Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8NAM6

- ZSCA4_HUMAN

UniProt

Q8NAM6 - ZSCA4_HUMAN

Protein

Zinc finger and SCAN domain-containing protein 4

Gene

ZSCAN4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Embryonic stem (ES) cell-specific transcription factor required to regulate ES cell pluripotency. Binds telomeres and plays a key role in genomic stability in ES cells by regulating telomere elongation. Acts as an activator of spontaneous telomere sister chromatid exchange (T-SCE) and telomere elongation in undifferentiated ES cells By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri312 – 33423C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri340 – 36223C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri368 – 39023C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri396 – 41823C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. telomere maintenance via telomere lengthening Source: UniProtKB
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger and SCAN domain-containing protein 4
    Alternative name(s):
    Zinc finger protein 494
    Gene namesi
    Name:ZSCAN4
    Synonyms:ZNF494
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:23709. ZSCAN4.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation. Chromosometelomere By similarity

    GO - Cellular componenti

    1. nuclear chromosome, telomeric region Source: UniProtKB

    Keywords - Cellular componenti

    Chromosome, Nucleus, Telomere

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134878313.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 433433Zinc finger and SCAN domain-containing protein 4PRO_0000047751Add
    BLAST

    Proteomic databases

    PaxDbiQ8NAM6.
    PRIDEiQ8NAM6.

    PTM databases

    PhosphoSiteiQ8NAM6.

    Expressioni

    Gene expression databases

    BgeeiQ8NAM6.
    CleanExiHS_ZSCAN4.
    GenevestigatoriQ8NAM6.

    Organism-specific databases

    HPAiHPA006491.

    Interactioni

    Protein-protein interaction databases

    BioGridi128392. 3 interactions.
    IntActiQ8NAM6. 2 interactions.
    MINTiMINT-1184273.
    STRINGi9606.ENSP00000321963.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NAM6.
    SMRiQ8NAM6. Positions 36-124, 253-419.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini44 – 12683SCAN boxPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 4 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 SCAN box domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri312 – 33423C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri340 – 36223C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri368 – 39023C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri396 – 41823C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000146439.
    HOVERGENiHBG067140.
    InParanoidiQ8NAM6.
    KOiK09230.
    OMAiECHKGFF.
    OrthoDBiEOG7CK36Z.
    PhylomeDBiQ8NAM6.
    TreeFamiTF337216.

    Family and domain databases

    Gene3Di3.30.160.60. 4 hits.
    InterProiIPR008916. Retrov_capsid_C.
    IPR003309. Tscrpt_reg_SCAN.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF02023. SCAN. 1 hit.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 4 hits.
    [Graphical view]
    SUPFAMiSSF47353. SSF47353. 1 hit.
    PROSITEiPS50804. SCAN_BOX. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 4 hits.
    PS50157. ZINC_FINGER_C2H2_2. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NAM6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALDLRTIFQ CEPSENNLGS ENSAFQQSQG PAVQREEGIS EFSRMVLNSF    50
    QDSNNSYARQ ELQRLYRIFH SWLQPEKHSK DEIISLLVLE QFMIGGHCND 100
    KASVKEKWKS SGKNLERFIE DLTDDSINPP ALVHVHMQGQ EALFSEDMPL 150
    RDVIVHLTKQ VNAQTTREAN MGTPSQTSQD TSLETGQGYE DEQDGWNSSS 200
    KTTRVNENIT NQGNQIVSLI IIQEENGPRP EEGGVSSDNP YNSKRAELVT 250
    ARSQEGSING ITFQGVPMVM GAGCISQPEQ SSPESALTHQ SNEGNSTCEV 300
    HQKGSHGVQK SYKCEECPKV FKYLCHLLAH QRRHRNERPF VCPECQKGFF 350
    QISDLRVHQI IHTGKKPFTC SMCKKSFSHK TNLRSHERIH TGEKPYTCPF 400
    CKTSYRQSST YHRHMRTHEK ITLPSVPSTP EAS 433
    Length:433
    Mass (Da):48,957
    Last modified:October 1, 2002 - v1
    Checksum:i2B3061C197F2D388
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti387 – 3871E → K.
    Corresponds to variant rs11668570 [ dbSNP | Ensembl ].
    VAR_052926

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK092424 mRNA. Translation: BAC03886.1.
    BC101738 mRNA. Translation: AAI01739.1.
    BC101740 mRNA. Translation: AAI01741.1.
    CCDSiCCDS12958.1.
    RefSeqiNP_689890.1. NM_152677.2.
    XP_006723141.1. XM_006723078.1.
    UniGeneiHs.469663.

    Genome annotation databases

    EnsembliENST00000318203; ENSP00000321963; ENSG00000180532.
    GeneIDi201516.
    KEGGihsa:201516.
    UCSCiuc002qpu.3. human.

    Polymorphism databases

    DMDMi55976744.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK092424 mRNA. Translation: BAC03886.1 .
    BC101738 mRNA. Translation: AAI01739.1 .
    BC101740 mRNA. Translation: AAI01741.1 .
    CCDSi CCDS12958.1.
    RefSeqi NP_689890.1. NM_152677.2.
    XP_006723141.1. XM_006723078.1.
    UniGenei Hs.469663.

    3D structure databases

    ProteinModelPortali Q8NAM6.
    SMRi Q8NAM6. Positions 36-124, 253-419.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 128392. 3 interactions.
    IntActi Q8NAM6. 2 interactions.
    MINTi MINT-1184273.
    STRINGi 9606.ENSP00000321963.

    PTM databases

    PhosphoSitei Q8NAM6.

    Polymorphism databases

    DMDMi 55976744.

    Proteomic databases

    PaxDbi Q8NAM6.
    PRIDEi Q8NAM6.

    Protocols and materials databases

    DNASUi 201516.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000318203 ; ENSP00000321963 ; ENSG00000180532 .
    GeneIDi 201516.
    KEGGi hsa:201516.
    UCSCi uc002qpu.3. human.

    Organism-specific databases

    CTDi 201516.
    GeneCardsi GC19P058180.
    HGNCi HGNC:23709. ZSCAN4.
    HPAi HPA006491.
    MIMi 613419. gene.
    neXtProti NX_Q8NAM6.
    PharmGKBi PA134878313.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000146439.
    HOVERGENi HBG067140.
    InParanoidi Q8NAM6.
    KOi K09230.
    OMAi ECHKGFF.
    OrthoDBi EOG7CK36Z.
    PhylomeDBi Q8NAM6.
    TreeFami TF337216.

    Miscellaneous databases

    GenomeRNAii 201516.
    NextBioi 90160.
    PROi Q8NAM6.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8NAM6.
    CleanExi HS_ZSCAN4.
    Genevestigatori Q8NAM6.

    Family and domain databases

    Gene3Di 3.30.160.60. 4 hits.
    InterProi IPR008916. Retrov_capsid_C.
    IPR003309. Tscrpt_reg_SCAN.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF02023. SCAN. 1 hit.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 4 hits.
    [Graphical view ]
    SUPFAMi SSF47353. SSF47353. 1 hit.
    PROSITEi PS50804. SCAN_BOX. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 4 hits.
    PS50157. ZINC_FINGER_C2H2_2. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Cerebellum.

    Entry informationi

    Entry nameiZSCA4_HUMAN
    AccessioniPrimary (citable) accession number: Q8NAM6
    Secondary accession number(s): Q3MIQ2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 23, 2004
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3