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Q8NAM6 (ZSCA4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger and SCAN domain-containing protein 4
Alternative name(s):
Zinc finger protein 494
Gene names
Name:ZSCAN4
Synonyms:ZNF494
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length433 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Embryonic stem (ES) cell-specific transcription factor required to regulate ES cell pluripotency. Binds telomeres and plays a key role in genomic stability in ES cells by regulating telomere elongation. Acts as an activator of spontaneous telomere sister chromatid exchange (T-SCE) and telomere elongation in undifferentiated ES cells By similarity.

Subcellular location

Nucleus By similarity. Chromosometelomere By similarity.

Sequence similarities

Contains 4 C2H2-type zinc fingers.

Contains 1 SCAN box domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 433433Zinc finger and SCAN domain-containing protein 4
PRO_0000047751

Regions

Domain44 – 12683SCAN box
Zinc finger312 – 33423C2H2-type 1
Zinc finger340 – 36223C2H2-type 2
Zinc finger368 – 39023C2H2-type 3
Zinc finger396 – 41823C2H2-type 4

Natural variations

Natural variant3871E → K.
Corresponds to variant rs11668570 [ dbSNP | Ensembl ].
VAR_052926

Sequences

Sequence LengthMass (Da)Tools
Q8NAM6 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 2B3061C197F2D388

FASTA43348,957
        10         20         30         40         50         60 
MALDLRTIFQ CEPSENNLGS ENSAFQQSQG PAVQREEGIS EFSRMVLNSF QDSNNSYARQ 

        70         80         90        100        110        120 
ELQRLYRIFH SWLQPEKHSK DEIISLLVLE QFMIGGHCND KASVKEKWKS SGKNLERFIE 

       130        140        150        160        170        180 
DLTDDSINPP ALVHVHMQGQ EALFSEDMPL RDVIVHLTKQ VNAQTTREAN MGTPSQTSQD 

       190        200        210        220        230        240 
TSLETGQGYE DEQDGWNSSS KTTRVNENIT NQGNQIVSLI IIQEENGPRP EEGGVSSDNP 

       250        260        270        280        290        300 
YNSKRAELVT ARSQEGSING ITFQGVPMVM GAGCISQPEQ SSPESALTHQ SNEGNSTCEV 

       310        320        330        340        350        360 
HQKGSHGVQK SYKCEECPKV FKYLCHLLAH QRRHRNERPF VCPECQKGFF QISDLRVHQI 

       370        380        390        400        410        420 
IHTGKKPFTC SMCKKSFSHK TNLRSHERIH TGEKPYTCPF CKTSYRQSST YHRHMRTHEK 

       430 
ITLPSVPSTP EAS 

« Hide

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Cerebellum.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK092424 mRNA. Translation: BAC03886.1.
BC101738 mRNA. Translation: AAI01739.1.
BC101740 mRNA. Translation: AAI01741.1.
CCDSCCDS12958.1.
RefSeqNP_689890.1. NM_152677.2.
XP_006723141.1. XM_006723078.1.
UniGeneHs.469663.

3D structure databases

ProteinModelPortalQ8NAM6.
SMRQ8NAM6. Positions 36-124, 253-419.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid128392. 3 interactions.
IntActQ8NAM6. 2 interactions.
MINTMINT-1184273.
STRING9606.ENSP00000321963.

PTM databases

PhosphoSiteQ8NAM6.

Polymorphism databases

DMDM55976744.

Proteomic databases

PaxDbQ8NAM6.
PRIDEQ8NAM6.

Protocols and materials databases

DNASU201516.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000318203; ENSP00000321963; ENSG00000180532.
GeneID201516.
KEGGhsa:201516.
UCSCuc002qpu.3. human.

Organism-specific databases

CTD201516.
GeneCardsGC19P058180.
HGNCHGNC:23709. ZSCAN4.
HPAHPA006491.
MIM613419. gene.
neXtProtNX_Q8NAM6.
PharmGKBPA134878313.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000146439.
HOVERGENHBG067140.
InParanoidQ8NAM6.
KOK09230.
OMAECHKGFF.
OrthoDBEOG7CK36Z.
PhylomeDBQ8NAM6.
TreeFamTF337216.

Gene expression databases

BgeeQ8NAM6.
CleanExHS_ZSCAN4.
GenevestigatorQ8NAM6.

Family and domain databases

Gene3D3.30.160.60. 4 hits.
InterProIPR008916. Retrov_capsid_C.
IPR003309. Tscrpt_reg_SCAN.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF02023. SCAN. 1 hit.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 4 hits.
[Graphical view]
SUPFAMSSF47353. SSF47353. 1 hit.
PROSITEPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi201516.
NextBio90160.
PROQ8NAM6.
SOURCESearch...

Entry information

Entry nameZSCA4_HUMAN
AccessionPrimary (citable) accession number: Q8NAM6
Secondary accession number(s): Q3MIQ2
Entry history
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM