Reviewed, UniProtKB/Swiss-Prot Q8NAR6 (CR058_HUMAN)

Names and origin

Protein names

Recommended name:
    Uncharacterized protein C18orf58

Gene names

Name:

C18orf58

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	391 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 391	391	Uncharacterized protein C18orf58		PRO_0000288925
Regions
	Transmembrane	109 – 129	21	Potential
	Transmembrane	138 – 158	21	Potential
	Transmembrane	208 – 228	21	Potential
	Transmembrane	361 – 381	21	Potential
	Compositional bias	325 – 352	28	Glu-rich

Sequences

	Sequence		Length	Mass (Da)
	Q8NAR6-1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 0A2CBEE625757CC5	FASTA	391	44,642
	10 20 30 40 50 60 MFIASLTIWL LCRNIVQKPV TDEAAQSNPE FENEELAEGE KIDSEEALIY EEDFNGGDGV 70 80 90 100 110 120 EGELEESTKL KMFRRLASVA SKLKEFIGNM ITTAGKVVVT ILLGSSGMML PSLTSSVYFF 130 140 150 160 170 180 VFLGLCTWWS WCRTFDPLLF SCLCVLLAIF TAGHLIGLYL YQFQFFQEAV PPNDYYARLF 190 200 210 220 230 240 GIKSVIQTDC SSTWKIIVNP DLSWYHHANP ILLLVMYYTL ATLIRIWLQE PLVQDEGTKE 250 260 270 280 290 300 EDKALACSPI QITAGRRRSL WYATHYPTDE RKLLSMTQDD YKPSDGLLVT VNGNPVDYHT 310 320 330 340 350 360 IHPSLPMENG PGKADLYSTP QYRWEPFDES SEKREEEEEE KEEFEEERSR EEKRSIKVHA 370 380 390 MVSVFQFIMK QSYICALIAM MRPGASPITA G

References

[1]

"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Teratocarcinoma.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AK092226 mRNA. Translation: BAC03832.1.
IPI	IPI00300770.
UniGene	Hs.436902
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q8NAR6.
Genome annotation databases
Ensembl	ENST00000302079; ENSP00000303316; ENSG00000168738; Homo sapiens. [Genome view]
UCSC	uc002kow.1. human.
Organism-specific databases
GeneCards	GC18M010787. GC18U900455.
HGNC	HGNC:26631. C18orf58.
PharmGKB	PA134974259.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q8NAR6.
HOVERGEN	Q8NAR6.
Gene expression databases
ArrayExpress	Q8NAR6.
Bgee	Q8NAR6.
CleanEx	HS_C18orf58.
Genevestigator	Q8NAR6.
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

CR058_HUMAN

Accession

Primary (citable) accession number: Q8NAR6

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
Last sequence update:	October 1, 2002
Last modified:	October 13, 2009
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.