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Protein

Zinc finger and SCAN domain-containing protein 4

Gene

ZSCAN4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Embryonic stem (ES) cell-specific transcription factor required to regulate ES cell pluripotency. Binds telomeres and plays a key role in genomic stability in ES cells by regulating telomere elongation. Acts as an activator of spontaneous telomere sister chromatid exchange (T-SCE) and telomere elongation in undifferentiated ES cells (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri312 – 33423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri340 – 36223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri368 – 39023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri396 – 41823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. telomere maintenance via telomere lengthening Source: UniProtKB
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and SCAN domain-containing protein 4
Alternative name(s):
Zinc finger protein 494
Gene namesi
Name:ZSCAN4
Synonyms:ZNF494
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:23709. ZSCAN4.

Subcellular locationi

Nucleus PROSITE-ProRule annotation. Chromosometelomere By similarity

GO - Cellular componenti

  1. nuclear chromosome, telomeric region Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus, Telomere

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134878313.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 433433Zinc finger and SCAN domain-containing protein 4PRO_0000047751Add
BLAST

Proteomic databases

PaxDbiQ8NAM6.
PRIDEiQ8NAM6.

PTM databases

PhosphoSiteiQ8NAM6.

Expressioni

Gene expression databases

BgeeiQ8NAM6.
CleanExiHS_ZSCAN4.
GenevestigatoriQ8NAM6.

Organism-specific databases

HPAiHPA006491.

Interactioni

Protein-protein interaction databases

BioGridi128392. 3 interactions.
IntActiQ8NAM6. 2 interactions.
MINTiMINT-1184273.
STRINGi9606.ENSP00000321963.

Structurei

3D structure databases

ProteinModelPortaliQ8NAM6.
SMRiQ8NAM6. Positions 281-419.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini44 – 12683SCAN boxPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 4 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 SCAN box domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri312 – 33423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri340 – 36223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri368 – 39023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri396 – 41823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00390000012244.
HOGENOMiHOG000146439.
HOVERGENiHBG067140.
InParanoidiQ8NAM6.
KOiK09230.
OMAiINRHCSD.
OrthoDBiEOG7CK36Z.
PhylomeDBiQ8NAM6.
TreeFamiTF337216.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR008916. Retrov_capsid_C.
IPR003309. Tscrpt_reg_SCAN.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF02023. SCAN. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 4 hits.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
PROSITEiPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NAM6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALDLRTIFQ CEPSENNLGS ENSAFQQSQG PAVQREEGIS EFSRMVLNSF
60 70 80 90 100
QDSNNSYARQ ELQRLYRIFH SWLQPEKHSK DEIISLLVLE QFMIGGHCND
110 120 130 140 150
KASVKEKWKS SGKNLERFIE DLTDDSINPP ALVHVHMQGQ EALFSEDMPL
160 170 180 190 200
RDVIVHLTKQ VNAQTTREAN MGTPSQTSQD TSLETGQGYE DEQDGWNSSS
210 220 230 240 250
KTTRVNENIT NQGNQIVSLI IIQEENGPRP EEGGVSSDNP YNSKRAELVT
260 270 280 290 300
ARSQEGSING ITFQGVPMVM GAGCISQPEQ SSPESALTHQ SNEGNSTCEV
310 320 330 340 350
HQKGSHGVQK SYKCEECPKV FKYLCHLLAH QRRHRNERPF VCPECQKGFF
360 370 380 390 400
QISDLRVHQI IHTGKKPFTC SMCKKSFSHK TNLRSHERIH TGEKPYTCPF
410 420 430
CKTSYRQSST YHRHMRTHEK ITLPSVPSTP EAS
Length:433
Mass (Da):48,957
Last modified:October 1, 2002 - v1
Checksum:i2B3061C197F2D388
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti387 – 3871E → K.
Corresponds to variant rs11668570 [ dbSNP | Ensembl ].
VAR_052926

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK092424 mRNA. Translation: BAC03886.1.
BC101738 mRNA. Translation: AAI01739.1.
BC101740 mRNA. Translation: AAI01741.1.
CCDSiCCDS12958.1.
RefSeqiNP_689890.1. NM_152677.2.
XP_006723141.1. XM_006723078.1.
UniGeneiHs.469663.

Genome annotation databases

EnsembliENST00000318203; ENSP00000321963; ENSG00000180532.
ENST00000612521; ENSP00000480210; ENSG00000180532.
GeneIDi201516.
KEGGihsa:201516.
UCSCiuc002qpu.3. human.

Polymorphism databases

DMDMi55976744.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK092424 mRNA. Translation: BAC03886.1.
BC101738 mRNA. Translation: AAI01739.1.
BC101740 mRNA. Translation: AAI01741.1.
CCDSiCCDS12958.1.
RefSeqiNP_689890.1. NM_152677.2.
XP_006723141.1. XM_006723078.1.
UniGeneiHs.469663.

3D structure databases

ProteinModelPortaliQ8NAM6.
SMRiQ8NAM6. Positions 281-419.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128392. 3 interactions.
IntActiQ8NAM6. 2 interactions.
MINTiMINT-1184273.
STRINGi9606.ENSP00000321963.

PTM databases

PhosphoSiteiQ8NAM6.

Polymorphism databases

DMDMi55976744.

Proteomic databases

PaxDbiQ8NAM6.
PRIDEiQ8NAM6.

Protocols and materials databases

DNASUi201516.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000318203; ENSP00000321963; ENSG00000180532.
ENST00000612521; ENSP00000480210; ENSG00000180532.
GeneIDi201516.
KEGGihsa:201516.
UCSCiuc002qpu.3. human.

Organism-specific databases

CTDi201516.
GeneCardsiGC19P058180.
HGNCiHGNC:23709. ZSCAN4.
HPAiHPA006491.
MIMi613419. gene.
neXtProtiNX_Q8NAM6.
PharmGKBiPA134878313.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00390000012244.
HOGENOMiHOG000146439.
HOVERGENiHBG067140.
InParanoidiQ8NAM6.
KOiK09230.
OMAiINRHCSD.
OrthoDBiEOG7CK36Z.
PhylomeDBiQ8NAM6.
TreeFamiTF337216.

Miscellaneous databases

GenomeRNAii201516.
NextBioi90160.
PROiQ8NAM6.
SOURCEiSearch...

Gene expression databases

BgeeiQ8NAM6.
CleanExiHS_ZSCAN4.
GenevestigatoriQ8NAM6.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR008916. Retrov_capsid_C.
IPR003309. Tscrpt_reg_SCAN.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF02023. SCAN. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 4 hits.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
PROSITEiPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Cerebellum.

Entry informationi

Entry nameiZSCA4_HUMAN
AccessioniPrimary (citable) accession number: Q8NAM6
Secondary accession number(s): Q3MIQ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: October 1, 2002
Last modified: January 7, 2015
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.