Q8NAM6 (ZSCA4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger and SCAN domain-containing protein 4

Alternative name(s):
Zinc finger protein 494

Gene names

Name:	ZSCAN4
Synonyms:	ZNF494

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	433 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Embryonic stem (ES) cell-specific transcription factor required to regulate ES cell pluripotency. Binds telomeres and plays a key role in genomic stability in ES cells by regulating telomere elongation. Acts as an activator of spontaneous telomere sister chromatid exchange (T-SCE) and telomere elongation in undifferentiated ES cells By similarity.
Subcellular location	Nucleus By similarity. Chromosome › telomere By similarity.
Sequence similarities	Contains 4 C2H2-type zinc fingers. Contains 1 SCAN box domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Chromosome Nucleus Telomere
Coding sequence diversity	Polymorphism
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	telomere maintenance via telomere lengthening Inferred from sequence or structural similarity. Source: UniProtKB transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW viral reproduction Inferred from electronic annotation. Source: InterPro
Cellular_component	nuclear chromosome, telomeric region Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 433	433	Zinc finger and SCAN domain-containing protein 4		PRO_0000047751
Regions
	Domain	44 – 126	83	SCAN box
	Zinc finger	312 – 334	23	C2H2-type 1
	Zinc finger	340 – 362	23	C2H2-type 2
	Zinc finger	368 – 390	23	C2H2-type 3
	Zinc finger	396 – 418	23	C2H2-type 4
Natural variations
	Natural variant	387	1	E → K. Corresponds to variant rs11668570 [ dbSNP | Ensembl ].		VAR_052926

Sequences

	Sequence		Length	Mass (Da)
	Q8NAM6 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 2B3061C197F2D388	FASTA	433	48,957
	10 20 30 40 50 60 MALDLRTIFQ CEPSENNLGS ENSAFQQSQG PAVQREEGIS EFSRMVLNSF QDSNNSYARQ 70 80 90 100 110 120 ELQRLYRIFH SWLQPEKHSK DEIISLLVLE QFMIGGHCND KASVKEKWKS SGKNLERFIE 130 140 150 160 170 180 DLTDDSINPP ALVHVHMQGQ EALFSEDMPL RDVIVHLTKQ VNAQTTREAN MGTPSQTSQD 190 200 210 220 230 240 TSLETGQGYE DEQDGWNSSS KTTRVNENIT NQGNQIVSLI IIQEENGPRP EEGGVSSDNP 250 260 270 280 290 300 YNSKRAELVT ARSQEGSING ITFQGVPMVM GAGCISQPEQ SSPESALTHQ SNEGNSTCEV 310 320 330 340 350 360 HQKGSHGVQK SYKCEECPKV FKYLCHLLAH QRRHRNERPF VCPECQKGFF QISDLRVHQI 370 380 390 400 410 420 IHTGKKPFTC SMCKKSFSHK TNLRSHERIH TGEKPYTCPF CKTSYRQSST YHRHMRTHEK 430 ITLPSVPSTP EAS

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Cerebellum.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK092424 mRNA. Translation: BAC03886.1. BC101738 mRNA. Translation: AAI01739.1. BC101740 mRNA. Translation: AAI01741.1.
IPI	IPI00168043.
RefSeq	NP_689890.1. NM_152677.2.
UniGene	Hs.469663.
3D structure databases
ProteinModelPortal	Q8NAM6.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-1184273.
STRING	9606.ENSP00000321963.
PTM databases
PhosphoSite	Q8NAM6.
Polymorphism databases
DMDM	55976744.
Proteomic databases
PaxDb	Q8NAM6.
PRIDE	Q8NAM6.
Protocols and materials databases
DNASU	201516.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000318203; ENSP00000321963; ENSG00000180532.
GeneID	201516.
KEGG	hsa:201516.
UCSC	uc002qpu.3. human.
Organism-specific databases
CTD	201516.
GeneCards	GC19P058180.
HGNC	HGNC:23709. ZSCAN4.
HPA	HPA006491.
MIM	613419. gene.
neXtProt	NX_Q8NAM6.
PharmGKB	PA134878313.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5048.
HOGENOM	HOG000146439.
HOVERGEN	HBG067140.
InParanoid	Q8NAM6.
KO	K09230.
OMA	MRTHEKI.
OrthoDB	EOG48PMK3.
PhylomeDB	Q8NAM6.
Gene expression databases
Bgee	Q8NAM6.
CleanEx	HS_ZSCAN4.
Genevestigator	Q8NAM6.
GermOnline	ENSG00000180532. Homo sapiens.
Family and domain databases
Gene3D	3.30.160.60. 4 hits.
InterPro	IPR008916. Retrov_capsid_C. IPR003309. Tscrpt_reg_SCAN. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Pfam	PF02023. SCAN. 1 hit. [Graphical view]
SMART	SM00355. ZnF_C2H2. 4 hits. [Graphical view]
SUPFAM	SSF47353. Retrov_capsid_C. 1 hit.
PROSITE	PS50804. SCAN_BOX. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 4 hits. PS50157. ZINC_FINGER_C2H2_2. 4 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	201516.
NextBio	90160.
SOURCE	Search...

Entry information

Entry name

ZSCA4_HUMAN

Accession

Primary (citable) accession number: Q8NAM6
Secondary accession number(s): Q3MIQ2

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 23, 2004
Last sequence update:	October 1, 2002
Last modified:	May 1, 2013
This is version 87 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.