Q8NAP3 (ZBT38_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger and BTB domain-containing protein 38

Gene names

Name:

ZBTB38

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1195 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Acts as a transcriptional activator. May be involved in the differentiation and/or survival of late postmitotic neurons By similarity. UniProtKB Q5EXX3
Subcellular location	Nucleus By similarity UniProtKB Q5EXX3.
Polymorphism	Genetic variations in ZBTB38 define the stature quantitative trait locus 10 (STQTL10) [MIM:612221]. Adult height is an easily observable and highly heritable complex continuous trait. Because of this, it is a model trait for studying genetic influence on quantitative traits.
Sequence similarities	Contains 1 BTB (POZ) domain. Contains 10 C2H2-type zinc fingers.
Sequence caution	The sequence BAC03868.1 differs from that shown. Reason: Frameshift at position 147.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Activator
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	positive regulation of transcription from RNA polymerase II promoter Inferred from sequence or structural similarity. Source: UniProtKB transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW sequence-specific DNA binding transcription factor activity Inferred from sequence or structural similarity. Source: UniProtKB zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1195	1195	Zinc finger and BTB domain-containing protein 38		PRO_0000047742
Regions
	Domain	33 – 100	68	BTB
	Zinc finger	342 – 364	23	C2H2-type 1
	Zinc finger	371 – 395	25	C2H2-type 2; degenerate
	Zinc finger	460 – 482	23	C2H2-type 3
	Zinc finger	488 – 510	23	C2H2-type 4
	Zinc finger	516 – 539	24	C2H2-type 5
	Zinc finger	1010 – 1032	23	C2H2-type 6
	Zinc finger	1038 – 1060	23	C2H2-type 7
	Zinc finger	1066 – 1088	23	C2H2-type 8
	Zinc finger	1094 – 1116	23	C2H2-type 9
	Zinc finger	1125 – 1147	23	C2H2-type 10
Amino acid modifications
	Modified residue	130	1	Phosphoserine Ref.4 Ref.5
	Modified residue	181	1	Phosphoserine Ref.6
	Modified residue	309	1	Phosphoserine Ref.4
Natural variations
	Natural variant	319	1	S → A. Corresponds to variant rs16851435 [ dbSNP | Ensembl ].		VAR_052917
	Natural variant	615	1	T → M. Corresponds to variant rs17787670 [ dbSNP | Ensembl ].		VAR_052918
	Natural variant	809	1	A → T. Corresponds to variant rs3732867 [ dbSNP | Ensembl ].		VAR_052919

Sequences

	Sequence		Length	Mass (Da)
	Q8NAP3 [UniParc]. Last modified July 5, 2005. Version 2. Checksum: A44561D86ACCC2D8	FASTA	1,195	134,257
	10 20 30 40 50 60 MTVMSLSRDL KDDFHSDTVL SILNEQRIRG ILCDVTIIVE DTKFKAHSNV LAASSLYFKN 70 80 90 100 110 120 IFWSHTICIS SHVLELDDLK AEVFTEILNY IYSSTVVVKR QETVTDLAAA GKKLGISFLE 130 140 150 160 170 180 DLTDRNFSNS PGPYVFCITE KGVVKEEKNE KRHEEPAITN GPRITNAFSI IETENSNNMF 190 200 210 220 230 240 SPLDLRASFK KVSDSMRTAS LCLERTDVCH EAEPVRTLAE HSYAVSSVAE AYRSQPVREH 250 260 270 280 290 300 DGSSPGNTGK ENCEALAAKP KTCRKPKTFS IPQDSDSATE NIPPPPVSNL EVNQERSPQP 310 320 330 340 350 360 AAVLTRSKSP NNEGDVHFSR EDENQSSDVP GPPAAEVPPL VYNCSCCSKA FDSSTLLSAH 370 380 390 400 410 420 MQLHKPTQEP LVCKYCNKQF TTLNRLDRHE QICMRSSHMP IPGGNQRFLE NYPTIGQNGG 430 440 450 460 470 480 SFTGPEPLLS ENRIGEFSST GSTLPDTDHM VKFVNGQMLY SCVVCKRSYV TLSSLRRHAN 490 500 510 520 530 540 VHSWRRTYPC HYCNKVFALA EYRTRHEIWH TGERRYQCIF CLETFMTYYI LKNHQKSFHA 550 560 570 580 590 600 IDHRLSISKK TANGGLKPSV YPYKLYRLLP MKCKRAPYKS YRNSSYENAR ENSQMNESAP 610 620 630 640 650 660 GTYVVQNPHS SELPTLNFQD TVNTLTNSPA IPLETSACQD IPTSANVQNA EGTKWGEEAL 670 680 690 700 710 720 KMDLDNNFYS TEVSVSSTEN AVSSDLRAGD VPVLSLSNSS ENAASVISYS GSAPSVIVHS 730 740 750 760 770 780 SQFSSVIMHS NAIAAMTSSN HRAFSDPAVS QSLKDDSKPE PDKVGRFASR PKSIKEKKKT 790 800 810 820 830 840 TSHTRGEIPE ESNYVADPGG SLSKTTNIAE ETSKIETYIA KPALPGTSTN SNVAPLCQIT 850 860 870 880 890 900 VKIGNEAIVK RHILGSKLFY KRGRRPKYQM QEEPLPQGND PEPSGDSPLG LCQSECMEMS 910 920 930 940 950 960 EVFDDASDQD STDKPWRPYY NYKPKKKSRQ LKKMRKVNWR KEHGNRSPSH KCKYPAELDC 970 980 990 1000 1010 1020 AVGKAPQDKP FEEEETKEMP KLQCELCDGD KAVGAGNQGR PHRHLTSRPY ACELCAKQFQ 1030 1040 1050 1060 1070 1080 SPSTLKMHMR CHTGEKPYQC KTCGRCFSVQ GNLQKHERIH LGLKEFVCQY CNKAFTLNET 1090 1100 1110 1120 1130 1140 LKIHERIHTG EKRYHCQFCF QRFLYLSTKR NHEQRHIREH NGKGYACFQC PKICKTAAAL 1150 1160 1170 1180 1190 GMHQKKHLFK SPSQQEKIGD VCHENSNPLE NQHFIGSEDN DQKDNIQTGV ENVVL

References

[1]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed: 16641997] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-775. Tissue: Brain.
[4]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-130 AND SER-309, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[5]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-130, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[6]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-181, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC010184 Genomic DNA. No translation available. CH471052 Genomic DNA. Translation: EAW79004.1. CH471052 Genomic DNA. Translation: EAW79005.1. AK092355 mRNA. Translation: BAC03868.1. Frameshift.
IPI	IPI01010566.
RefSeq	NP_001073881.2. NM_001080412.2.
UniGene	Hs.518301.
3D structure databases
ProteinModelPortal	Q8NAP3.
SMR	Q8NAP3. Positions 11-122, 334-542, 991-1175.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8NAP3.
PTM databases
PhosphoSite	Q8NAP3.
Polymorphism databases
DMDM	68566212.
Proteomic databases
PeptideAtlas	Q8NAP3.
PRIDE	Q8NAP3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000321464; ENSP00000372635; ENSG00000177311. ENST00000441582; ENSP00000406955; ENSG00000177311.
GeneID	253461.
KEGG	hsa:253461.
UCSC	uc003etw.1. human.
Organism-specific databases
CTD	253461.
GeneCards	GC03P141043.
H-InvDB	HIX0003727.
HGNC	HGNC:26636. ZBTB38.
HPA	HPA014865.
MIM	612218. gene. 612221. phenotype.
neXtProt	NX_Q8NAP3.
PharmGKB	PA142670542.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	HBG084299.
InParanoid	Q8NAP3.
OMA	SMRTASL.
PhylomeDB	Q8NAP3.
Gene expression databases
ArrayExpress	Q8NAP3.
Bgee	Q8NAP3.
CleanEx	HS_ZBTB38.
Genevestigator	Q8NAP3.
GermOnline	ENSG00000177311. Homo sapiens.
Family and domain databases
InterPro	IPR000210. BTB/POZ-like. IPR011333. BTB/POZ_fold. IPR013069. BTB_POZ. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Gene3D	G3DSA:3.30.710.10. BTB/POZ_fold. 1 hit. G3DSA:3.30.160.60. Znf_C2H2/integrase_DNA-bd. 6 hits.
KO	K10510.
Pfam	PF00651. BTB. 1 hit. PF00096. zf-C2H2. 5 hits. [Graphical view]
SMART	SM00225. BTB. 1 hit. SM00355. ZnF_C2H2. 10 hits. [Graphical view]
SUPFAM	SSF54695. BTB/POZ_fold. 1 hit.
PROSITE	PS50097. BTB. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 9 hits. PS50157. ZINC_FINGER_C2H2_2. 9 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	92101.
SOURCE	Search...

Entry information

Entry name

ZBT38_HUMAN

Accession

Primary (citable) accession number: Q8NAP3
Secondary accession number(s): D3DNF6

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 5, 2005
Last sequence update:	July 5, 2005
Last modified:	January 25, 2012
This is version 81 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.