSN 200
LLQNIWKAEP ATLLPSLQEV FASISSTDAS FEPSVALASL VQHIPLQMIT 250
VLIRSLTTDP NVKDASMTQA LCRMIDWLSW PLAQHVDTWV IALLKGLAAV 300
QKFTILIDVT LLKIELVFNR LWFPLVRPGA LAVLSHMLLS FQHSPEAFHL 350
IVPHVVNLVH SFKNDGLPSS TAFLVQLTEL IHCMMYHYSG FPDLYEPILE 400
AIKDFPKPSE EKIKLILNQS AWTSQSNSLA SCLSRLSGKS ETGKTGLINL 450
GNTCYMNSVI QALFMATDFR RQVLSLNLNG CNSLMKKLQH LFAFLAHTQR 500
EAYAPRIFFE ASRPPWFTPR SQQDCSEYLR FLLDRLHEEE KILKVQASHK 550
PSEILECSET SLQEVASKAA VLTETPRTSD GEKTLIEKMF GGKLRTHIRC 600
LNCRSTSQKV EAFTDLSLAF CPSSSLENMS VQDPASSPSI QDGGLMQASV 650
PGPSEEPVVY NPTTAAFICD SLVNEKTIGS PPNEFYCSEN TSVPNESNKI 700
LVNKDVPQKP GGETTPSVTD LLNYFLAPEI LTGDNQYYCE NCASLQNAEK 750
TMQITEEPEY LILTLLRFSY DQKYHVRRKI LDNVSLPLVL ELPVKRITSF 800
SSLSESWSVD VDFTDLSENL AKKLKPSGTD EASCTKLVPY LLSSVVVHSG 850
ISSESGHYYS YARNITSTDS SYQMYHQSEA LALASSQSHL LGRDSPSAVF 900
EQDLENKEMS KEWFLFNDSR VTFTSFQSVQ KITSRFPKDT AYVLLYKKQH 950
STNGLSGNNP TSGLWINGDP PLQKELMDAI TKDNKLYLQE QELNARARAL 1000
QAASASCSFR PNGFDDNDPP GSCGPTGGGG GGGFNTVGRL VF 1042
Length:1,042
Mass (Da):116,546
Last modified:October 10, 2003 - v2
Checksum:iD888D4F44C6E7251
GO
Isoform 2 (identifier: Q8NB14-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     990-1042: EQELNARARALQAASASCSFRPNGFDDNDPPGSCGPTGGGGGGGFNTVGRLVF → VSWKYKLYLLKILNN

Note: No experimental confirmation available.

Show »
Length:1,004
Mass (Da):113,157
Checksum:i89960B24E70287A4
GO

Sequence cautioni

The sequence BAC03730.1 differs from that shown. Reason: The absence of the residues from Tyr-840 to Ser-871 is not the result of an alternative splicing.
The sequence AAK26248.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAB71627.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei990 – 104253EQELN…GRLVF → VSWKYKLYLLKILNN in isoform 2.
VSP_054486Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti646 – 6461M → V in BAC03730. 1 Publication
Sequence conflicti919 – 9191S → G in BAB71627. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK057992 mRNA. Translation: BAB71627.1. Different initiation.
AK091712 mRNA. Translation: BAC03730.1. Sequence problems.
AK126943 mRNA. Translation: BAG54405.1.
AL833976 mRNA. Translation: CAD38820.1.
AC099549 Genomic DNA. No translation available.
AC116175 Genomic DNA. No translation available.
CH471056 Genomic DNA. Translation: EAX05075.1.
CH471056 Genomic DNA. Translation: EAX05076.1.
BC039115 mRNA. Translation: AAH39115.1.
BC068975 mRNA. Translation: AAH68975.1.
AB067478 mRNA. Translation: BAB67784.1.
AF211481 mRNA. Translation: AAK26248.1. Different initiation.
CCDSiCCDS3758.1. [Q8NB14-1]
RefSeqiNP_001277254.1. NM_001290325.1. [Q8NB14-2]
NP_001277255.1. NM_001290326.1.
NP_115946.2. NM_032557.6. [Q8NB14-1]
UniGeneiHs.480848.

Genome annotation databases

EnsembliENST00000307017; ENSP00000303434; ENSG00000170185.
ENST00000510377; ENSP00000427647; ENSG00000170185.
GeneIDi84640.
KEGGihsa:84640.
UCSCiuc003ija.4. human.
uc003ijb.3. human. [Q8NB14-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK057992 mRNA. Translation: BAB71627.1 . Different initiation.
AK091712 mRNA. Translation: BAC03730.1 . Sequence problems.
AK126943 mRNA. Translation: BAG54405.1 .
AL833976 mRNA. Translation: CAD38820.1 .
AC099549 Genomic DNA. No translation available.
AC116175 Genomic DNA. No translation available.
CH471056 Genomic DNA. Translation: EAX05075.1 .
CH471056 Genomic DNA. Translation: EAX05076.1 .
BC039115 mRNA. Translation: AAH39115.1 .
BC068975 mRNA. Translation: AAH68975.1 .
AB067478 mRNA. Translation: BAB67784.1 .
AF211481 mRNA. Translation: AAK26248.1 . Different initiation.
CCDSi CCDS3758.1. [Q8NB14-1 ]
RefSeqi NP_001277254.1. NM_001290325.1. [Q8NB14-2 ]
NP_001277255.1. NM_001290326.1.
NP_115946.2. NM_032557.6. [Q8NB14-1 ]
UniGenei Hs.480848.

3D structure databases

ProteinModelPortali Q8NB14.
SMRi Q8NB14. Positions 433-633, 717-946.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124165. 7 interactions.
IntActi Q8NB14. 6 interactions.
STRINGi 9606.ENSP00000303434.

Protein family/group databases

MEROPSi C19.056.

PTM databases

PhosphoSitei Q8NB14.

Proteomic databases

MaxQBi Q8NB14.
PaxDbi Q8NB14.
PRIDEi Q8NB14.

Protocols and materials databases

DNASUi 84640.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000307017 ; ENSP00000303434 ; ENSG00000170185 .
ENST00000510377 ; ENSP00000427647 ; ENSG00000170185 .
GeneIDi 84640.
KEGGi hsa:84640.
UCSCi uc003ija.4. human.
uc003ijb.3. human. [Q8NB14-1 ]

Organism-specific databases

CTDi 84640.
GeneCardsi GC04P144106.
HGNCi HGNC:20067. USP38.
HPAi HPA047948.
neXtProti NX_Q8NB14.
PharmGKBi PA134880611.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5560.
HOGENOMi HOG000007432.
HOVERGENi HBG060424.
InParanoidi Q8NB14.
KOi K11854.
OMAi HYYSYAR.
PhylomeDBi Q8NB14.
TreeFami TF324529.

Miscellaneous databases

ChiTaRSi USP38. human.
GenomeRNAii 84640.
NextBioi 74575.
PROi Q8NB14.

Gene expression databases

ArrayExpressi Q8NB14.
Bgeei Q8NB14.
CleanExi HS_USP38.
Genevestigatori Q8NB14.

Family and domain databases

InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
[Graphical view ]
PROSITEi PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain, Chondrocyte and Gastric mucosa.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain and Testis.
  6. "Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins."
    Nagase T., Kikuno R., Ohara O.
    DNA Res. 8:179-187(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 263-1042 (ISOFORM 1), TISSUE SPECIFICITY.
    Tissue: Brain.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 633-1042 (ISOFORM 1).
    Tissue: Adrenal gland.
  8. "Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases."
    Quesada V., Diaz-Perales A., Gutierrez-Fernandez A., Garabaya C., Cal S., Lopez-Otin C.
    Biochem. Biophys. Res. Commun. 314:54-62(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, ENZYME ACTIVITY.
  9. "Profiling ubiquitin linkage specificities of deubiquitinating enzymes with branched ubiquitin isopeptide probes."
    Iphofer A., Kummer A., Nimtz M., Ritter A., Arnold T., Frank R., van den Heuvel J., Kessler B.M., Jansch L., Franke R.
    ChemBioChem 13:1416-1420(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, LINKAGE SPECIFICITY.

Entry informationi

Entry nameiUBP38_HUMAN
AccessioniPrimary (citable) accession number: Q8NB14
Secondary accession number(s): B3KX93
, Q3ZCV1, Q8NDF5, Q96DK6, Q96PZ6, Q9BY55
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 10, 2003
Last modified: September 3, 2014
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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